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T. Hagen · SciRah

Researcher profile · Semantic Scholar

T. Hagen

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T. Hagen — researcher profile on SciRah

h-index: 30
Works: 75
Citations: 4,935

Most-cited papers

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.
Chen-Yu Zhang, G. Baffy, P. Perret, S. Krauss +11 more
2001Cell965 citations Open access
Semantic Scholar
Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α
T. Hagen, C. Taylor, Francis Lam, S. Moncada
2003Science749 citations
Semantic Scholar
Energy Metabolism in Uncoupling Protein 3 Gene Knockout Mice*
A. Vidal-Puig, D. Grujic, Chen-Yu Zhang, T. Hagen +8 more
2000Journal of Biological Chemistry722 citations Open access
Semantic Scholar
Stabilization of Hypoxia-inducible Factor-1α Protein in Hypoxia Occurs Independently of Mitochondrial Reactive Oxygen Species Production*
Liu-Chua Yee, E. Dufour, E. Dassa, P. Rustin +3 more
2010Journal of Biological Chemistry183 citations Open access
Semantic Scholar
Utilizing hydrogen sulfide as a novel anti‐cancer agent by targeting cancer glycolysis and pH imbalance
Z. Lee, Xin-Yi Teo, E. Y. Tay, Choon-Hong Tan +3 more
2014British Journal of Pharmacology143 citations Open access
Semantic Scholar
Inhibition of cellular respiration by endogenously produced carbon monoxide
G. D'Amico, Francis Lam, T. Hagen, S. Moncada
2006Journal of Cell Science132 citations Open access
Semantic Scholar
Characterisation of the phosphorylation of beta-catenin at the GSK-3 priming site Ser45.
T. Hagen, A. Vidal-Puig
2002Biochemical and Biophysical Research Communications - BBRC114 citations
Semantic Scholar
Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system
Chen-Yu Zhang, T. Hagen, V. Mootha, L. Slieker +1 more
1999FEBS Letters112 citations Open access
Semantic Scholar
Expression and Characterization of GSK-3 Mutants and Their Effect on β-Catenin Phosphorylation in Intact Cells*
T. Hagen, E. Di Daniel, A. Culbert, A. Reith
2002Journal of Biological Chemistry104 citations Open access
Semantic Scholar
Oncogenic activation of the PI3K/Akt pathway promotes cellular glucose uptake by downregulating the expression of thioredoxin-interacting protein.
Shin-Yee Hong, Fa‐Xing Yu, Yan Luo, T. Hagen
2016Cellular Signalling103 citations
Semantic Scholar
Oxygen versus Reactive Oxygen in the Regulation of HIF-1α: The Balance Tips
T. Hagen
2012Biochemistry Research International102 citations Open access
Semantic Scholar
Substrate-mediated Regulation of Cullin Neddylation*
Eng-Hui Chew, T. Hagen
2007Journal of Biological Chemistry93 citations Open access
Semantic Scholar
GSK‐3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and β‐catenin stabilisation without elevation of glycogen synthase activity
A. Culbert, Murray J. B. Brown, S. Frame, T. Hagen +3 more
2001FEBS Letters92 citations Open access
Semantic Scholar
Hydrogen sulfide donors in research and drug development
Z. Song, M. Ng, Z. Lee, Weilu Dai +5 more
201491 citations
Semantic Scholar
Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol.
T. Hagen, G. D'Amico, M. Quintero, M. Palacios-Callender +3 more
2004Biochemical and Biophysical Research Communications - BBRC72 citations
Semantic Scholar
Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells--evidence for cullin dimerization.
Eng-Hui Chew, Thurka Poobalasingam, C. Hawkey, T. Hagen
2007Cellular Signalling68 citations
Semantic Scholar
Characterization of a Non‐UBA Domain Missense Mutation of Sequestosome 1 (SQSTM1) in Paget's Disease of Bone
D. Najat, T. Garner, T. Hagen, B. Shaw +8 more
2009Journal of Bone and Mineral Research62 citations
Semantic Scholar
Neddylation-induced conformational control regulates cullin RING ligase activity in vivo.
B. K. Boh, Peter G. Smith, T. Hagen
2011Journal of Molecular Biology54 citations
Semantic Scholar
Inhibition of Hypoxia-Inducible Factor-1α (HIF-1α) Protein Synthesis by DNA Damage Inducing Agents
