Researcher profile · Semantic Scholar

T. Garner

h-index: 22
Works: 39
Citations: 1,892

Most-cited papers

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives
Jaime Anguiano, T. Garner, M. Mahalingam, B. Das +2 more
2013Nature Chemical Biology207 citations Open access
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Direct activation of BAX by BTSA1 overcomes apoptosis resistance in acute myeloid leukemia
D. Reyna, T. Garner, Andrea López, F. Kopp +10 more
2017Cancer Cell153 citations Open access
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Inhibition of Pro-Apoptotic BAX by a Noncanonical Interaction Mechanism
L. Barclay, T. Wales, T. Garner, F. Wachter +8 more
2015Molecules and Cells130 citations Open access
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Modulating mitofusins to control mitochondrial function and signaling
Emmanouil Zacharioudakis, B. Agianian, Vasantha Kumar M.V., N. Biris +17 more
2022Nature Communications117 citations Open access
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Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling.
J. Long, T. Garner, M. Pandya, C. Craven +5 more
2010Journal of Molecular Biology117 citations
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A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy
Dulguun Amgalan, T. Garner, Ryan Pekson, Xiaotong Jia +24 more
2020Nature Cancer115 citations Open access
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Small Molecule Allosteric Inhibitors of BAX
T. Garner, Dulguun Amgalan, D. Reyna, Sheng Li +2 more
2019Nature Chemical Biology101 citations Open access
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Progress in targeting the BCL-2 family of proteins
T. Garner, Andrea López, D. Reyna, A. Spitz +1 more
2017Current Opinion in Chemical Biology100 citations Open access
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An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway
T. Garner, D. Reyna, A. Priyadarshi, Hui-Chen Chen +7 more
2016Molecules and Cells93 citations Open access
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Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase
H. Takeuchi, Rodrigo Fernandez‐Valdivia, Devin S Caswell, Aleksandra Nita-lazar +6 more
2011Proceedings of the National Academy of Sciences of the United States of America77 citations Open access
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Repression of translation of human estrogen receptor alpha by G-quadruplex formation.
Graham D. Balkwill, K. Derecka, T. Garner, C. Hodgman +2 more
2009Biochemistry76 citations
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Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes.
Jörg Linder, T. Garner, Huw E. L. Williams, M. Searle +1 more
2011Journal of the American Chemical Society75 citations
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Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures.
T. Garner, Huw E. L. Williams, Katarzyna I Gluszyk, S. Roe +4 more
2009Organic and biomolecular chemistry70 citations
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Characterization of a Non‐UBA Domain Missense Mutation of Sequestosome 1 (SQSTM1) in Paget's Disease of Bone
D. Najat, T. Garner, T. Hagen, B. Shaw +8 more
2009Journal of Bone and Mineral Research62 citations
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Eltrombopag directly inhibits BAX and prevents cell death
A. Spitz, Emmanouil Zacharioudakis, D. Reyna, T. Garner +1 more
2021Nature Communications57 citations Open access
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Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration
Raquel Gómez-Sintes, Qisheng Xin, J. I. Jiménez-Loygorri, Mericka McCabe +12 more
2022Nature Communications49 citations Open access
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Insights into the molecular composition of endogenous unanchored polyubiquitin chains.
J. Strachan, Lucy V. Roach, Kleitos Sokratous, D. Tooth +5 more
2012Journal of Proteome Research37 citations
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Impact of p62/SQSTM1 UBA domain mutations linked to Paget's disease of bone on ubiquitin recognition.
T. Garner, J. Long, R. Layfield, M. Searle
2011Biochemistry35 citations
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Independent interactions of ubiquitin-binding domains in a ubiquitin-mediated ternary complex.
T. Garner, J. Strachan, Elizabeth C Shedden, J. Long +4 more
2011Biochemistry31 citations
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On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts
S. Iachettini, M. F. Stevens, M. Frigerio, M. Hummersone +16 more
