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K. Rouschop · SciRah

Researcher profile · Semantic Scholar

K. Rouschop

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K. Rouschop — researcher profile on SciRah

h-index: 39
Works: 80
Citations: 26K

Most-cited papers

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
C. Théry, Kenneth W. Witwer, E. Aikawa, M. Alcaraz +378 more
2018Journal of Extracellular Vesicles9,895 citations Open access
Semantic Scholar
Guidelines for the use and interpretation of assays for monitoring autophagy
D. Klionsky, F. C. Abdalla, H. Abeliovich, Robert T. Abraham +496 more
20124,979 citations Open access
Semantic Scholar
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
D. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, M. Abdellatif +496 more
2021Autophagy4,016 citations Open access
Semantic Scholar
Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652
D. Klionsky, K. Abdelmohsen, A. Abe, M. Abedin +496 more
20161,544 citations Open access
Semantic Scholar
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.
K. Rouschop, T. van den Beucken, L. Dubois, H. Niessen +10 more
2010Journal of Clinical Investigation820 citations Open access
Semantic Scholar
Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney.
J. Leemans, G. Stokman, N. Claessen, K. Rouschop +6 more
2005Journal of Clinical Investigation601 citations Open access
Semantic Scholar
LC3/GABARAP family proteins: autophagy‐(un)related functions
Marco B. E. Schaaf, Tom G. Keulers, M. Vooijs, K. Rouschop
2016The FASEB Journal576 citations Open access
Semantic Scholar
Correction to “Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches”
Delaram Khamari, E. Khomyakova, A. Khvorova, Peter Kierulf +159 more
2024Journal of Extracellular Vesicles256 citations Open access
Semantic Scholar
PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS
K. Rouschop, L. Dubois, T. Keulers, T. van den Beucken +5 more
2013Proceedings of the National Academy of Sciences of the United States of America228 citations Open access
Semantic Scholar
Hypoxia Induced Impairment of NK Cell Cytotoxicity against Multiple Myeloma Can Be Overcome by IL-2 Activation of the NK Cells
Subhashis Sarkar, W. Germeraad, K. Rouschop, E. Steeghs +3 more
2013PLoS ONE164 citations Open access
Semantic Scholar
Autophagy is required during cycling hypoxia to lower production of reactive oxygen species.
K. Rouschop, Chantal Ramaekers, Marco B. E. Schaaf, T. Keulers +4 more
2009Radiotherapy and Oncology149 citations
Semantic Scholar
Protection against renal ischemia reperfusion injury by CD44 disruption.
K. Rouschop, J. Roelofs, N. Claessen, Paula A. da Costa Martins +4 more
2005Journal of the American Society of Nephrology147 citations
Semantic Scholar
Level of activation of the unfolded protein response correlates with Paneth cell apoptosis in human small intestine exposed to ischemia/reperfusion.
J. Grootjans, C. Hodin, J. de Haan, J. Derikx +6 more
2011Gastroenterology132 citations
Semantic Scholar
CD44 deficiency increases tubular damage but reduces renal fibrosis in obstructive nephropathy.
K. Rouschop, M. Sewnath, N. Claessen, J. Roelofs +6 more
2004Journal of the American Society of Nephrology128 citations Open access
Semantic Scholar
Hypoxic Activation of the PERK/eIF2α Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3
H. Mujcic, A. Nagelkerke, K. Rouschop, S. Chung +8 more
2013Clinical Cancer Research119 citations Open access
Semantic Scholar
EGFR signaling and autophagy dependence for growth, survival, and therapy resistance
B. Jutten, K. Rouschop
2014Cell Cycle116 citations Open access
Semantic Scholar
Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium
E. O. Pettersen, P. Ebbesen, R. Gieling, K. Williams +43 more
2015Journal of Enzyme Inhibition and Medicinal Chemistry113 citations Open access
Semantic Scholar
Regulation of autophagy through multiple independent hypoxic signaling pathways.
K. Rouschop, B. Wouters
2009Current molecular medicine112 citations
Semantic Scholar
Chloroquine combined with concurrent radiotherapy and temozolomide for newly diagnosed glioblastoma: a phase IB trial
I. Compter, D. Eekers, A. Hoeben, K. Rouschop +9 more
2020Autophagy110 citations Open access
Semantic Scholar
Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3.
H. Mujcic, T. Rzymski, K. Rouschop, M. Koritzinsky +3 more
2009Radiotherapy and Oncology108 citations Open access
Semantic Scholar
Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response
M. Wennemers, J. Bussink, B. Scheijen, I. Nagtegaal +7 more
2011Breast Cancer Research98 citations Open access
Semantic Scholar
Small-Molecule Activation of p53 Blocks Hypoxia-Inducible Factor 1α and Vascular Endothelial Growth Factor Expression In Vivo and Leads to Tumor Cell Apoptosis in Normoxia and Hypoxia
Jun Yang, Afshan Ahmed, E. Poon, N. Perusinghe +7 more
2009Molecular and Cellular Biology93 citations Open access
Semantic Scholar
Tissue-type plasminogen activator modulates inflammatory responses and renal function in ischemia reperfusion injury.
J. Roelofs, K. Rouschop, J. Leemans, N. Claessen +5 more
2005Journal of the American Society of Nephrology85 citations
Semantic Scholar
Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells
E. Bowler, S. Porazinski, Simon Uzor, Philippe Thibault +6 more
2018BMC Cancer82 citations Open access
Semantic Scholar
Impact of supervised gene signatures of early hypoxia on patient survival.
