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T. Hishiki · SciRah

Researcher profile · Semantic Scholar

T. Hishiki

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T. Hishiki — researcher profile on SciRah

h-index: 37
Works: 98
Citations: 4,417

Most-cited papers

Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes.
S. Tohyama, Fumiyuki Hattori, M. Sano, T. Hishiki +17 more
2013Cell Stem Cell658 citations Open access
Semantic Scholar
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue
Yoichi Imaizumi, Y. Okada, W. Akamatsu, M. Koike +26 more
2012Molecular Brain380 citations Open access
Semantic Scholar
Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway
T. Morikawa, M. Kajimura, Tomomi Nakamura, T. Hishiki +15 more
2012Proceedings of the National Academy of Sciences of the United States of America238 citations Open access
Semantic Scholar
Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells.
S. Tohyama, J. Fujita, T. Hishiki, Tomomi Matsuura +15 more
2016Cell Metabolism232 citations Open access
Semantic Scholar
Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway
Takehiro Yamamoto, Naoharu Takano, Kyoko Ishiwata, Mitsuyo Ohmura +8 more
2014Nature Communications229 citations Open access
Semantic Scholar
4-hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathway.
Yan Zhang, M. Sano, K. Shinmura, K. Tamaki +11 more
2010Journal of Molecular and Cellular Cardiology148 citations
Semantic Scholar
Metabolic Remodeling Induced by Mitochondrial Aldehyde Stress Stimulates Tolerance to Oxidative Stress in the Heart
J. Endo, M. Sano, T. Katayama, T. Hishiki +21 more
2009Circulation Research137 citations
Semantic Scholar
Capillary Endothelial Fatty Acid Binding Proteins 4 and 5 Play a Critical Role in Fatty Acid Uptake in Heart and Skeletal Muscle
T. Iso, K. Maeda, H. Hanaoka, T. Suga +13 more
2013Arteriosclerosis, Thrombosis and Vascular Biology127 citations Open access
Semantic Scholar
Paradoxical ATP Elevation in Ischemic Penumbra Revealed by Quantitative Imaging Mass Spectrometry
Katsuji Hattori, M. Kajimura, T. Hishiki, Tsuyoshi Nakanishi +9 more
2010Antioxidants and Redox Signaling106 citations Open access
Semantic Scholar
Generation of human adult hepatocyte organoids with metabolic functions
Ryo Igarashi, Mayumi Oda, Ryo Okada, Tomoki Yano +12 more
2025Nature86 citations
Semantic Scholar
Cystathionine β‐synthase as a carbon monoxide–sensitive regulator of bile excretion
Tsunehiro Shintani, T. Iwabuchi, T. Soga, Yuichiro Kato +12 more
2009Hepatology84 citations Open access
Semantic Scholar
The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells.
T. Kondo, M. Ando, Nao Nagai, Wataru Tomisato +13 more
2019Cancer Research81 citations Open access
Semantic Scholar
IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer
K. Shigeta, M. Hasegawa, T. Hishiki, Y. Naito +9 more
2023EMBO Journal80 citations Open access
Semantic Scholar
A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system
Takuya Iizumi, Shinichi Takahashi, K. Mashima, Kazushi Minami +6 more
2016Journal of Neuroinflammation73 citations Open access
Semantic Scholar
Development of a Highly Sensitive Device for Counting the Number of Disease-Specific Exosomes in Human Sera.
Y. Kabe, M. Suematsu, S. Sakamoto, Miwa Hirai +12 more
2018Clinical Chemistry71 citations
Semantic Scholar
HIF-1alpha is necessary to support gluconeogenesis during liver regeneration.
T. Tajima, N. Goda, Natsu Fujiki, T. Hishiki +7 more
2009Biochemical and Biophysical Research Communications - BBRC71 citations
Semantic Scholar
Roles of Hemoglobin Allostery in Hypoxia-induced Metabolic Alterations in Erythrocytes
Ayako Kinoshita, Kosuke Tsukada, T. Soga, T. Hishiki +4 more
