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R. Dehaven · SciRah

Researcher profile · Semantic Scholar

R. Dehaven

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R. Dehaven — researcher profile on SciRah

h-index: 21
Works: 55
Citations: 1,427

Most-cited papers

Further evidence for cholinergic habenulo-interpeduncular neurons: pharmacologic and functional characteristics.
M. Kuhar, R. Dehaven, H. Yamamura, Hans Rommelspacher +1 more
1975Brain Research137 citations
Semantic Scholar
Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).
B. Le Bourdonnec, R. Windh, Christopher W. Ajello, L. Leister +19 more
2008Journal of Medicinal Chemistry97 citations Open access
Semantic Scholar
Peripheral effects of the kappa-opioid agonist EMD 61753 on pain and inflammation in rats and humans.
H. Machelska, M. Pflüger, Werner Weber, Mojgan Piranvisseh-Völk +3 more
1999Journal of Pharmacology and Experimental Therapeutics93 citations
Semantic Scholar
Leukotriene C4 binding to rat lung membranes.
Sheng-Shung Pong, R. Dehaven, F. A. Kuehl, R. Egan
1983Journal of Biological Chemistry86 citations Open access
Semantic Scholar
Dynorphin A as a potential endogenous ligand for four members of the opioid receptor gene family.
Sheng-Wen Zhang, Yan-He Tong, M. Tian, R. Dehaven +5 more
1998Journal of Pharmacology and Experimental Therapeutics84 citations
Semantic Scholar
Synthesis and biological activities of cyclic lanthionine enkephalin analogues : δ-opioid receptor selective ligands
Y. Rew, S. Malkmus, C. Svensson, T. Yaksh +6 more
2002Journal of Medicinal Chemistry82 citations Open access
Semantic Scholar
The involvement of the μ-opioid receptor in gastrointestinal pathophysiology: Therapeutic opportunities for antagonism at this receptor
D. Dehaven-Hudkins, R. Dehaven, P. J. Little, L. Techner
200876 citations
Semantic Scholar
[3H]Alvimopan binding to the μ opioid receptor: Comparative binding kinetics of opioid antagonists
J. Cassel, J. D. Daubert, R. Dehaven
200576 citations
Semantic Scholar
Identification of allosteric antagonists of receptor-guanine nucleotide-binding protein interactions.
R.-R. C. Huang, R. Dehaven, Anne H. Cheung, R. E. Diehl +2 more
1990Molecular Pharmacology70 citations
Semantic Scholar
Development of a novel series of styrylquinoline compounds as high-affinity leukotriene D4 receptor antagonists: synthetic and structure-activity studies leading to the discovery of (+-)-3-[[[3-[2-(7-chloro-2-quinolinyl)-(E)-ethenyl]phenyl][[3- (dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic
R. Zamboni, M. Belley, E. Champion, L. Charette +6 more
1992Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
NMR and modeling studies of a synthetic extracellular loop II of the kappa opioid receptor in a DPC micelle.
Li Zhang, R. Dehaven, M. Goodman
2002Biochemistry38 citations
Semantic Scholar
Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208.
R. Dolle, Mathieu Michaut, B. Martínez-Teipel, Pamela R. Seida +4 more
2009Bioorganic & Medicinal Chemistry Letters35 citations Open access
Semantic Scholar
[(3)H]Alvimopan binding to the micro opioid receptor: comparative binding kinetics of opioid antagonists.
J. Cassel, J. D. Daubert, R. Dehaven
2005European Journal of Pharmacology32 citations
Semantic Scholar
Stereospecific synthesis, assignment of absolute configuration, and biological activity of the enantiomers of 3-[[[3-[2-(7-chloroquinolin-2-yl)-(E)-ethenyl]phenyl] [[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid, a potent and specific leukotriene D4 receptor antagonist.
J. Gauthier, T. Jones, E. Champion, L. Charette +6 more
1990Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Structure-activity relationships of dynorphin a analogues modified in the address sequence.
G. Schlechtingen, R. Dehaven, J. D. Daubert, J. Cassel +4 more
2003Journal of Medicinal Chemistry30 citations Open access
Semantic Scholar
Inhibition of high affinity choline uptake. Structure activity studies.
