L. Kay

Most-cited papers

Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation
Jacob P. Brady, Patrick J. Farber, A. Sekhar, Yi‐Hsuan Lin +7 more
2017Proceedings of the National Academy of Sciences of the United States of America455 citations Open access
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Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation
Tae Hun Kim, B. Tsang, R. Vernon, N. Sonenberg +2 more
2019Science306 citations Open access
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NMR spectroscopy captures the essential role of dynamics in regulating biomolecular function.
T. Alderson, L. Kay
2021Cell205 citations Open access
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An NMR View of Protein Dynamics in Health and Disease.
A. Sekhar, L. Kay
2019Annual Review of Biophysics142 citations Open access
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Probing conformational dynamics in biomolecules via chemical exchange saturation transfer: a primer
P. Vallurupalli, A. Sekhar, Tai-Ran Yuwen, L. Kay
2017Journal of Biomolecular NMR135 citations
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Interaction hot spots for phase separation revealed by NMR studies of a CAPRIN1 condensed phase
Tae Hun Kim, B. Payliss, Michael L. Nosella, I. Lee +3 more
2021Proceedings of the National Academy of Sciences of the United States of America97 citations Open access
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A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery
Z. A. Ripstein, S. Vahidi, W. Houry, J. Rubinstein +1 more
2019bioRxiv95 citations Open access
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Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles
Rina Rosenzweig, A. Sekhar, Jayashree Nagesh, L. Kay
2017eLife73 citations Open access
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Atomic resolution mechanism of ligand binding to a solvent inaccessible cavity in T4 lysozyme
Jagannath Mondal, N. Ahalawat, Subhendu Pandit, L. Kay +1 more
2018bioRxiv71 citations Open access
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Stabilization of amyloidogenic immunoglobulin light chains by small molecules
G. Morgan, Nicholas L. Yan, D. E. Mortenson, E. Rennella +12 more
2019Proceedings of the National Academy of Sciences of the United States of America69 citations Open access
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Conserved conformational selection mechanism of Hsp70 chaperone-substrate interactions
A. Sekhar, Algirdas Velyvis, Guy Zoltsman, Rina Rosenzweig +2 more
2018eLife65 citations Open access
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Role of domain interactions in the aggregation of full-length immunoglobulin light chains
E. Rennella, G. Morgan, J. Kelly, L. Kay
2018Proceedings of the National Academy of Sciences of the United States of America60 citations Open access
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An allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR
S. Vahidi, Z. A. Ripstein, Jordan B. Juravsky, E. Rennella +4 more
2019Proceedings of the National Academy of Sciences of the United States of America59 citations Open access
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Reversible inhibition of the ClpP protease via an N-terminal conformational switch
S. Vahidi, Z. A. Ripstein, Massimiliano Bonomi, Tai-Ran Yuwen +8 more
2018Proceedings of the National Academy of Sciences of the United States of America55 citations Open access
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Effects of maturation on the conformational free-energy landscape of SOD1
R. Culik, A. Sekhar, Jayashree Nagesh, H. Deol +3 more
2018Proceedings of the National Academy of Sciences of the United States of America54 citations Open access
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Mapping the per-residue surface electrostatic potential of CAPRIN1 along its phase-separation trajectory
Y. Toyama, A. Rangadurai, J. Forman-Kay, L. Kay
2022Proceedings of the National Academy of Sciences of the United States of America51 citations Open access
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The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage
Julianne Kitevski-LeBlanc, Amélie Fradet-Turcotte, P. Kukic, M. Wilson +11 more
2017eLife50 citations Open access
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A methyl-TROSY approach for NMR studies of high-molecular-weight DNA with application to the nucleosome core particle
Gili Abramov, Algirdas Velyvis, E. Rennella, L. Wong +1 more
2020Proceedings of the National Academy of Sciences of the United States of America47 citations Open access
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Correlating histone acetylation with nucleosome core particle dynamics and function
Tae Hun Kim, Michael L. Nosella, Nicolas Bolik-Coulon, Robert W. Harkness +2 more
2023Proceedings of the National Academy of Sciences of the United States of America45 citations Open access
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Polyubiquitin-photoactivatable crosslinking reagents for mapping ubiquitin interactome identify Rpn1 as a proteasome ubiquitin-associating subunit
Michał Chojnacki, W. Mansour, Dharjath S. Hameed, Rajesh K. Singh +9 more
2017Cell Chemical Biology45 citations Open access
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Design of amyloidogenic peptide traps
D. D. Sahtoe, E. Andrzejewska, Hannah L. Han, E. Rennella +13 more
2023bioRxiv44 citations Open access
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Investigating the Dynamics of Destabilized Nucleosomes Using Methyl-TROSY NMR.