2007Journal of Biological Chemistry71 citations Open access
Semantic Scholar
Fatty Acid Synthesis Is Indispensable for Survival of Human Pluripotent Stem Cells
Sho Tanosaki, S. Tohyama, J. Fujita, S. Someya +16 more
2020iScience70 citations Open access
Semantic Scholar
Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria.
H. Yamada, Noriyuki Akahoshi, S. Kamata, Yoshifumi Hagiya +11 more
2012Free Radical Biology & Medicine68 citations
Semantic Scholar
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
Tomohiro Suhara, T. Hishiki, Masataka Kasahara, Noriyo Hayakawa +7 more
2015Proceedings of the National Academy of Sciences of the United States of America62 citations Open access
Semantic Scholar
Large-area surface-enhanced Raman spectroscopy imaging of brain ischemia by gold nanoparticles grown on random nanoarrays of transparent boehmite.
S. Yamazoe, M. Naya, M. Shiota, T. Morikawa +6 more
2014ACS Nano61 citations Open access
Semantic Scholar
Energy Management by Enhanced Glycolysis in G1-phase in Human Colon Cancer Cells In Vitro and In Vivo
Yan Bao, K. Mukai, T. Hishiki, Akiko Kubo +10 more
2013Molecular Cancer Research61 citations
Semantic Scholar
A Critical Role of Fatty Acid Binding Protein 4 and 5 (FABP4/5) in the Systemic Response to Fasting
M. Syamsunarno, T. Iso, H. Hanaoka, A. Yamaguchi +18 more
2013PLoS ONE56 citations Open access
Semantic Scholar
PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
Takehiro Yamamoto, T. Hayashida, Y. Masugi, Kiyotaka Oshikawa +26 more
2024Cancer Research54 citations Open access
Semantic Scholar
Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: evidence from fatty acid-binding protein-4 and -5 knockout mice
Y. Umbarawan, M. Syamsunarno, N. Koitabashi, A. Yamaguchi +11 more
2018Cardiovascular Research52 citations Open access
Semantic Scholar
Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure
Y. Umbarawan, M. Syamsunarno, N. Koitabashi, Hideru Obinata +11 more
2018Scientific Reports50 citations Open access
Semantic Scholar
OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy.
Koichi Murakami, D. Kurotaki, Wataru Kawase, Shunsuke Soma +19 more
2021Cell Reports49 citations Open access
Semantic Scholar
Infrared spectroscopic and mutational studies on putidaredoxin-induced conformational changes in ferrous CO-P450cam.
S. Nagano, H. Shimada, A. Tarumi, T. Hishiki +7 more
2003Biochemistry49 citations
Semantic Scholar
Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice
D. Ochiai, N. Goda, T. Hishiki, Mai Kanai +5 more
2011Biochemical and Biophysical Research Communications - BBRC45 citations Open access
Semantic Scholar
Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart.
Tomohiro Matsuhashi, T. Hishiki, He-Ping Zhou, T. Ono +13 more
2015Journal of Molecular and Cellular Cardiology44 citations
Semantic Scholar
2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche
N. Koike, R. Kota, Y. Naito, Noriyo Hayakawa +8 more
2020Communications Biology43 citations Open access
Semantic Scholar
Xanthine oxidase inhibitor ameliorates postischemic renal injury in mice by promoting resynthesis of adenine nucleotides.
K. Fujii, Akiko Kubo, K. Miyashita, Masaaki Sato +9 more
2019JCI Insight42 citations Open access
Semantic Scholar
Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions
S. Nakano, I. Ishii, K. Shinmura, K. Tamaki +10 more
2015Journal of molecular medicine42 citations
Semantic Scholar
Gas biology: tiny molecules controlling metabolic systems.
M. Kajimura, Tsuyoshi Nakanishi, Toshiki Takenouchi, T. Morikawa +3 more
2012Respiratory Physiology & Neurobiology41 citations Open access
Semantic Scholar
Hypotaurine is an Energy-Saving Hepatoprotective Compound against Ischemia-Reperfusion Injury of the Rat Liver
