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G. Vladimer · SciRah

Researcher profile · Semantic Scholar

G. Vladimer

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G. Vladimer — researcher profile on SciRah

h-index: 21
Works: 53
Citations: 7,178

Most-cited papers

NLRP3 inflamasomes are required for atherogenesis and activated by cholesterol crystals that form early in disease
P. Duewell, H. Kono, Katey J. Rayner, C. Sirois +14 more
2010Nature2,687 citations Open access
Semantic Scholar
Somatic mutations of calreticulin in myeloproliferative neoplasms.
T. Klampfl, H. Gisslinger, A. Harutyunyan, H. Nivarthi +25 more
2013New England Journal of Medicine1,931 citations Open access
Semantic Scholar
The NLRP12 inflammasome recognizes Yersinia pestis
G. Vladimer, D. Weng, Sara W. Montminy-Paquette, S. Vanaja +13 more
2012Immunity365 citations Open access
Semantic Scholar
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death
D. Weng, R. Marty-Roix, Sandhya Ganesan, Megan K. Proulx +14 more
2014Proceedings of the National Academy of Sciences of the United States of America302 citations Open access
Semantic Scholar
A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses
Marielle S. Köberlin, B. Snijder, L. Heinz, Christoph L. Baumann +4 more
2015Cell214 citations Open access
Semantic Scholar
LZTR1 is a regulator of RAS ubiquitination and signaling
J. Bigenzahn, Giovanna M. Collu, F. Kartnig, Melanie Pieraks +14 more
2018Science203 citations Open access
Semantic Scholar
Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants*
R. Marty-Roix, G. Vladimer, K. Pouliot, D. Weng +7 more
2015Journal of Biological Chemistry192 citations Open access
Semantic Scholar
Inflammasomes and host defenses against bacterial infections
G. Vladimer, R. Marty-Roix, S. Ghosh, D. Weng +1 more
2013Current Opinion in Microbiology175 citations Open access
Semantic Scholar
Functional Precision Medicine Provides Clinical Benefit in Advanced Aggressive Hematologic Cancers and Identifies Exceptional Responders
C. Kornauth, T. Pemovska, G. Vladimer, G. Bayer +66 more
2021Cancer Discovery166 citations Open access
Semantic Scholar
Image-based ex-vivo drug screening for patients with aggressive haematological malignancies: interim results from a single-arm, open-label, pilot study
B. Snijder, G. Vladimer, N. Krall, K. Miura +30 more
2017The Lancet Haematology156 citations Open access
Semantic Scholar
Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity
K. Willmann, S. Klaver, F. Doğu, Elisangela Santos-Valente +21 more
2014Nature Communications137 citations Open access
Semantic Scholar
Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions
P. Valent, A. Orazi, M. Savona, M. Patnaik +26 more
2019Haematologica130 citations Open access
Semantic Scholar
IFITs: Emerging Roles as Key Anti-Viral Proteins
G. Vladimer, M. Górna, G. Superti-Furga
2014Frontiers in Immunology120 citations Open access
Semantic Scholar
A Role for the Adaptor Proteins TRAM and TRIF in Toll-like Receptor 2 Signaling*
N. Nilsen, G. Vladimer, J. Stenvik, Pontus Orning +9 more
2014Journal of Biological Chemistry110 citations Open access
Semantic Scholar
Global survey of the immunomodulatory potential of common drugs
G. Vladimer, B. Snijder, N. Krall, J. Bigenzahn +12 more
2017Nature Chemical Biology71 citations Open access
Semantic Scholar
Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL
Christian Schmidl, G. Vladimer, André F. Rendeiro, S. Schnabl +22 more
2019Nature Chemical Biology37 citations Open access
Semantic Scholar
Gadolinium-based Compounds Induce NLRP3-dependent IL-1β Production and Peritoneal Inflammation
C. Schmidt-Lauber, L. Bossaller, H. Abujudeh, G. Vladimer +6 more
2014Annals of the Rheumatic Diseases37 citations Open access
