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D. Orlicky · SciRah

Researcher profile · Semantic Scholar

D. Orlicky

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D. Orlicky — researcher profile on SciRah

h-index: 51
Works: 239
Citations: 8,498

Most-cited papers

High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism
M. Lanaspa, M. Kuwabara, Ana Andrés-Hernando, Nan-Xing Li +9 more
2018Proceedings of the National Academy of Sciences of the United States of America249 citations Open access
Semantic Scholar
1,4-Dioxane as an emerging water contaminant: State of the science and evaluation of research needs.
Krystal J. Godri Pollitt, Jae-Hong Kim, J. Peccia, M. Elimelech +15 more
2019Science of the Total Environment119 citations
Semantic Scholar
Deletion of fructokinase in the liver or in the intestine reveals differential effects on sugar-induced metabolic dysfunction
Ana Andrés-Hernando, D. Orlicky, M. Kuwabara, T. Ishimoto +3 more
2020Cell Metabolism109 citations Open access
Semantic Scholar
Dietary Lipids Differentially Shape Nonalcoholic Steatohepatitis Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages
B. McGettigan, Rachel H. McMahan, D. Orlicky, M. Burchill +6 more
2019Hepatology103 citations Open access
Semantic Scholar
TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy
Michael McLoughlin, D. Orlicky, J. R. Prigge, P. Krishna +15 more
2019Proceedings of the National Academy of Sciences of the United States of America93 citations Open access
Semantic Scholar
Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation
Ana Andrés-Hernando, Christina Cicerchi, M. Kuwabara, D. Orlicky +4 more
2021Nature Metabolism83 citations Open access
Semantic Scholar
Perilipin‐2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra‐hepatocyte actions
D. Orlicky, Andrew E. Libby, E. Bales, Rachel H. McMahan +3 more
2019Journal of Physiology79 citations Open access
Semantic Scholar
Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model
Katherine A. Waugh, Ross Minter, Jessica Baxter, Congwu Chi +28 more
2023Nature Genetics72 citations Open access
Semantic Scholar
The role of FXR and TGR5 in reversing and preventing progression of Western diet–induced hepatic steatosis, inflammation, and fibrosis in mice
Xiao-Xin X. Wang, Cen Xie, Andrew E. Libby, S. Ranjit +21 more
2022Journal of Biological Chemistry62 citations Open access
Semantic Scholar
Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet–fed mice
Shogo Takahashi, Yuhuan Luo, S. Ranjit, Cen Xie +16 more
2020Journal of Biological Chemistry57 citations Open access
Semantic Scholar
Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor
Ana Andrés-Hernando, T. Jensen, M. Kuwabara, D. Orlicky +12 more
2020JCI Insight48 citations Open access
Semantic Scholar
Oxidized Low-Density Lipoprotein Drives Dysfunction of the Liver Lymphatic System
M. Burchill, J. Finlon, A. Goldberg, Austin E. Gillen +13 more
2020Cellular and Molecular Gastroenterology and Hepatology45 citations Open access
Semantic Scholar
JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome
Kathryn D. Tuttle, Katherine A. Waugh, Paula Araya, Ross Minter +12 more
2020Cell Reports42 citations Open access
Semantic Scholar
Obesity Causes Renal Mitochondrial Dysfunction and Energy Imbalance and Accelerates Chronic Kidney Disease in Mice.
Ana Andrés-Hernando, M. Lanaspa, M. Kuwabara, D. Orlicky +6 more
2019AJP - Renal Physiology41 citations Open access
Semantic Scholar
Inhaled Silica Nanoparticles Causes Chronic Kidney Disease in Rats.
Fumihiko Sasai, Keegan L. Rogers, D. Orlicky, Arthur D. Stem +17 more
2022AJP - Renal Physiology39 citations Open access
Semantic Scholar
Bile Acids Modulate Colonic MAdCAM-1 Expression in a Murine Model of Combined Cholestasis and Colitis
Rachel Y. Gao, C. Shearn, D. Orlicky, Kayla D. Battista +7 more
2020Mucosal Immunology30 citations Open access
Semantic Scholar
Altered cell-cycle control, inflammation and adhesion in high-risk persistent bronchial dysplasia
D. Merrick, M. Edwards, W. Franklin, M. Sugita +23 more
2018Cancer Research28 citations Open access
Semantic Scholar
Oxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues
Brian Thompson, E. Davidson, Ying Chen, D. Orlicky +2 more
2021bioRxiv26 citations Open access
Semantic Scholar
Oxidative Stress and Genotoxicity in 1,4-Dioxane Liver Toxicity as Evidenced in a Mouse Model of Glutathione Deficiency
Ying Chen, Ye-Wei Wang, G. Charkoftaki, D. Orlicky +5 more
