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H. LaDuca · SciRah

Researcher profile · Semantic Scholar

H. LaDuca

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H. LaDuca — researcher profile on SciRah

h-index: 35
Works: 144
Citations: 4,742

Most-cited papers

Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families.
Xin Yang, Goska Leslie, Alicja Doroszuk, S. Schneider +115 more
2019Journal of Clinical Oncology371 citations Open access
Semantic Scholar
Triple-Negative Breast Cancer Risk Genes Identified by Multigene Hereditary Cancer Panel Testing
H. Shimelis, H. LaDuca, Chun-Ling Hu, S. Hart +25 more
2018Journal of the National Cancer Institute291 citations Open access
Semantic Scholar
False-positive results released by direct-to-consumer genetic tests highlight the importance of clinical confirmation testing for appropriate patient care
Stephany Tandy-Connor, Jenna Guiltinan, Kate Krempely, H. LaDuca +4 more
2018Genetics in Medicine261 citations Open access
Semantic Scholar
A clinical guide to hereditary cancer panel testing: evaluation of gene-specific cancer associations and sensitivity of genetic testing criteria in a cohort of 165,000 high-risk patients
H. LaDuca, E. Polley, Amal Yussuf, Lily Hoang +17 more
2019Genetics in Medicine197 citations Open access
Semantic Scholar
Ovarian and Breast Cancer Risks Associated With Pathogenic Variants in RAD51C and RAD51D
Xin Yang, Hong-Lin Song, Goska Leslie, C. Engel +57 more
2020Journal of the National Cancer Institute165 citations Open access
Semantic Scholar
Clinical features and cancer risk in families with pathogenic CDH1 variants irrespective of clinical criteria
R. Xicola, Shuwei Li, N. Rodriguez, P. Reinecke +5 more
2019Journal of Medical Genetics121 citations Open access
Semantic Scholar
The Contribution of Germline Predisposition Gene Mutations to Clinical Subtypes of Invasive Breast Cancer From a Clinical Genetic Testing Cohort
Chun-Ling Hu, E. Polley, S. Yadav, J. Lilyquist +9 more
2020Journal of the National Cancer Institute103 citations Open access
Semantic Scholar
Differences in TP53 Mutation Carrier Phenotypes Emerge From Panel-Based Testing
H. Rana, R. Gelman, H. LaDuca, R. McFarland +6 more
2018Journal of the National Cancer Institute84 citations Open access
Semantic Scholar
Prospective study of germline genetic testing in incident cases of pancreatic adenocarcinoma
R. Brand, E. Borazanci, V. Speare, Beth Dudley +23 more
2018Cancer83 citations Open access
Semantic Scholar
Differences in Cancer Phenotypes Among Frequent CHEK2 Variants and Implications for Clinical Care—Checking CHEK2
B. Bychkovsky, N. Ağaoğlu, C. Horton, Jing Zhou +9 more
2022JAMA Oncology78 citations Open access
Semantic Scholar
Splicing profile by capture RNA-seq identifies pathogenic germline variants in tumor suppressor genes
Tyler A. Landrith, Bing Li, Ashley A. Cass, B. Conner +49 more
2020npj Precision Oncology73 citations Open access
Semantic Scholar
Assessment of Diagnostic Outcomes of RNA Genetic Testing for Hereditary Cancer
R. Karam, B. Conner, H. LaDuca, K. McGoldrick +21 more
2019JAMA Network Open69 citations Open access
Semantic Scholar
Prevalence of Germline Mutations in Polyposis and Colorectal Cancer-Associated Genes in Patients With Multiple Colorectal Polyps.
P. Stanich, R. Pearlman, A. Hinton, S. Gutierrez +3 more
2019Clinical Gastroenterology and Hepatology60 citations Open access
Semantic Scholar
Rare Germline Pathogenic Mutations of DNA Repair Genes Are Most Strongly Associated with Grade Group 5 Prostate Cancer.
Yi-Shuo Wu, Hong-Jie Yu, Shuwei Li, K. Wiley +12 more
2020European Urology Oncology56 citations
Semantic Scholar
Multigene Hereditary Cancer Panels Reveal High-Risk Pancreatic Cancer Susceptibility Genes
Chun-Ling Hu, H. LaDuca, H. Shimelis, E. Polley +11 more
2018JCO Precision Oncology55 citations Open access
Semantic Scholar
Germline Pathogenic Variants in Cancer Predisposition Genes Among Women With Invasive Lobular Carcinoma of the Breast
S. Yadav, Chun-Ling Hu, K. Nathanson, J. Weitzel +38 more
2021Journal of Clinical Oncology47 citations Open access
Semantic Scholar
Classification of variants of uncertain significance in BRCA1 and BRCA2 using personal and family history of cancer from individuals in a large hereditary cancer multigene panel testing cohort