Semantic Scholar
A time-resolved molecular map of the macrophage response to VSV infection
R. K. Kandasamy, G. Vladimer, B. Snijder, A. Müller +13 more
2016npj Systems Biology and Applications32 citations Open access
Semantic Scholar
An inducible retroviral expression system for tandem affinity purification mass-spectrometry-based proteomics identifies MLKL as an HSP90 client
J. Bigenzahn, Astrid Fauster, M. Rebsamen, R. K. Kandasamy +7 more
2015Molecular & Cellular Proteomics30 citations Open access
Semantic Scholar
FOXO3 is involved in the tumor necrosis factor-driven inflammatory response in fibroblast-like synoviocytes
B. Brandstetter, K. Dalwigk, A. Platzer, B. Niederreiter +12 more
2019Laboratory Investigation23 citations Open access
Semantic Scholar
Deep Morphology Learning Enhances Ex Vivo Drug Profiling-Based Precision Medicine
T. Heinemann, C. Kornauth, Y. Severin, G. Vladimer +11 more
2022Blood Cancer Discovery22 citations Open access
Semantic Scholar
Patient-derived model systems and the development of next-generation anticancer therapeutics.
N. Krall, G. Superti-Furga, G. Vladimer
2020Current Opinion in Chemical Biology12 citations
Semantic Scholar
Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors
B. Sousa, C. R. de Almeida, Ana F Barahona, R. Lopes +19 more
2022ACS Pharmacology & Translational Science9 citations Open access
Semantic Scholar
Abstract 3930: AI-driven discovery and profiling of GTAEXS-617, a selective and highly potent inhibitor of CDK7
J-B. Besnard, J. Joseph, Haiyun Bai, R. Paveley +9 more
2022Cancer Research6 citations
Semantic Scholar
Frequent Mutations in the Calreticulin Gene CALR in Myeloproliferative Neoplasms
Klampfl Thorsten, H. Gisslinger, A. Harutyunyan, H. Nivarthi +25 more
20136 citations
Semantic Scholar
Abstract CT114: Data from first-in-human study of EXS21546, an A2A receptor antagonist, now progressing into phase 1 in RCC/NSCLC
Nieves Diaz, H. Garratt, Aleksandra Zemla-Brown, Maria Dominguez +11 more
2023Cancer Research5 citations
Semantic Scholar
Abstract 1731: EXS21546, a non-CNS penetrant A2AR-selective antagonist for anti-cancer immunotherapy
A. Payne, P. Fons, I. Alt, J. van Ham +11 more
2021Immunology5 citations
Semantic Scholar
23P Enriching for response: Patient selection criteria for A2AR inhibition by EXS-21546 through ex vivo modelling in primary patient material
G. Vladimer, I. Alt, R. Sehlke, A. Lobley +15 more
2022Immuno-Oncology and Technology4 citations Open access
Semantic Scholar
Treatment Guided By Next Generation Functional Drug Screening Provides Clinical Benefit in Advanced Aggressive Hematological Malignancies: Final Evaluation of the Open Label, Single Arm Exalt Trial
C. Kornauth, T. Pemovska, G. Vladimer, G. Bayer +58 more
20203 citations Open access
Semantic Scholar
Functional Precision Medicine in AML: Technical Performance Evaluation for in Vitro Diagnostics Using High-Throughput Image-Based Screening of Primary Patient Cells
N. Krall, N. Mészáros, K. Lind, Bojan Vilagos +2 more
2019Blood3 citations
Semantic Scholar
Defining activity and patient selection of a novel CDK7 inhibitor, GTAEXS-617, through AI-supported primary cancer tissue profiling
M. Somlyay, E. Durinikova, J. Besnard, O. Barbeau +16 more
2022European Journal of Cancer1 citations Open access
Semantic Scholar
Influence of cryopreservation on drug responses and gene expression of AML cells: Implications for the use of biobanked tissues
N. Mészáros, K. Lind, R. Sehlke, Bojan Vilagos +3 more
2022British Journal of Haematology1 citations Open access
Semantic Scholar
Abstract 3266: Distinct immune stimulatory functions of anti-human VISTA antibodies are determined by the antibody isotype
S. Mostböck, Helen Wu, T. Fenn, C. Taubert +2 more
