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T. Zvyaga · SciRah

Researcher profile · Semantic Scholar

T. Zvyaga

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T. Zvyaga — researcher profile on SciRah

h-index: 19
Works: 39
Citations: 1,554

Most-cited papers

Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F
S. Sheikh, T. Zvyaga, O. Lichtarge, T. Sakmar +1 more
1996Nature388 citations
Semantic Scholar
Characterization of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa. Mutations on the cytoplasmic surface affect transducin activation.
K. Min, T. Zvyaga, A. Cypess, T. Sakmar
1993Journal of Biological Chemistry136 citations Open access
Semantic Scholar
An Automated Liquid Chromatography-Mass Spectrometry Process to Determine Metabolic Stability Half-Life and Intrinsic Clearance of Drug Candidates by Substrate Depletion
C. Mcnaney, D. Drexler, Serhiy Y. Hnatyshyn, T. Zvyaga +3 more
2008Assay and drug development technologies134 citations
Semantic Scholar
Evaluation of Six Proton Pump Inhibitors As Inhibitors of Various Human Cytochromes P450: Focus on Cytochrome P450 2C19
T. Zvyaga, Shu-Ying Chang, Cliff Chen, Zheng Yang +6 more
2012Drug Metabolism And Disposition130 citations
Semantic Scholar
The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection.
P. Scola, Li-Qiang Sun, A. Wang, Jie Chen +46 more
2014Journal of Medicinal Chemistry104 citations
Semantic Scholar
Drug-Induced Perturbations of the Bile Acid Pool, Cholestasis, and Hepatotoxicity: Mechanistic Considerations beyond the Direct Inhibition of the Bile Salt Export Pump
A. D. Rodrigues, Yurong Lai, M. Cvijic, L. Elkin +2 more
2014Drug Metabolism And Disposition98 citations
Semantic Scholar
Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.
P. Scola, A. Wang, A. Good, Li-Qiang Sun +45 more
2014Journal of Medicinal Chemistry65 citations Open access
Semantic Scholar
A high-throughput bioanalytical platform using automated infusion for tandem mass spectrometric method optimization and its application in a metabolic stability screen.
Kasia Kieltyka, Jun Zhang, Shu Li, M. Vath +6 more
2009Rapid Communications in Mass Spectrometry46 citations
Semantic Scholar
Studies to Further Investigate the Inhibition of Human Liver Microsomal CYP2C8 by the Acyl-β-Glucuronide of Gemfibrozil
Susan M Jenkins, T. Zvyaga, Stephen R. Johnson, Jeremy Hurley +6 more
2011Drug Metabolism And Disposition36 citations
Semantic Scholar
Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR).
B. Das, Ankanahlli V. Madhukumar, Jaime Anguiano, Sean Kim +5 more
2008Bioorganic & Medicinal Chemistry Letters30 citations Open access
Semantic Scholar
Ultrafast mass spectrometry based bioanalytical method for digoxin supporting an in vitro P-glycoprotein (P-gp) inhibition screen.
Andrew D Wagner, Janet M. Kolb, C. Ozbal, J. Herbst +4 more
2011Rapid Communications in Mass Spectrometry28 citations
Semantic Scholar
An Automated High Throughput Liquid Chromatography–Mass Spectrometry Process to Assess the Metabolic Stability of Drug Candidates
D. Drexler, James V Belcastro, K. Dickinson, K. Edinger +9 more
2007Assay and drug development technologies28 citations
Semantic Scholar
Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1).
Haixia Wang, J. Robl, L. Hamann, L. Simpkins +6 more
2011Bioorganic & Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.
Li-Qiang Sun, E. Mull, B. Zheng, S. D'Andrea +52 more
2016Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11β-hydroxydehydrogenase 1 (11β-HSD1).
Shung C. Wu, David S Yoon, J. Chin, Katy van Kirk +27 more
2011Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors.
Michael M. Miller, Yalei Liu, Ji Jiang, James A. Johnson +17 more
2012Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Coupling Laser Diode Thermal Desorption with Acoustic Sample Deposition to Improve Throughput of Mass Spectrometry–Based Screening
Zuzana Haarhoff, Andrew D Wagner, P. Picard, D. Drexler +2 more
2016Journal of biomolecular screening21 citations Open access
Semantic Scholar
A high-speed liquid chromatography/tandem mass spectrometry platform using multiplexed multiple-injection chromatography controlled by single software and its application in discovery ADME screening.
Jun Zhang, M. Vath, Cheryl A Ferraro, Y. Li +4 more
