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H. Maun · SciRah

Researcher profile · Semantic Scholar

H. Maun

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H. Maun — researcher profile on SciRah

h-index: 16
Works: 33
Citations: 1,077

Most-cited papers

Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent
M. Merchant, Xiao-Lei Ma, H. Maun, Zhong Zheng +25 more
2013Proceedings of the National Academy of Sciences of the United States of America245 citations Open access
Semantic Scholar
Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site
H. Maun, Xiaohui Wen, A. Lingel, F. D. de Sauvage +3 more
2010Journal of Biological Chemistry137 citations Open access
Semantic Scholar
Suppressor of Fused Regulates Gli Activity through a Dual Binding Mechanism
M. Merchant, F. Vajdos, M. Ultsch, H. Maun +6 more
2004Molecular and Cellular Biology135 citations Open access
Semantic Scholar
An allosteric anti-tryptase antibody for the treatment of mast cell-mediated severe asthma
H. Maun, J. Jackman, D. Choy, K. Loyet +46 more
2019Cell95 citations Open access
Semantic Scholar
Structural and Functional Basis of the Serine Protease-like Hepatocyte Growth Factor β-Chain in Met Binding and Signaling*
D. Kirchhofer, Xiao-Yi Yao, Mark Peek, C. Eigenbrot +7 more
2004Journal of Biological Chemistry87 citations Open access
Semantic Scholar
Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist
D. Kirchhofer, M. T. Lipari, L. Santell, K. Billeci +6 more
2007Proceedings of the National Academy of Sciences of the United States of America44 citations Open access
Semantic Scholar
Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis
Joseph Chavarria-Smith, C. Chiu, J. Jackman, Jianping Yin +29 more
2022Science Translational Medicine42 citations Open access
Semantic Scholar
Crystal structure analysis of free and substrate-bound 6-hydroxy-L-nicotine oxidase from Arthrobacter nicotinovorans.
G. Kachalova, G. Bourenkov, T. Mengesdorf, S. Schenk +5 more
2010Journal of Molecular Biology41 citations
Semantic Scholar
Efficient production of antibodies against a mammalian integral membrane protein by phage display.
I. Hötzel, Vicki Chiang, J. Diao, Homer Pantua +2 more
2011Protein engineering, design & selection : PEDS39 citations
Semantic Scholar
Engineering Exosite Peptides for Complete Inhibition of Factor VIIa Using a Protease Switch with Substrate Phage*
H. Maun, C. Eigenbrot, R. Lazarus
2003Journal of Biological Chemistry33 citations Open access
Semantic Scholar
3-2-1: Structural insights from stepwise shrinkage of a three-helix Fc-binding domain to a single helix
M. Ultsch, A. Braisted, H. Maun, C. Eigenbrot
2017Protein engineering, design & selection : PEDS28 citations Open access
Semantic Scholar
An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides.
K. Landgraf, M. Steffek, C. Quan, J. Tom +5 more
2014Nature Chemical Biology24 citations
Semantic Scholar
Functional Consequences of the Macrophage Stimulating Protein 689C Inflammatory Bowel Disease Risk Allele
S. Kauder, L. Santell, Elaine Mai, Lilyan Y. T. Wright +16 more
2013PLoS ONE21 citations Open access
Semantic Scholar
Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge
H. Maun, R. Vij, Benjamin T. Walters, Ashley Morando +14 more
2020Nature Communications20 citations Open access
Semantic Scholar
Allosteric Peptide Activators of Pro-Hepatocyte Growth Factor Stimulate Met Signaling
K. Landgraf, L. Santell, K. Billeci, C. Quan +4 more
2010Journal of Biological Chemistry20 citations Open access
Semantic Scholar
Dual functionality of β-tryptase protomers as both proteases and cofactors in the active tetramer
H. Maun, Peter S. Liu, Y. Franke, C. Eigenbrot +3 more
2018Journal of Biological Chemistry18 citations Open access
