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Noriyuki Akahoshi · SciRah

Researcher profile · Semantic Scholar

Noriyuki Akahoshi

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Noriyuki Akahoshi — researcher profile on SciRah

h-index: 19
Works: 43
Citations: 1,350

Most-cited papers

Murine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression.
I. Ishii, Noriyuki Akahoshi, Xiaonian Yu, Y. Kobayashi +3 more
2004Biochemical Journal292 citations Open access
Semantic Scholar
Cystathionine γ-Lyase-deficient Mice Require Dietary Cysteine to Protect against Acute Lethal Myopathy and Oxidative Injury*
I. Ishii, Noriyuki Akahoshi, Hidenori Yamada, S. Nakano +2 more
2010Journal of Biological Chemistry234 citations Open access
Semantic Scholar
Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4.
Daisuke Yasuda, Daiki Kobayashi, Noriyuki Akahoshi, Takayo Ohto-Nakanishi +5 more
2019Journal of Clinical Investigation111 citations Open access
Semantic Scholar
Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria.
H. Yamada, Noriyuki Akahoshi, S. Kamata, Yoshifumi Hagiya +11 more
2012Free Radical Biology & Medicine68 citations
Semantic Scholar
Dietary selenium deficiency or selenomethionine excess drastically alters organ selenium contents without altering the expression of most selenoproteins in mice.
Noriyuki Akahoshi, Y. Anan, Yurimi Hashimoto, Natsumi Tokoro +6 more
2019Journal of Nutritional Biochemistry57 citations
Semantic Scholar
Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia.
Noriyuki Akahoshi, Chiho Kobayashi, Y. Ishizaki, T. Izumi +3 more
2008Human Molecular Genetics53 citations
Semantic Scholar
Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility
A. Takeda, Daichi Kobayashi, Keita Aoi, N. Sasaki +18 more
2016eLife48 citations Open access
Semantic Scholar
Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions
S. Nakano, I. Ishii, K. Shinmura, K. Tamaki +10 more
2015Journal of molecular medicine42 citations
Semantic Scholar
Cystathionine &ggr;-Lyase–Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure
I. Szijartó, L. Markó, M. Filipović, J. Miljkovic +11 more
2018HYPERTENSION38 citations Open access
Semantic Scholar
Frequent spontaneous seizures followed by spatial working memory/anxiety deficits in mice lacking sphingosine 1-phosphate receptor 2.
Noriyuki Akahoshi, Y. Ishizaki, H. Yasuda, Y. Murashima +5 more
2011Epilepsy & Behavior37 citations
Semantic Scholar
Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes
E. Hata, N. Sasaki, A. Takeda, K. Tohya +9 more
2015International Immunology34 citations Open access
Semantic Scholar
The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells
H. Igarashi, Noriyuki Akahoshi, Takayo Ohto-Nakanishi, Daisuke Yasuda +1 more
2015Scientific Reports30 citations Open access
Semantic Scholar
TDAG8 activation inhibits osteoclastic bone resorption
H. Hikiji, D. Endo, K. Horie, T. Harayama +8 more
2014The FASEB Journal30 citations
Semantic Scholar
Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice.
Yoshifumi Hagiya, S. Kamata, Saya Mitsuoka, N. Okada +9 more
2015Toxicology and Applied Pharmacology25 citations
Semantic Scholar
Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures.
Noriyuki Akahoshi, Y. Murashima, T. Himi, Y. Ishizaki +1 more
2007Neuroscience Letters25 citations
Semantic Scholar
LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model.
R. Tsukahara, Shinji Yamamoto, Keisuke Yoshikawa, M. Gotoh +11 more
2018Journal of Pharmacological Sciences24 citations Open access
Semantic Scholar
The Gα12/13-coupled receptor LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity.
K. Yanagida, H. Igarashi, Daisuke Yasuda, Daiki Kobayashi +12 more
