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L. Désiré · SciRah

Researcher profile · Semantic Scholar

L. Désiré

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L. Désiré — researcher profile on SciRah

h-index: 23
Works: 60
Citations: 3,161

Most-cited papers

Wnt signalling regulates adult hippocampal neurogenesis
D. Lie, S. Colamarino, Hong-jun Song, L. Désiré +7 more
2005Nature1,575 citations
Semantic Scholar
Etazolate, a neuroprotective drug linking GABAA receptor pharmacology to amyloid precursor protein processing
Maryline Marcade, Jérôme Bourdin, Nadia Loiseau, Hélène Peillon +4 more
2008Journal of Neurochemistry157 citations
Semantic Scholar
EHT0202 in Alzheimer's disease: a 3-month, randomized, placebo-controlled, double-blind study.
B. Vellas, O. Sol, P. Snyder, P. Ousset +5 more
2011Current Alzheimer Research126 citations
Semantic Scholar
RAC1 Inhibition Targets Amyloid Precursor Protein Processing by γ-Secretase and Decreases Aβ Production in Vitro and in Vivo*
L. Désiré, Jérôme Bourdin, Nadia Loiseau, Hélène Peillon +9 more
2005Journal of Biological Chemistry122 citations Open access
Semantic Scholar
A novel DYRK1A (Dual specificity tyrosine phosphorylation‐regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro
Séverine Coutadeur, Hélène Benyamine, L. Delalonde, Catherine Castelo Branco de Oliveira +8 more
2015Journal of Neurochemistry108 citations
Semantic Scholar
Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac.
A. Pollitt, B. Grygielska, B. Leblond, L. Désiré +2 more
2010Blood89 citations Open access
Semantic Scholar
Endogenous and Exogenous Fibroblast Growth Factor 2 Support Survival of Chick Retinal Neurons by Control of Neuronal Neuronal bcl‐xL and bcl‐2 Expression Through a Fibroblast Berowth Factor Receptor 1‐ and Erk‐Dependent Pathway
L. Désiré, Y. Courtois, J. Jeanny
2000Journal of Neurochemistry89 citations
Semantic Scholar
Rap1-Rac1 Circuits Potentiate Platelet Activation
L. Stefanini, Y. Boulaftali, T. D. Ouellette, M. Holinstat +5 more
2011Arteriosclerosis, Thrombosis and Vascular Biology83 citations Open access
Semantic Scholar
DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3
B. Thompson, R. Bhansali, Lauren P. Diebold, Daniel E. Cook +7 more
2015Journal of Experimental Medicine80 citations Open access
Semantic Scholar
Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer
Adena E. Rosenblatt, M. I. García, L. Lyons, Ying-Qiu Xie +4 more
2010Endocrine-Related Cancer74 citations Open access
Semantic Scholar
RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.
L. Désiré, Jérôme Bourdin, Nadia Loiseau, Hélène Peillon +9 more
2005Journal of Biological Chemistry63 citations
Semantic Scholar
Validation of AclarusDx™, a Blood-Based Transcriptomic Signature for the Diagnosis of Alzheimer's Disease
Pascale Fehlbaum-Beurdeley, O. Sol, L. Désiré, J. Touchon +10 more
2012Journal of Alzheimer's Disease58 citations
Semantic Scholar
Etazolate improves performance in a foraging and homing task in aged rats.
Jason Drott, L. Désiré, D. Drouin, M. Pando +1 more
2010European Journal of Pharmacology53 citations
Semantic Scholar
The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein*
Claudia Walliser, Elisabeth Hermkes, A. Schade, Sebastian Wiese +6 more
2016Journal of Biological Chemistry52 citations Open access
Semantic Scholar
Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part I
Alicia Foucourt, Damien Hédou, Carole Dubouilh-Benard, L. Désiré +5 more
2014Molecules46 citations Open access
Semantic Scholar
An Unusual Binding Model of the Methyl 9-Anilinothiazolo[5,4-f] quinazoline-2-carbimidates (EHT 1610 and EHT 5372) Confers High Selectivity for Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases.
A. Chaikuad, J. Diharce, Martin Schröder, Alicia Foucourt +6 more
2016Journal of Medicinal Chemistry37 citations Open access