2019Immunology1 citations
Semantic Scholar
Viral RNA binding by the human IFIT1-IFIT3 protein complex in the innate immune response.
M. Górna, G. Vladimer, Y. Abbas, A. Gebhardt +8 more
20151 citations Open access
Semantic Scholar
Inflammasomes and the Innate Immune Response Against Yersinia Pestis: A Dissertation
G. Vladimer
20131 citations
Semantic Scholar
Functional Profiling of Rheumatoid Arthritis Reveals Disease-Specific Immunomodulatory Responses and Novel Therapeutic Targets 2256858
Christophe Boudesco, Ize Buphamalai, Katherine Driscoll, Desy Vallorani +5 more
2026Journal of Immunology0 citations
Semantic Scholar
Abstract 1893: Deep learning supported high content analysis of primary patient samples identifies ALK inhibition as a novel mechanism of action in a subset of ovarian cancers
Irene Gutierrez-Perez, J. van Ham, Valentin Aranha, Rin Okumura +13 more
2022Cancer Research0 citations
Semantic Scholar
Abstract 1303: AI driven single cell analysis of drug action in solid tumor material: An entry point to functional precision medicine
Valentin Aranha, Diogo Tomaz, I. G. Pérez, F. Rohrer +8 more
2021Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract 5233: Towards patient-centric drug discovery: Analyzing drug action in malignant pleural effusions and ascites using high content imaging and deep learning
R. Sehlke, C. Taubert, I. Alt, F. Rohrer +11 more
2020Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract A08: Genetic drug resistance screen identifies LZTR1 as regulator of RAS ubiquitination and signaling
J. Bigenzahn, Giovanna M. Collu, F. Kartnig, Melanie Pieraks +14 more
20200 citations
Semantic Scholar
Towards patient-centric drug discovery: Drug action in malignant pleural effusions and ascites using high content imaging and deep learning.
N. Krall, R. Sehlke, C. Taubert, I. Alt +11 more
20200 citations
Semantic Scholar
Abstract 319: Integrated ATAC-seq and single-cell synergistic chemosensitivity profiling identifies rational drug combinations in ibrutinib treated CLL patients
G. Vladimer, C. Schmidl, Andre Renderio, S. Schnabl +4 more
2019Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract 2689: High-content imaging and single-cell analysis of drug response ex vivo is predictive of clinical outcome for hematologic cancer patients
G. Vladimer, B. Snijder, N. Krall, C. Kornauth +4 more
2019Experimental and Molecular Therapeutics0 citations
Semantic Scholar
How to end a viral RNA - lessons from the IFIT proteins
N. Karolak, Y. Abbas, G. Vladimer, M. Klimecka +8 more
20180 citations
Semantic Scholar
Unbiased Profiling of the Immunomodulatory Properties of Soluble Proteins
N. Krall, G. Vladimer, B. Snijder, N. Mészáros +3 more
20170 citations
Semantic Scholar
04.13 The transcription factor foxo3 differentially regulates the expression of proinflammatory genes in rheumatoid fibroblast-like synoviocytes
B. Brandstetter, K. Dalwigk, G. Vladimer, G. Steiner +3 more
20170 citations
Semantic Scholar
Integrated ATAC-Seq and Chemosensitivity Profiling Identifies Rational Drug Combinations in Ibrutinib-Treated CLL Patients
G. Vladimer, Christian Schmidl, Andre Renderio, S. Schnabl +20 more
20170 citations
Semantic Scholar
Identification and secondary structure characterization of the 5 ' non-coding regions of p 53 mRNA transcripts in mouse
Joanna Boros-Majewska, M. Kowalska, K. Młynarczyk, G. Superti-Furga +7 more
20160 citations
Semantic Scholar
Monocouche de cmsp ou de cellules de la moelle osseuse et leurs utilisations
Giulio Superti-Furga, B. Snijder, G. Vladimer
20150 citations
Semantic Scholar
The NLRP12 Infl ammasome Recognizes Yersinia
G. Vladimer, D. Weng, Sara W. Montminy Paquett
20120 citations
Semantic Scholar

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