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Y. Gasche · SciRah

Researcher profile · Semantic Scholar

Y. Gasche

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Y. Gasche — researcher profile on SciRah

h-index: 43
Works: 110
Citations: 8,792

Most-cited papers

Targeted temperature management at 33°C versus 36°C after cardiac arrest.
N. Nielsen, J. Wetterslev, T. Cronberg, D. Erlinge +29 more
2013New England Journal of Medicine2,301 citations Open access
Semantic Scholar
Codeine intoxication associated with ultrarapid CYP2D6 metabolism.
Y. Gasche, Y. Daali, M. Fathi, Alberto Chiappe +3 more
2004New England Journal of Medicine686 citations Open access
Semantic Scholar
Matrix Metalloproteinase Inhibition Prevents Oxidative Stress-Associated Blood–Brain Barrier Disruption after Transient Focal Cerebral Ischemia
Y. Gasche, J. Copin, T. Sugawara, M. Fujimura +1 more
2001Journal of Cerebral Blood Flow and Metabolism391 citations
Semantic Scholar
Standardized EEG interpretation accurately predicts prognosis after cardiac arrest
E. Westhall, A. Rossetti, A. van Rootselaar, Troels Wesenberg Kjaer +18 more
2016Neurology365 citations Open access
Semantic Scholar
Early appearance of activated matrix metalloproteinase-9 and blood-brain barrier disruption in mice after focal cerebral ischemia and reperfusion.
M. Fujimura, Y. Gasche, Y. Morita-Fujimura, J. Massengale +2 more
1999Brain Research348 citations
Semantic Scholar
Neuron-Specific Enolase as a Predictor of Death or Poor Neurological Outcome After Out-of-Hospital Cardiac Arrest and Targeted Temperature Management at 33°C and 36°C.
P. Stammet, O. Collignon, C. Hassager, M. Wise +15 more
2015Journal of the American College of Cardiology304 citations Open access
Semantic Scholar
Overexpression of Copper/Zinc Superoxide Dismutase in Transgenic Rats Protects Vulnerable Neurons against Ischemic Damage by Blocking the Mitochondrial Pathway of Caspase Activation
T. Sugawara, N. Noshita, A. Lewén, Y. Gasche +4 more
2002Journal of Neuroscience276 citations Open access
Semantic Scholar
Effects of Global Ischemia Duration on Neuronal, Astroglial, Oligodendroglial, and Microglial Reactions in the Vulnerable Hippocampal CA1 Subregion in Rats
T. Sugawara, A. Lewén, N. Noshita, Y. Gasche +1 more
2002Journal of Neurotrauma208 citations
Semantic Scholar
Neurologic Function and Health-Related Quality of Life in Patients Following Targeted Temperature Management at 33°C vs 36°C After Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial.
T. Cronberg, G. Lilja, J. Horn, J. Kjaergaard +20 more
2015JAMA Neurology183 citations Open access
Semantic Scholar
Target Temperature Management after out-of-hospital cardiac arrest--a randomized, parallel-group, assessor-blinded clinical trial--rationale and design.
N. Nielsen, J. Wetterslev, N. Al-Subaie, B. Andersson +36 more
2012American Heart Journal176 citations Open access
Semantic Scholar
Neurodegeneration in Striatum Induced by the Mitochondrial Toxin 3-Nitropropionic Acid: Role of Matrix Metalloproteinase-9 in Early Blood-Brain Barrier Disruption?
G. Kim, Y. Gasche, Susanna M. Grzeschik, J. Copin +2 more
2003Journal of Neuroscience135 citations Open access
Semantic Scholar
Overexpression of SOD1 protects vulnerable motor neurons after spinal cord injury by attenuating mitochondrial cytochrome c release
T. Sugawara, A. Lewén, Y. Gasche, F. Yu +1 more
2002The FASEB Journal117 citations
Semantic Scholar
Overexpression of Copper and Zinc Superoxide Dismutase in Transgenic Mice Prevents the Induction and Activation of Matrix Metalloproteinases after Cold Injury-Induced Brain Trauma
Y. Morita-Fujimura, M. Fujimura, Y. Gasche, J. Copin +1 more
2000Journal of Cerebral Blood Flow and Metabolism108 citations Open access
Semantic Scholar
Matrix metalloproteinases and diseases of the central nervous system with a special emphasis on ischemic brain.
Y. Gasche, P. Soccal, Michiko Kanemitsu, J. Copin
2006Frontiers in Bioscience103 citations Open access
Semantic Scholar
Survival in patients without acute ST elevation after cardiac arrest and association with early coronary angiography: a post hoc analysis from the TTM trial
J. Dankiewicz, N. Nielsen, M. Annborn, T. Cronberg +6 more
2015Intensive Care Medicine98 citations Open access
Semantic Scholar
