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R. Booth · SciRah

Researcher profile · Semantic Scholar

R. Booth

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R. Booth — researcher profile on SciRah

h-index: 24
Works: 76
Citations: 1,449

Most-cited papers

Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase.
David M. Mottola, J. Kilts, M. Lewis, H. Connery +9 more
2002Journal of Pharmacology and Experimental Therapeutics131 citations Open access
Semantic Scholar
Effects of polychlorinated biphenyls (PCBs) on brain tyrosine hydroxylase activity and dopamine synthesis in rats.
N. Choksi, P. Kodavanti, H. Tilson, R. Booth
1997Fundamental and Applied Toxicology80 citations
Semantic Scholar
Domain Swapping in the Human Histamine H1 Receptor
R. Bakker, G. Dees, Juan J. Carrillo, R. Booth +4 more
2004Journal of Pharmacology and Experimental Therapeutics79 citations
Semantic Scholar
“Selective” serotonin 5-HT2A receptor antagonists
Austen B. Casey, Meng Cui, R. Booth, Clinton E. Canal
2022Biochemical Pharmacology78 citations Open access
Semantic Scholar
(+)-6,7-benzomorphan sigma ligands stimulate dopamine synthesis in rat corpus striatum tissue.
R. Booth, R. Baldessarini
1991Brain Research58 citations
Semantic Scholar
Support for 5-HT2C receptor functional selectivity in vivo utilizing structurally diverse, selective 5-HT2C receptor ligands and the 2,5-dimethoxy-4-iodoamphetamine elicited head-twitch response model
Clinton E. Canal, R. Booth, D. Morgan
2013Neuropharmacology57 citations Open access
Semantic Scholar
Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines.
W. Sirawaraporn, R. Sertsrivanich, R. Booth, C. Hansch +2 more
1988Molecular and biochemical parasitology (Print)54 citations
Semantic Scholar
Novel ligands for the human histamine H1 receptor: synthesis, pharmacology, and comparative molecular field analysis studies of 2-dimethylamino-5-(6)-phenyl-1,2,3,4-tetrahydronaphthalenes.
Ola Ghoneim, Jacqueline A Legere, A. Golbraikh, A. Tropsha +1 more
2006Bioorganic & Medicinal Chemistry49 citations
Semantic Scholar
GPCR proteomics: Mass spectrometric and functional analysis of histamine H1 receptor after baculovirus‐driven and in vitro cell free expression
K. Sansuk, Crina I. A. Balog, A. M. van der Does, R. Booth +5 more
2008Journal of Proteome Research44 citations
Semantic Scholar
Dopamine D1 autoreceptor function: possible expression in developing rat prefrontal cortex and striatum.
Martin H. Teicher, A. Gallitano, H. Gelbard, H. K. Evans +3 more
1991Brain research. Developmental brain research39 citations
Semantic Scholar
An Orally Active Phenylaminotetralin-Chemotype Serotonin 5-HT7 and 5-HT1A Receptor Partial Agonist that Corrects Motor Stereotypy in Mouse Models.
Clinton E. Canal, D. Felsing, Yue Liu, Wan-Ying Zhu +4 more
2015ACS Chemical Neuroscience38 citations
Semantic Scholar
(1R, 3S)-(−)-Trans-PAT: A novel full-efficacy serotonin 5-HT2C receptor agonist with 5-HT2A and 5-HT2B receptor inverse agonist/antagonist activity
R. Booth, Li-Juan Fang, Ying-Su Huang, Andrzej M. Wilczynski +1 more
2009European Journal of Pharmacology38 citations Open access
Semantic Scholar
Intracerebral microdialysis neurotoxicity studies of quinoline and isoquinoline derivatives related to MPTP/MPP+.
R. Booth, N. Castagnoli, H. Rollema
1989Neuroscience Letters38 citations
Semantic Scholar
Inhibition of NADH oxidation by pyridine derivatives.
R. R. Ramsay, K. McKeown, E. Johnson, R. Booth +1 more
1987Biochemical and Biophysical Research Communications - BBRC38 citations
Semantic Scholar
Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth.
R. Booth, C. Selassie, Corwin H. Hansch, D. Santi
1987Journal of Medicinal Chemistry36 citations Open access
Semantic Scholar
In vivo dopaminergic neurotoxicity of the 2-beta-methylcarbolinium ion, a potential endogenous MPP+ analog.
H. Rollema, R. Booth, N. Castagnoli
1988European Journal of Pharmacology34 citations
Semantic Scholar
Ligand-Directed Functional Heterogeneity of Histamine H1 Receptors: Novel Dual-Function Ligands Selectively Activate and Block H1-Mediated Phospholipase C and Adenylyl Cyclase Signaling
N. H. Moniri, Dawn Covington-Strachan, R. Booth
2004Journal of Pharmacology and Experimental Therapeutics33 citations Open access
Semantic Scholar
Neuronal nitric oxide modulates morphine antinociceptive tolerance by enhancing constitutive activity of the μ-opioid receptor
