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M. Swingle · SciRah

Researcher profile · Semantic Scholar

M. Swingle

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M. Swingle — researcher profile on SciRah

h-index: 15
Works: 35
Citations: 1,277

Most-cited papers

Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse.
M. Swingle, Li Ni, R. Honkanen
2007Methods in molecular biology302 citations Open access
Semantic Scholar
Natal homing in juvenile loggerhead turtles (Caretta caretta)
B. Bowen, A. Bass, S. Chow, Meredith A. Bostrom +15 more
2004Molecular Ecology191 citations
Semantic Scholar
Structural Basis for the Catalytic Activity of Human Serine/Threonine Protein Phosphatase-5*
M. Swingle, R. Honkanen, E. Ciszak
2004Journal of Biological Chemistry104 citations Open access
Semantic Scholar
Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition.
S. Buck, C. Hardouin, S. Ichikawa, D. R. Soenen +6 more
2003Journal of the American Chemical Society104 citations
Semantic Scholar
Serine / threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling
D. Dean, G. Urban, I. Aragon, M. Swingle +5 more
2001BMC Cell Biology76 citations Open access
Semantic Scholar
Cardioprotection by Mild Hypothermia During Ischemia Involves Preservation of ERK Activity
Xiu-Lan Yang, Yan-Ping Liu, Xi-Ming Yang, Fan Hu +7 more
2011Basic Research in Cardiology64 citations Open access
Semantic Scholar
Structure-Activity Relationship Studies of Fostriecin, Cytostatin, and Key Analogs, with PP1, PP2A, PP5, and (β12–β13)-Chimeras (PP1/PP2A and PP5/PP2A), Provide Further Insight into the Inhibitory Actions of Fostriecin Family Inhibitors
M. Swingle, Lauren Amable, B. Lawhorn, S. Buck +5 more
2009Journal of Pharmacology and Experimental Therapeutics56 citations Open access
Semantic Scholar
The Antitumor Drug LB-100 is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active Site Catalytic Metals in PPP5C
B. D’Arcy, M. Swingle, C. M. Papke, Kevin A. Abney +3 more
2019Molecular Cancer Therapeutics54 citations Open access
Semantic Scholar
PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors
M. S. Choy, M. Swingle, B. D’Arcy, Kevin A. Abney +5 more
2017Journal of the American Chemical Society49 citations Open access
Semantic Scholar
Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition.
B. Lawhorn, S. B. Boga, S. Wolkenberg, David A. Colby +5 more
2006Journal of the American Chemical Society42 citations Open access
Semantic Scholar
A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth
C. M. Papke, Kali A. Smolen, M. Swingle, Lauren E. Cressey +8 more
2021Journal of Biological Chemistry41 citations Open access
Semantic Scholar
Total Synthesis and Evaluation of Phostriecin and Key Structural Analogues
C. Burke, M. Swingle, R. Honkanen, D. Boger
2010Journal of Organic Chemistry29 citations Open access
Semantic Scholar
Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C
D. Chattopadhyay, M. Swingle, E. A. Salter, E. Wood +15 more
2016Biochemical Pharmacology28 citations Open access
Semantic Scholar
Inhibitors of Serine/Threonine Protein Phosphatases: Biochemical and Structural Studies Provide Insight for Further Development
M. Swingle, R. Honkanen
2019Current Medicinal Chemistry27 citations Open access
Semantic Scholar
B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan’s syndrome mutations
Cheng-Guo Wu, V. Balakrishnan, Ronald A. Merrill, P. S. Parihar +15 more
2023Proceedings of the National Academy of Sciences of the United States of America19 citations Open access
Semantic Scholar
Development and Validation of a Robust and Sensitive Assay for the Discovery of Selective Inhibitors for Serine/Threonine Protein Phosphatases PP1α (PPP1C) and PP5 (PPP5C)
M. Swingle, R. Honkanen
2014Assay and drug development technologies13 citations Open access
Semantic Scholar
