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L. Pearn · SciRah

Researcher profile · Semantic Scholar

L. Pearn

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L. Pearn — researcher profile on SciRah

h-index: 10
Works: 24
Citations: 750

Most-cited papers

Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling.
P. Hole, J. Zabkiewicz, C. Munje, Z. Newton +7 more
2013Blood234 citations Open access
Semantic Scholar
Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells.
P. Hole, L. Pearn, A. Tonks, P. James +3 more
2010Blood128 citations
Semantic Scholar
Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia
A. Tonks, L. Pearn, Megan Musson, A. Gilkes +3 more
2007Leukemia98 citations Open access
Semantic Scholar
The role of PKC and PDK1 in monocyte lineage specification by Ras.
L. Pearn, J. Fisher, A. Burnett, R. Darley
2007Blood57 citations
Semantic Scholar
The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts
J. Zabkiewicz, L. Pearn, R. Hills, R. Morgan +3 more
2014Haematologica54 citations Open access
Semantic Scholar
γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin
R. Morgan, L. Pearn, K. Liddiard, S. Pumford +3 more
2012Leukemia52 citations Open access
Semantic Scholar
Expression of AML1-ETO in human myelomonocytic cells selectively inhibits granulocytic differentiation and promotes their self-renewal
A. Tonks, A. Tonks, L. Pearn, L. Pearce +5 more
2004Leukemia46 citations Open access
Semantic Scholar
Protein kinase C mediates mutant N-Ras-induced developmental abnormalities in normal human erythroid cells.
R. Darley, L. Pearn, N. Omidvar, M. Sweeney +4 more
2002Blood32 citations Open access
Semantic Scholar
Ral Is both Necessary and Sufficient for the Inhibition of Myeloid Differentiation Mediated by Ras
N. Omidvar, L. Pearn, A. Burnett, R. Darley
2006Molecular and Cellular Biology23 citations
Semantic Scholar
Optimized Retroviral Transduction Protocol Which Preserves the Primitive Subpopulation of Human Hematopoietic Cells
A. Tonks, A. Tonks, L. Pearn, Z. Mohamad +2 more
2008Biotechnology progress (Print)22 citations
Semantic Scholar
The sensitivity of human cells expressing RUNX1-RUNX1T1 to chemotherapeutic agents
A. Tonks, L. Pearn, K. Mills, A. K. Burnett +1 more
2006Leukemia3 citations Open access
Semantic Scholar
Distinct regulation of beta- and gamma-Catenin throughout hematopoietic development contrasts with their cooperative roles in acute myeloid leukemia [Abstract]
R. Morgan, L. Pearn, K. Liddiard, R. Hills +3 more
20101 citations
Semantic Scholar
RUNX1-RUNX1T1 Induces Over-Expression of γ-Catenin in Human CD34+ Cells, Increasing Self Renewal and Impairing Granulocytic Differentiation.
A. Tonks, L. Pearn, Megan Musson, A. Gilkes +3 more
20051 citations
Semantic Scholar
Mediated by Ras Inhibition of Myeloid Differentiation Ral Is both Necessary and Sufficient for the
L. Darley, N. Omidvar, L. Pearn, A. K. Burnett +1 more
20140 citations
Semantic Scholar
primary erythroid cells The AML1-ETO fusion gene promotes extensive self-renewal of human
J. Downing, A. Burnett, R. Darley, A. Tonks +6 more
20130 citations
Semantic Scholar
abnormalities in normal human erythroid cells induced developmental - Protein kinase C mediates mutant N-Ras
A. Burnett, R. Darley, L. Pearn, N. Omidvar +3 more
20130 citations
Semantic Scholar
Running Title: PKC mediates N-Ras-induced dyserythropoiesis
R. Darley, L. Pearn, N. Omidvar, M. Sweeney +4 more
20130 citations
Semantic Scholar
A distinct role for the Wnt signalling protein γ-catenin in normal haematopoiesis and its dysregulation in acute myeloid leukaemia
R. Morgan, L. Pearn, K. Liddiard, R. Hills +3 more
20100 citations
Semantic Scholar
PDK1 Overexpression In Acute Myeloid Leukemia; Clinical Significance and Potential as a Therapeutic Target
J. Zabkiewicz, L. Pearn, R. Hills, R. Morgan +3 more
20100 citations
Semantic Scholar
Ras Promotes Production of Reactive Oxygen Species in Normal Human CD34+ Cells: Role in Promoting Cell Survival and Protein Phosphorylation
P. Hole, L. Pearn, P. James, A. Burnett +2 more
20080 citations
Semantic Scholar
Expression of RUNX1-RUNX1T1 Alone Has No Effect on the Intrinsic Susceptibility to Cytotoxic Chemicals.
A. Tonks, L. Pearn, A. Tonks, K. Mills +2 more
20060 citations
Semantic Scholar
Aberrant Megakaryocyte Antigen Expression on Myelodysplastic Erythroid Cells: Role of Protein Kinase C?.
R. Elliott, L. Pearn, A. Al-Sabah, S. Knapper +2 more
20060 citations
Semantic Scholar
abnormalities in normal human erythroid cells Protein kinase C mediates mutant N-Ras-induced developmental
A. Burnett, R. Darley, L. Pearn, N. Omidvar +4 more
20020 citations
Semantic Scholar
Mutant RAS promotes amplification of primitive human erythroid cells
R. Darley, L. Pearn, A. Burnett
20000 citations
Semantic Scholar

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