2021Science of the Total Environment25 citations Open access
Semantic Scholar
Dietary fat promotes antibiotic-induced Clostridioides difficile mortality in mice
K. Hazleton, C. Martin, D. Orlicky, Kathleen L. Arnolds +5 more
2019npj Biofilms and Microbiomes24 citations Open access
Semantic Scholar
Lenvatinib Plus Anti-PD-1 Combination Therapy for Advanced Cancers: Defining Mechanisms of Resistance in an Inducible Transgenic Model of Thyroid Cancer
Bruna C. Bertol, E. Bales, Jacob Calhoun, Alan K. Mayberry +6 more
2021Thyroid23 citations Open access
Semantic Scholar
Lipidomics and Redox Lipidomics Indicate Early Stage Alcohol‐Induced Liver Damage
J. Koelmel, W. Y. Tan, Yang Li, John A. Bowden +21 more
2021Hepatology Communications21 citations Open access
Semantic Scholar
Sugar causes obesity and metabolic syndrome in mice independently of sweet taste.
Ana Andrés-Hernando, M. Kuwabara, D. Orlicky, A. Vandenbeuch +5 more
2020American Journal of Physiology. Endocrinology and Metabolism21 citations Open access
Semantic Scholar
Using the Novel Pelvic Organ Prolapse Histology Quantification System to Identify Phenotypes in Uterosacral Ligaments in Women with Pelvic Organ Prolapse.
D. Orlicky, M. Guess, E. Bales, L. Rascoff +4 more
2020American Journal of Obstetrics and Gynecology21 citations Open access
Semantic Scholar
Liver metabolomics identifies bile acid profile changes at early stages of alcoholic liver disease in mice
G. Charkoftaki, Wan-Ying Tan, Pablo Berríos-Cárcamo, D. Orlicky +6 more
2022Chemico-Biological Interactions20 citations Open access
Semantic Scholar
Quantifying Competition Among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism
Hadi R Ali, Mohammed A. Assiri, Peter S. Harris, Cole R. Michel +10 more
2019Journal of Proteome Research20 citations Open access
Semantic Scholar
Phosphate depletion in insulin-insensitive skeletal muscle drives AMPD activation and sarcopenia in chronic kidney disease
Ana Andrés-Hernando, Christina Cicerchi, G. Garcia, D. Orlicky +3 more
2023iScience19 citations Open access
Semantic Scholar
High Fructose Corn Syrup Accelerates Kidney Disease and Mortality in Obese Mice with Metabolic Syndrome
Ana Andrés-Hernando, D. Orlicky, Christina Cicerchi, M. Kuwabara +5 more
2023Biomolecules19 citations Open access
Semantic Scholar
AMPK activation in pregnant human myometrial arteries from high-altitude and intrauterine growth-restricted pregnancies.
R. Lorca, Christopher J. Matarazzo, E. Bales, J. Houck +4 more
2020American Journal of Physiology. Heart and Circulatory Physiology19 citations Open access
Semantic Scholar
Cholestatic liver disease results increased production of reactive aldehydes and an atypical periportal hepatic antioxidant response.
C. Shearn, B. Fennimore, D. Orlicky, Yue Gao +10 more
2019Free Radical Biology & Medicine19 citations Open access
Semantic Scholar
Proteomic Analysis of Alcohol-associated Hepatitis Reveals Glycoprotein NMB (GPNMB) as a Novel Hepatic and Serum Biomarker
Peter S. Harris, Cole R. Michel, Youngho Yun, Courtney D. McGinnis +8 more
2021Alcohol18 citations Open access
Semantic Scholar
A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age
Rachel H. McMahan, K. Najarro, Juliet E. Mullen, Madison T. Paul +3 more
2021Immunity & Ageing16 citations Open access
Semantic Scholar
Perilipin-2 promotes lipid droplet-plasma membrane interactions that facilitate apocrine lipid secretion in secretory epithelial cells of the mouse mammary gland
J. Monks, D. Orlicky, Andrew E. Libby, M. Dzieciatkowska +2 more
2022Frontiers in Cell and Developmental Biology15 citations Open access
Semantic Scholar
Disruption of monocyte-macrophage differentiation and trafficking by a heme analog during active inflammation
Rachel E. M. Schaefer, R. Callahan, Shaikh M. Atif, D. Orlicky +4 more
2021Mucosal Immunology15 citations Open access
Semantic Scholar
Disruption in glutathione metabolism and altered energy production in the liver and kidney after ischemic acute kidney injury in mice
Peter R Baker, Amy S. Li, Benjamin R. Griffin, H. Gil +15 more
2024Scientific Reports14 citations Open access
Semantic Scholar
Electron Tomography Revels that Milk Lipids Originate from Endoplasmic Reticulum Domains with Novel Structural Features
M. Ladinsky, G. Mardones, D. Orlicky, K. Howell +1 more
2019Journal of mammary gland biology and neoplasia14 citations Open access
Semantic Scholar
SNARE proteins rescue impaired autophagic flux in Down syndrome
S. Aivazidis, Abhilasha Jain, Abhishek K. Rauniyar, C. Anderson +7 more