Hong-Yan Li, H. LaDuca, T. Pesaran, Elizabeth C. Chao +9 more
2019Genetics in Medicine45 citations Open access
Semantic Scholar
Strong functional data for pathogenicity or neutrality classify BRCA2 DNA-binding-domain variants of uncertain significance
Marcy E. Richardson, Chun-Ling Hu, Kun Y. Lee, H. LaDuca +11 more
2021American Journal of Human Genetics44 citations Open access
Semantic Scholar
Diagnosing hereditary cancer predisposition in men with prostate cancer
Mary Pritzlaff, Yuan Tian, P. Reineke, A. Stuenkel +8 more
2020Genetics in Medicine43 citations Open access
Semantic Scholar
Diagnostic Outcomes of Concurrent DNA and RNA Sequencing in Individuals Undergoing Hereditary Cancer Testing
C. Horton, Lily Hoang, Heather Zimmermann, C. Young +10 more
2023JAMA Oncology40 citations Open access
Semantic Scholar
Breast cancer risk in neurofibromatosis type 1 is a function of the type of NF1 gene mutation: a new genotype-phenotype correlation
I. Frayling, V. Mautner, R. van Minkelen, R. Kallionpää +19 more
2018Journal of Medical Genetics39 citations Open access
Semantic Scholar
Universal Germline Panel Testing for Individuals With Pheochromocytoma and Paraganglioma Produces High Diagnostic Yield
C. Horton, H. LaDuca, Ashley Deckman, Kate M. Durda +6 more
2022Journal of Clinical Endocrinology and Metabolism38 citations Open access
Semantic Scholar
Racial and Ethnic Differences in Multigene Hereditary Cancer Panel Test Results for Women With Breast Cancer
S. Yadav, H. LaDuca, E. Polley, Chun-Ling Hu +14 more
2020Journal of the National Cancer Institute36 citations Open access
Semantic Scholar
Validation of a prostate cancer polygenic risk score
M. Black, Shuwei Li, H. LaDuca, Min-Tzu Lo +13 more
2020The Prostate32 citations Open access
Semantic Scholar
Comprehensive Paired Tumor/Germline Testing for Lynch Syndrome: Bringing Resolution to the Diagnostic Process
M. U. Salvador, M. Truelson, C. Mason, B. Souders +17 more
2019Journal of Clinical Oncology32 citations Open access
Semantic Scholar
Mutation prevalence tables for hereditary cancer derived from multi-gene panel testing
S. Hart, E. Polley, Amal Yussuf, S. Yadav +8 more
2019Human Mutation32 citations Open access
Semantic Scholar
Risk of Late-Onset Breast Cancer in Genetically Predisposed Women
N. Boddicker, Chun-Ling Hu, J. Weitzel, P. Kraft +47 more
2021Journal of Clinical Oncology30 citations Open access
Semantic Scholar
Mutational and splicing landscape in a cohort of 43,000 patients tested for hereditary cancer
C. Horton, Ashley A. Cass, B. Conner, Lily Hoang +18 more
2022npj Genomic Medicine28 citations Open access
Semantic Scholar
Genotype–phenotype associations among panel-based TP53+ subjects
H. Rana, J. Clifford, Lily Hoang, H. LaDuca +7 more
2019Genetics in Medicine25 citations Open access
Semantic Scholar
Monoallelic MUTYH carrier status is not associated with increased breast cancer risk in a multigene panel cohort
K. Fulk, H. LaDuca, M. Black, D. Qian +4 more
2018Familial Cancer23 citations
Semantic Scholar
Quality of Clinician-Reported Cancer History When Ordering Genetic Testing.
H. LaDuca, R. McFarland, S. Gutierrez, Amal Yussuf +7 more
2018JCO Clinical Cancer Informatics22 citations
Semantic Scholar
First international workshop of the ATM and Cancer Risk Group (4–5 December 2019)
F. Lesueur, D. Easton, A. Renault, S. Tavtigian +49 more
2021Familial Cancer20 citations Open access
Semantic Scholar
Prevalence and spectrum of pathogenic variants among patients with multiple primary cancers evaluated by clinical characteristics
B. Bychkovsky, Min-Tzu Lo, Amal Yussuf, Carrie Horton +4 more
2021Cancer19 citations Open access
Semantic Scholar
Prevalence of germline variants in inflammatory breast cancer
H. Rana, R. Sacca, C. Drogan, S. Gutierrez +7 more
2019Cancer17 citations Open access
Semantic Scholar
Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C
Chun-Ling Hu, Anil Belur Nagaraj, H. Shimelis, G. Montalban +40 more
2023Cancer Research14 citations Open access
Semantic Scholar
Quantifying evidence toward pathogenicity for rare phenotypes: The case of succinate dehydrogenase genes, SDHB and SDHD
A. Garrett, C. Loveday, L. King, Samantha Butler +29 more
2021Genetics in Medicine12 citations Open access
Semantic Scholar