Overexpression of copper/zinc superoxide dismutase does not prevent neonatal lethality in mutant mice that lack manganese superoxide dismutase.
J. Copin, Y. Gasche, Pak H. Chan
2000Free Radical Biology & Medicine94 citations
Semantic Scholar
Oxidative cellular damage and the reduction of APE/Ref-1 expression after experimental traumatic brain injury.
A. Lewén, T. Sugawara, Y. Gasche, M. Fujimura +1 more
2001Neurobiology of Disease88 citations Open access
Semantic Scholar
Predictive value of interleukin-6 in post-cardiac arrest patients treated with targeted temperature management at 33 °C or 36 °C.
J. Bro-Jeppesen, J. Kjaergaard, P. Stammet, M. Wise +14 more
2016Resuscitation80 citations
Semantic Scholar
Protein S100 as outcome predictor after out-of-hospital cardiac arrest and targeted temperature management at 33 °C and 36 °C
P. Stammet, J. Dankiewicz, N. Nielsen, F. Fays +18 more
2017Critical Care72 citations Open access
Semantic Scholar
Intravascular versus surface cooling for targeted temperature management after out-of-hospital cardiac arrest – an analysis of the TTM trial data
G. Glover, R. Thomas, G. Vamvakas, N. Al-Subaie +18 more
2016Critical Care70 citations Open access
Semantic Scholar
Treatment with Evasin-3 Reduces Atherosclerotic Vulnerability for Ischemic Stroke, but Not Brain Injury in Mice
J. Copin, R. D. da Silva, Rodrigo A. Fraga-Silva, L. Capettini +15 more
2013Journal of Cerebral Blood Flow and Metabolism70 citations Open access
Semantic Scholar
Single versus Serial Measurements of Neuron-Specific Enolase and Prediction of Poor Neurological Outcome in Persistently Unconscious Patients after Out-Of-Hospital Cardiac Arrest – A TTM-Trial Substudy
S. Wiberg, C. Hassager, P. Stammet, M. Winther-Jensen +17 more
2017PLoS ONE68 citations Open access
Semantic Scholar
Is tracheostomy still an option in amyotrophic lateral sclerosis? Reflections of a multidisciplinary work group.
A. H. Barras, D. Adler, R. I. Ferfoglia, B. Ricou +6 more
2013Swiss medical weekly67 citations Open access
Semantic Scholar
Role of matrix metalloproteinases in apoptosis after transient focal cerebral ischemia in rats and mice
J. Copin, Marie-Christelle Goodyear, J. Gidday, Aarti R. Shah +4 more
2005European Journal of Neuroscience66 citations
Semantic Scholar
Target temperature management of 33°C and 36°C in patients with out-of-hospital cardiac arrest with initial non-shockable rhythm - a TTM sub-study.
M. Frydland, J. Kjaergaard, D. Erlinge, M. Wanscher +14 more
2015Resuscitation57 citations Open access
Semantic Scholar
Mortality and neurological outcome in the elderly after target temperature management for out-of-hospital cardiac arrest.
M. Winther-Jensen, T. Pellis, M. Kuiper, M. Koopmans +14 more
2015Resuscitation56 citations Open access
Semantic Scholar
Clinical features and viral kinetics in a rapidly cured patient with Ebola virus disease: a case report.
M. Schibler, P. Vetter, P. Cherpillod, T. Petty +17 more
2015Lancet. Infectious Diseases (Print)51 citations Open access
Semantic Scholar
MATRIX METALLOPROTEINASES CORRELATE WITH ALVEOLAR-CAPILLARY PERMEABILITY ALTERATION IN LUNG ISCHEMIA-REPERFUSION INJURY
P. Soccal, Y. Gasche, J. Pache, O. Schneuwly +5 more
2000Transplantation51 citations Open access
Semantic Scholar
Analysis of the expression of nine secreted matrix metalloproteinases and their endogenous inhibitors in the brain of mice subjected to ischaemic stroke
S. Lenglet, F. Montecucco, F. Mach, K. Schaller +2 more
2014Thrombosis and Haemostasis50 citations Open access
Semantic Scholar
Impact of time to return of spontaneous circulation on neuroprotective effect of targeted temperature management at 33 or 36 degrees in comatose survivors of out-of hospital cardiac arrest.
J. Kjaergaard, N. Nielsen, M. Winther-Jensen, M. Wanscher +16 more
2015Resuscitation49 citations
Semantic Scholar
Matrix Metalloproteinase Inhibition Decreases Ischemia‐Reperfusion Injury After Lung Transplantation
P. Soccal, Y. Gasche, Douglas N. Miniati, G. Hoyt +4 more
2004American Journal of Transplantation49 citations Open access
Semantic Scholar
Persisting vasculitis after pneumococcal meningitis
D. Pugin, J. Copin, Marie-Christelle Goodyear, T. Landis +1 more
2006Neurocritical Care47 citations Open access
Semantic Scholar
Recombinant tissue plasminogen activator induces blood–brain barrier breakdown by a matrix metalloproteinase‐9‐independent pathway after transient focal cerebral ischemia in mouse