2013Rapid Communications in Mass Spectrometry20 citations Open access
Semantic Scholar
Utility of high-resolution accurate MS to eliminate interferences in the bioanalysis of ribavirin and its phosphate metabolites.
Cong Wei, J. Grace, T. Zvyaga, D. Drexler
2012Bioanalysis20 citations
Semantic Scholar
Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481
Kenneth M. Boy, Jason M. Guernon, Dmitry Zuev, Li Xu +25 more
2019ACS Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor.
Kyle Parcella, K. Eastman, Kap-Sun Yeung, Katharine A Grant-Young +21 more
2017ACS Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Bacterial Mode of Replication with Eukaryotic-Like Machinery in a Hyperthermophilic Archaeon
D. Farrens, C. Altenbach, K. Yang, W. Hubbell +9 more
200018 citations
Semantic Scholar
Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.
Li-Qiang Sun, E. Mull, S. D'Andrea, B. Zheng +33 more
2020Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.
K. Eastman, Kyle Parcella, Kap-Sun Yeung, Katharine A Grant-Young +27 more
2017MedChemComm14 citations Open access
Semantic Scholar
Drug-Induced Perturbations of the Bile Acid Pool , Cholestasis , and Hepatotoxicity : Mechanistic Considerations Beyond the Direct Inhibition of the Bile Salt Export Pump
A. Rodrigues, Yurong Lai, M. Cvijic, L. Elkin +2 more
201314 citations
Semantic Scholar
Functional expression in vitro of bovine visual rhodopsin.
S. Zozulya, V. Gurevich, T. Zvyaga, E. P. Shirokova +5 more
1990Protein Engineering14 citations
Semantic Scholar
Development, optimization and implementation of a centralized metabolic soft spot assay.
Anthony A. Paiva, Cheryl Klakouski, Shu Li, Benjamin M. Johnson +5 more
2017Bioanalysis13 citations
Semantic Scholar
Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780
J. Toyn, L. Thompson, K. Lentz, J. Meredith +37 more
2014International Journal of Alzheimer's Disease13 citations Open access
Semantic Scholar
Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties.
M. D. Hill, Haiquan Fang, Derek J. Norris, George V. Delucca +28 more
2022ACS Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Development of BET inhibitors as potential treatments for cancer: A search for structural diversity.
M. D. Hill, Haiquan Fang, J. Tokarski, Carolynn Fanslau +19 more
2021Bioorganic & Medicinal Chemistry Letters6 citations Open access
Semantic Scholar
Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype.
M. D. Hill, C. Quesnelle, J. Tokarski, Haiquan Fang +20 more
2021Bioorganic & Medicinal Chemistry Letters6 citations Open access
Semantic Scholar
Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase.
P. Sivaprakasam, Zhong-Yu Wang, N. Meanwell, Javed A. Khan +17 more
2020Bioorganic & Medicinal Chemistry Letters6 citations Open access
Semantic Scholar
Anticipating and Minimizing Drug Interactions in a Drug Discovery and Development Setting: An Industrial Perspective
R. Vuppugalla, Sean Kim, T. Zvyaga, Yong-Hae Han +3 more
20105 citations
Semantic Scholar
Pharmacodynamics‐based approach for efficacious human dose projection of BMS‐986260, a small molecule transforming growth factor beta receptor 1 inhibitor
Karen E. Parrish, Jesse Swanson, Lihong Cheng, Emily Luk +13 more
2020Biopharmaceutics & drug disposition3 citations
Semantic Scholar
Comprehensive evaluation of liver microsomal cytochrome P450 3A (CYP3A) inhibition: comparison of cynomolgus monkey and human
Zuzana Haarhoff, M. Kramer, T. Zvyaga, Jun Zhang +3 more
2017Xenobiotica; the fate of foreign compounds in biological systems3 citations Open access
Semantic Scholar
Evaluation of Six Proton Pump Inhibitors as Inhibitors of Various Human Cytochromes P450: Focus on Cytochrome P450 2C19
T. Zvyaga, Shu-Ying Chang, Cliff Chen, Zheng Yang +6 more
20121 citations
Semantic Scholar
DMD054205 566..574
A. Rodrigues, Yurong Lai, M. Cvijic, L. Elkin +2 more
20140 citations
Semantic Scholar
Evaluation of Six Proton Pump Inhibitors as Inhibitors of Various Human Cytochromes P450: Focus on Cytochrome P450 2C19
T. Zvyaga, Shu-Ying Chang, Cliff Chen, Zheng Yang +6 more
20120 citations
Semantic Scholar
In vitro synthesis of visual rhodopsin for a protein engineering study
S. Zozulya, V. Gurevich, T. Zvyaga, I. Dumler +5 more
1989Journal of Protein Chemistry0 citations
Semantic Scholar

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