Julianne Kitevski-LeBlanc, Tai-Ran Yuwen, P. Dyer, J. Rudolph +2 more
2018Journal of the American Chemical Society44 citations
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Dramatic Decrease in CEST Measurement Times Using Multi-Site Excitation.
Tai-Ran Yuwen, L. Kay, G. Bouvignies
2018ChemPhysChem44 citations Open access
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Opening of a cryptic pocket in β-lactamase increases penicillinase activity
Catherine R. Knoverek, Upasana L. Mallimadugula, Sukrit Singh, E. Rennella +5 more
2021Proceedings of the National Academy of Sciences of the United States of America43 citations Open access
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Cooperative subunit dynamics modulate p97 function
Rui Huang, Z. A. Ripstein, J. Rubinstein, L. Kay
2018Proceedings of the National Academy of Sciences of the United States of America43 citations Open access
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Separating Dipolar and Chemical Exchange Magnetization Transfer Processes in 1 H-CEST.
Tai-Ran Yuwen, A. Sekhar, L. Kay
2017Angewandte Chemie42 citations
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Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson’s disease
Satra Nim, Darren M O'Hara, Carles Corbi-Verge, Albert Perez-Riba +14 more
2023Nature Communications41 citations Open access
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Exploiting conformational plasticity in the AAA+ protein VCP/p97 to modify function
A. Schütz, E. Rennella, L. Kay
2017Proceedings of the National Academy of Sciences of the United States of America41 citations Open access
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A Methyl-TROSY-Based 1 H Relaxation Dispersion Experiment for Studies of Conformational Exchange in High Molecular Weight Proteins.
Tai-Ran Yuwen, Rui Huang, P. Vallurupalli, L. Kay
2019Angewandte Chemie36 citations
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Probing Conformational Exchange in Weakly Interacting, Slowly Exchanging Protein Systems via Off-Resonance R1ρ Experiments: Application to Studies of Protein Phase Separation.
Tai-Ran Yuwen, Jacob P. Brady, L. Kay
2018Journal of the American Chemical Society35 citations
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ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores
M. Mabanglo, E. Leung, S. Vahidi, T. V. Seraphim +16 more
2019Communications Biology34 citations Open access
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Oligomeric assembly regulating mitochondrial HtrA2 function as examined by methyl-TROSY NMR
Y. Toyama, Robert W. Harkness, Tim Y. T. Lee, J. Maynes +1 more
2021Proceedings of the National Academy of Sciences of the United States of America32 citations Open access
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An intrinsically disordered motif regulates the interaction between the p47 adaptor and the p97 AAA+ ATPase
Alexander E. Conicella, Rui Huang, Z. A. Ripstein, Ai Nguyen +6 more
2020Proceedings of the National Academy of Sciences of the United States of America27 citations Open access
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Self-Assembly of Human Profilin-1 Detected by Carr-Purcell-Meiboom-Gill Nuclear Magnetic Resonance (CPMG NMR) Spectroscopy.
E. Rennella, A. Sekhar, L. Kay
2017Biochemistry27 citations
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Probing the cooperativity of Thermoplasma acidophilum proteasome core particle gating by NMR spectroscopy
Rui Huang, Felipe Pérez, L. Kay
2017Proceedings of the National Academy of Sciences of the United States of America26 citations Open access
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Exploring methods to expedite the recording of CEST datasets using selective pulse excitation.