Semantic Scholar
Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease.
Sylvia E. Perez, D. Getova, Bin He, S. Counts +6 more
2012American Journal of Pathology36 citations Open access
Semantic Scholar
BCL-2 is upregulated in human SH-SY5Y neuroblastoma cells differentiated by overexpression of fibroblast growth factor 1.
Gilda Raguenez, L. Désiré, Valérie Lantrua, Y. Courtois
1999Biochemical and Biophysical Research Communications - BBRC36 citations
Semantic Scholar
Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer
Riley A. Hampsch, K. Shee, Darcy J. P. Bates, L. Lewis +6 more
2017OncoTarget35 citations Open access
Semantic Scholar
Suppression of fibroblast growth factor 2 expression by antisense oligonucleotides inhibits embryonic chick neural retina cell differentiation and survival in vivo
L. Désiré, Mark W. Head, Nicole A. Fayein, Y. Courtois +1 more
1998Developmental Dynamics34 citations Open access
Semantic Scholar
Multiplex Antibody Detection for Noninvasive Genus-Level Diagnosis of Prosthetic Joint Infection
S. Marmor, T. Bauer, N. Desplaces, B. Heym +10 more
2016Journal of Clinical Microbiology32 citations Open access
Semantic Scholar
Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part II
Alicia Foucourt, Damien Hédou, Carole Dubouilh-Benard, A. Girard +5 more
2014Molecules32 citations Open access
Semantic Scholar
Suppression of fibroblast growth factors 1 and 2 by antisense oligonucleotides in embryonic chick retinal cells in vitro inhibits neuronal differentiation and survival.
L. Désiré, Y. Courtois, J. Jeanny
1998Experimental Cell Research28 citations
Semantic Scholar
Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding.
E. Beausoleil, C. Chauvignac, T. Taverne, S. Lacombe +12 more
2009Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Functional characterization of phospholipase C-γ2 mutant protein causing both somatic ibrutinib resistance and a germline monogenic autoinflammatory disorder
Claudia Walliser, Martin Wist, Elisabeth Hermkes, Yuan Zhou +8 more
2018OncoTarget16 citations Open access
Semantic Scholar
Sustained delivery of growth factors from methylidene malonate 2.1.2-based polymers.
L. Désiré, E. Mysiakine, David Bonnafous, P. Couvreur +3 more
2006Biomaterials15 citations
Semantic Scholar
Blood Transcriptomic Biomarkers of Alzheimer's Disease Patients Treated with EHT 0202
L. Désiré, Elodie Blondiaux, J. Carrière, R. Haddad +5 more
2013Journal of Alzheimer's Disease14 citations
Semantic Scholar
Role of nitric oxide in photoreceptor survival in embryonic chick retinal cell culture
O. Goureau, F. Régnier‐Ricard, L. Désiré, Y. Courtois
1999Journal of Neuroscience Research10 citations
Semantic Scholar
O3‐05–02: EHT‐0202: A neuroprotective and procognitive alpha‐secretase stimulator targeted towards Alzheimer disease therapy
L. Désiré, L. Buée, N. Lambeng, D. Drouin +1 more
20089 citations
Semantic Scholar
Microencapsulation of nanoparticulate complexes of DNA with cationic lipids and polymers in pectin beads for targeted gene delivery
R. Harvey, S. Bourgeois, Peter Pietzonka, L. Désiré +1 more
20057 citations
Semantic Scholar
DYRK 1 A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D 3
B. Thompson, R. Bhansali, Lauren P. Diebold, Daniel E. Cook +7 more
20155 citations
Semantic Scholar
Abstract 2165: Structure activity relationship of a novel chemical class of Dyrk inhibitors.
A. Casagrande, F. Bachelot, Séverine Coutadeur, B. Leblond +3 more
20135 citations
Semantic Scholar
Erratum to: Assessment of the novel tubulin-binding agent EHT 6706 in combination with ionizing radiation or chemotherapy
C. Clémenson, Cyrus Chargari, L. Désiré, A. Casagrande +2 more
2012Investigational new drugs4 citations Open access
Semantic Scholar
P4–252: Novel compounds active in the prevention of amyloid–beta accumulation, ROS production, and related neurotoxicity
