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V. Broccoli · SciRah

Researcher profile · Semantic Scholar

V. Broccoli

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V. Broccoli — researcher profile on SciRah

h-index: 66
Works: 174
Citations: 15K

Most-cited papers

Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson’s Disease Models
Angelo Iannielli, Simone Bido, Lucrezia Folladori, Alice Segnali +13 more
2018Cell Reports214 citations Open access
Semantic Scholar
Direct Conversion of Fibroblasts into Functional Astrocytes by Defined Transcription Factors
Massimiliano Caiazzo, S. Giannelli, P. Valente, G. Lignani +9 more
2014Stem Cell Reports203 citations Open access
Semantic Scholar
dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice.
G. Colasante, G. Lignani, S. Brusco, C. Di Berardino +15 more
2020Molecular Therapy202 citations Open access
Semantic Scholar
Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity
Simone Bido, Sharon Muggeo, Luca Massimino, M. Marzi +14 more
2021Nature Communications181 citations Open access
Semantic Scholar
Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming.
G. Colasante, G. Lignani, Alicia Rubio, L. Medrihan +17 more
2015Cell Stem Cell168 citations Open access
Semantic Scholar
Primary Skin Fibroblasts as a Model of Parkinson's Disease
G. Auburger, M. Klinkenberg, J. Drost, K. Marcus +7 more
2012Molecular Neurobiology143 citations Open access
Semantic Scholar
The endoplasmic reticulum-mitochondria interface is perturbed in PARK2 knockout mice and patients with PARK2 mutations.
C. Gautier, Z. Erpapazoglou, F. Mouton-Liger, M. Muriel +13 more
2016Human Molecular Genetics140 citations
Semantic Scholar
A human bi-specific antibody against Zika virus with high therapeutic potential
Jiaqi Wang, M. Bardelli, Diego A. Espinosa, M. Pedotti +30 more
2017Cell137 citations Open access
Semantic Scholar
PRRT2 controls neuronal excitability by negatively modulating Na+ channel 1.2/1.6 activity
Floriana Fruscione, P. Valente, Bruno Sterlini, Alessandra Romei +15 more
2018Brain : a journal of neurology127 citations Open access
Semantic Scholar
Cas9/sgRNA selective targeting of the P23H Rhodopsin mutant allele for treating retinitis pigmentosa by intravitreal AAV9.PHP.B-based delivery
S. Giannelli, Mirko Luoni, V. Castoldi, Luca Massimino +6 more
2018Human Molecular Genetics124 citations Open access
Semantic Scholar
AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy.
Giuseppe Morabito, S. Giannelli, Gabriele Ordazzo, Simone Bido +12 more
2017Molecular Therapy116 citations Open access
Semantic Scholar
In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy
G. Colasante, Yichen Qiu, Luca Massimino, C. Di Berardino +10 more
2020Brain : a journal of neurology112 citations Open access
Semantic Scholar
Remote control of induced dopaminergic neurons in parkinsonian rats.
Maria Teresa Dell'Anno, Massimiliano Caiazzo, D. Leo, E. Dvoretskova +12 more
2014Journal of Clinical Investigation111 citations Open access
Semantic Scholar
SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub
R. Piazza, V. Magistroni, S. Redaelli, Mario Mauri +23 more
2018Nature Communications108 citations Open access
Semantic Scholar
Rapid Generation of Functional Dopaminergic Neurons From Human Induced Pluripotent Stem Cells Through a Single‐Step Procedure Using Cell Lineage Transcription Factors
Ilda Theka, Massimiliano Caiazzo, E. Dvoretskova, D. Leo +8 more
2013Stem Cells Translational Medicine97 citations Open access
Semantic Scholar
SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring.
A. Sessa, L. Fagnocchi, G. Mastrototaro, Luca Massimino +12 more
2019Neuron96 citations Open access
Semantic Scholar
Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion
Valeria Fumagalli, M. Ravà, D. Marotta, P. Di Lucia +18 more
2021Science immunology92 citations Open access
Semantic Scholar
Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
S. Ghezzi, Lynsay C Cooper, Alicia Rubio, I. Pagani +9 more
2017Antiviral Research91 citations Open access
Semantic Scholar
Coenzyme A corrects pathological defects in human neurons of PANK2‐associated neurodegeneration
Daniel I. Orellana, P. Santambrogio, Alicia Rubio, Latefa Yekhlef +12 more
2016EMBO Molecular Medicine87 citations Open access
Semantic Scholar
Frataxin gene editing rescues Friedreich’s ataxia pathology in dorsal root ganglia organoid-derived sensory neurons
P. Mazzara, Sharon Muggeo, Mirko Luoni, Luca Massimino +16 more
2020Nature Communications80 citations Open access
Semantic Scholar
Stem Cell Modeling of Neuroferritinopathy Reveals Iron as a Determinant of Senescence and Ferroptosis during Neuronal Aging
A. Cozzi, Daniel I. Orellana, P. Santambrogio, Alicia Rubio +11 more
2019Stem Cell Reports74 citations Open access
Semantic Scholar
SCN1A/NaV1.1 channelopathies: Mechanisms in expression systems, animal models, and human iPSC models
M. Mantegazza, V. Broccoli
2019Epilepsia72 citations Open access
Semantic Scholar
Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients
P. Santambrogio, S. Dusi, M. Guaraldo, L. Rotundo +4 more
2015Neurobiology of Disease71 citations Open access
Semantic Scholar
Rapid and efficient CRISPR/Cas9 gene inactivation in human neurons during human pluripotent stem cell differentiation and direct reprogramming
Alicia Rubio, Mirko Luoni, S. Giannelli, Isabella Radice +8 more
2016Scientific Reports70 citations Open access
Semantic Scholar
MICAL2 is a novel human cancer gene controlling mesenchymal to epithelial transition involved in cancer growth and invasion
S. Mariotti, Ivana Barravecchia, C. Vindigni, A. Pucci +12 more
2015OncoTarget70 citations Open access
Semantic Scholar
Scn1a gene reactivation after symptom onset rescues pathological phenotypes in a mouse model of Dravet syndrome
Nicholas Valassina, S. Brusco, Alessia Salamone, L. Serra +10 more
2022Nature Communications67 citations Open access
Semantic Scholar
ARX regulates cortical intermediate progenitor cell expansion and upper layer neuron formation through repression of Cdkn1c.
G. Colasante, Jacqueline C. Simonet, R. Calogero, S. Crispi +4 more
2015Cerebral Cortex67 citations Open access
Semantic Scholar
Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy
A. Danese, S. Patergnani, A. Maresca, Camille Peron +26 more
2022Cell Reports65 citations Open access
Semantic Scholar
Human Endometrial Stromal Cells Are Highly Permissive To Productive Infection by Zika Virus
I. Pagani, S. Ghezzi, A. Ulisse, Alicia Rubio +9 more
2016Scientific Reports59 citations Open access
Semantic Scholar
MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis
Francisca F. Vasconcelos, A. Sessa, Cátia Laranjeira, A. Raposo +6 more
2016Cell Reports59 citations Open access
Semantic Scholar
Whole brain delivery of an instability-prone Mecp2 transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome
Mirko Luoni, S. Giannelli, M. Indrigo, A. Niro +9 more
2019bioRxiv54 citations Open access
Semantic Scholar
Generation of Human Induced Pluripotent Stem Cell‐Derived Bona Fide Neural Stem Cells for Ex Vivo Gene Therapy of Metachromatic Leukodystrophy
Vasco Meneghini, G. Frati, D. Sala, S. De Cicco +12 more
2016Stem Cells Translational Medicine51 citations Open access
Semantic Scholar
Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses
Angelo Iannielli, Giovanni Stefano Ugolini, C. Cordiglieri, Simone Bido +6 more
2019Cell Reports50 citations Open access
Semantic Scholar
Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome
A. Cozzi, P. Santambrogio, D. Privitera, V. Broccoli +7 more
2013Journal of Experimental Medicine50 citations Open access
Semantic Scholar
Selective homing of CAR-CIK cells to the bone marrow niche enhances control of the acute myeloid leukemia burden