Frederick Batzold, R. Dehaven, M. Kuhar, N. J. M. Birdsall
1980Biochemical Pharmacology28 citations
Semantic Scholar
Antipruritic and antihyperalgesic actions of loperamide and analogs.
D. Dehaven-Hudkins, A. Cowan, Luz Cortes Burgos, J. D. Daubert +4 more
2002Life Science27 citations
Semantic Scholar
Novel malonamide derivatives as potent κ opioid receptor agonists
Guo-Hua Chu, Minghua Gu, J. Cassel, S. Belanger +7 more
200726 citations Open access
Semantic Scholar
(4-Carboxamido)phenylalanine is a surrogate for tyrosine in opioid receptor peptide ligands.
R. Dolle, Mathieu Machaut, B. Martínez-Teipel, S. Belanger +4 more
2004Bioorganic & Medicinal Chemistry Letters25 citations
Semantic Scholar
Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of mu-opioid receptor antagonists.
B. Le Bourdonnec, Allan J. Goodman, Mathieu Michaut, Hai-Fen Ye +6 more
2006Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints.
Guo-Hua Chu, Minghua Gu, J. Cassel, S. Belanger +7 more
2005Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Azepinone as a conformational constraint in the design of κ-opioid receptor agonists
Tuthill Paul Anson, Pamela R. Seida, W. Barker, J. Cassel +7 more
200420 citations Open access
Semantic Scholar
CB2 selective sulfamoyl benzamides: optimization of the amide functionality.
Allan J. Goodman, Christopher W. Ajello, Karin Worm, B. Le Bourdonnec +11 more
2009Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Synthesis and evaluation of novel peripherally restricted κ-opioid receptor agonists
Virendra Kumar, De-Qi Guo, J. Cassel, J. D. Daubert +9 more
200519 citations Open access
Semantic Scholar
trans-3,4-dimethyl-4-(3-carboxamidophenyl)piperidines: a novel class of micro-selective opioid antagonists.
B. Le Bourdonnec, S. Belanger, J. Cassel, Gabriel J. Stabley +2 more
2003Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Discovery of a series of aminopiperidines as novel iNOS inhibitors.
B. Le Bourdonnec, L. Leister, C. Ajello, J. Cassel +7 more
2008Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists.
Guo-Hua Chu, Christopher T. Saeui, Karin Worm, Damian G. Weaver +10 more
2009Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Synthesis and pharmacological evaluation of novel octahydro-1H-pyrido[1,2-a]pyrazine as mu-opioid receptor antagonists.
B. Le Bourdonnec, Allan J. Goodman, T. Graczyk, S. Belanger +3 more
2006Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
Arylacetamide κ opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity
B. Le Bourdonnec, Christopher W. Ajello, Pamela R. Seida, R. Susnow +6 more
200513 citations Open access
Semantic Scholar
Design and synthesis of sodium (beta R*, gamma S*)-4-[[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl] thio]-gamma-hydroxy-beta-methylbenzenebutanoate: a novel, selective, and orally active receptor antagonist of leukotriene D4.
R. Young, P. Bélanger, E. Champion, R. Dehaven +6 more
1986Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
Novel sulfamoyl benzamides as selective CB(2) agonists with improved in vitro metabolic stability.
I. Sellitto, B. Le Bourdonnec, Karin Worm, Allan J. Goodman +13 more
2010Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors
Guo-Hua Chu, B. Le Bourdonnec, Minghua Gu, Christopher W. Ajello +7 more
2009Open Medicinal Chemistry Journal10 citations Open access
Semantic Scholar
Pharmacological characterization of human kappa/mu opioid receptor chimeras that retain high affinity for dynorphin A.
R. Dehaven, E. Mansson, J. D. Daubert, J. Cassel
2005Current Topics in Medicinal Chemistry9 citations
Semantic Scholar
Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands.
Y. Rew, S. Malkmus, Camilla I. Svensson, Tony L. Yaksh +6 more
2002Journal of Medicinal Chemistry9 citations
Semantic Scholar
Peripheral Effects of the κ-Opioid Agonist EMD 61753 on Pain and Inflammation in Rats and Humans
H. Machelska, M. Pflüger, Werner Weber, Mojgan Piranvisseh-Völk +3 more