Women with breast and uterine cancer are more likely to harbor germline mutations than women with breast or uterine cancer alone: A case for expanded gene testing.
K. Fulk, M. R. Milam, Shuwei Li, Amal Yussuf +4 more
2019Gynecologic Oncology12 citations
Semantic Scholar
Germline pathogenic variants in cancer risk genes among patients with thyroid cancer and suspected predisposition
J. Kamihara, Jing Zhou, H. LaDuca, A. Wassner +3 more
2022Cancer Medicine10 citations Open access
Semantic Scholar
Prevalence of Germline Pathogenic and Likely Pathogenic Variants in Patients With Second Breast Cancers
Katharine A. Yao K, J. Clifford, Shuwei Li, H. LaDuca +3 more
2020JNCI Cancer Spectrum10 citations Open access
Semantic Scholar
Polygenic risk score for breast cancer in high-risk women.
M. Black, Shuwei Li, H. LaDuca, Jefferey Chen +8 more
20189 citations
Semantic Scholar
Development and Validation of the PREMMplus Model for Multigene Hereditary Cancer Risk Assessment
M. Yurgelun, H. Uno, C. S. Furniss, C. Ukaegbu +6 more
2022Journal of Clinical Oncology8 citations Open access
Semantic Scholar
Tumour characteristics provide evidence for germline mismatch repair missense variant pathogenicity
Shuwei Li, D. Qian, B. Thompson, S. Gutierrez +6 more
2019Journal of Medical Genetics8 citations
Semantic Scholar
Clinical germline diagnostic exome sequencing for hereditary cancer: Findings within novel candidate genes are prevalent.
Z. Powis, C. Espenschied, H. LaDuca, K. D. Farwell Hagman +8 more
2018Cancer Genetics8 citations
Semantic Scholar
Triple-Negative Breast Cancer Risk Genes Identified by Multigene Hereditary Cancer Panel Testing
H. Shimelis, H. LaDuca, Chun-Ling Hu, S. Hart +28 more
20188 citations
Semantic Scholar
An integrative model for the comprehensive classification of BRCA1 and BRCA2 variants of uncertain clinical significance
E. Iversen, G. Lipton, S. Hart, Kun Y. Lee +10 more
2022npj Genomic Medicine6 citations Open access
Semantic Scholar
Clinical, splicing, and functional analysis to classify BRCA2 exon 3 variants: Application of a points‐based ACMG/AMP approach
M. Thomassen, Romy L. S. Mesman, Thomas V. O. Hansen, M. Menéndez +46 more
2022Human Mutation6 citations Open access
Semantic Scholar
Case–case analysis addressing ascertainment bias for multigene panel testing implicates BRCA1 and PALB2 in endometrial cancer
S. Johnatty, T. Pesaran, Jill S. Dolinsky, Amal Yussuf +4 more
2021Human Mutation6 citations Open access
Semantic Scholar
Pathogenic variants among females with breast cancer and a non-breast cancer reveal opportunities for cancer interception
B. Bychkovsky, Min-Tzu Lo, Amal Yussuf, Carrie Horton +5 more
2023Breast Cancer Research and Treatment5 citations Open access
Semantic Scholar
Sequencing approaches in hereditary cancer testing: strengths, limitations and future directions
Sami Belhadj, Christopher J. Hatch, H. LaDuca, C. Horton +2 more
2026European Journal of Human Genetics4 citations Open access
Semantic Scholar
Advocating for the consumer: clinical confirmation of all direct-to-consumer raw data alterations remains critical
Stephany Tandy-Connor, Kate Krempely, T. Pesaran, H. LaDuca +2 more
2018Genetics in Medicine4 citations Open access
Semantic Scholar

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Jill S. Dolinsky×22
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Jill S. Dolinsky — researcher profile on SciRah
Amal Yussuf×19
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Amal Yussuf — researcher profile on SciRah
T. Pesaran×18
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T. Pesaran — researcher profile on SciRah
F. Couch×17
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Elizabeth C. Chao

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Elizabeth C. Chao — researcher profile on SciRah

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D. Goldgar — researcher profile on SciRah

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M. Black — researcher profile on SciRah

Chun-Ling Hu×13

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Chun-Ling Hu — researcher profile on SciRah

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S. Hart — researcher profile on SciRah

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E. Polley — researcher profile on SciRah

S. Gutierrez×13

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