Semantic Scholar
Structural and Functional Basis of the Serine Protease-like Hepatocyte Growth Factor (cid:1) -Chain in Met Binding and Signaling*
D. Kirchhofer, Xiao-Yi Yao, Mark Peek, C. Eigenbrot +7 more
200414 citations
Semantic Scholar
Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma.
J. Jackman, A. Stockwell, David D. Choy, M. M. Xie +26 more
2022Journal of Allergy and Clinical Immunology12 citations Open access
Semantic Scholar
Pseudo-active sites of protease domains: HGF/Met and Sonic hedgehog signaling in cancer
H. Maun, D. Kirchhofer, R. Lazarus
2010Biological chemistry9 citations
Semantic Scholar
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
H. Maun, J. Jackman, D. Choy, K. Loyet +46 more
2020Cell7 citations Open access
Semantic Scholar
Development of a specific immunoassay to selectively measure active tryptase in airway samples.
Gizette Sperinde, Meire C. D. Bremer, H. Maun, A. Baruch +6 more
2020Bioanalysis2 citations
Semantic Scholar
Structural and functional basis of the serine protease-like HGF b -chain in Met binding and signaling
D. Kirchhofer, Xiao-Yi Yao, Mark Peek, C. Eigenbrot +7 more
20042 citations
Semantic Scholar
Development of LRRC15-binding disulfide-constrained peptides for PET imaging of cancer-associated fibroblasts
Benjamin J. Tombling, Fei Cai, T. Wendorff, A. Ogasawara +19 more
2026Nature Communications1 citations Open access
Semantic Scholar
A Machine Learning-Enabled Venom Peptide Platform for Rapid Drug Discovery
Fei Cai, Lijuan Zhou, B. Delgado, Wenping Chang +8 more
2026Pharmaceuticals1 citations
Semantic Scholar
Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches
Afshin Derakhshani, L. Mahajan, K. Lesack, Navid Saranjam +6 more
2026Pharmacological Reviews1 citations Open access
Semantic Scholar
Complete inhibition of β-tryptase by tetramer dissociation and active site allostery due to a single antibody residue
H. Maun, C. Azumaya, Benjamin T. Walters, R. Vij +5 more
2026Nature Communications1 citations Open access
Semantic Scholar
Anti-tryptase antibodies, compositions thereof, and uses thereof
Xiaocheng Chen, M. Dennis, J. Jackman, J. T. Koerber +7 more
20181 citations
Semantic Scholar
α and β Tryptase Is Released From Mast Cells by IgE Cross-linking and Increased α/β Ratio Is Associated With Diminished PAR-2 Activity
N. Rathore, Peter J. Liu, H. Maun, R. Lazarus +2 more
2023B31. ASTHMA: FROM MICE TO MEN, AND BACK AGAIN0 citations
Semantic Scholar
Abstract 2335: Structure of the anti-MET antibody, onartuzumab (MetMAb) with MET demonstrates the primary mechanism of action is inhibition of hepatocyte growth factor (HGF) α-chain binding.
H. Maun, Xiao-Lei Ma, M. Merchant, R. Lazarus +1 more
20130 citations
Semantic Scholar
Crystal structure of fab fragment of anti-Shh 5E1 chimera
S. Hymowitz, H. Maun
20100 citations
Semantic Scholar
Crystal structure Sonic hedgehog bound to the 5E1 fab fragment
S. Hymowitz, H. Maun
20100 citations
Semantic Scholar
Protease-like domain from 2-chain hepatocyte growth factor
D. Kirchhofer, Xiao-Yi Yao, Mark Peek, C. Eigenbrot +6 more
20040 citations
Semantic Scholar
Human Suppressor of Fused (N-terminal domain)
M. Merchant, F. Vajdos, M. Ultsch, H. Maun +5 more
20040 citations
Semantic Scholar

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R. Lazarus×23
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R. Lazarus — researcher profile on SciRah
D. Kirchhofer×11
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C. Eigenbrot×10
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L. Santell×9
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M. T. Lipari — researcher profile on SciRah

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