1999Journal of Pharmacology and Experimental Therapeutics9 citations
Semantic Scholar
Discovery of N-(3-(morpholinomethyl)-phenyl)-amides as potent and selective CB2 agonists.
Karin Worm, Damian G. Weaver, R. Green, Christopher T. Saeui +10 more
2009Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles.
B. Le Bourdonnec, W. Barker, S. Belanger, Daniel D Wiant +7 more
2008Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Further studies of tyrosine surrogates in opioid receptor peptide ligands.
R. Dolle, Mathieu Michaut, B. Martínez-Teipel, S. Belanger +2 more
2007Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Novel phenylamino acetamide derivatives as potent and selective κ opioid receptor agonists
Guo-Hua Chu, Minghua Gu, J. Cassel, S. Belanger +7 more
20067 citations Open access
Semantic Scholar
Use of receptor chimeras to identify small molecules with high affinity for the dynorphin A binding domain of the kappa opioid receptor.
Virendra Kumar, De-Qi Guo, M. A. Marella, J. Cassel +3 more
2008Bioorganic & Medicinal Chemistry Letters6 citations Open access
Semantic Scholar
Synthesis and evaluation of novel peripherally restricted kappa-opioid receptor agonists.
Virendra Kumar, De-Qi Guo, J. Cassel, J. D. Daubert +9 more
2005Bioorganic & Medicinal Chemistry Letters5 citations
Semantic Scholar
Novel malonamide derivatives as potent kappa opioid receptor agonists.
Guo-Hua Chu, Minghua Gu, J. Cassel, S. Belanger +7 more
2007Bioorganic & Medicinal Chemistry Letters4 citations
Semantic Scholar
Peripheral Effects of the k-Opioid Agonist EMD 61753 on Pain and Inflammation in Rats and Humans
H. Machelska, M. Pflüger, W. Weber, Mojgan Piranvisseh-Völk +3 more
19994 citations
Semantic Scholar
Novel arylthio- and arylsulfonylpropyloxyacetophenones: design and synthesis of L-648,051 and L-649,923, potent antagonists of leukotriene D4.
R. Young, T. Jones, J. G. Atkinson, P. Bélanger +6 more
1987Advances in prostaglandin, thromboxane, and leukotriene research4 citations
Semantic Scholar
Amino acid conjugates as kappa opioid receptor agonists.
Virendra Kumar, De-Qi Guo, J. D. Daubert, J. Cassel +4 more
2005Bioorganic & Medicinal Chemistry Letters3 citations
Semantic Scholar
Synthesis and structure-activity relationships of a new series of 2alpha-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as mu-selective opioid antagonists.
B. Le Bourdonnec, Allan J. Goodman, Mathieu Michaut, Hai-Fen Ye +4 more
2006Bioorganic & Medicinal Chemistry Letters2 citations Open access
Semantic Scholar
Amino acid conjugates as κ opioid receptor agonists
Virendra Kumar, De-Qi Guo, J. D. Daubert, J. Cassel +4 more
20052 citations Open access
Semantic Scholar
Arylacetamide kappa opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity.
B. Le Bourdonnec, Christopher W. Ajello, Pamela R. Seida, R. Susnow +6 more
2005Bioorganic & Medicinal Chemistry Letters2 citations
Semantic Scholar
L-648,051: an aerosol active leukotriene D4 receptor antagonist.
T. R. Jones, Y. Guindon, E. Champion, L. Charette +6 more
1987Advances in prostaglandin, thromboxane, and leukotriene research2 citations
Semantic Scholar
Novel phenylamino acetamide derivatives as potent and selective kappa opioid receptor agonists.
Guo-Hua Chu, Minghua Gu, J. Cassel, S. Belanger +7 more
2006Bioorganic & Medicinal Chemistry Letters1 citations
Semantic Scholar

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J. Cassel×30
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R. Dolle×23
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S. Belanger×16
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D. Dehaven-Hudkins×16
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B. Le Bourdonnec

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Michael Koblish×13

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P. J. Little×13

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J. D. Daubert×13

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