L. Désiré, Jérôme Bourdin, V. Picard, B. Leblond +2 more
20064 citations
Semantic Scholar
Vascular disrupting activity and the mechanism of action of EHT 6706, a novel anticancer tubulin polymerization inhibitor
Anne-Sophie Belzacq-Casagrande, F. Bachelot, Catherine Castelo Branco de Oliveira, Séverine Coutadeur +10 more
2013Investigational new drugs3 citations
Semantic Scholar
The Chromosome 21 Kinase DYRK1A Controls Cell Cycle Exit and Survival During Lymphoid Development and Is a Novel Therapeutic Target In Acute Lymphoblastic Leukemia
B. Thompson, Lauren P. Diebold, Sébastien Malinge, B. Leblond +6 more
20132 citations
Semantic Scholar
Assessment of the novel tubulin-binding agent EHT 6706 in combination with ionizing radiation or chemotherapy
C. Clémenson, C. Chargari, L. Désiré, A. Casagrande +2 more
2012Investigational new drugs2 citations
Semantic Scholar
Abstract 2620: 3D multicellular pancreatic cancer spheroids as drug screening tool for pharmacological evaluation of EHT 5372 and other Mirk/DYRK1B inhibitors
A. Casagrande, F. Bachelot, Émeline Throo, F. Mahé +4 more
20141 citations
Semantic Scholar
A NOVEL SEROLOGICAL IMMUNOASSAY FOR THE GENUS LEVEL DIAGNOSIS OF PROSTHETIC JOINT INFECTION: A PROSPECTIVE STUDY
S. Marmor, N. Desplaces, T. Bauer, B. Heym +8 more
20150 citations
Semantic Scholar
Synthesis and biological evaluation of new thiazolo [5,4-f]quinazolines as serine/threonine kinases inhibitors
Damien Hédou, Corinne Fruit, A. Casagrande, L. Désiré +3 more
20150 citations Open access
Semantic Scholar
Abstract 2164: Mirk/dyrk1B kinase inhibitor reduces the viability of patient-derived ovarian cancer ascites cells and the size of murine tumor xenografts.
Xiao-Bing Deng, Jing Hu, M. Cunningham, B. Leblond +4 more
20130 citations
Semantic Scholar
Abstract 4147: An alternative splicing study approach to discriminate between NSCLC subtypes.
L. Désiré, A. Casagrande, F. Mahé, Émeline Throo +1 more
20130 citations
Semantic Scholar
Abstract 1260: Alternative splicing studies for the identification of novel cancer markers and targets for antibody-based therapy
A. Casagrande, F. Mahé, Émeline Throo, V. Kotraiah +3 more
20120 citations
Semantic Scholar
425 Structure Activity Relationship of a Novel Chemical Class of Microtubule-disrupting Agents
L. Désiré, A. Casagrande, F. Bachelot, S. Coutadeur +6 more
20120 citations
Semantic Scholar
Abstract 2794: Cytotoxic and vascular disrupting activity of EHT 6706, a novel tubulin polymerization inhibitor
A. Casagrande, F. Bachelot, Catherine Castelo Branco de Oliveira, Séverine Coutadeur +9 more
20120 citations
Semantic Scholar
P4‐290: Blood transcriptomic signatures of Alzheimer's patients treated with a novel Alzheimer's disease drug, EHT 0202, allow identification of novel potential biomarkers correlated with treatment response and efficacy
L. Désiré, J. Carrière, Elodie Blondiaux, J. Lemarié +3 more
20110 citations
Semantic Scholar
Abstract 4860: Identification of novel epitopes, drug resistance markers and drug resistance mechanism using alternative splicing studies
A. Casagrande, F. Mahé, V. Kotraiah, M. Pando +1 more
20110 citations
Semantic Scholar
PP 81 Alternative splicing studies for the identification of novel cancer markers
A. Casagrande, V. Kotraiah, D. Toema, D. Kong +3 more
20110 citations
Semantic Scholar
353 Integrating alternative splicing studies as a tool for innovative therapeutical interventions: focus on novel drug targets and novel epitopes
A. Casagrande, M. Pando, L. Désiré
20100 citations
Semantic Scholar
P2‐325: EHT0202, an alpha‐secretase stimulator active against amyloid‐beta accumulation and neurotoxicity that improves attention and cognition
L. Désiré, N. Lambeng, Maryline Marcade, Hélène Peillon +3 more
20080 citations
Semantic Scholar

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