Tai-Ran Yuwen, G. Bouvignies, L. Kay
2018Journal of magnetic resonance (San Diego, Calif. 1997 : Print)25 citations
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Probing slow timescale dynamics in proteins using methyl 1H CEST
Tai-Ran Yuwen, Rui Huang, L. Kay
2017Journal of Biomolecular NMR25 citations
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Revisiting 1HN CPMG relaxation dispersion experiments: a simple modification can eliminate large artifacts
Tai-Ran Yuwen, L. Kay
2019Journal of Biomolecular NMR23 citations
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The Role of Protein Thermodynamics and Primary Structure in Fibrillogenesis of Variable Domains from Immunoglobulin Light Chains
E. Rennella, G. Morgan, Nicholas L. Yan, J. Kelly +1 more
2019Journal of the American Chemical Society23 citations Open access
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Surface electrostatics dictate RNA-binding protein CAPRIN1 condensate concentration and hydrodynamic properties
Y. Toyama, A. Rangadurai, J. Forman-Kay, L. Kay
2022Journal of Biological Chemistry22 citations Open access
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Measuring Solvent Hydrogen Exchange Rates by Multifrequency Excitation 15N CEST: Application to Protein Phase Separation.
Tai-Ran Yuwen, Alaji Bah, Jacob P. Brady, F. Ferrage +2 more
2018Journal of Physical Chemistry B21 citations
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Conformational heterogeneity in the Hsp70 chaperone‐substrate ensemble identified from analysis of NMR‐detected titration data
A. Sekhar, Jayashree Nagesh, Rina Rosenzweig, L. Kay
2017Protein Science21 citations Open access
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The A39G FF domain folds on a volcano-shaped free energy surface via separate pathways
V. P. Tiwari, Y. Toyama, D. De, L. Kay +1 more
2021Proceedings of the National Academy of Sciences of the United States of America20 citations Open access
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Simultaneous NMR characterisation of multiple minima in the free energy landscape of an RNA UUCG tetraloop
Aditi N. Borkar, P. Vallurupalli, C. Camilloni, L. Kay +1 more
2017Physical Chemistry, Chemical Physics - PCCP20 citations Open access
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Less is more: A simple methyl-TROSY based pulse scheme offers improved sensitivity in applications to high molecular weight complexes.
Nicolas Bolik-Coulon, Alexander I. M. Sever, Robert W. Harkness, J. Aramini +3 more
2022Journal of magnetic resonance (San Diego, Calif. 1997 : Print)19 citations Open access
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Competing stress-dependent oligomerization pathways regulate self-assembly of the periplasmic protease-chaperone DegP
Robert W. Harkness, Y. Toyama, Z. A. Ripstein, Hua-Ying Zhao +6 more
2021Proceedings of the National Academy of Sciences of the United States of America19 citations Open access
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Measuring Diffusion Constants of Invisible Protein Conformers by Triple-Quantum 1 H CPMG Relaxation Dispersion.
Tai-Ran Yuwen, A. Sekhar, Andrew J. Baldwin, P. Vallurupalli +1 more
2018Angewandte Chemie19 citations
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Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins
Nicholas L. Yan, D. Santos-Martins, E. Rennella, Brittany B. Sanchez +6 more
2020Bioorganic & Medicinal Chemistry Letters18 citations Open access
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Exploring long-range cooperativity in the 20S proteasome core particle from Thermoplasma acidophilum using methyl-TROSY–based NMR
E. Rennella, Rui Huang, Zanlin Yu, L. Kay
2020Proceedings of the National Academy of Sciences of the United States of America18 citations Open access
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Exploiting conformational dynamics to modulate the function of designed proteins
E. Rennella, D. D. Sahtoe, D. Baker, L. Kay
2023Proceedings of the National Academy of Sciences of the United States of America16 citations Open access
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