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E. Scolnick · SciRah

Researcher profile · Semantic Scholar

E. Scolnick

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E. Scolnick — researcher profile on SciRah

h-index: 99
Works: 362
Citations: 52K

Most-cited papers

Biological Insights From 108 Schizophrenia-Associated Genetic Loci
S. Ripke, B. Neale, A. Corvin, J. Walters +296 more
2014Nature7,486 citations Open access
Semantic Scholar
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
S. H. S. B. M. S. V. S. M. R. H. B. Lee Ripke Neale Faraone Purcell Perlis Mowry Thapa, Hong S. Lee, S. Ripke, B. Neale +367 more
2013Nature Genetics2,210 citations Open access
Semantic Scholar
De novo mutations in schizophrenia implicate synaptic networks
M. Fromer, A. Pocklington, D. Kavanagh, H. Williams +28 more
2014Nature1,629 citations Open access
Semantic Scholar
Rare chromosomal deletions and duplications increase risk of schizophrenia
Jennifer L. Stone, M. O'Donovan, H. Gurling, G. Kirov +70 more
2008Nature1,531 citations Open access
Semantic Scholar
A polygenic burden of rare disruptive mutations in schizophrenia
S. Purcell, J. Moran, M. Fromer, D. Ruderfer +28 more
2014Nature1,472 citations Open access
Semantic Scholar
A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects: CNV Analysis Group and the Schizophrenia Working Group of the Psychiatric Genomics Consortium
C. Marshall, D. Howrigan, D. Merico, B. Thiruvahindrapuram +265 more
2016bioRxiv1,294 citations Open access
Semantic Scholar
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
Manuel A. R. Ferreira, M. O'Donovan, Y. Meng, I. Jones +58 more
2008Nature Genetics1,282 citations Open access
Semantic Scholar
Distinct mechanism for antidepressant activity by blockade of central substance P receptors.
M. Kramer, N. Cutler, J. Feighner, R. Shrivastava +23 more
1998Science1,058 citations
Semantic Scholar
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
C. Marshall, D. Howrigan, D. Merico, B. Thiruvahindrapuram +259 more
2016Nature Genetics959 citations Open access
Semantic Scholar
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
Colm Lizzy Phil H Laramie Neelroop N Stephen Stephan Be O'Dushlaine Rossin Lee Duncan Parikshak Newhouse R, C. O'Dushlaine, L. Rossin, P. Lee +372 more
2015Nature Neuroscience765 citations Open access
Semantic Scholar
Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia
S. Ripke, C. O'Dushlaine, K. Chambert, J. Moran +163 more
2013Nature Genetics757 citations Open access
Semantic Scholar
Validating therapeutic targets through human genetics
R. Plenge, E. Scolnick, D. Altshuler
2013Nature reviews. Drug discovery700 citations
Semantic Scholar
Rare coding variants in 10 genes confer substantial risk for schizophrenia
T. Singh, T. Poterba, D. Curtis, H. Akil +107 more
2022Nature687 citations Open access
Semantic Scholar
Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes
D. Ruderfer, S. Ripke, A. McQuillin, J. Boocock +496 more
2018Cell675 citations Open access
Semantic Scholar
Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor.
N. Kohl, S. Mosser, S. Desolms, E. Giuliani +6 more
1993Science602 citations
Semantic Scholar
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder The International Schizophrenia
N. Wray, Jennifer L. Stone, P. M. Visscher, M. O'Donovan +60 more
2010518 citations
Semantic Scholar
Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life.
D. Charney, C. Reynolds, L. Lewis, B. Lebowitz +35 more
2003Archives of General Psychiatry474 citations
Semantic Scholar
Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions
S. Raychaudhuri, R. Plenge, E. Rossin, A. Ng +6 more
2009PLoS Genetics471 citations Open access
Semantic Scholar
N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-d-aspartate receptor activity
C. Sur, P. Mallorga, M. Wittmann, M. Jacobson +6 more
2003Proceedings of the National Academy of Sciences of the United States of America301 citations Open access
Semantic Scholar
Copy Number Variation in Schizophrenia in Sweden
J. Szatkiewicz, C. O'Dushlaine, Guan-Hua Chen, K. Chambert +21 more
2014Molecular Psychiatry269 citations Open access
Semantic Scholar
Cure therapeutics and strategic prevention: raising the bar for mental health research
T. Insel, E. Scolnick
2006Molecular Psychiatry252 citations
Semantic Scholar
Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.
J. Gibbs, D. Pompliano, S. Mosser, E. Rands +5 more
1993Journal of Biological Chemistry236 citations Open access
Semantic Scholar
Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder
R. Maier, G. Moser, Guo-Bo Chen, S. Ripke +373 more
2015American Journal of Human Genetics226 citations Open access
Semantic Scholar
Recurrence risks for schizophrenia in a Swedish National Cohort
P. Lichtenstein, Camilla Björk, C. Hultman, E. Scolnick +2 more
2006Psychological Medicine206 citations
Semantic Scholar
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder
You-Fang Liu, D. Blackwood, S. Caesar, E. de Geus +40 more
2011Molecular Psychiatry198 citations Open access
Semantic Scholar
The Future of Psychiatric Research: Genomes and Neural Circuits
H. Akil, S. Brenner, E. Kandel, K. Kendler +4 more
2010Science173 citations Open access