R. Seigneuric, M. Starmans, G. Fung, B. Krishnapuram +10 more
2007Radiotherapy and Oncology78 citations Open access
Semantic Scholar
Hypoxia-induced Expression of Carbonic Anhydrase 9 Is Dependent on the Unfolded Protein Response*
T. van den Beucken, M. Koritzinsky, H. Niessen, L. Dubois +10 more
2009Journal of Biological Chemistry71 citations Open access
Semantic Scholar
Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia.
M. Koritzinsky, K. Rouschop, T. van den Beucken, M. G. Magagnin +3 more
2007Radiotherapy and Oncology69 citations
Semantic Scholar
Urothelial CD44 Facilitates Escherichia coli Infection of the Murine Urinary Tract1
K. Rouschop, M. Sylva, G. Teske, Inge Hoedemaeker +4 more
2006Journal of Immunology62 citations
Semantic Scholar
Optimal selection of natural killer cells to kill myeloma: the role of HLA-E and NKG2A
Subhashis Sarkar, M. van Gelder, W. Noort, Yun-Ping Xu +8 more
2015Cancer Immunology and Immunotherapy58 citations Open access
Semantic Scholar
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP 1 LC 3 B and ATG 5
K. Rouschop, T. van den Beucken, L. Dubois, H. Niessen +12 more
201754 citations
Semantic Scholar
Extracellular Vesicles as Transmitters of Hypoxia Tolerance in Solid Cancers
Marijke I. Zonneveld, T. Keulers, K. Rouschop
2019Cancers52 citations Open access
Semantic Scholar
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
D. Klionsky, K. Abdelmohsen, A. Abe, J. Abedin +496 more
201650 citations Open access
Semantic Scholar
The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia.
Marco B. E. Schaaf, Dan Cojocari, T. Keulers, B. Jutten +8 more
2013Radiotherapy and Oncology48 citations
Semantic Scholar
EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival.
B. Jutten, T. Keulers, Marco B. E. Schaaf, Kim G. M. Savelkouls +5 more
2013Radiotherapy and Oncology44 citations
Semantic Scholar
CD44 disruption prevents degeneration of the capillary network in obstructive nephropathy via reduction of TGF-beta1-induced apoptosis.
K. Rouschop, N. Claessen, S. Pals, J. Weening +1 more
2006Journal of the American Society of Nephrology44 citations
Semantic Scholar
Learning radiation oncology in Europe: Results of the ESTRO multidisciplinary survey
J. Bibault, P. Franco, G. Borst, W. van Elmpt +9 more
2018Clinical and Translational Radiation Oncology43 citations Open access
Semantic Scholar
EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition
B. Jutten, T. Keulers, Hanneke J M Peeters, Marco B. E. Schaaf +15 more
2018Autophagy43 citations Open access
Semantic Scholar
Renal expression of CD44 correlates with acute renal allograft rejection.
K. Rouschop, J. Roelofs, M. Sylva, A. Rowshani +3 more
2006Kidney International41 citations Open access
Semantic Scholar
Autophagy-Dependent Secretion: Contribution to Tumor Progression
T. Keulers, Marco B. E. Schaaf, K. Rouschop
2016Frontiers in Oncology40 citations Open access
Semantic Scholar
Secretion of pro‐angiogenic extracellular vesicles during hypoxia is dependent on the autophagy‐related protein GABARAPL1
T. Keulers, S. Libregts, Joel E. J. Beaumont, Kim G. M. Savelkouls +10 more
2021Journal of Extracellular Vesicles35 citations Open access
Semantic Scholar
Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2
N. Vaes, Simone L. Schonkeren, G. Rademakers, A. M. Holland +18 more
2021EMBO Reports34 citations Open access
Semantic Scholar
Identification of Potential Prognostic and Predictive Immunological Biomarkers in Patients with Stage I and Stage III Non-Small Cell Lung Cancer (NSCLC): A Prospective Exploratory Study
R. Vaes, K. Reynders, J. Sprooten, K. Nevola +7 more
2021Cancers33 citations Open access
Semantic Scholar
Reciprocal functions of hepatocyte growth factor and transforming growth factor-beta1 in the progression of renal diseases: a role for CD44?
S. Florquin, K. Rouschop
2003Kidney international. Supplement32 citations Open access
Semantic Scholar
ATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer
T. Keulers, A. Koch, M. V. van Gisbergen, L. Barbeau +7 more
2021Autophagy30 citations Open access
Semantic Scholar
Deficient carbonic anhydrase 9 expression in UPR-impaired cells is associated with reduced survival in an acidic microenvironment.
T. van den Beucken, Chantal Ramaekers, K. Rouschop, M. Koritzinsky +1 more
2009Radiotherapy and Oncology27 citations
Semantic Scholar
The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to γ-secretase inhibition
J. Hounjet, R. Habets, Marco B. E. Schaaf, Tessa C. Hendrickx +5 more
2019Oncogene26 citations
Semantic Scholar
GABARAPL1 is required for increased EGFR membrane expression during hypoxia.
T. Keulers, Marco B. E. Schaaf, Hanneke J M Peeters, Kim G. M. Savelkouls +4 more
2015Radiotherapy and Oncology25 citations
Semantic Scholar
Canonical autophagy does not contribute to cellular radioresistance.
Marco B. E. Schaaf, B. Jutten, T. Keulers, Kim G. M. Savelkouls +6 more
2015Radiotherapy and Oncology24 citations
Semantic Scholar
Opposite role of CD44-standard and CD44-variant-3 in tubular injury and development of renal fibrosis during chronic obstructive nephropathy.
E. Rampanelli, K. Rouschop, N. Claessen, G. Teske +3 more
2014Kidney International24 citations Open access
Semantic Scholar
Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction.
K. Rouschop, L. Dubois, Marco B. E. Schaaf, T. van den Beucken +7 more
2011Radiotherapy and Oncology24 citations Open access
Semantic Scholar

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