J. Copin, Daniel Jiménez Bengualid, R. D. da Silva, O. Kargiotis +2 more
2011European Journal of Neuroscience46 citations Open access
Semantic Scholar
Effect of hypotension severity on hippocampal CA1 neurons in a rat global ischemia model.
T. Sugawara, M. Kawase, A. Lewén, N. Noshita +3 more
2000Brain Research46 citations
Semantic Scholar
Incidence and Outcome of Aneurysmal Subarachnoid Hemorrhage
B. Schatlo, C. Fung, M. Stienen, A. Fathi +55 more
2020Stroke44 citations Open access
Semantic Scholar
Delayed matrix metalloproteinase inhibition reduces intracerebral hemorrhage after embolic stroke in rats.
J. Copin, P. Merlani, T. Sugawara, P. H. Chan +1 more
2008Experimental Neurology44 citations Open access
Semantic Scholar
No difference in mortality between men and women after out-of-hospital cardiac arrest.
M. Winther-Jensen, J. Kjaergaard, M. Wanscher, N. Nielsen +13 more
2015Resuscitation43 citations
Semantic Scholar
Increase of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit
J. Badaut, J. Copin, A M Fukuda, Y. Gasche +2 more
2012Journal of Neuroinflammation37 citations Open access
Semantic Scholar
Polymorphisms in the lectin pathway of complement activation influence the incidence of acute rejection and graft outcome after kidney transplantation.
D. Golshayan, A. Wójtowicz, S. Bibert, N. Pyndiah +76 more
2016Kidney International35 citations Open access
Semantic Scholar
Recombinant Tissue Plasminogen Activator Enhances Microglial Cell Recruitment after Stroke in Mice
S. Lenglet, F. Montecucco, Á. Dénes, G. Coutts +5 more
2014Journal of Cerebral Blood Flow and Metabolism35 citations Open access
Semantic Scholar
Identifying Risk Factors for Central Pontine and Extrapontine Myelinolysis After Liver Transplantation: A Case–Control Study
I. Morard, Y. Gasche, M. Kneteman, C. Toso +5 more
2014Neurocritical Care33 citations Open access
Semantic Scholar
Resting-State Brain Activity for Early Prediction Outcome in Postanoxic Patients in a Coma with Indeterminate Clinical Prognosis
D. Pugin, J. Hofmeister, Y. Gasche, S. Vulliémoz +3 more
2020American Journal of Neuroradiology32 citations Open access
Semantic Scholar
Infectious complications after out-of-hospital cardiac arrest-A comparison between two target temperatures.
J. Dankiewicz, N. Nielsen, A. Linder, M. Kuiper +17 more
2017Resuscitation32 citations
Semantic Scholar
Detailed statistical analysis plan for the target temperature management after out-of-hospital cardiac arrest trial
N. Nielsen, P. Winkel, T. Cronberg, D. Erlinge +13 more
2013Trials32 citations Open access
Semantic Scholar
Matrix metalloproteinase-9 concentration in the cerebral extracellular fluid of patients during the acute phase of aneurysmal subarachnoid hemorrhage
A. Sarrafzadeh, J. Copin, Daniel Jiménez Bengualid, N. Turck +4 more
2012Neurological Research31 citations
Semantic Scholar
The Prognostic Significance of the Serum Biomarker Heart-Fatty Acidic Binding Protein in Comparison with S100b in Severe Traumatic Brain Injury
B. Walder, X. Robin, Marie My Lien Rebetez, J. Copin +3 more
2013Journal of Neurotrauma30 citations Open access
Semantic Scholar
Matrix metalloproteinase 9 and cellular fibronectin plasma concentrations are predictors of the composite endpoint of length of stay and death in the intensive care unit after severe traumatic brain injury
J. Copin, Marie My Lien Rebetez, N. Turck, X. Robin +4 more
2012Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine28 citations Open access
Semantic Scholar
Two structurally different T‐type Ca2+ channel inhibitors, mibefradil and pimozide, protect CA1 neurons from delayed death after global ischemia in rats
M. Bancila, J. Copin, Y. Daali, B. Schatlo +2 more
2011Fundamental & Clinical Pharmacology27 citations
Semantic Scholar
Decompressive Craniectomy for Space Occupying Hemispheric and Cerebellar Ischemic Strokes: Swiss Recommendations
P. Michel, M. Arnold, H. Hungerbühler, Felix Müller +21 more
2009International Journal of Stroke26 citations Open access
Semantic Scholar
Improvement of drug-induced chronic renal failure in lung transplantation.
P. Soccal, Y. Gasche, H. Favre, A. Spiliopoulos +1 more
1999Transplantation24 citations Open access
Semantic Scholar

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