R. Egan

Most-cited papers

Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
P. van Eerdewegh, R. D. Little, J. Dupuis, R. D. Del Mastro +34 more
2002Nature1,121 citations
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Prostaglandins, arachidonic acid, and inflammation.
F. Kuehl, R. Egan
1980Science707 citations
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Mechanism for irreversible self-deactivation of prostaglandin synthetase.
R. Egan, J. Paxton, F. Kuehl
1976Journal of Biological Chemistry553 citations
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The Binding Specificity and Selective Antagonism of Vedolizumab, an Anti-α4β7 Integrin Therapeutic Antibody in Development for Inflammatory Bowel Diseases
D. Soler, T. Chapman, Li-Li Yang, T. Wyant +2 more
2009Journal of Pharmacology and Experimental Therapeutics456 citations
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Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes. IL-10 and IL-4 suppress cytokine synthesis by different mechanisms.
P. Wang, P. Wu, M. Siegel, R. Egan +1 more
1995Journal of Biological Chemistry395 citations
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Th2 cytokines and asthma — The role of interleukin-5 in allergic eosinophilic disease
S. Greenfeder, S. Umland, F. Cuss, R. Chapman +1 more
2001Respiratory Research256 citations Open access
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Peroxidase-dependent deactivation of prostacyclin synthetase.
E. A. Ham, R. Egan, D. Soderman, P. Gale +1 more
1979Journal of Biological Chemistry217 citations
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Measuring leukotrienes of slow reacting substance of anaphylaxis: development of a specific radioimmunoassay.
Edward C. Hayes, D. Lombardo, Yves Girard, Alan L. Maycock +5 more
1983Journal of Immunology197 citations Open access
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Functional TRPV4 channels are expressed in human airway smooth muscle cells.
Yan-Lin Jia, Xin Wang, Lori A. Varty, C. Rizzo +5 more
2004American Journal of Physiology - Lung cellular and Molecular Physiology183 citations
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Role of CXCR2 in cigarette smoke-induced lung inflammation.
T. Thatcher, N. McHugh, R. Egan, R. Chapman +6 more
2005American Journal of Physiology - Lung cellular and Molecular Physiology168 citations Open access
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Reduction of hydroperoxides in the prostaglandin biosynthetic pathway by a microsomal peroxidase.
R. Egan, P. Gale, F. Kuehl
1979Journal of Biological Chemistry152 citations Open access
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Mast cells modulate allergic pulmonary eosinophilia in mice.
Ted T. Kung, D. Stelts, J. Zurcher, H. Jones +4 more
1995American Journal of Respiratory Cell and Molecular Biology148 citations
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Hydrophile-lipophile balance and critical micelle concentration as key factors influencing surfactant disruption of mitochondrial membranes.
R. Egan
1976Journal of Biological Chemistry128 citations Open access
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Oxidation reactions by prostaglandin cyclooxygenase-hydroperoxidase.
R. Egan, P. Gale, E. M. Baptista, K. L. Kennicott +4 more
1981Journal of Biological Chemistry113 citations Open access
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Microarray profile of differentially expressed genes in a monkey model of allergic asthma
Jun Zou, Simon Young, Feng Zhu, F. Gheyas +9 more
2002Genome Biology107 citations Open access
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Nociceptin inhibits cough in the guinea‐pig by activation of ORL1 receptors
R. Mcleod, L. E. Parra, J. Mutter, Christine H. Erickson +7 more
2001British Journal of Pharmacology100 citations Open access
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Anandamide induces cough in conscious guinea‐pigs through VR1 receptors
Yan-Lin Jia, R. Mcleod, Xin Wang, L. E. Parra +2 more
2002British Journal of Pharmacology88 citations Open access
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Leukotriene C4 binding to rat lung membranes.
Sheng-Shung Pong, R. Dehaven, F. A. Kuehl, R. Egan
1983Journal of Biological Chemistry86 citations Open access
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Combined Histamine H1 and H3 Receptor Blockade Produces Nasal Decongestion in an Experimental Model of Nasal Congestion
R. Mcleod, G. Mingo, C. Herczku, Frances DeGennaro-Culver +3 more
1999American Journal of Rhinology74 citations
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Inhibition of pulmonary eosinophilia and hyperreactivity by antibodies to interleukin-5.
R. Egan, D. Athwahl, Chuan-Chu Chou, S. Emtage +5 more
1995International Archives of Allergy and Immunology66 citations Open access
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Inhibition of sympathetic hypertensive responses in the guinea‐pig by prejunctional histamine H3‐receptors
J. A. Hey, M. Prado, R. Egan, W. Kreutner +1 more
1992British Journal of Pharmacology62 citations Open access
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Human ADAM33: protein maturation and localization.
C. Garlisi, Jun Zou, Kristine E Devito, Fang Tian +7 more
2003Biochemical and Biophysical Research Communications - BBRC61 citations
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Mechanism of oxygen transfer by prostaglandin hydroperoxidase.
R. Egan, P. Gale, W. Vandenheuvel, E. M. Baptista +1 more
1980Journal of Biological Chemistry61 citations
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Eosinophil granule proteins increase microvascular macromolecular transport in the hamster cheek pouch.
M. Minnicozzi, W. Durán, G. Gleich, R. Egan
1994Journal of Immunology60 citations
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Inflammation: the role of peroxidase-derived products.
F. Kuehl, J. Humes, E. A. Ham, R. Egan +1 more
1980Advances in prostaglandin and thromboxane research60 citations
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Inhibition of experimental acute pulmonary inflammation by pirfenidone.
J. Spond, N. Case, R. Chapman, Yvette Crawley +7 more
2003Pulmonary Pharmacology & Therapeutics52 citations
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Tachykinin NK3-receptor deficiency does not inhibit pulmonary eosinophilia in allergic mice.
