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L. Pendyala · SciRah

Researcher profile · Semantic Scholar

L. Pendyala

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L. Pendyala — researcher profile on SciRah

h-index: 28
Works: 104
Citations: 2,654

Most-cited papers

In vitro cytotoxicity, protein binding, red blood cell partitioning, and biotransformation of oxaliplatin.
L. Pendyala, P. Creaven
1993Cancer Research226 citations
Semantic Scholar
VX-710 (Biricodar) Increases Drug Retention and Enhances Chemosensitivity in Resistant Cells Overexpressing P-Glycoprotein, Multidrug Resistance Protein, and Breast Cancer Resistance Protein
H. Minderman, K. O'Loughlin, L. Pendyala, M. Baer
2004Clinical Cancer Research167 citations
Semantic Scholar
In vitro studies on the mechanisms of oxaliplatin resistance
S. Hector, W. Bolanowska-Higdon, Joseph Zdanowicz, Sandra Hitt +1 more
2001Cancer Chemotherapy and Pharmacology166 citations
Semantic Scholar
The Role of DNA Polymerase η in Translesion Synthesis Past Platinum–DNA Adducts in Human Fibroblasts
E. Bassett, Nicole M. King, M. F. Bryant, S. Hector +3 more
2004Cancer Research111 citations
Semantic Scholar
Oxaliplatin in combination with protracted-infusion fluorouracil and radiation: report of a clinical trial for patients with esophageal cancer.
N. Khushalani, C. Leichman, G. Proulx, H. Nava +11 more
2002Journal of Clinical Oncology110 citations
Semantic Scholar
Therapeutic Synergy Between Irinotecan and 5-Fluorouracil against Human Tumor Xenografts
R. Azrak, Shou-Song Cao, H. Slocum, K. Toth +6 more
2004Clinical Cancer Research99 citations Open access
Semantic Scholar
Pharmacokinetic and pharmacodynamic studies of N-acetylcysteine, a potential chemopreventive agent during a phase I trial.
L. Pendyala, P. Creaven
1995Cancer Epidemiology, Biomarkers and Prevention94 citations
Semantic Scholar
Gene expression profiling of a clonal isolate of oxaliplatin-resistant ovarian carcinoma cell line A2780/C10.
Ram Varma, S. Hector, K. Clark, W. Greco +2 more
2005Oncology Report79 citations
Semantic Scholar
Identification of cis-dichloro-bis-isopropylamine platinum(II) as a major metabolite of iproplatin in humans.
L. Pendyala, J. Cowens, G. Chheda, S. Dutta +1 more
1988Cancer Research76 citations
Semantic Scholar
A Phase I, Pharmacokinetic, and Pharmacodynamic Study of Vorinostat in Combination with 5-Fluorouracil, Leucovorin, and Oxaliplatin in Patients with Refractory Colorectal Cancer
M. Fakih, L. Pendyala, Gerald J. Fetterly, K. Toth +7 more
2009Clinical Cancer Research66 citations Open access
Semantic Scholar
A Functional Genetic Polymorphism on Human Carbonyl Reductase 1 (CBR1 V88I) Impacts on Catalytic Activity and NADPH Binding Affinity
V. González-Covarrubias, D. Ghosh, S. S. Lakhman, L. Pendyala +1 more
2007Drug Metabolism And Disposition64 citations Open access
Semantic Scholar
Translational studies of glutathione in bladder cancer cell lines and human specimens.
L. Pendyala, S. Velagapudi, K. Toth, Joseph Zdanowicz +6 more
1997Clinical Cancer Research63 citations
Semantic Scholar
Phase I clinical trial of cis-dichloro-trans-dihydroxy-bis-isopropylamine platinum(IV) (CHIP).
P. Creaven, S. Madajewicz, L. Pendyala, A. Mittelman +4 more
1983Cancer treatment reports63 citations
Semantic Scholar
Lack of Microvessels in Well-Differentiated Regions of Human Head and Neck Squamous Cell Carcinoma A253 Associated with Functional Magnetic Resonance Imaging Detectable Hypoxia, Limited Drug Delivery, and Resistance to Irinotecan Therapy
A. Bhattacharya, K. Toth, R. Mazurchuk, Joseph A. Spernyak +6 more
2004Clinical Cancer Research54 citations Open access
Semantic Scholar
Polyamine catabolism in platinum drug action: Interactions between oxaliplatin and the polyamine analogue N1,N11-diethylnorspermine at the level of spermidine/spermine N1-acetyltransferase.
S. Hector, C. Porter, D. Kramer, K. Clark +5 more
2004Molecular Cancer Therapeutics52 citations
Semantic Scholar
Unusual central nervous system toxicity in a phase I study of N1N11diethylnorspermine in patients with advanced malignancy
P. Creaven, R. Perez, L. Pendyala, N. Meropol +4 more
2004Investigational new drugs50 citations
Semantic Scholar
Celecoxib and Mucosal Protection: Translation from an Animal Model to a Phase I Clinical Trial of Celecoxib, Irinotecan, and 5-Fluorouracil
M. Javle, Shou-Song Cao, F. Durrani, L. Pendyala +6 more
2007Clinical Cancer Research40 citations Open access
Semantic Scholar