Jessica Jie Wei Lou, Liu-Chua Yee, Eng-Hui Chew, Jie Gao +2 more
2010PLoS ONE54 citations Open access
Semantic Scholar
Increased Concentrations of Fructose 2,6-Bisphosphate Contribute to the Warburg Effect in Phosphatase and Tensin Homolog (PTEN)-deficient Cells*
L. Cordero-Espinoza, T. Hagen
2013Journal of Biological Chemistry51 citations Open access
Semantic Scholar
A potential mechanism of metformin-mediated regulation of glucose homeostasis: inhibition of Thioredoxin-interacting protein (Txnip) gene expression.
Tin-Fan Chai, Shin-Yee Hong, Hongpeng He, Li-Ling Zheng +3 more
2012Cellular Signalling48 citations
Semantic Scholar
Thioredoxin-interacting Protein (Txnip) Gene Expression
Fa‐Xing Yu, Tin-Fan Chai, Hongpeng He, T. Hagen +1 more
2010Journal of Biological Chemistry48 citations Open access
Semantic Scholar
Structure Activity Analysis of 2-Methoxyestradiol Analogues Reveals Targeting of Microtubules as the Major Mechanism of Antiproliferative and Proapoptotic Activity
Shin-Chua Yee, Liu-Chua Yee, T. Hagen
2010Molecular Cancer Therapeutics46 citations Open access
Semantic Scholar
Thioredoxin-dependent regulation of AIF-mediated DNA damage.
S. B. Shelar, Kamila K. Kaminska, Shridhivya A. Reddy, Dilip Kumar +6 more
2015Free Radical Biology & Medicine45 citations
Semantic Scholar
Signalling activity of beta-catenin targeted to different subcellular compartments.
T. Hagen, Jaswinder K. Sethi, N. Foxwell, A. Vidal-Puig
2004Biochemical Journal40 citations Open access
Semantic Scholar
mTORC1 Dependent Regulation of REDD1 Protein Stability
Chia-Yee Tan, T. Hagen
2013PLoS ONE35 citations Open access
Semantic Scholar
Regulation of Cullin RING E3 Ubiquitin Ligases by CAND1 In Vivo
Shin-Chua Yee, B. K. Boh, Wanpen Ponyeam, T. Hagen
2011PLoS ONE32 citations Open access
Semantic Scholar
Mechanism of Cullin3 E3 Ubiquitin Ligase Dimerization
Y. Y. Choo, T. Hagen
2012PLoS ONE31 citations Open access
Semantic Scholar
Permeability transition in rat liver mitochondria is modulated by the ATP-Mg/Pi carrier.
T. Hagen, C. Lagace, J. Modica-Napolitano, J. Aprille
2003American Journal of Physiology - Gastrointestinal and Liver Physiology31 citations
Semantic Scholar
The Role of Mitochondrial Non-Enzymatic Protein Acylation in Ageing
Shin-Yee Hong, L. Ng, L. Ng, Takao Inoue +3 more
2016PLoS ONE30 citations Open access
Semantic Scholar
Regulation of the NRF2 transcription factor by andrographolide and organic extracts from plant endophytes
D. P. W. Wong, M. Ng, Jia-Yu Leung, B. K. Boh +8 more
2018PLoS ONE28 citations Open access
Semantic Scholar
2-Deoxyglucose induces the expression of thioredoxin interacting protein (TXNIP) by increasing O-GlcNAcylation - Implications for targeting the Warburg effect in cancer cells.
Shin-Yee Hong, T. Hagen
2015Biochemical and Biophysical Research Communications - BBRC28 citations
Semantic Scholar
Structure-activity analysis of 2'-modified cinnamaldehyde analogues as potential anticancer agents.
Fei-Fei Gan, Shin-Chua Yee, S. Scarmagnani, P. Palaniappan +5 more
2009Biochemical and Biophysical Research Communications - BBRC28 citations
Semantic Scholar
Multiple myeloma Leu167Ile (c.499C>A) mutation prevents XBP1 mRNA splicing
Shin-Yee Hong, T. Hagen
2013British Journal of Haematology27 citations
Semantic Scholar
Mechanistic target of rapamycin (mTOR) dependent regulation of thioredoxin interacting protein (TXNIP) transcription in hypoxia.
R. Wong, T. Hagen
2013Biochemical and Biophysical Research Communications - BBRC25 citations
Semantic Scholar
Characterization of the Cullin7 E3 ubiquitin ligase--heterodimerization of cullin substrate receptors as a novel mechanism to regulate cullin E3 ligase activity.
Wanpen Ponyeam, T. Hagen
2012Cellular Signalling25 citations
Semantic Scholar
Biochemical and cellular effects of inhibiting Nedd8 conjugation.
Yee Chin Leck, Y. Y. Choo, Chia-Yee Tan, Peter G. Smith +1 more
