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E. Meiering · SciRah

Researcher profile · Semantic Scholar

E. Meiering

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E. Meiering — researcher profile on SciRah

h-index: 29
Works: 71
Citations: 2,458

Most-cited papers

Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis show enhanced formation of aggregates in vitro
P. Stathopulos, Jessica A. Rumfeldt, G. Scholz, R. Irani +4 more
2003Proceedings of the National Academy of Sciences of the United States of America263 citations Open access
Semantic Scholar
Effect of active site residues in barnase on activity and stability.
E. Meiering, Luis Serrano, A. Fersht
1992Journal of Molecular Biology200 citations
Semantic Scholar
Conformational stability and folding mechanisms of dimeric proteins.
Jessica A. Rumfeldt, Céline Galvagnion, K. A. Vassall, E. Meiering
2008Progress in Biophysics and Molecular Biology116 citations Open access
Semantic Scholar
Decreased stability and increased formation of soluble aggregates by immature superoxide dismutase do not account for disease severity in ALS
K. A. Vassall, H. Stubbs, Heather A. Primmer, Ming Tong +7 more
2011Proceedings of the National Academy of Sciences of the United States of America113 citations Open access
Semantic Scholar
Computational tools help improve protein stability but with a solubility tradeoff
A. Broom, Zachary E. Jacobi, Kyle Trainor, E. Meiering
2017Journal of Biological Chemistry102 citations Open access
Semantic Scholar
Modular evolution and the origins of symmetry: reconstruction of a three-fold symmetric globular protein.
A. Broom, A. Doxey, Yuri D. Lobsanov, Lisa G. Berthin +4 more
2012Structure97 citations Open access
Semantic Scholar
Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways
A. Sekhar, Jessica A. Rumfeldt, Helen R. Broom, Colleen M. Doyle +3 more
2015eLife96 citations Open access
Semantic Scholar
Calorimetric Analysis of Thermodynamic Stability and Aggregation for Apo and Holo Amyotrophic Lateral Sclerosis-associated Gly-93 Mutants of Superoxide Dismutase*
P. Stathopulos, Jessica A. Rumfeldt, F. Karbassi, Clare A. Siddall +2 more
2006Journal of Biological Chemistry91 citations Open access
Semantic Scholar
Mechanism and thermodynamics of guanidinium chloride-induced denaturation of ALS-associated mutant Cu,Zn superoxide dismutases.
Jessica A. Rumfeldt, P. Stathopulos, Avijit Chakrabarrty, J. Lepock +1 more
2006Journal of Molecular Biology72 citations
Semantic Scholar
Exploring the relationships between protein sequence, structure and solubility.
Kyle Trainor, A. Broom, E. Meiering
2017Current Opinion in Structural Biology71 citations
Semantic Scholar
Unfolding and folding kinetics of amyotrophic lateral sclerosis-associated mutant Cu,Zn superoxide dismutases.
Jessica A. Rumfeldt, J. Lepock, E. Meiering
2009Journal of Molecular Biology64 citations
Semantic Scholar
A Descriptor Set for Quantitative Structure‐property Relationship Prediction in Biologics
Kannan Sankar, Kyle Trainor, Levi L. Blazer, Jarrett J. Adams +4 more
2022Molecular Informatics63 citations Open access
Semantic Scholar
ALS-linked misfolded SOD1 species have divergent impacts on mitochondria
Sarah R Pickles, Sabrina Semmler, Helen R. Broom, Laurie Destroismaisons +5 more
2016Acta Neuropathologica Communications63 citations Open access
Semantic Scholar
Nonamyloid Aggregates Arising from Mature Copper/Zinc Superoxide Dismutases Resemble Those Observed in Amyotrophic Lateral Sclerosis*
Y. Hwang, P. Stathopulos, K. Dimmick, Hong Yang +6 more
2010Journal of Biological Chemistry61 citations Open access
Semantic Scholar
Equilibrium thermodynamic analysis of amyotrophic lateral sclerosis-associated mutant apo Cu,Zn superoxide dismutases.
K. A. Vassall, P. Stathopulos, Jessica A. Rumfeldt, J. Lepock +1 more
2006Biochemistry61 citations
Semantic Scholar
Effects of maturation on the conformational free-energy landscape of SOD1
R. Culik, A. Sekhar, Jayashree Nagesh, H. Deol +3 more
2018Proceedings of the National Academy of Sciences of the United States of America54 citations Open access