2019PLoS ONE14 citations Open access
Semantic Scholar
SODB1 is essential for Leishmania major infection of macrophages and pathogenesis in mice
Bennett J Davenport, C. Martin, S. Beverley, D. Orlicky +2 more
2018PLoS Neglected Tropical Diseases14 citations Open access
Semantic Scholar
Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury
C. Shearn, Aimee L. Anderson, C. Miller, Reed C. Noyd +5 more
2023Hepatology Communications13 citations Open access
Semantic Scholar
The developing murine lung is susceptible to acetaminophen toxicity.
Evgenia Dobrinskikh, Laurie G Sherlock, D. Orlicky, Li-Jun Zheng +5 more
2021American Journal of Physiology - Lung cellular and Molecular Physiology13 citations Open access
Semantic Scholar
Impaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 function
Brian Thompson, Ying Chen, E. Davidson, R. Garcia-Milian +6 more
2021The ocular surface13 citations Open access
Semantic Scholar
Toxic Acetaminophen Exposure Induces Distal Lung ER Stress, Proinflammatory Signaling, and Emphysematous Changes in the Adult Murine Lung
J. Sandoval, D. Orlicky, A. Allawzi, B. Butler +8 more
2019Oxidative Medicine and Cellular Longevity13 citations Open access
Semantic Scholar
Profiling the Oxylipidome in Aged Mice after Chronic Ethanol Feeding: Identifying Lipid Metabolites as Drivers of Hepatocyte Stress
Paige Anton, L. Rutt, Courtney Capper, D. Orlicky +1 more
2022Alcohol12 citations Open access
Semantic Scholar
Ethanol Intoxication Impairs Respiratory Function and Bacterial Clearance and Is Associated With Neutrophil Accumulation in the Lung After Streptococcus pneumoniae Infection
Holly J. Hulsebus, K. Najarro, Rachel H. McMahan, D. Boe +2 more
2022Frontiers in Immunology12 citations Open access
Semantic Scholar
Identification of dose-dependent DNA damage and repair responses from subchronic exposure to 1,4-dioxane in mice using a systems analysis approach.
G. Charkoftaki, Jaya Prakash Golla, Á. Santos-Neto, D. Orlicky +11 more
2021Toxicological Sciences12 citations Open access
Semantic Scholar
Loss of prdm1a accelerates melanoma onset and progression
R. Iwanaga, Brittany T. Truong, Jessica Y. Hsu, K. Lambert +6 more
2019bioRxiv12 citations Open access
Semantic Scholar
Endogenous Fructose Production and Metabolism Drive Metabolic Dysregulation and Liver Disease in Mice with Hereditary Fructose Intolerance
Ana Andrés-Hernando, D. Orlicky, M. Kuwabara, Christina Cicerchi +5 more
2023Nutrients11 citations Open access
Semantic Scholar
Age-Related Intestinal Dysbiosis and Enrichment of Gut-specific Bacteria in the Lung Are Associated With Increased Susceptibility to Streptococcus pneumoniae Infection in Mice
Rachel H. McMahan, Holly J. Hulsebus, K. Najarro, L. Giesy +3 more
2022Frontiers in Aging11 citations Open access
Semantic Scholar
Up‐regulation of miR‐let7a‐5p Leads to Decreased Expression of ABCC2 in Obstructive Cholestasis
N. Balasubramaniyan, M. Devereaux, D. Orlicky, R. Sokol +1 more
2019Hepatology Communications11 citations Open access
Semantic Scholar
Interplay between APC and ALDH1B1 in a newly developed mouse model of colorectal cancer
Jaya Prakash Golla, Aikaterini Kandyliari, Tan-Wan Ying, Ying Chen +4 more
2020Chemico-Biological Interactions10 citations Open access
Semantic Scholar

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M. Lanaspa×9
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M. Lanaspa — researcher profile on SciRah
Ana Andrés-Hernando×9
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Ana Andrés-Hernando — researcher profile on SciRah
M. Kuwabara×8
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M. Kuwabara — researcher profile on SciRah
Christina Cicerchi×8
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Christina Cicerchi — researcher profile on SciRah

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V. Vasiliou — researcher profile on SciRah

Richard J. Johnson×6

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Rachel H. McMahan×6

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Rachel H. McMahan — researcher profile on SciRah

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C. Shearn — researcher profile on SciRah

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Ying Chen — researcher profile on SciRah

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G. Charkoftaki — researcher profile on SciRah

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E. Bales — researcher profile on SciRah