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N. Denko · SciRah

Researcher profile · Semantic Scholar

N. Denko

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N. Denko — researcher profile on SciRah

h-index: 44
Works: 112
Citations: 12K

Most-cited papers

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.
I. Papandreou, R. Cairns, Lucrezia Fontana, Ai-Lin Lim +1 more
2006Cell Metabolism2,307 citations Open access
Semantic Scholar
Hypoxia, HIF1 and glucose metabolism in the solid tumour
N. Denko
2008Nature Reviews. Cancer1,668 citations
Semantic Scholar
FoxO3 regulates neural stem cell homeostasis
V. Renault, Victoria A. Rafalski, Alexander A. Morgan, Dervis A M Salih +9 more
2009Cell Stem Cell597 citations Open access
Semantic Scholar
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma.
I. Papandreou, N. Denko, Michael L. Olson, Heleen van Melckebeke +7 more
2011Blood457 citations Open access
Semantic Scholar
Hypoxic gene expression and metastasis
Q. Le, N. Denko, A. Giaccia
2004Cancer Metastasis Review414 citations
Semantic Scholar
Candidate genes for the hypoxic tumor phenotype.
A. Koong, N. Denko, K. M. Hudson, C. Schindler +7 more
2000Cancer Research353 citations
Semantic Scholar
Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L
I. Papandreou, Ai-Lin Lim, K. Laderoute, N. Denko
2008Cell Death and Differentiation346 citations
Semantic Scholar
Hypoxia Links ATR and p53 through Replication Arrest
E. Hammond, N. Denko, M. Dorie, R. Abraham +1 more
2002Molecular and Cellular Biology343 citations Open access
Semantic Scholar
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.
L. Romero-Ramírez, Hongbin Cao, Daniel W. Nelson, E. Hammond +8 more
2004Cancer Research339 citations Open access
Semantic Scholar
Overcoming Physiologic Barriers to Cancer Treatment by Molecularly Targeting the Tumor Microenvironment
R. Cairns, I. Papandreou, N. Denko
2006Molecular Cancer Research338 citations Open access
Semantic Scholar
Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth
R. Sun, N. Denko
2014Cell Metabolism335 citations Open access
Semantic Scholar
Investigating hypoxic tumor physiology through gene expression patterns
N. Denko, Lucrezia Fontana, K. M. Hudson, P. Sutphin +3 more
2003Oncogene326 citations
Semantic Scholar
XBP1 Is Essential for Survival under Hypoxic Conditions and Is Required for Tumor Growth
L. Romero-Ramírez, Hongbin Cao, Daniel W. Nelson, E. Hammond +8 more
2004Cancer Research296 citations Open access
Semantic Scholar
Role of Prolyl Hydroxylation in Oncogenically Stabilized Hypoxia-inducible Factor-1α*
D. Chan, P. Sutphin, N. Denko, A. Giaccia
2002Journal of Biological Chemistry289 citations Open access
Semantic Scholar
Hypoxia induces a novel signature of chromatin modifications and global repression of transcription.
A. Johnson, N. Denko, M. Barton
2008Mutation research257 citations Open access
Semantic Scholar
Oxygen Consumption Can Regulate the Growth of Tumors, a New Perspective on the Warburg Effect
Yi-Jun Chen, R. Cairns, I. Papandreou, A. Koong +1 more
2009PLoS ONE188 citations Open access
Semantic Scholar
Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy
R. Cairns, I. Papandreou, P. Sutphin, N. Denko
2007Proceedings of the National Academy of Sciences of the United States of America183 citations Open access
Semantic Scholar
Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism
M. Benej, Xiang-Qian Hong, Sandip M. Vibhute, Sabina A. Scott +9 more
2018Proceedings of the National Academy of Sciences of the United States of America156 citations Open access
Semantic Scholar
Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?
I. Papandreou, T. Goliasova, N. Denko
2011International Journal of Cancer155 citations Open access
Semantic Scholar
Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment.
I. Papandreou, C. Krishna, F. Kaper, Deli Cai +2 more
