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Simon Wisnovsky · SciRah

Researcher profile · Semantic Scholar

Simon Wisnovsky

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Simon Wisnovsky — researcher profile on SciRah

h-index: 13
Works: 29
Citations: 1,877

Most-cited papers

Lysosome-targeting chimaeras for degradation of extracellular proteins
Steven M. Banik, Kayvon Pedram, Simon Wisnovsky, Green Ahn +2 more
2020Nature999 citations Open access
Semantic Scholar
Elucidating the cellular determinants of targeted membrane protein degradation by lysosome-targeting chimeras
Green Ahn, N. Riley, Roarke A. Kamber, Simon Wisnovsky +4 more
2023Science167 citations Open access
Semantic Scholar
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
Simon Wisnovsky, L. Möckl, S. Malaker, Kayvon Pedram +7 more
2021Proceedings of the National Academy of Sciences of the United States of America129 citations Open access
Semantic Scholar
Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells
B. Schumann, S. Malaker, Simon Wisnovsky, M. Debets +13 more
2020Molecules and Cells96 citations Open access
Semantic Scholar
Design of a mucin-selective protease for targeted degradation of cancer-associated mucins
Kayvon Pedram, D. J. Shon, Gabrielle S. Tender, N. Mantuano +15 more
2022bioRxiv81 citations Open access
Semantic Scholar
Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation
M. Debets, Omur Y. Tastan, Simon Wisnovsky, S. Malaker +23 more
2020Proceedings of the National Academy of Sciences of the United States of America78 citations Open access
Semantic Scholar
Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth
E. Scott, Kirsty Hodgson, Beatriz Calle, H. Turner +55 more
2023Oncogene70 citations Open access
Semantic Scholar
MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint
Benjamin A. H. Smith, Anja Deutzmann, Kristina Correa, Corleone S. Delaveris +12 more
2023Proceedings of the National Academy of Sciences of the United States of America67 citations Open access
Semantic Scholar
Reading the glyco-code: New approaches to studying protein–carbohydrate interactions
Simon Wisnovsky, C. Bertozzi
2022Current Opinion in Structural Biology49 citations Open access
Semantic Scholar
The glycoimmune checkpoint receptor Siglec-7 interacts with T-cell ligands and regulates T-cell activation
Natalie Stewart, John Daly, Olivia Drummond-Guy, Vignesh K Krishnamoorthy +5 more
2023Journal of Biological Chemistry37 citations Open access
Semantic Scholar
Antibody-lectin chimeras for glyco-immune checkpoint blockade
Jessica C. Stark, M. Gray, Itziar Ibarlucea-Benitez, M. Lustig +17 more
2024bioRxiv31 citations Open access
Semantic Scholar
The glycosyltransferase ST3GAL4 drives immune evasion in acute myeloid leukemia by synthesizing ligands for the glyco-immune checkpoint receptor Siglec-9
Vignesh K Krishnamoorthy, John Daly, Jimmy Kim, Lidia Piatnitca +7 more
2024Leukemia30 citations Open access
Semantic Scholar
Bridging Glycomics and Genomics: New Uses of Functional Genetics in the Study of Cellular Glycosylation
Natalie Stewart, Simon Wisnovsky
2022Frontiers in Molecular Biosciences16 citations Open access
Semantic Scholar
The 5′ Binding MID Domain of Human Argonaute2 Tolerates Chemically Modified Nucleotide Analogues
G. Deleavey, F. Frank, M. Hassler, Simon Wisnovsky +2 more
2013Nucleic Acid Therapeutics13 citations
Semantic Scholar
CRISPR activation screens map the genomic landscape of cancer glycome remodeling
John Daly, Lidia Piatnitca, Mohammed Al-Seragi, Vignesh K Krishnamoorthy +1 more
2025bioRxiv8 citations Open access
Semantic Scholar
Identifying Genetic Regulators of Protein‐Glycan Interactions with Genome‐Wide CRISPR Screening
Vignesh K Krishnamoorthy, J. Daly, Simon Wisnovsky
2023Current Protocols5 citations
Semantic Scholar
Polysialic acid is upregulated on activated immune cells and negatively regulates anticancer immune activity
Olivia Drummond-Guy, John Daly, Angeline Wu, Natalie Stewart +5 more
2025Frontiers in Oncology4 citations Open access
Semantic Scholar
A Genome-Wide CRISPR Screen Identifies Sortilin as the Receptor Responsible for Galectin-1 Lysosomal Trafficking
J. Donnelly, Roarke A. Kamber, Simon Wisnovsky, David S. Roberts +3 more
2024bioRxiv4 citations Open access
Semantic Scholar
Chemical precision glyco-mutagenesis by glycosyltransferase engineering in living cells
B. Schumann, S. Malaker, Simon Wisnovsky, M. Debets +12 more
2019bioRxiv3 citations Open access
Semantic Scholar
CRISPR screens to identify and characterize ligands for glycan-binding proteins.
Jimmy Kim, Halen Kovacs, Simon Wisnovsky
2026Methods in Enzymology1 citations
Semantic Scholar
A lectin-based magnetic CRISPR screening protocol permits rapid discovery of genes regulating cell-surface glycosylation
Jimmy Kim, Halen Kovacs, Simon Wisnovsky
2025bioRxiv1 citations Open access
Semantic Scholar
3101 – THE GLYCOSYLTRANSFERASE ST3GAL4 DRIVES IMMUNE EVASION IN ACUTE MYELOID LEUKEMIA BY SYNTHESIZING LIGANDS FOR THE GLYCO-IMMUNE CHECKPOINT RECEPTOR SIGLEC-9
Vignesh K Krishnamoorthy, John Daly, Jimmy Kim, Lidia Piatnitca +7 more
2025Experimental Hematology1 citations
Semantic Scholar
A genome-wide CRISPR screen reveals cancer-specific regulators of hyaluronan binding and cellular invasion
Jimmy Kim, Halen Kovacs, Anjali Parthasarathy, Shi-Ni Chen +8 more
2026bioRxiv0 citations Open access
Semantic Scholar
Rapid discovery of cell-surface glycosylation regulators using a lectin-based magnetic CRISPR screen
Jimmy Kim, Halen Kovacs, Simon Wisnovsky
2026Cell Reports Methods0 citations Open access
Semantic Scholar
982 Targeting glycans for cancer immunotherapy
Jessica C. Stark, Melissa A Gray, Itziar Ibarlucea-Benitez, M. Lustig +17 more
2025Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
522 A systems glycobiology platform reveals novel immunotherapy targets in acute myeloid leukemia
Simon Wisnovsky
2024Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
1187 Antibody-lectin bispecifics for glyco-immune checkpoint blockade
Jessica C. Stark, Melissa A Gray, Simon Wisnovsky, Itziar Ibarlucea-Benitez +9 more
2023Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
1209 Antibody-lectin bispecifics for glyco-immune checkpoint blockade
Jessica C. Stark, M. Gray, Simon Wisnovsky, Itziar Ibarlucea-Benitez +4 more
2022Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
Abstract A95: A genome-wide CRISPR screen identifies novel ligands for the Siglec family of glyco-immune checkpoint receptors
Simon Wisnovsky, C. Bertozzi
20200 citations
Semantic Scholar

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