Semantic Scholar
Computational Modeling of Protein Stability: Quantitative Analysis Reveals Solutions to Pervasive Problems.
A. Broom, Kyle Trainor, Zachary E. Jacobi, E. Meiering
2020Structure53 citations Open access
Semantic Scholar
Destabilization of the dimer interface is a common consequence of diverse ALS‐associated mutations in metal free SOD1
Helen R. Broom, Jessica A. Rumfeldt, K. A. Vassall, E. Meiering
2015Protein Science52 citations Open access
Semantic Scholar
Probing the free energy landscapes of ALS disease mutants of SOD1 by NMR spectroscopy
A. Sekhar, Jessica A. Rumfeldt, Helen R. Broom, Colleen M. Doyle +3 more
2016Proceedings of the National Academy of Sciences of the United States of America49 citations Open access
Semantic Scholar
Energetics of oligomeric protein folding and association.
Colleen M. Doyle, Jessica A. Rumfeldt, Helen R. Broom, A. Broom +4 more
2013Archives of Biochemistry and Biophysics48 citations
Semantic Scholar
NMR solution structure of the antitumor compound PT523 and NADPH in the ternary complex with human dihydrofolate reductase.
Jason M. Johnson, E. Meiering, J. Wright, J. Pardo +2 more
1997Biochemistry38 citations
Semantic Scholar
Nonnative interactions regulate folding and switching of myristoylated protein
Dalit Shental-Bechor, Martin T. J. Smith, Duncan W S MacKenzie, A. Broom +6 more
2012Proceedings of the National Academy of Sciences of the United States of America35 citations Open access
Semantic Scholar
Purification and characterization of recombinant Thermotoga maritima dihydrofolate reductase.
V. Wilquet, J. A. Gaspar, Monica van de Lande, M. Van de Casteele +3 more
1998European Journal of Biochemistry35 citations Open access
Semantic Scholar
Many roads lead to Rome? Multiple modes of Cu,Zn superoxide dismutase destabilization, misfolding and aggregation in amyotrophic lateral sclerosis.
Helen R. Broom, Jessica A. Rumfeldt, E. Meiering
2014Essays in Biochemistry33 citations
Semantic Scholar
The Threat of Instability: Neurodegeneration Predicted by Protein Destabilization and Aggregation Propensity
E. Meiering
2008PLoS Biology33 citations Open access
Semantic Scholar
Temperature dependence of NMR chemical shifts: Tracking and statistical analysis
Kyle Trainor, Jeffrey A. Palumbo, Duncan W S MacKenzie, E. Meiering
2019Protein Science32 citations Open access
Semantic Scholar
Insights into the evolutionary origins of clostridial neurotoxins from analysis of the Clostridium botulinum strain A neurotoxin gene cluster
A. Doxey, M. Lynch, Kirsten M. Müller, E. Meiering +1 more
2008BMC Evolutionary Biology32 citations Open access
Semantic Scholar
pH and urea dependence of amide hydrogen-deuterium exchange rates in the beta-trefoil protein hisactophilin.
R. Houliston, Cheng-Song Liu, Laila M. R. Singh, E. Meiering
2002Biochemistry30 citations
Semantic Scholar
Concurrent Increases and Decreases in Local Stability and Conformational Heterogeneity in Cu, Zn Superoxide Dismutase Variants Revealed by Temperature-Dependence of Amide Chemical Shifts.
Colleen M. Doyle, Jessica A. Rumfeldt, Helen R. Broom, A. Sekhar +2 more
2016Biochemistry29 citations
Semantic Scholar
Characterization of phosphate binding in the active site of barnase by site-directed mutagenesis and NMR.
E. Meiering, M. Bycroft, A. Fersht
1991Biochemistry27 citations
Semantic Scholar
Kinetic stability of the streptavidin-biotin interaction enhanced in the gas phase.
Lu Deng, A. Broom, E. Kitova, M. R. Richards +4 more
2012Journal of the American Chemical Society26 citations
Semantic Scholar
Spectrophotometric method for simultaneous measurement of zinc and copper in metalloproteins using 4-(2-pyridylazo)resorcinol.
Colleen M. Doyle, Dalia Naser, Heather A Bauman, Jessica A. Rumfeldt +1 more
2019Analytical Biochemistry25 citations Open access
Semantic Scholar
Protein unfolding rates correlate as strongly as folding rates with native structure
A. Broom, S. Gosavi, E. Meiering
2015Protein Science24 citations Open access
Semantic Scholar