M. Biondi, Sarah Tettamanti, S. Galimberti, Beatrice Cerina +13 more
2023Blood49 citations Open access
Semantic Scholar
Human induced pluripotent stem cells differentiate into insulin-producing cells able to engraft in vivo
S. Pellegrini, Federica Ungaro, A. Mercalli, R. Melzi +5 more
2015Acta Diabetologica44 citations
Semantic Scholar
SETBP1 accumulation induces P53 inhibition and genotoxic stress in neural progenitors underlying neurodegeneration in Schinzel-Giedion syndrome
Federica Banfi, Alicia Rubio, M. Zaghi, Luca Massimino +13 more
2021Nature Communications43 citations Open access
Semantic Scholar
SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System
K. Neyrinck, Johanna Van Den Daele, T. Vervliet, J. De Smedt +16 more
2021Stem Cell Reviews and Reports40 citations Open access
Semantic Scholar
H3K36 Methylation in Neural Development and Associated Diseases
M. Zaghi, V. Broccoli, A. Sessa
2020Frontiers in Genetics40 citations Open access
Semantic Scholar
Wnt signaling has opposing roles in the developing and the adult brain that are modulated by Hipk1.
C. Marinaro, M. Pannese, Franziska Weinandy, A. Sessa +7 more
2012Cerebral Cortex40 citations Open access
Semantic Scholar
The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways.
A. Sessa, E. Ciabatti, Daniela Drechsel, Luca Massimino +6 more
2017Cerebral Cortex35 citations Open access
Semantic Scholar
Two factor-based reprogramming of rodent and human fibroblasts into Schwann cells
P. Mazzara, Luca Massimino, Marta Pellegatta, G. Ronchi +12 more
2017Nature Communications34 citations Open access
Semantic Scholar
KMT2B Is Selectively Required for Neuronal Transdifferentiation, and Its Loss Exposes Dystonia Candidate Genes
G. Barbagiovanni, Pierre-Luc Germain, M. Zech, S. Atashpaz +11 more
2018Cell Reports33 citations Open access
Semantic Scholar
Modeling physiological and pathological human neurogenesis in the dish
V. Broccoli, S. Giannelli, P. Mazzara
2014Frontiers in Neuroscience32 citations Open access
Semantic Scholar
Glucocerebrosidase Gene Therapy Induces Alpha-Synuclein Clearance and Neuroprotection of Midbrain Dopaminergic Neurons in Mice and Macaques
Diego Sucunza, A. J. Rico, E. Roda, M. Collantes +7 more
2021International Journal of Molecular Sciences31 citations Open access
Semantic Scholar
The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways
A. Sessa, E. Ciabatti, Daniela Drechsel, Luca Massimino +6 more
2016Cerebral Cortex31 citations Open access
Semantic Scholar
Zrf1 is required to establish and maintain neural progenitor identity
Luigi Aloia, B. D. Di Stefano, A. Sessa, L. Morey +7 more
2014Genes & Development30 citations Open access
Semantic Scholar
Generation of Human Induced Pluripotent Stem Cell-Derived Bona Fide Neural Stem Cells for Ex Vivo Gene Therapy of Metachromatic Leukodystrophy.
Vasco Meneghini, G. Frati, D. Sala, S. De Cicco +12 more
2016Stem Cells Translational Medicine28 citations
Semantic Scholar
Direct Neuronal Reprogramming Reveals Unknown Functions for Known Transcription Factors
G. Colasante, Alicia Rubio, Luca Massimino, V. Broccoli
2019Frontiers in Neuroscience26 citations Open access
Semantic Scholar
Gene therapy approaches in the non-human primate model of Parkinson’s disease
Diego Pignataro, Diego Sucunza, A. J. Rico, Iria M. Gonzalez Dopeso-Reyes +7 more
2018Journal of neural transmission25 citations
Semantic Scholar

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Luca Massimino×17
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A. Sessa×15
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Alicia Rubio×13
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Angelo Iannielli×8

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Simone Bido — researcher profile on SciRah

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G. Lignani — researcher profile on SciRah