Tadayuki Sakuragawa, T. Hishiki, Yuki Ueno, Satsuki Ikeda +4 more
2010Journal of clinical biochemistry and nutrition39 citations Open access
Semantic Scholar
O-Glycan-Altered Extracellular Vesicles: A Specific Serum Marker Elevated in Pancreatic Cancer
T. Yokose, Y. Kabe, A. Matsuda, M. Kitago +28 more
2020Cancers38 citations Open access
Semantic Scholar
X-ray crystal structure and catalytic properties of Thr252Ile mutant of cytochrome P450cam: roles of Thr252 and water in the active center.
T. Hishiki, Hideo Shimada, Shingo Nagano, Tsuyoshi Egawa +6 more
2000Journal of Biochemistry (Tokyo)38 citations
Semantic Scholar
Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice.
Y. Umbarawan, M. Syamsunarno, Hideru Obinata, A. Yamaguchi +13 more
2017Metabolism: Clinical and Experimental36 citations Open access
Semantic Scholar
On-tissue polysulfide visualization by surface-enhanced Raman spectroscopy benefits patients with ovarian cancer to predict post-operative chemosensitivity
K. Honda, T. Hishiki, Sohei Yamamoto, Takehiro Yamamoto +36 more
2021Redox Biology35 citations Open access
Semantic Scholar
Carbon monoxide: impact on remethylation/transsulfuration metabolism and its pathophysiologic implications
T. Hishiki, Takehiro Yamamoto, T. Morikawa, Akiko Kubo +2 more
2012Journal of molecular medicine35 citations Open access
Semantic Scholar
The hypotaurine-taurine pathway as an antioxidative mechanism in patients with acute liver failure
Takamasa Mizota, T. Hishiki, M. Shinoda, Y. Naito +10 more
2021Journal of clinical biochemistry and nutrition33 citations Open access
Semantic Scholar
Therapeutic hypothermia achieves neuroprotection via a decrease in acetylcholine with a concurrent increase in carnitine in the neonatal hypoxia-ischemia
Toshiki Takenouchi, Y. Sugiura, T. Morikawa, Tsuyoshi Nakanishi +10 more
2015Journal of Cerebral Blood Flow and Metabolism33 citations Open access
Semantic Scholar
The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure
T. Ono, Naomi Kamimura, Tomohiro Matsuhashi, T. Nagai +12 more
2017Scientific Reports32 citations Open access
Semantic Scholar
Neuroprotective Role of Astroglia in Parkinson Disease by Reducing Oxidative Stress Through Dopamine-Induced Activation of Pentose-Phosphate Pathway
K. Mashima, Shinichi Takahashi, Kazushi Minami, Yoshikane Izawa +6 more
2018ASN Neuro30 citations Open access
Semantic Scholar
Involvement of the yciW gene in l-cysteine and l-methionine metabolism in Escherichia coli.
Y. Kawano, I. Ohtsu, A. Tamakoshi, Maeka Shiroyama +8 more
2015Journal of Bioscience and Bioengineering30 citations
Semantic Scholar
Use of serum and urine metabolome analysis for the detection of metabolic changes in patients with stage 1-2 chronic kidney disease
Kaori Hayashi, H. Sasamura, T. Hishiki, M. Suematsu +3 more
201128 citations
Semantic Scholar
Putidaredoxin-Cytochrome P450cam Interaction
H. Shimada, S. Nagano, Yoko Ariga, M. Unno +6 more
1999Journal of Biological Chemistry26 citations Open access
Semantic Scholar
Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry.
Mitsuyo Ohmura, T. Hishiki, Takehiro Yamamoto, Tsuyoshi Nakanishi +7 more
2015Nitric oxide22 citations Open access
Semantic Scholar
Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testis.
Chikanori Kuramori, Y. Hase, Koichi Hoshikawa, Keiko Watanabe +10 more
2009Toxicological Sciences21 citations Open access
Semantic Scholar
Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria
K. Ikeda, Akiko Kubo, Noriyuki Akahoshi, H. Yamada +7 more
2011Analytical and Bioanalytical Chemistry20 citations
Semantic Scholar

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