Quantitative proteomics and phosphoproteomics of PP2A-PPP2R5D variants reveal deregulation of RPS6 phosphorylation via converging signaling cascades
Kali A. Smolen, C. M. Papke, M. Swingle, A. Musiyenko +5 more
2023Journal of Biological Chemistry12 citations Open access
Semantic Scholar
Rehabilitation and homing behavior of a satellite-tracked harbor porpoise (Phocoena phocoena)
David T. Schofield, G. Early, F. Wenzel, K. Matassa +6 more
200812 citations
Semantic Scholar
Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth
Leia C. Shuhaibar, N. Kaci, J. Egbert, Thibault Horville +9 more
2021JCI Insight11 citations Open access
Semantic Scholar
An Ultra-High Throughput Screen for catalytic Inhibitors of Serine /Threonine Protein Phosphatases Types 1 and 5 (PP1C and PP5C)
M. Swingle, C. Volmar, S. Saldanha, P. Chase +8 more
2016SLAS discovery : advancing life sciences R & D7 citations Open access
Semantic Scholar
Quantum-based modeling implies that bidentate Arg89-substrate binding enhances serine/threonine protein phosphatase-2A(PPP2R5D/PPP2R1A/PPP2CA)-mediated dephosphorylation
E. A. Salter, A. Wierzbicki, R. Honkanen, M. Swingle
2023Frontiers in Cell and Developmental Biology6 citations Open access
Semantic Scholar
Total Synthesis and Evaluation of Cytostatin, Its C10—C11 Diastereomers, and Additional Key Analogues: Impact on PP2A Inhibition.
B. Lawhorn, S. B. Boga, S. Wolkenberg, David A. Colby +5 more
20076 citations
Semantic Scholar
Development of a Synthetic 3-ketosteroid Δ1-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells
B. D’Arcy, M. Swingle, L. Schambeau, L. Pannell +2 more
2019Scientific Reports5 citations Open access
Semantic Scholar
The phosphatase activity of the PPP2R5D-PP2A holoenzyme modulates liprin-α1 liquid-liquid phase separation
Abigail Mayer, Rita Derua, Elijah Spahn, Iris Verbinnen +7 more
2025Journal of Biological Chemistry4 citations Open access
Semantic Scholar
Using nanobodies for breast cancer treatment.
S. L. Galappaththi, M. Swingle
2025Journal of Pharmacology and Experimental Therapeutics3 citations
Semantic Scholar
The role of liprin-α1 phosphorylation in its liquid-liquid phase separation: regulation by PPP2R5D/PP2A holoenzyme
Abigail Mayer, Rita Derua, Elijah Spahn, Iris Verbinnen +6 more
2024bioRxiv3 citations Open access
Semantic Scholar
[39] Photoreceptor serine/threonine protein phosphatase type 7: Cloning, expression, and functional analysis
Xizhong Huang, M. Swingle, R. Honkanen
20003 citations
Semantic Scholar
Photoreceptor serine/threonine protein phosphatase type 7: cloning, expression, and functional analysis.
X. Huang, M. Swingle, R. Honkanen
2000Methods in Enzymology2 citations
Semantic Scholar
Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme
Cheng-Guo Wu, V. Balakrishnan, P. S. Parihar, Kirill Konovolov +15 more
2023bioRxiv1 citations Open access
Semantic Scholar
The phosphatase inhibitor LB-100 acts synergistically with the NPR2 agonist BMN-111 to improve bone growth
Leia C. Shuhaibar, N. Kaci, J. Egbert, L. Loisay +7 more
2020bioRxiv1 citations Open access
Semantic Scholar
Co-crystal structures of PP5 in complex with 5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
D. Chattopadhyay, M. Swingle, E. A. Salter, A. Wierzbicki +1 more
20161 citations
Semantic Scholar
Structure of serine/threonine protein phosphatase 5
M. Swingle, R. Honkanen, E. Ciszak
20041 citations
Semantic Scholar
PPM1B utilizes a trinuclear metal architecture for phosphatase activity
R. Stevens, V. Solodushko, A. Wierzbicki, T. C. Rich +13 more
2026bioRxiv0 citations Open access
Semantic Scholar
Structure of PP5C with LB-100; 7-oxabicyclo[2.2.1]heptane-2,3-dicarbonyl moiety modeled in the density
B. D’Arcy, M. Swingle, R. Honkanen, Aishwarya Prakash
20180 citations
Semantic Scholar
Synthesis of Cytostatin
B. Lawhorn, S. B. Boga, S. Wolkenberg, David A. Colby +5 more
20070 citations
Semantic Scholar

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