Ted T. Kung, Yvette Crawley, H. Jones, B. Luo +9 more
2004Pharmacological Research51 citations
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Interleukin-5 mRNA stability in human T cells is regulated differently than interleukin-2, interleukin-3, interleukin-4, granulocyte/macrophage colony-stimulating factor, and interferon-gamma.
S. Umland, S. Razac, H. Shah, D. Nahrebne +2 more
1998American Journal of Respiratory Cell and Molecular Biology48 citations
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The IL-5 receptor on human bronchus selectively primes for hyperresponsiveness.
C. Rizzo, Richard Yang, S. Greenfeder, R. Egan +2 more
2002Journal of Allergy and Clinical Immunology47 citations
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Specific inhibition and oxidative regulation of 5-lipoxygenase.
R. Egan, A. Tischler, E. M. Baptista, E. A. Ham +2 more
1983Advances in prostaglandin, thromboxane, and leukotriene research46 citations
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Antitussive effect of nociceptin/orphanin FQ in experimental cough models.
R. Mcleod, D. Bolser, Yan-Lin Jia, L. E. Parra +5 more
2002Pulmonary Pharmacology & Therapeutics42 citations
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SCH 206272: a potent, orally active tachykinin NK(1), NK(2), and NK(3) receptor antagonist.
J. Anthes, R. Chapman, C. Richard, S. Eckel +17 more
2002European Journal of Pharmacology41 citations Open access
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Radical scavenging as the mechanism for stimulation of prostaglandin cyclooxygenase and depression of inflammation by lipoic acid and sodium iodide.
R. Egan, P. Gale, G. Beveridge, Grace B. Phillips +1 more
1978Prostaglandins41 citations
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Direct and indirect involvement of radical scavengers during prostaglandin biosynthesis.
R. Egan, P. Gale, G. Beveridge, L. Marnett +1 more
1980Advances in prostaglandin and thromboxane research39 citations
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Phospholipase C and phospholipase D are activated independently of each other in chemotactic peptide‐stimulated human neutrophils
Theodore J. Mullmann, B. Cheewatrakoolpong, J. Anthes, M. I. Siegel +2 more
1993Journal of Leukocyte Biology38 citations
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Effects of interleukin 5-induced pulmonary eosinophilia on airway reactivity in the guinea pig.
C. Lilly, R. Chapman, S. Sehring, P. Mauser +2 more
1996American Journal of Physiology37 citations
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Pharmacology of N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (SCH 351591), a novel, orally active phosphodiesterase 4 inhibitor.
M. Billah, N. Cooper, M. Minnicozzi, J. Warneck +14 more
2002Journal of Pharmacology and Experimental Therapeutics36 citations
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Transcription of the Murine Interleukin 5 Gene Is Regulated by Multiple Promoter Elements (*)
Kimberly S. Stranick, F. Payvandi, Demetris N. Zambas, S. Umland +2 more
1995Journal of Biological Chemistry36 citations Open access
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The role of neutrophils in LPS-induced changes in pulmonary function in conscious rats.
J. Spond, M. Billah, R. Chapman, R. Egan +4 more
2004Pulmonary Pharmacology & Therapeutics35 citations
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Inhibition of mammalian 5-lipoxygenase by aromatic disulfides.
R. Egan, P. Gale
1985Journal of Biological Chemistry35 citations Open access
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Human cord blood-derived mast cells synthesize and release I-309 in response to IgE.
H. Gilchrest, B. Cheewatrakoolpong, M. Billah, R. Egan +2 more
2003Life Science34 citations
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L-651,392: a novel, potent and selective 5-lipoxygenase inhibitor.
Y. Guindon, Y. Girard, A. Maycock, A. Ford-hutchinson +6 more
1987Advances in prostaglandin, thromboxane, and leukotriene research34 citations
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Pharmacological Characterization of the Novel Histamine H3-Receptor Antagonist N-(3,5-Dichlorophenyl)-N′-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687)
R. Mcleod, C. Rizzo, R. West, R. Aslanian +10 more
2003Journal of Pharmacology and Experimental Therapeutics33 citations Open access
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Pulmonary biology of anti-interleukin 5 antibodies.
R. Egan, D. Athwahl, C.-C. Chou, R. Chapman +6 more
1997Memórias do Instituto Oswaldo Cruz32 citations Open access
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The Flash Oxidation (FOX) System: A Novel Laser-Free Fast Photochemical Oxidation Protein Footprinting Platform
J. Sharp, Emily E. Chea, Sandeep K. Misra, R. Orlando +4 more
2021Journal of the American Society for Mass Spectrometry31 citations Open access
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The profiles of human and primate []N∝-methylhistamine binding differ from that of rodents
R. West, Ren-Long Wu, M. Billah, R. Egan +1 more
199929 citations
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Real Time Normalization of Fast Photochemical Oxidation of Proteins Experiments by Inline Adenine Radical Dosimetry
J. Sharp, Sandeep K. Misra, Jeffrey J. Persoff, R. Egan +1 more
2018bioRxiv28 citations Open access
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Comparative Oral and Topical Decongestant Effects of Phenylpropanolamine and d-Pseudoephedrine
Christine H. Erickson, R. Mcleod, G. Mingo, R. Egan +2 more
2001American Journal of Rhinology28 citations
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Antihistamine activity, central nervous system and cardiovascular profiles of histamine H1 antagonists: comparative studies with loratadine, terfenadine and sedating antihistamines in guinea‐pigs
J. Hey, M. Prado, F. Cuss, R. Egan +3 more
1995Clinical and Experimental Allergy28 citations
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Cough reflex in allergic dogs.
A. House, C. Celly, S. Skeans, James Lamca +3 more
2004European Journal of Pharmacology24 citations
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