2010Biochemical and Biophysical Research Communications - BBRC25 citations
Semantic Scholar
Intramitochondrial protein synthesis is regulated by matrix adenine nucleotide content and requires calcium.
J. Joyal, T. Hagen, June R. Aprille
1995Archives of Biochemistry and Biophysics25 citations
Semantic Scholar
Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity
Y. Y. Choo, B. K. Boh, Jessica Jie Wei Lou, Jolane Eng +4 more
2011Molecular Biology of the Cell23 citations Open access
Semantic Scholar
Inhibition of cullin RING ligases by cycle inhibiting factor: evidence for interference with Nedd8-induced conformational control.
B. K. Boh, M. Ng, Yee Chin Leck, B. Shaw +6 more
2011Journal of Molecular Biology22 citations
Semantic Scholar
Hypoxia‐inducible factor independent down‐regulation of thioredoxin‐interacting protein in hypoxia
Tin-Fan Chai, Yee Chin Leck, Hongpeng He, Fa‐Xing Yu +2 more
2011FEBS Letters20 citations Open access
Semantic Scholar
Investigating the Molecular Basis of Siah1 and Siah2 E3 Ubiquitin Ligase Substrate Specificity
A. Gopalsamy, T. Hagen, K. Swaminathan
2014PLoS ONE19 citations Open access
Semantic Scholar
Post-translational regulation of mTOR complex 1 in hypoxia and reoxygenation.
Chia-Yee Tan, T. Hagen
2013Cellular Signalling17 citations
Semantic Scholar
Antitumor quinols: role of glutathione in modulating quinol-induced apoptosis and identification of putative cellular protein targets.
Eng-Hui Chew, C. Matthews, Ji-Hong Zhang, A. McCarroll +4 more
2006Biochemical and Biophysical Research Communications - BBRC17 citations
Semantic Scholar
FRAT1, a Substrate-specific Regulator of Glycogen Synthase Kinase-3 Activity, Is a Cellular Substrate of Protein Kinase A*
T. Hagen, D. Cross, A. Culbert, A. West +3 more
2006Journal of Biological Chemistry17 citations Open access
Semantic Scholar
Net adenine nucleotide transport in rat kidney mitochondria.
T. Hagen, J. Joyal, W. Henke, J. Aprille
1993Archives of Biochemistry and Biophysics16 citations
Semantic Scholar
Dronedarone-Induced Cardiac Mitochondrial Dysfunction and Its Mitigation by Epoxyeicosatrienoic Acids
Aneesh V. Karkhanis, Jacqueline Wen Hui Leow, T. Hagen, E. C. Chan
2018Toxicological Sciences15 citations Open access
Semantic Scholar
Galactose 1‐phosphate accumulates to high levels in galactose‐treated cells due to low GALT activity and absence of product inhibition of GALK
Sher Li Oh, Yi-Cheng Li, Jie-Fu J. Zhou, W. Henke +1 more
2019Journal of Inherited Metabolic Disease13 citations
Semantic Scholar
p21-Activated kinase interacts with Wnt signaling to regulate tissue polarity and gene expression
Kah Yee Goh, Natalie Ng, T. Hagen, Takao Inoue
2012Proceedings of the National Academy of Sciences of the United States of America13 citations Open access
Semantic Scholar
Detection and identification of NAD-catabolizing activities in rat tissue homogenates.
T. Hagen, M. Ziegler
1997Biochimica et Biophysica Acta11 citations
Semantic Scholar

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Shin-Yee Hong×5
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Shin-Yee Hong — researcher profile on SciRah
Eng-Hui Chew×5
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Eng-Hui Chew — researcher profile on SciRah
B. K. Boh×5
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A. Vidal-Puig×4
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A. Vidal-Puig — researcher profile on SciRah

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Fa‐Xing Yu — researcher profile on SciRah

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Chen-Yu Zhang×3

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Francis Lam — researcher profile on SciRah

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Liu-Chua Yee×3

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A. Culbert — researcher profile on SciRah

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A. Reith — researcher profile on SciRah