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J. Lorsch · SciRah

Researcher profile · Semantic Scholar

J. Lorsch

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J. Lorsch — researcher profile on SciRah

h-index: 52
Works: 134
Citations: 11K

Most-cited papers

The mechanism of eukaryotic translation initiation: new insights and challenges.
A. Hinnebusch, J. Lorsch
2012Cold Spring Harbor Perspectives in Biology513 citations Open access
Semantic Scholar
A mechanistic overview of translation initiation in eukaryotes
Colin Echeverría Aitken, J. Lorsch
2012Nature Structural &Molecular Biology438 citations
Semantic Scholar
The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome.
L. Passmore, T. Schmeing, David Maag, Drew Applefield +4 more
2007Molecules and Cells365 citations Open access
Semantic Scholar
Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex
J. Llácer, T. Hussain, Laura E. Marler, Colin Echeverría Aitken +4 more
2015Molecules and Cells225 citations Open access
Semantic Scholar
Structural Changes Enable Start Codon Recognition by the Eukaryotic Translation Initiation Complex
T. Hussain, J. Llácer, I. Fernández, Antonio M. Muñoz +5 more
2014Cell217 citations Open access
Semantic Scholar
Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo.
Y. Cheung, David Maag, Sarah F. Mitchell, Christie A. Fekete +6 more
2007Genes & Development174 citations Open access
Semantic Scholar
Fixing problems with cell lines
J. Lorsch, F. Collins, J. Lippincott-Schwartz
2014Science166 citations Open access
Semantic Scholar
Reconstitution of yeast translation initiation.
M. Acker, S. Kolitz, Sarah F. Mitchell, J. Nanda +1 more
2007Methods in Enzymology153 citations
Semantic Scholar
The 5′-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and block an alternative pathway
Sarah F. Mitchell, Sarah E. Walker, Mikkel A. Algire, E. Park +2 more
2010Molecules and Cells146 citations Open access
Semantic Scholar
Molecular architecture of a eukaryotic translational initiation complex
I. Fernández, Xiao-Chen Bai, T. Hussain, A. C. Kelley +3 more
2013Science133 citations Open access
Semantic Scholar
N‐ and C‐terminal residues of eIF1A have opposing effects on the fidelity of start codon selection
Christie A. Fekete, Sarah F. Mitchell, V. Cherkasova, Drew Applefield +5 more
2007EMBO Journal132 citations Open access
Semantic Scholar
eIF1 controls multiple steps in start codon recognition during eukaryotic translation initiation
J. Nanda, Y. Cheung, Julie E. Takacs, Pilar Martin-Marcos +3 more
2009Journal of Molecular Biology129 citations Open access
Semantic Scholar
Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosome.
A. Saini, J. Nanda, J. Lorsch, A. Hinnebusch
2010Genes & Development120 citations Open access
Semantic Scholar
Multiple elements in the eIF4G1 N‐terminus promote assembly of eIF4G1•PABP mRNPs in vivo
E. Park, Sarah E. Walker, Joseph M. Lee, Stefan Rothenburg +2 more
2011EMBO Journal99 citations Open access
Semantic Scholar
Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition
J. Llácer, T. Hussain, A. Saini, J. Nanda +6 more
2018bioRxiv98 citations Open access
Semantic Scholar
Molecular View of 43 S Complex Formation and Start Site Selection in Eukaryotic Translation Initiation*
J. Lorsch, T. Dever
2010Journal of Biological Chemistry96 citations Open access
Semantic Scholar
Coordinated Movements of Eukaryotic Translation Initiation Factors eIF1, eIF1A, and eIF5 Trigger Phosphate Release from eIF2 in Response to Start Codon Recognition by the Ribosomal Preinitiation Complex*
J. Nanda, A. Saini, Antonio M. Muñoz, A. Hinnebusch +1 more
2013Journal of Biological Chemistry89 citations Open access
Semantic Scholar