2018JCI Insight24 citations Open access
Semantic Scholar
Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts.
Y. Taketomi, T. Higashi, K. Kano, Yoshimi Miki +16 more
2024Immunity21 citations Open access
Semantic Scholar
Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria
K. Ikeda, Akiko Kubo, Noriyuki Akahoshi, H. Yamada +7 more
2011Analytical and Bioanalytical Chemistry20 citations
Semantic Scholar
Neutral aminoaciduria in cystathionine β-synthase-deficient mice; an animal model of homocystinuria.
Noriyuki Akahoshi, S. Kamata, M. Kubota, T. Hishiki +9 more
2014AJP - Renal Physiology18 citations
Semantic Scholar
Different Coactivator Recruitment to Human PPARα/δ/γ Ligand-Binding Domains by Eight PPAR Agonists to Treat Nonalcoholic Fatty Liver Disease
S. Kamata, Akihiro Honda, Nonoka Kashiwagi, Ayumi Shimamura +5 more
2024Biomedicines14 citations Open access
Semantic Scholar
Increased Urinary 3-Mercaptolactate Excretion and Enhanced Passive Systemic Anaphylaxis in Mice Lacking Mercaptopyruvate Sulfurtransferase, a Model of Mercaptolactate-Cysteine Disulfiduria
Noriyuki Akahoshi, Tatsuro Minakawa, Masashi Miyashita, Uran Sugiyama +7 more
2020International Journal of Molecular Sciences14 citations Open access
Semantic Scholar
Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines.
S. Kamata, Reina Hashiyama, Hiroto Hana-Ika, Issei Ohkubo +7 more
2020Toxicology in Vitro13 citations
Semantic Scholar
Differential induction of cystathionine gamma-lyase in the livers and kidneys of mouse dams during gestation and lactation.
Noriyuki Akahoshi, T. Izumi, Y. Ishizaki, I. Ishii
2006Biological and Pharmaceutical Bulletin13 citations Open access
Semantic Scholar
Preeclampsia-Like Features and Partial Lactation Failure in Mice Lacking Cystathionine γ-Lyase—An Animal Model of Cystathioninuria
Noriyuki Akahoshi, Hiroki Handa, Rintaro Takemoto, S. Kamata +3 more
2019International Journal of Molecular Sciences10 citations Open access
Semantic Scholar
Abnormal Amino Acid Profiles of Blood and Cerebrospinal Fluid from Cystathionine β-Synthase-Deficient Mice, an Animal Model of Homocystinuria.
Noriyuki Akahoshi, A. Yokoyama, T. Nagata, Asumi Miura +2 more
2019Biological and Pharmaceutical Bulletin10 citations Open access
Semantic Scholar
Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice
K. Borowczyk, J. Wróblewski, J. Suliburska, Noriyuki Akahoshi +2 more
2018International Journal of Genomics10 citations Open access
Semantic Scholar
A High-Methionine Diet for One-Week Induces a High Accumulation of Methionine in the Cerebrospinal Fluid and Confers Bipolar Disorder-like Behavior in Mice
I. Ishii, S. Kamata, S. Ito, Aya Shimonaga +8 more
2022International Journal of Molecular Sciences9 citations Open access
Semantic Scholar
2D DIGE proteomic analysis reveals fasting‐induced protein remodeling through organ‐specific transcription factor(s) in mice
S. Kamata, Junya Yamamoto, Haruka Ohtani, Yuka Tosaka +3 more
2018FEBS Open Bio8 citations Open access
Semantic Scholar
Opposing Roles of Sphingosine 1-Phosphate Receptors 1 and 2 in Fat Deposition and Glucose Tolerance in Obese Male Mice
Motochika Asano, K. Kajita, M. Fuwa, Toshiko Kajita +4 more
2023Endocrinology7 citations Open access
Semantic Scholar
2D DIGE proteomic analysis highlights delayed postnatal repression of α-fetoprotein expression in homocystinuria model mice
S. Kamata, Noriyuki Akahoshi, I. Ishii
2015FEBS Open Bio6 citations Open access
Semantic Scholar
TOF-SIMS imaging of halide/thiocyanate anions and hydrogen sulfide in mouse kidney sections using silver-deposited plates
Noriyuki Akahoshi, I. Ishizaki, M. Naya, T. Maekawa +6 more
