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Heather L. Osswald · SciRah

Researcher profile · Semantic Scholar

Heather L. Osswald

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Heather L. Osswald — researcher profile on SciRah

h-index: 16
Works: 26
Citations: 1,381

Most-cited papers

Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS
A. Ghosh, Heather L. Osswald, Gary Prato
2016Journal of Medicinal Chemistry381 citations Open access
Semantic Scholar
BACE1 (β-Secretase) Inhibitors for the Treatment of Alzheimer's Disease
A. Ghosh, Heather L. Osswald
2014Chemical Society Reviews281 citations Open access
Semantic Scholar
Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro)
S. Tomar, Melanie L. Johnston, S. E. St. John, Heather L. Osswald +5 more
2015Journal of Biological Chemistry136 citations Open access
Semantic Scholar
Coronaviruses Resistant to a 3C-Like Protease Inhibitor Are Attenuated for Replication and Pathogenesis, Revealing a Low Genetic Barrier but High Fitness Cost of Resistance
Xu-Fang Deng, S. StJohn, Heather L. Osswald, A. O'Brien +5 more
2014Journal of Virology85 citations Open access
Semantic Scholar
A Mouse Model for Betacoronavirus Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant
S. Agnihothram, B. Yount, Eric F. Donaldson, Jeremy Huynh +15 more
2014mBio69 citations Open access
Semantic Scholar
Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-like Oxotricyclic Core as the P2-Ligand to Combat Multidrug-Resistant HIV Variants
A. Ghosh, Kalapala Venkateswara Rao, Prasanth R. Nyalapatla, Heather L. Osswald +9 more
2017Journal of Medicinal Chemistry62 citations Open access
Semantic Scholar
Highly Potent HIV-1 Protease Inhibitors with Novel Tricyclic P2-ligands: Design, Synthesis, and Protein-ligand X-Ray Studies
A. Ghosh, Garth L. Parham, C. Martyr, Prasanth R. Nyalapatla +6 more
2013Journal of Medicinal Chemistry46 citations Open access
Semantic Scholar
A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency
M. Aoki, H. Hayashi, Kalapala Venkateswara Rao, D. Das +18 more
2017eLife42 citations Open access
Semantic Scholar
Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants
A. Ghosh, Kalapala Venkateswara Rao, Prasanth R. Nyalapatla, Satish Kovela +9 more
2018ChemMedChem40 citations Open access
Semantic Scholar
Modular, stereocontrolled Cβ–H/Cα–C activation of alkyl carboxylic acids
Ming Shang, K. S. Feu, Julien C. Vantourout, Lisa M Barton +15 more
2019Proceedings of the National Academy of Sciences of the United States of America36 citations Open access
Semantic Scholar
Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2-ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis
A. Ghosh, Prasanth R. Nyalapatla, Satish Kovela, Kalapala Venkateswara Rao +8 more
2018Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Structure-based Design of Potent HIV-1 Protease Inhibitors with Modified P1 - Biphenyl Ligands: Synthesis, Biological Evaluation, and Enzyme-inhibitor X-ray Structural studies
A. Ghosh, Xu-Fen Yu, Heather L. Osswald, J. Agniswamy +4 more
2015Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies
A. Ghosh, Satish Kovela, Heather L. Osswald, Masayuki Amano +5 more
2020Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
X-Ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: structural implications for drug design
S. E. St. John, Matthew D. Therkelsen, Prasanth R. Nyalapatla, Heather L. Osswald +2 more
2015Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Design and Synthesis of Potent Macrocyclic HIV-1 Protease Inhibitors Involving P1-P2 Ligands
A. Ghosh, G. Schiltz, L. Rusere, Heather L. Osswald +3 more
2014Organic and biomolecular chemistry18 citations Open access
Semantic Scholar
Simultaneous Online Monitoring of Multiple Reactions Using a Miniature Mass Spectrometer.
Christopher J. Pulliam, R. M. Bain, Heather L. Osswald, Dalton T. Snyder +4 more
2017Analytical Chemistry17 citations Open access
Semantic Scholar
Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation
A. Ghosh, Heather L. Osswald, Kristof Glauninger, J. Agniswamy +5 more
2016Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
The Design, Development, and Evaluation of BACE1 Inhibitors for the Treatment of Alzheimer’s Disease
A. Ghosh, E. L. Cárdenas, Heather L. Osswald
201614 citations
Semantic Scholar
Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation and Protein-ligand X-ray Studies
A. Ghosh, C. Martyr, Heather L. Osswald, Venkata Reddy Sheri +8 more
2015Journal of Medicinal Chemistry14 citations Open access
Semantic Scholar
Diversity-oriented synthesis encoded by deoxyoligonucleotides
L. Hudson, J. W. Mason, Matthias V. Westphal, Matthieu J. R. Richter +30 more
2023Nature Communications13 citations Open access
Semantic Scholar
Enantioselective Synthesis of Dioxatriquinane Structural Motifs for HIV-1 Protease Inhibitors Using a Cascade Radical Cyclization
A. Ghosh, Chun-Xiao Xu, Heather L. Osswald
2015Tetrahedron Letters6 citations Open access
Semantic Scholar
Design, Synthesis, and X-Ray Studies of Potent HIV-1 Protease Inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands.
A. Ghosh, R. Jadhav, Hannah M. Simpson, Satish Kovela +6 more
2018European journal of medicinal chemistry4 citations Open access
Semantic Scholar
Generative Molecular Design and Experimental Validation of Selective Histamine H1 Inhibitors
K. McLoughlin, Da Shi, J. Mast, J. Bucci +12 more
2023bioRxiv3 citations Open access
Semantic Scholar
Diversity-oriented synthesis encoded by deoxyoligonucleotides
L. Hudson, J. W. Mason, Matthias V. Westphal, Matthieu J. R. Richter +30 more
2023bioRxiv0 citations Open access
Semantic Scholar
Front Cover: Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants (ChemMedChem 8/2018)
A. Ghosh, K. Rao, Prasanth R. Nyalapatla, Satish Kovela +9 more
20180 citations Open access
Semantic Scholar
Structure-Based Design and Synthesis of Novel Inhibitors of HIV-1 Protease and Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1
Heather L. Osswald
20170 citations
Semantic Scholar

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A. Ghosh×20
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A. Ghosh — researcher profile on SciRah
H. Mitsuya×12
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H. Mitsuya — researcher profile on SciRah
J. Agniswamy×10
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J. Agniswamy — researcher profile on SciRah
Yuan-Fang Wang×10
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Yuan-Fang Wang — researcher profile on SciRah

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I. Weber — researcher profile on SciRah

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M. Aoki — researcher profile on SciRah

Prasanth R. Nyalapatla×7

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Prasanth R. Nyalapatla — researcher profile on SciRah

Masayuki Amano×5

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Masayuki Amano — researcher profile on SciRah

Satish Kovela×5

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Satish Kovela — researcher profile on SciRah

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A. Mesecar — researcher profile on SciRah

Kalapala Venkateswara Rao×4

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Kalapala Venkateswara Rao — researcher profile on SciRah

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H. Hayashi — researcher profile on SciRah