Kinetic and thermodynamic analysis of the role of start codon/anticodon base pairing during eukaryotic translation initiation.
S. Kolitz, Julie E. Takacs, J. Lorsch
2008RNA: A publication of the RNA Society86 citations Open access
Semantic Scholar
Yeast eIF4B binds to the head of the 40S ribosomal subunit and promotes mRNA recruitment through its N-terminal and internal repeat domains.
Sarah E. Walker, Fu-Jun Zhou, Sarah F. Mitchell, V. Larson +3 more
2013RNA: A publication of the RNA Society80 citations Open access
Semantic Scholar
Kinetic analysis of late steps of eukaryotic translation initiation
M. Acker, B. Shin, J. Nanda, A. Saini +2 more
2008Journal of Molecular Biology79 citations Open access
Semantic Scholar
C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β
R. Luna, H. Arthanari, H. Hiraishi, J. Nanda +18 more
2012Cell Reports72 citations Open access
Semantic Scholar
Initiation Factor eIF2γ Promotes eIF2–GTP–Met-tRNAiMet Ternary Complex Binding to the 40S Ribosome
B. Shin, Joo-Ran Kim, Sarah E. Walker, Jin-Sheng Dong +2 more
2011Nature Structural &Molecular Biology72 citations Open access
Semantic Scholar
Coupled Release of Eukaryotic Translation Initiation Factors 5B and 1A from 80S Ribosomes following Subunit Joining
J. Fringer, M. Acker, Christie A. Fekete, J. Lorsch +1 more
2007Molecular and Cellular Biology72 citations Open access
Semantic Scholar
Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity
Paul Yourik, Colin Echeverría Aitken, Fu-Jun Zhou, Neha Gupta +2 more
2017eLife70 citations Open access
Semantic Scholar
Labeling a protein with fluorophores using NHS ester derivitization.
J. Nanda, J. Lorsch
2014Methods in Enzymology69 citations
Semantic Scholar
eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast
Pilar Martin-Marcos, Fu-Jun Zhou, Charm Karunasiri, Fan Zhang +8 more
2017eLife68 citations Open access
Semantic Scholar
RNA purification--precipitation methods.
Sarah E. Walker, J. Lorsch
2013Methods in Enzymology68 citations
Semantic Scholar
Eukaryotic translation initiation factor 3 plays distinct roles at the mRNA entry and exit channels of the ribosomal preinitiation complex
Colin Echeverría Aitken, Petra Beznosková, Vladislava Vlčková, Wen-Ling Chiu +4 more
2016bioRxiv67 citations Open access
Semantic Scholar
Specific Domains in Yeast Translation Initiation Factor eIF4G Strongly Bias RNA Unwinding Activity of the eIF4F Complex toward Duplexes with 5′-Overhangs*
V. Rajagopal, E. Park, A. Hinnebusch, J. Lorsch
2012Journal of Biological Chemistry64 citations Open access
Semantic Scholar
Eukaryotic Initiator tRNA: Finely Tuned and Ready for Action
S. Kolitz, J. Lorsch
2010FEBS Letters63 citations Open access
Semantic Scholar
Yeast Ded1 promotes 48S translation pre-initiation complex assembly in an mRNA-specific and eIF4F-dependent manner
Neha Gupta, J. Lorsch, A. Hinnebusch
2018bioRxiv62 citations Open access
Semantic Scholar
Should I Stay or Should I Go? Eukaryotic Translation Initiation Factors 1 and 1A Control Start Codon Recognition*
Sarah F. Mitchell, J. Lorsch
2008Journal of Biological Chemistry61 citations Open access
Semantic Scholar
Rps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codons
Jin-Sheng Dong, Colin Echeverría Aitken, A. Thakur, B. Shin +2 more
2017Proceedings of the National Academy of Sciences of the United States of America56 citations Open access
Semantic Scholar
β-Hairpin Loop of Eukaryotic Initiation Factor 1 (eIF1) Mediates 40 S Ribosome Binding to Regulate Initiator tRNAMet Recruitment and Accuracy of AUG Selection in Vivo * ♦
Pilar Martin-Marcos, J. Nanda, R. Luna, G. Wagner +2 more
2013Journal of Biological Chemistry48 citations Open access
Semantic Scholar
Ribosome recycling step in yeast cytoplasmic protein synthesis is catalyzed by eEF3 and ATP