2012Analytical and Bioanalytical Chemistry4 citations
Semantic Scholar
Differential Roles of Cystathionine Gamma-Lyase and Mercaptopyruvate Sulfurtransferase in Hapten-Induced Colitis and Contact Dermatitis in Mice
Noriyuki Akahoshi, Ryoka Hasegawa, Shingo Yamamoto, Rintaro Takemoto +3 more
2023International Journal of Molecular Sciences3 citations Open access
Semantic Scholar
Combination therapy with clinically approved PPARα/δ/γ subtype-selective agonists pemafibrate, seladelpar, and pioglitazone in a 4-week diet-induced early-stage MASLD mouse model.
Akihiro Honda, S. Kamata, Reina Tanaka, Y. Minomo +8 more
2026Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2 citations Open access
Semantic Scholar
硫化水素産生・代謝酵素の役割：ヒト遺伝病と病態モデルマウスからの知見
Noriyuki Akahoshi, 軌征赤星, Isao Ishii, 功石井
20210 citations
Semantic Scholar
Homocysteine Hypothesis on the Impaired Peripheral but Not Central Nervous System Oxytocin Responses in Cystathionine γ-Lyase-Deficient Dam Mice.
Noriyuki Akahoshi, Waka Kamichatani, I. Ishii
2020Biological and Pharmaceutical Bulletin0 citations Open access
Semantic Scholar
Comparative analysis of Mpst and Cth single-deficient mice and Mpst/Cth double-deficient mice.
Noriyuki Akahoshi
20200 citations
Semantic Scholar
Selenoprotein profiling in various tissues of mice fed with selenium‐deficient and high‐selenomethionine diets.
Isao Ishii, Noriyuki Akahoshi, S. Kamata, Yurimi Hashimoto +5 more
20180 citations
Semantic Scholar
Author response: Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility
A. Takeda, Daichi Kobayashi, Keita Aoi, N. Sasaki +18 more
20150 citations Open access
Semantic Scholar
Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions
S. Nakano, I. Ishii, K. Shinmura, K. Tamaki +10 more
2015Journal of molecular medicine0 citations
Semantic Scholar
Abstract 17695: Transsulfuration Pathway is Essential for Fasting-Induced Cardioprotection Against Ischemic/Reperfusion Injury
S. Nakano, I. Ishii, Noriyuki Akahoshi, K. Tamaki +3 more
2011Circulation0 citations
Semantic Scholar
GeneChip analysis of the neocortical and hippocampal gene expression in kainate- and nicotine-injected mice
Noriyuki Akahoshi, Y. Murashima, T. Himi, Y. Ishizaki +1 more
20070 citations
Semantic Scholar
A case of obstructive jaundice due to abdominal blunt trauma.
N. Ohtsuka, Noriyuki Akahoshi, K. Togami, H. Hongoh +3 more
19850 citations Open access
Semantic Scholar

Frequent co-authors

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I. Ishii×27
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I. Ishii — researcher profile on SciRah
S. Kamata×17
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S. Kamata — researcher profile on SciRah
M. Suematsu×10
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M. Suematsu — researcher profile on SciRah
S. Ishii×8
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S. Ishii — researcher profile on SciRah

×7

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Y. Ishizaki — researcher profile on SciRah

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T. Hishiki — researcher profile on SciRah

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H. Igarashi — researcher profile on SciRah

Waka Kamichatani×5

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Waka Kamichatani — researcher profile on SciRah

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S. Nakano — researcher profile on SciRah

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T. Izumi — researcher profile on SciRah

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Y. Kumagai — researcher profile on SciRah

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Y. Anan — researcher profile on SciRah