Characterization of Pt-, Pd-spermine complexes for their effect on polyamine pathway and cisplatin resistance in A2780 ovarian carcinoma cells
R. Tummala, P. Diegelman, S. M. Fiuza, Luís A. E. Batista de Carvalho +6 more
2010Oncology Report39 citations Open access
Semantic Scholar
A Phase I and pharmacokinetic study of selenomethionine in combination with a fixed dose of irinotecan in solid tumors
M. Fakih, L. Pendyala, W. Brady, Patrick F. Smith +5 more
2008Cancer Chemotherapy and Pharmacology39 citations
Semantic Scholar
Phase II study of weekly intravenous oxaliplatin combined with oral daily capecitabine and radiotherapy with biologic correlates in neoadjuvant treatment of rectal adenocarcinoma.
M. Fakih, K. Bullarddunn, Gary Y. Yang, L. Pendyala +8 more
2008International Journal of Radiation Oncology, Biology, Physics39 citations
Semantic Scholar
Evaluation of alpha-difluoromethylornithine as a potential chemopreventive agent: tolerance to daily oral administration in humans.
P. Creaven, L. Pendyala, N. Petrelli
1993Cancer Epidemiology, Biomarkers and Prevention39 citations
Semantic Scholar
A phase I and pharmacokinetic study of fixed-dose selenomethionine and irinotecan in solid tumors.
M. Fakih, L. Pendyala, Patrick F. Smith, P. Creaven +6 more
2006Clinical Cancer Research35 citations Open access
Semantic Scholar
Effect of glutathione depletion on the cytotoxicity of cisplatin and iproplatin in a human melanoma cell line
L. Pendyala, R. P. Perez, A. Weinstein, Joseph Zdanowicz +1 more
1997Cancer Chemotherapy and Pharmacology34 citations
Semantic Scholar
A Phase I study of weekly intravenous oxaliplatin in combination with oral daily capecitabine and radiation therapy in the neoadjuvant treatment of rectal adenocarcinoma.
M. Fakih, A. Rajput, Gary Y. Yang, L. Pendyala +4 more
2006International Journal of Radiation Oncology, Biology, Physics32 citations
Semantic Scholar
In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells
H. Minderman, J. Conroy, K. O'Loughlin, D. McQuaid +5 more
2005Molecular Cancer Therapeutics32 citations
Semantic Scholar
Intravenous ifosfamide/mesna is associated with depletion of plasma thiols without depletion of leukocyte glutathione.
L. Pendyala, P. Creaven, Gary Schwartz, Neal J. Meropol +4 more
2000Clinical Cancer Research31 citations
Semantic Scholar
Phase I/pharmacodynamic study of N-acetylcysteine/oltipraz in smokers: early termination due to excessive toxicity.
L. Pendyala, Gary G. Schwartz, Wanda Bolanowska-Higdon, Sandra Hitt +4 more
2001Cancer Epidemiology, Biomarkers and Prevention29 citations
Semantic Scholar
Phase I evaluation of carboplatin by use of a dosing strategy based on a targeted area under the platinum concentration-versus-time curve and individual glomerular filtration rate in cats with tumors.
D. Bailey, K. Rassnick, N. Dykes, L. Pendyala
2009American Journal of Veterinary Research28 citations Open access
Semantic Scholar
Platinum drug effects on the expression of genes in the polyamine pathway: time-course and concentration-effect analysis based on Affymetrix gene expression profiling of A2780 ovarian carcinoma cells
Ram Varma, S. Hector, W. Greco, K. Clark +3 more
2007Cancer Chemotherapy and Pharmacology27 citations
Semantic Scholar
Pharmacokinetics and metabolism of nilutamide.
P. Creaven, L. Pendyala, D. Tremblay
1991Urology27 citations
Semantic Scholar
Expression of Na,K-ATPase-β1 subunit increases uptake and sensitizes carcinoma cells to oxaliplatin
R. Tummala, Daniel Wolle, S. Barwe, Valerie B. Sampson +2 more
2009Cancer Chemotherapy and Pharmacology26 citations Open access
Semantic Scholar
Polyamine catabolism in colorectal cancer cells following treatment with oxaliplatin, 5-fluorouracil and N1, N11 diethylnorspermine
S. Hector, R. Tummala, N. Kisiel, P. Diegelman +6 more
2008Cancer Chemotherapy and Pharmacology26 citations
Semantic Scholar
Intracellular glutathione and cytotoxicity of platinum complexes
L. Pendyala, P. Creaven, R. P. Perez, Joseph Zdanowicz +1 more
2004Cancer Chemotherapy and Pharmacology26 citations
Semantic Scholar
Efficacy of increasing the therapeutic index of irinotecan, plasma and tissue selenium concentrations is methylselenocysteine dose dependent.
R. Azrak, Shou-Song Cao, L. Pendyala, F. Durrani +5 more
2007Biochemical Pharmacology25 citations Open access
Semantic Scholar
Urinary and erythrocyte polyamines during the evaluation of oral alpha-difluoromethylornithine in a phase I chemoprevention clinical trial.
L. Pendyala, P. Creaven, C. Porter
1993Cancer Epidemiology, Biomarkers and Prevention23 citations
Semantic Scholar