S. Kurata, K. H. Nielsen, Sarah F. Mitchell, J. Lorsch +2 more
2010Proceedings of the National Academy of Sciences of the United States of America48 citations Open access
Semantic Scholar
Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complex
A. Saini, J. Nanda, Pilar Martin-Marcos, Jin-Sheng Dong +4 more
2014Nucleic Acids Research46 citations Open access
Semantic Scholar
Functional interplay between DEAD-box RNA helicases Ded1 and Dbp1 in preinitiation complex attachment and scanning on structured mRNAs in vivo.
N. D. Sen, Neha Gupta, Stuart K. Archer, T. Preiss +2 more
2019Nucleic Acids Research41 citations Open access
Semantic Scholar
Enhanced eIF1 binding to the 40S ribosome impedes conformational rearrangements of the preinitiation complex and elevates initiation accuracy
Pilar Martin-Marcos, J. Nanda, R. Luna, Fan Zhang +5 more
2014RNA: A publication of the RNA Society41 citations Open access
Semantic Scholar
Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNA(Met) and AUG selection.
Jin-Sheng Dong, J. Nanda, Hafsa Rahman, Margaret R. Pruitt +4 more
2008Genes & Development40 citations Open access
Semantic Scholar
Maximizing the return on taxpayers' investments in fundamental biomedical research
J. Lorsch
2015Molecular Biology of the Cell39 citations Open access
Semantic Scholar
Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo
Suna P. Gulay, Neha Gupta, J. Lorsch, A. Hinnebusch
2020eLife37 citations Open access
Semantic Scholar
4 The Mechanism of Translation Initiation in Eukaryotes
T. Pestova, J. Lorsch, C. Hellen
200737 citations
Semantic Scholar
eIF1 discriminates against suboptimal initiation sites to prevent excessive uORF translation genome-wide
Fu-Jun Zhou, Hongen Zhang, Shardul Kulkarni, J. Lorsch +1 more
2020RNA: A publication of the RNA Society36 citations Open access
Semantic Scholar
Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery.
Julie E. Takacs, Timothy B. Neary, Nicholas T. Ingolia, A. Saini +4 more
2011RNA: A publication of the RNA Society32 citations Open access
Semantic Scholar
Labeling of a protein with fluorophores using maleimide derivitization.
J. Nanda, J. Lorsch
2014Methods in Enzymology31 citations
Semantic Scholar
Basic science: Bedrock of progress.
F. Collins, James M. Anderson, Christopher P. Austin, J. Battey +36 more
2016Science30 citations Open access
Semantic Scholar
Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon
Jin-Sheng Dong, Antonio M. Muñoz, S. Kolitz, A. Saini +4 more
2014Genes & Development30 citations Open access
Semantic Scholar
Yeast Eukaryotic Initiation Factor 4B (eIF4B) Enhances Complex Assembly between eIF4A and eIF4G in Vivo*
E. Park, Sarah E. Walker, Fu-Jun Zhou, Joseph M. Lee +3 more
2012Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Practical steady-state enzyme kinetics.
J. Lorsch
2014Methods in Enzymology28 citations
Semantic Scholar
Protein Affinity Purification using Intein/Chitin Binding Protein Tags.
Sarah F. Mitchell, J. Lorsch
2015Methods in Enzymology25 citations
Semantic Scholar

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A. Hinnebusch×29
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A. Hinnebusch — researcher profile on SciRah
J. Nanda×14
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A. Saini×10
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A. Saini — researcher profile on SciRah
Pilar Martin-Marcos×8
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Pilar Martin-Marcos — researcher profile on SciRah

Sarah F. Mitchell

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Sarah E. Walker×6

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T. Hussain — researcher profile on SciRah