2013Journal of experimental & clinical cancer research : CR29 citations Open access
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Design, Synthesis and Evaluation of Marinopyrrole Derivatives as Selective Inhibitors of Mcl-1 Binding to Pro-apoptotic Bim and Dual Mcl-1/Bcl-xL Inhibitors
Rong-Shi Li, Chunwei Cheng, M. Balasis, Yan Liu +6 more
2014European journal of medicinal chemistry24 citations Open access
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Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1).
K. Derecka, Graham D. Balkwill, T. Garner, C. Hodgman +2 more
2010Biochemistry22 citations
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Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains.
M. Searle, T. Garner, J. Strachan, J. Long +4 more
2012Biochemical Society Transactions19 citations
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Folding topology of a bimolecular DNA quadruplex containing a stable mini-hairpin motif within the diagonal loop.
Graham D. Balkwill, T. Garner, Huw E. L. Williams, M. Searle
2008Journal of Molecular Biology19 citations
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Mutant p62/SQSTM1 UBA domains linked to Paget's disease of bone differ in their abilities to function as stabilization signals
C. Heinen, T. Garner, J. Long, C. Böttcher +5 more
2010FEBS Letters16 citations
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An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.
T. Garner, D. Reyna, A. Priyadarshi, Hui-Chen Chen +6 more
2016Molecules and Cells15 citations Open access
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Mass spectrometry insights into a tandem ubiquitin‐binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin
D. Scott, T. Garner, J. Long, J. Strachan +6 more
2016Proteomics12 citations Open access
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A Kazal-Type Serine Protease Inhibitor from the Defense Gland Secretion of the Subterranean Termite Coptotermes formosanus Shiraki
H. Negulescu, You-Zhong Guo, T. Garner, O. Goodwin +3 more
2015PLoS ONE11 citations Open access
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Marinopyrrole Derivatives with Sulfide Spacers as Selective Disruptors of Mcl-1 Binding to Pro-Apoptotic Protein Bim
Chunwei Cheng, Yan Liu, M. Balasis, T. Garner +10 more
2014Marine Drugs10 citations Open access
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Folding of single-stranded DNA quadruplexes containing an autonomously stable mini-hairpin loop.
Graham D. Balkwill, T. Garner, M. Searle
2009Molecular Biosystems7 citations
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Direct Small Molecule Activation of Mitofusins
Emmanouil Zacharioudakis, N. Biris, T. Garner, Yun Chen +6 more
2018bioRxiv5 citations Open access
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BCL-2 Protein Family Interaction Analysis by Nuclear Magnetic Resonance Spectroscopy
T. Garner, E. Gavathiotis
2018Methods in molecular biology2 citations Open access
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On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts
S. Iachettini, M. F. Stevens, M. Frigerio, M. Hummersone +16 more
2013Journal of experimental & clinical cancer research : CR2 citations Open access
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Abstract 951: Direct small-molecule BAX activation in acute myeloid leukemia
D. Reyna, T. Garner, Andrea López, F. Kopp +10 more
2018Experimental and Molecular Therapeutics0 citations
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NMR structure of a Kazal-type serine protease inhibitor from the subterranean termite defense gland of Coptotermes Formosanus Shiraki soldiers
H. Negulescu, Y. Guo, T. Garner, O. Goodwin +3 more
20130 citations
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A CHARACTERIZATION OF GOLD NANOPARTICLE UPTAKE BY MAMMALIAN CELLS
T. Garner
20130 citations
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Structural and biophysical investigations into ubiquitin binding proteins
T. Garner
20110 citations
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Solution structure of the non-covalent complex of the ZNF216 A20 domain with ubiquitin
T. Garner, J. Long, M. Searle, R. Layfield
20110 citations
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Solution NMR structure of the ZNF216 A20 zinc finger
T. Garner, J. Long, M. Searle, R. Layfield
20110 citations
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D. Reyna

×7

Andrea López×4

R. Kitsis×4

B. Shaw×4

Graham D. Balkwill×4

J. Cavey×4

J. Strachan×4

Swathi-Rao Narayanagari×3