Semantic Scholar
Anthrax lethal factor inhibition
W. Shoop, Y. Xiong, J. Wiltsie, A. Woods +20 more
2005Proceedings of the National Academy of Sciences of the United States of America171 citations Open access
Semantic Scholar
A Genomewide Association Study of Response to Lithium for Prevention of Recurrence in Bipolar Disorder
R. Perlis, J. Smoller, Manuel A. R. Ferreira, A. McQuillin +8 more
2009American Journal of Psychiatry154 citations Open access
Semantic Scholar
Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.
M. Mutsuddi, D. Morris, Skye G. Waggoner, M. Daly +2 more
2006American Journal of Human Genetics131 citations Open access
Semantic Scholar
Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry
T. Bigdeli, G. Genovese, Penelope Georgakopoulos, J. Meyers +54 more
2019Molecular Psychiatry117 citations Open access
Semantic Scholar
AKT Kinase Activity Is Required for Lithium to Modulate Mood-Related Behaviors in Mice
Jen Q. Pan, M. Lewis, J. Ketterman, Elizabeth L. Clore +12 more
2011Neuropsychopharmacology115 citations Open access
Semantic Scholar
Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia
T. Singh, T. Poterba, David Curtis, H. Akil +106 more
2020medRxiv111 citations Open access
Semantic Scholar
Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues
Sarah E. Williams, Maxence Noel, Sylvain D. Lehoux, Murat Çetinbas +6 more
2022Nature Communications109 citations Open access
Semantic Scholar
A peptide-based fluorescence resonance energy transfer assay for Bacillus anthracis lethal factor protease
R. Cummings, S. Salowe, B. R. Cunningham, J. Wiltsie +6 more
2002Proceedings of the National Academy of Sciences of the United States of America101 citations Open access
Semantic Scholar
Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers
F. Wagner, Y.-L. Zhang, D. Fass, N. Joseph +17 more
2014Chemical Science100 citations Open access
Semantic Scholar
Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog selective inhibitors for use in acute myeloid leukemia
F. Wagner, L. Benajiba, Arthur J. Campbell, M. Weïwer +26 more
2018Science Translational Medicine98 citations Open access
Semantic Scholar
Developing novel treatments for mood disorders: accelerating discovery.
C. Tamminga, C. Nemeroff, R. Blakely, L. Brady +17 more
2002Biological Psychiatry94 citations
Semantic Scholar
Regulation of gene expression by lithium and depletion of inositol in slices of adult rat cortex.
P. Brandish, M. Su, D. Holder, P. Hodor +13 more
2005Neuron84 citations Open access
Semantic Scholar
Scintillation proximity assay of inositol phosphates in cell extracts: high-throughput measurement of G-protein-coupled receptor activation.
P. Brandish, L. Hill, Wei Zheng, E. Scolnick
2003Analytical Biochemistry82 citations
Semantic Scholar
Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.
F. Wagner, J. Bishop, J. Gale, Xi Shi +32 more
2016ACS Chemical Biology69 citations Open access
Semantic Scholar
Aberrant glycosylation in schizophrenia: A review of 25 years of post-mortem brain studies
Sarah E. Williams, R. Mealer, E. Scolnick, J. Smoller +1 more
2020Molecular Psychiatry67 citations Open access
Semantic Scholar
Glycobiology and schizophrenia: A biological hypothesis emerging from genomic research
R. Mealer, Sarah E. Williams, M. Daly, E. Scolnick +2 more
2020Molecular Psychiatry66 citations Open access
Semantic Scholar
Support of association between BRD1 and both schizophrenia and bipolar affective disorder
M. Nyegaard, J. Severinsen, T. Als, A. Hedemand +17 more
2010American Journal of Medical Genetics Part B: Neuropsychiatric Genetics57 citations Open access
Semantic Scholar
Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome
Patrick K. McCamphill, Laura J Stoppel, R. Senter, M. Lewis +13 more
2020Science Translational Medicine55 citations Open access
Semantic Scholar
A Cell-Based Ultra-High-Throughput Screening Assay for Identifying Inhibitors of D-Amino Acid Oxidase
P. Brandish, Chi-Sung Chiu, Jonathan E. Schneeweis, N. Brandon +5 more
2006Journal of biomolecular screening55 citations Open access
Semantic Scholar
The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation
R. Mealer, B. Jenkins, Chia-Yen Chen, M. Daly +11 more
2020Scientific Reports54 citations Open access
Semantic Scholar
The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection.
Y. Xiong, J. Wiltsie, A. Woods, Jian Guo +15 more
2006Bioorganic & Medicinal Chemistry Letters48 citations Open access
Semantic Scholar
An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis
D. Morris, R. Pearson, P. Cormican, E. Kenny +52 more
2014Human Molecular Genetics44 citations Open access
Semantic Scholar
Functional Analysis of Rare Variants Found in Schizophrenia Implicates a Critical Role for GIT1-PAK3 Signaling in Neuroplasticity
M. J. Kim, J. Biag, D. Fass, M. Lewis +11 more
2016Molecular Psychiatry38 citations Open access
Semantic Scholar
AAK1 Identified as an Inhibitor of Neuregulin-1/ErbB4-Dependent Neurotrophic Factor Signaling Using Integrative Chemical Genomics and Proteomics
Le-Tian Kuai, Shao-En Ong, J. Madison, Xiang Wang +10 more
2011Chemistry and Biology37 citations Open access
Semantic Scholar

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