Modulation of plasma thiols and mixed disulfides by BNP7787 in patients receiving paclitaxel/cisplatin therapy
L. Pendyala, G. Schwartz, Patrick F. Smith, Joseph Zdanowicz +2 more
2003Cancer Chemotherapy and Pharmacology22 citations
Semantic Scholar
Studies on the pharmacokinetics and metabolism of cis-dichloro-trans-dihydroxy-bis-isopropylamine platinum(IV) in the dog.
L. Pendyala, J. Cowens, P. Creaven
1982Cancer treatment reports22 citations
Semantic Scholar
Cryptosporidium parvum Induces an Endoplasmic Stress Response in the Intestinal Adenocarcinoma HCT-8 Cell Line*
Mary Morada, L. Pendyala, Gang Wu, S. Merali +1 more
2013Journal of Biological Chemistry19 citations Open access
Semantic Scholar
Combination effects of platinum drugs and N1, N11 diethylnorspermine on spermidine/spermine N1-acetyltransferase, polyamines and growth inhibition in A2780 human ovarian carcinoma cells and their oxaliplatin and cisplatin-resistant variants
R. Tummala, P. Diegelman, S. Hector, D. Kramer +5 more
2010Cancer Chemotherapy and Pharmacology18 citations Open access
Semantic Scholar
Thoracoscopic organ suffusion for regional lung chemotherapy (preliminary results).
T. Demmy, G. Tomaszewski, G. Dy, S. Yendamuri +4 more
2009Annals of Thoracic Surgery18 citations
Semantic Scholar
DNA binding of iproplatin and its divalent metabolitecis-dichloro-bis-isopropylamine platinum(II)
L. Pendyala, A. V. Arakali, P. Sansone, J. Cowens +1 more
2004Cancer Chemotherapy and Pharmacology18 citations
Semantic Scholar
Phase I and pharmacokinetic study of etoposide phosphate by protracted venous infusion in patients with advanced cancer.
N. Soni, Neal J. Meropol, L. Pendyala, D. Noel +3 more
1997Journal of Clinical Oncology18 citations
Semantic Scholar
Title: Disregulation of Purine Nucleotide Biosynthesis Pathways Modulates Cisplatin Cytotoxicity in Saccharomyces cerevisiae
D. Kowalski, L. Pendyala, B. Daignan-Fornier, S. Howell +2 more
200817 citations
Semantic Scholar
Capecitabine, Oxaliplatin and Radiotherapy: A Phase IB Neoadjuvant Study for Esophageal Cancer with Gene Expression Analysis
M. Javle, Gary Y. Yang, C. Nwogu, G. Wilding +9 more
2009Cancer Investigation15 citations
Semantic Scholar
Irinotecan pharmacokinetic and pharmacogenomic alterations induced by methylselenocysteine in human head and neck xenograft tumors
R. Azrak, Jin-Sheng Yu, L. Pendyala, Patrick F. Smith +6 more
2005Molecular Cancer Therapeutics15 citations Open access
Semantic Scholar
Pharmacokinetics of cis-dichloro-trans-dihydroxy-bis-isopropylamine platinum IV (CHIP) in patients with advanced cancer
L. Pendyala, W. Greco, J. Cowens, S. Madajewicz +1 more
2004Cancer Chemotherapy and Pharmacology15 citations
Semantic Scholar
Pharmacokinetics and Pharmacodynamics of Mesna‐Mediated Plasma Cysteine Depletion
Patrick F. Smith, B. M. Booker, P. Creaven, R. Perez +1 more
2003Journal of clinical pharmacology14 citations
Semantic Scholar
Initial clinical trial and pharmacokinetics of ThymitaqTM (AG337) by 10-day continuous infusion in patients with advanced solid tumors
P. Creaven, L. Pendyala, N. Meropol, N. Clendeninn +5 more
1997Cancer Chemotherapy and Pharmacology14 citations
Semantic Scholar
Developmental-stage-dependent adenine transport in Neurospora crassa
L. Pendyala, A. Wellman
1977Journal of Bacteriology14 citations Open access
Semantic Scholar
Simultaneous modeling of concentration-effect and time-course patterns in gene expression data from microarrays.
Yseult F. Brun, Ram Varma, S. Hector, L. Pendyala +2 more
2008Cancer Genomics & Proteomics13 citations
Semantic Scholar

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P. Creaven×22
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P. Creaven — researcher profile on SciRah
Y. Rustum×10
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Patrick F. Smith×9
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S. Hector×8
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S. Hector — researcher profile on SciRah

Joseph Zdanowicz

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K. Clark — researcher profile on SciRah

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M. Fakih — researcher profile on SciRah

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C. Porter — researcher profile on SciRah

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W. Greco — researcher profile on SciRah

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R. Azrak — researcher profile on SciRah

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