2005Cancer Research138 citations Open access
Semantic Scholar
Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor.
K. Laderoute, Rodolfo M. Alarcon, M. Brody, J. Calaoagan +5 more
2000Clinical Cancer Research118 citations
Semantic Scholar
HIF-1α in Endurance Training: Suppression of Oxidative Metabolism
Steven D. Mason, H. Rundqvist, I. Papandreou, Roger Duh +7 more
2007115 citations
Semantic Scholar
The hypoxic tumor microenvironment and gene expression.
C. Leo, A. Giaccia, N. Denko
2004Seminars in Radiation Oncology108 citations
Semantic Scholar
Histology-Based Expression Profiling Yields Novel Prognostic Markers in Human Glioblastoma
Shumin Dong, C. Nutt, R. Betensky, A. Stemmer-Rachamimov +4 more
2005Journal of Neuropathology and Experimental Neurology107 citations
Semantic Scholar
Epigenetic Regulation of Gene Expression in Cervical Cancer Cells by the Tumor Microenvironment 1
N. Denko, C. Schindler, A. Koong, K. Laderoute +2 more
2000100 citations
Semantic Scholar
β-catenin Regulates Hepatic Mitochondrial Function and Energy Balance in Livers of Mice
N. Lehwald, G. Tao, K. Jang, I. Papandreou +7 more
2012Gastroenterology99 citations Open access
Semantic Scholar
Visualization of the unfolded protein response in primary tumors reveals unique microenvironments that reflect metabolic variations and predict for tumor growth
M. Spiotto, A. Banh, I. Papandreou, Hongbin Cao +5 more
2009Cancer Research99 citations Open access
Semantic Scholar
Tumor hypoxia, the physiological link between Trousseau's syndrome (carcinoma-induced coagulopathy) and metastasis.
N. Denko, A. Giaccia
2001Cancer Research96 citations
Semantic Scholar
Topical Treatment with Inhibitors of the Phosphatidylinositol 3′-Kinase/Akt and Raf/Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Pathways Reduces Melanoma Development in Severe Combined Immunodeficient Mice
B. Bedogni, Melony S. O’Neill, S. Welford, D. Bouley +3 more
2004Cancer Research83 citations
Semantic Scholar
Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway
K. Ameri, E. Hammond, C. Culmsee, M. Raida +7 more
2007Oncogene81 citations Open access
Semantic Scholar
Tumor Hypoxia Blocks Wnt Processing and Secretion through the Induction of Endoplasmic Reticulum Stress
Meletios Verras, I. Papandreou, Ai-Lin Lim, N. Denko
2008Molecular and Cellular Biology74 citations Open access
Semantic Scholar
Cellular reaction to hypoxia: sensing and responding to an adverse environment.
I. Papandreou, Ashley A. Powell, Ai-Lin Lim, N. Denko
2005Mutation research72 citations
Semantic Scholar
Highly Conserved RNA Sequences That Are Sensors of Environmental Stress
A. Spicher, Oivin M. Guicherit, L. Duret, A. Aslanian +4 more
1998Molecular and Cellular Biology66 citations Open access
Semantic Scholar
HIF-1alpha in endurance training: suppression of oxidative metabolism.
Steven D. Mason, H. Rundqvist, I. Papandreou, Roger Duh +7 more
2007American Journal of Physiology. Regulatory Integrative and Comparative Physiology64 citations
Semantic Scholar
The RGD Domain of Human Osteopontin Promotes Tumor Growth and Metastasis through Activation of Survival Pathways
D. Courter, Hongbin Cao, S. Kwok, Christina S. Kong +9 more
2010PLoS ONE61 citations Open access
Semantic Scholar
5′-AMP-activated Protein Kinase (AMPK) Supports the Growth of Aggressive Experimental Human Breast Cancer Tumors*
K. Laderoute, J. Calaoagan, W. Chao, Đ. Đình +7 more
2014Journal of Biological Chemistry60 citations Open access
Semantic Scholar
HILPDA regulates lipid metabolism, lipid droplet abundance, and response to microenvironmental stress in solid tumors.
M. Vandekopple, Jinghai Wu, Erich N Auer, A. Giaccia +2 more
2019Molecular Cancer Research59 citations Open access
Semantic Scholar
The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation
G. Cerniglia, S. Dey, Shannon M. Gallagher-Colombo, Natalie A. Daurio +9 more