E. Heinzen, R. Booth, G. M. Pollack
200532 citations
Semantic Scholar
A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors.
R. Booth, N. H. Moniri, R. Bakker, N. Choksi +3 more
2002Journal of Pharmacology and Experimental Therapeutics28 citations Open access
Semantic Scholar
A Novel Aminotetralin-Type Serotonin (5-HT) 2C Receptor-Specific Agonist and 5-HT2A Competitive Antagonist/5-HT2B Inverse Agonist with Preclinical Efficacy for Psychoses
Clinton E. Canal, D. Morgan, D. Felsing, Krishnakanth Kondabolu +4 more
2014Journal of Pharmacology and Experimental Therapeutics25 citations Open access
Semantic Scholar
Molecular Pharmacology and Ligand Docking Studies Reveal a Single Amino Acid Difference between Mouse and Human Serotonin 5-HT2A Receptors That Impacts Behavioral Translation of Novel 4-Phenyl-2-dimethylaminotetralin Ligands
Clinton E. Canal, Tania Cordova-Sintjago, Yue Liu, M. S. Kim +2 more
2013Journal of Pharmacology and Experimental Therapeutics25 citations Open access
Semantic Scholar
Effect of (−)-trans-PAT, a novel 5-HT2C receptor agonist, on intake of palatable food in mice
N. Rowland, Erica M. Crump, Nancy K. Nguyen, Kimberly L. Robertson +2 more
2008Pharmacology, Biochemistry and Behavior25 citations Open access
Semantic Scholar
Actions of (±)-7-hydroxy-N,N-dipropylaminotetralin (7-OH-DPAT) on dopamine synthesis in limbic and extrapyramidal regions of rat brain
R. Booth, R. Baldessarini, E. Marsh, Constance E. Owens
199425 citations
Semantic Scholar
In vivo intracerebral microdialysis studies in rats of MPP+ (1-methyl-4-phenylpyridinium) analogs and related charged species
H. Rollema, E. Johnson, R. Booth, Patricia Caldera +5 more
199024 citations
Semantic Scholar
(S)-5-(2'-Fluorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine, a Serotonin Receptor Modulator, Possesses Anticonvulsant, Prosocial, and Anxiolytic-like Properties in an Fmr1 Knockout Mouse Model of Fragile X Syndrome and Autism Spectrum Disorder.
J. Armstrong, Austen B. Casey, Tanishka S. Saraf, Munmun Mukherjee +2 more
2020ACS Pharmacology & Translational Science23 citations Open access
Semantic Scholar
Drug discovery targeting human 5-HT2C receptors: Residues S3.36 and Y7.43 impact ligand—binding pocket structure via hydrogen bond formation
Clinton E. Canal, Tania Cordova-Sintjago, Nancy Y. Villa, Li-Juan Fang +1 more
2011European Journal of Pharmacology22 citations Open access
Semantic Scholar
The serotonin-2 receptor modulator, (−)-trans-PAT, decreases voluntary ethanol consumption in rats
James M. Kasper, R. Tikamdas, M. S. Kim, Kaley Macfadyen +5 more
2013European Journal of Pharmacology18 citations Open access
Semantic Scholar
Aromatic interactions impact ligand binding and function at serotonin 5-HT2C G protein-coupled receptors: Receptor homology modeling, ligand docking, and molecular dynamics results validated by experimental studies
Tania Cordova-Sintjago, Nancy Y. Villa, Li-Juan Fang, R. Booth
2013Molecular Physics17 citations Open access
Semantic Scholar
Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HT1A and 5-HT7 G protein-coupled receptor affinity, 3D-QSAR and molecular modeling.
Charles K. Perry, Austen B. Casey, D. Felsing, Rajender Vemula +6 more
2019Bioorganic & Medicinal Chemistry16 citations Open access
Semantic Scholar
Molecular Determinants for Ligand Binding at Serotonin 5-HT2A and 5-HT2C GPCRs: Experimental Affinity Results Analyzed by Molecular Modeling and Ligand Docking Studies
Tania Cordova-Sintjago, Rajeev Sakhuja, Krishnakanth Kondabolu, Clinton E. Canal +1 more
2012International Journal of Quantum Chemistry16 citations Open access
Semantic Scholar
Molecular determinants of ligand binding at the human histamine H1 receptor: Site-directed mutagenesis results analyzed with ligand docking and molecular dynamics studies at H1 homology and crystal structure models
Tania Cordova-Sintjago, Li-Juan Fang, M. Bruysters, R. Leurs +1 more
2012Journal of Chemical and Pharmaceutical Research16 citations
Semantic Scholar
Neuronal nitric oxide modulates morphine antinociceptive tolerance by enhancing constitutive activity of the mu-opioid receptor.
E. Heinzen, R. Booth, G. M. Pollack
2005Biochemical Pharmacology16 citations
Semantic Scholar
Molecular and behavioral pharmacology of two novel orally-active 5HT2 modulators: potential utility as antipsychotic medications