Raman and far-infrared study of the lattice vibrations of methanol
A. Anderson, B. Andrews, E. Meiering, B. Torrie
198822 citations
Semantic Scholar
TNF receptor–associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation
Sabrina Semmler, Myriam Gagné, P. Garg, Sarah R Pickles +18 more
2020Journal of Biological Chemistry19 citations Open access
Semantic Scholar
Combined Isothermal Titration and Differential Scanning Calorimetry Define Three-State Thermodynamics of fALS-Associated Mutant Apo SOD1 Dimers and an Increased Population of Folded Monomer.
Helen R. Broom, K. A. Vassall, Jessica A. Rumfeldt, Colleen M. Doyle +3 more
2016Biochemistry19 citations Open access
Semantic Scholar
Non-linear effects of temperature and urea on the thermodynamics and kinetics of folding and unfolding of hisactophilin.
H. Wong, P. Stathopulos, J. M. Bonner, Marc Sawyer +1 more
2004Journal of Molecular Biology19 citations
Semantic Scholar
Energetics and mechanisms of folding and flipping the myristoyl switch in the β-trefoil protein, hisactophilin
Martin T. J. Smith, J. Meissner, Samantha Esmonde, H. Wong +1 more
2010Proceedings of the National Academy of Sciences of the United States of America17 citations Open access
Semantic Scholar
Interaction of dibucaine with the transmembrane domain of the Ca(2+)-ATPase of sarcoplasmic reticulum.
Celia Anteneodo, A. M. Rodahl, E. Meiering, M. Heynen +2 more
1994Biochemistry17 citations
Semantic Scholar
Ensemble Modeling and Intracellular Aggregation of an Engineered Immunoglobulin-Like Domain.
Kyle Trainor, Zachary Gingras, Cicely Shillingford, Heather Malakian +3 more
2016Journal of Molecular Biology15 citations
Semantic Scholar
Folding and association of thermophilic dimeric and trimeric DsrEFH proteins: Tm0979 and Mth1491.
Céline Galvagnion, Martin T. J. Smith, A. Broom, K. A. Vassall +5 more
2009Biochemistry15 citations
Semantic Scholar
Asymmetric Anchoring Is Required for Efficient Ω-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase.
Danica S. Cui, A. Broom, M. McLeod, E. Meiering +1 more
2017Biochemistry13 citations Open access
Semantic Scholar
Wild‐type and mutant SOD1 localizes to RNA‐rich structures in cells and mice but does not bind RNA
Matteo Da Ros, H. Deol, Alexandre Savard, Hui-Shan Guo +2 more
2020Journal of Neurochemistry11 citations
Semantic Scholar
Insight into the autosomal-dominant inheritance pattern of SOD1-associated ALS from native mass spectrometry
J. Cvetićanin, Tridib Mondal, E. Meiering, M. Sharon +1 more
2020bioRxiv11 citations Open access
Semantic Scholar
Folding and Aggregation of Cu, Zn-Superoxide Dismutase
Helen R. Broom, Heather A. Primmer, Jessica A. Rumfeldt, P. Stathopulos +3 more
201211 citations Open access
Semantic Scholar
Methodological advances and strategies for high resolution structure determination of cellular protein aggregates
Anna Schaefer, Dalia Naser, Bruna Siebeneichler, Michael V. Tarasca +1 more
2022Journal of Biological Chemistry10 citations Open access
Semantic Scholar
Using natural sequences and modularity to design common and novel protein topologies.
A. Broom, Kyle Trainor, Duncan W S MacKenzie, E. Meiering
2016Current Opinion in Structural Biology9 citations
Semantic Scholar
A novel member of the YchN‐like fold: Solution structure of the hypothetical protein Tm0979 from Thermotoga maritima
J. A. Gaspar, Cheng-Song Liu, K. A. Vassall, Gabriela Meglei +7 more
2005Protein Science9 citations Open access
Semantic Scholar
Evolution of magnetization due to asymmetric dimerization: theoretical considerations and application to aberrant oligomers formed by apoSOD1(2SH).
A. Sekhar, A. D. Bain, Jessica A. Rumfeldt, E. Meiering +1 more
2016Physical Chemistry, Chemical Physics - PCCP8 citations
Semantic Scholar
Dissecting the molecular determinants of ligand-binding-induced macromolecular switching using thermodynamic cycles.
Martin T. J. Smith, Duncan W S MacKenzie, E. Meiering
2011Protein engineering, design & selection : PEDS8 citations Open access
Semantic Scholar

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