2015Molecular Cancer Therapeutics59 citations Open access
Semantic Scholar
Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment.
N. Denko, C. Schindler, A. Koong, K. Laderoute +2 more
2000Clinical Cancer Research59 citations
Semantic Scholar
Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours
Tereza Golias, I. Papandreou, R. Sun, Bhavna Kumar +7 more
2016Scientific Reports57 citations Open access
Semantic Scholar
Hypoxia Actively Represses Transcription by Inducing Negative Cofactor 2 (Dr1/DrAP1) and Blocking Preinitiation Complex Assembly*
N. Denko, K. Wernke-Dollries, A. Johnson, Ester M Hammond +2 more
2003Journal of Biological Chemistry54 citations Open access
Semantic Scholar
Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor growth
Nancy P. Echeverri Ruiz, Vijay Mohan, Jinghai Wu, Sabina A. Scott +5 more
2021Cancer & Metabolism39 citations Open access
Semantic Scholar
Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response
Dadi Jiang, Connor R. Lynch, B. C. Medeiros, M. Liedtke +10 more
2016Scientific Reports37 citations Open access
Semantic Scholar
CA IX Stabilizes Intracellular pH to Maintain Metabolic Reprogramming and Proliferation in Hypoxia
M. Benej, E. Svastova, R. Banova, J. Kopáček +9 more
2020Frontiers in Oncology34 citations Open access
Semantic Scholar
Pharmacologically Increased Tumor Hypoxia Can Be Measured by 18F-Fluoroazomycin Arabinoside Positron Emission Tomography and Enhances Tumor Response to Hypoxic Cytotoxin PR-104
R. Cairns, K. Bennewith, E. Graves, A. Giaccia +2 more
2009Clinical Cancer Research31 citations Open access
Semantic Scholar
Functional characterization of human proapoptotic molecules in yeast S. cerevisiae
F. Guscetti, N. Nath, N. Denko
2005The FASEB Journal31 citations
Semantic Scholar
Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Cytotoxic to Human Multiple Myeloma
Dadi Jiang, A. Tam, M. Alagappan, M. Hay +9 more
2016Molecular Cancer Therapeutics29 citations Open access
Semantic Scholar
Hypoxic adaptation of mitochondria and its impact on tumor cell function
M. Benej, I. Papandreou, N. Denko
2024Seminars in Cancer Biology26 citations Open access
Semantic Scholar
Plant Stilbenes Induce Endoplasmic Reticulum Stress and Their Anti-Cancer Activity can be Enhanced by Inhibitors of Autophagy
I. Papandreou, Meletios Verras, B. McNeil, A. Koong +1 more
2015Experimental Cell Research26 citations Open access
Semantic Scholar
Genetic determinants that influence hypoxia-induced apoptosis.
Rodolfo M. Alarcon, N. Denko, A. Giaccia
2001Novartis Foundation symposium26 citations
Semantic Scholar

Frequent co-authors

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I. Papandreou×22
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I. Papandreou — researcher profile on SciRah
A. Giaccia×22
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A. Giaccia — researcher profile on SciRah
A. Koong×13
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A. Koong — researcher profile on SciRah
Q. Le×9
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Q. Le — researcher profile on SciRah

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R. Cairns — researcher profile on SciRah

K. Laderoute×5

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K. Laderoute — researcher profile on SciRah

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Ai-Lin Lim — researcher profile on SciRah

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E. Hammond — researcher profile on SciRah

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Hongbin Cao — researcher profile on SciRah

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M. Benej — researcher profile on SciRah

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A. Tam — researcher profile on SciRah

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D. Bouley — researcher profile on SciRah