D. Morgan, Krishnakanth Kondabolu, A. Kuipers, Rajeev Sakhuja +3 more
2013Neuropharmacology15 citations Open access
Semantic Scholar
Role of PKA and PKC in histamine H1 receptor-mediated activation of catecholamine neurotransmitter synthesis.
N. H. Moniri, R. Booth
2006Neuroscience Letters14 citations
Semantic Scholar
Evaluation of Lorcaserin as an Anticonvulsant in Juvenile Fmr1 Knockout Mice
Tanishka S. Saraf, D. Felsing, J. Armstrong, R. Booth +1 more
2021Epilepsy Research13 citations Open access
Semantic Scholar
Ligand-directed serotonin 5-HT2C receptor desensitization and sensitization
D. Felsing, Clinton E. Canal, R. Booth
2019European Journal of Pharmacology13 citations Open access
Semantic Scholar
A novel phenylaminotetralin (PAT) recognizes histamine H1 receptors and stimulates dopamine synthesis in vivo in rat brain.
N. Choksi, W. Nix, S. Wyrick, R. Booth
2000Brain Research13 citations
Semantic Scholar
FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT1A, 5-HT1B, and 5-HT1D Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Fmr1 Knockout Mice
Tanishka S. Saraf, Ryan P. McGlynn, Omkar Bhatavdekar, R. Booth +1 more
2022ACS Chemical Neuroscience11 citations Open access
Semantic Scholar
2-Phenylaminoadenosine stimulates dopamine synthesis in rat forebrain in vitro and in vivo via adenosine A2 receptors.
N. Choksi, Anwar Hussain, R. Booth
1997Brain Research11 citations
Semantic Scholar
A new class of 5‐HT2A/5‐HT2C receptor inverse agonists: Synthesis, molecular modeling, in vitro and in vivo pharmacology of novel 2‐aminotetralins
Austen B. Casey, Munmun Mukherjee, Ryan P. McGlynn, Meng Cui +2 more
2021British Journal of Pharmacology10 citations Open access
Semantic Scholar
Mutagenesis Analysis Reveals Distinct Amino Acids of the Human Serotonin 5-HT2C Receptor Underlying the Pharmacology of Distinct Ligands.
Yue Liu, Clinton E. Canal, Tania Cordova-Sintjago, Wan-Ying Zhu +1 more
2017ACS Chemical Neuroscience10 citations
Semantic Scholar
Human Serotonin 5-HT2C G Protein-Coupled Receptor Homology Model from the β2 Adrenoceptor Structure: Ligand Docking and Mutagenesis Studies
Tania Có Rdova-Sintjago, Nancy Y. Villa, Clinton E. Canal, R. Booth
2011International Journal of Quantum Chemistry10 citations Open access
Semantic Scholar
New Approach to 4-Phenyl-β-aminotetralin from 4-(3-Halophenyl)tetralen-2-ol Phenylacetate
Adam Vincek, R. Booth
2009Tetrahedron Letters9 citations Open access
Semantic Scholar
Effects of (−)‐MBP, a novel 5‐HT2C agonist and 5‐HT2A/2B antagonist/inverse agonist on brain activity: A phMRI study on awake mice
Preeti K Sathe, Gargi R Ramdasi, Kaylie Giammatteo, Harvens Beauzile +5 more
2023Pharmacology Research & Perspectives8 citations Open access
Semantic Scholar
Serotonin-2C Receptor Agonists Decrease Potassium-Stimulated GABA Release In the Nucleus Accumbens
James M. Kasper, R. Booth, J. Peris
2014Synapse8 citations Open access
Semantic Scholar
A novel potential therapeutic avenue for autism: Design, synthesis and pharmacophore generation of SSRIs with dual action
Ola Ghoneim, D. Ibrahim, I. El-Deeb, So-Ha Lee +1 more
2011Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Molecular determinants of ligand-directed signaling for the histamine H1 receptor
R. Booth, Li-Juan Fang, Andrzej M. Wilczynski, S. Sivendren +5 more
2008Inflammation Research7 citations Open access
Semantic Scholar
Functional heterogeneity of histamine H1 receptors
Nader H. Moniri, R. Booth
2004Inflammation Research7 citations
Semantic Scholar
Synthesis and Pharmacological Evaluation of 1‐Phenyl‐3‐amino‐1,2,3,4‐ tetrahydronaphthalenes as Ligands for a Novel Receptor with σ‐ Like Neuromodulatory Activity.
S. Wyrick, R. Booth, Andrew M. Myers, Constance E. Owens +4 more
19945 citations
Semantic Scholar
Development of 2-Aminotetralin-Type Serotonin 5-HT1 Agonists: Molecular Determinants for Selective Binding and Signaling at 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT1F Receptors
Ryan P. McGlynn, Meng Cui, Brittany M. Brems, Otto Holbrook +1 more
2023ACS Chemical Neuroscience4 citations Open access
Semantic Scholar

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Clinton E. Canal — researcher profile on SciRah
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N. Choksi — researcher profile on SciRah

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