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H. Puthalakath · SciRah

Researcher profile · Semantic Scholar

H. Puthalakath

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H. Puthalakath — researcher profile on SciRah

h-index: 36
Works: 82
Citations: 17K

Most-cited papers

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
L. Galluzzi, I. Vitale, S. Aaronson, J. Abrams +165 more
2018Cell Death and Differentiation6,079 citations Open access
Semantic Scholar
ER stress triggers apoptosis by activating BH3-only protein Bim.
H. Puthalakath, L. O'Reilly, Priscilla A. Gunn, L. Lee +10 more
2007Cell1,461 citations Open access
Semantic Scholar
The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex.
H. Puthalakath, David C. S. Huang, L. O'Reilly, S. King +1 more
1999Molecules and Cells1,132 citations Open access
Semantic Scholar
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
L. Galluzzi, J. M. Bravo-San Pedro, I. Vitale, S. Aaronson +104 more
2014Cell Death and Differentiation985 citations Open access
Semantic Scholar
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
P. Bouillet, Jared F. Purton, D. Godfrey, Li-Chen Zhang +6 more
2002Nature856 citations
Semantic Scholar
Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins
H. Puthalakath, A. Strasser
2002Cell Death and Differentiation776 citations
Semantic Scholar
Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis
H. Puthalakath, A. Villunger, L. O'Reilly, J. Beaumont +4 more
2001Science676 citations
Semantic Scholar
Programmed Cell Death
H. Puthalakath, C. Hawkins
2016Methods in Molecular Biology510 citations
Semantic Scholar
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
J. Kuroda, H. Puthalakath, M. Cragg, Priscilla N. Kelly +8 more
2006Proceedings of the National Academy of Sciences of the United States of America359 citations Open access
Semantic Scholar
Apoptotic cell death in disease—Current understanding of the NCCD 2023
I. Vitale, F. Pietrocola, E. Guilbaud, S. Aaronson +224 more
2023Cell Death and Differentiation346 citations Open access
Semantic Scholar
To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.
G. Dewson, T. Kratina, H-W. Sim, H. Puthalakath +3 more
2008Molecules and Cells343 citations Open access
Semantic Scholar
Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells
A. Enders, P. Bouillet, H. Puthalakath, Yuekang Xu +2 more
2003Journal of Experimental Medicine323 citations Open access
Semantic Scholar
Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
N. Huntington, H. Puthalakath, Priscilla A. Gunn, E. Naik +11 more
2007Nature Immunology286 citations Open access
Semantic Scholar
Sepsis: Inflammation Is a Necessary Evil
Christina Nedeva, Joseph Menassa, H. Puthalakath
2019Front. Cell Dev. Biol.274 citations Open access
Semantic Scholar
Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate
C. Navarro, H. Puthalakath, J. Adams, A. Strasser +1 more
2004Nature Cell Biology208 citations
Semantic Scholar
Bcl‐2 family proteins: The sentinels of the mitochondrial apoptosis pathway
W. Wong, H. Puthalakath
2008IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology188 citations Open access
Semantic Scholar
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation
Erinna F. Lee, P. Czabotar, M. V. van Delft, Ewa M. Michalak +7 more
2008Journal of Cell Biology168 citations Open access
Semantic Scholar
The Role of Bim, a Proapoptotic BH3‐Only Member of the Bcl‐2 Family, in Cell‐Death Control
A. Strasser, H. Puthalakath, P. Bouillet, David C. S. Huang +5 more
2000Annals of the New York Academy of Sciences158 citations
Semantic Scholar
Fatal Hepatitis Mediated by TNFα Requires Caspase-8 and Involves the BH3-only Proteins Bid and Bim
T. Kaufmann, P. Jost, M. Pellegrini, H. Puthalakath +10 more
2009Immunity139 citations Open access
Semantic Scholar
BH3‐only proteins: a 20‐year stock‐take
M. Doerflinger, Jason A. Glab, H. Puthalakath
2015The FEBS Journal97 citations
Semantic Scholar
MEK/ERK-Mediated Phosphorylation of Bim is Required to Ensure Survival of T and B Lymphocytes during Mitogenic Stimulation
L. O'Reilly, E. Kruse, H. Puthalakath, Priscilla N. Kelly +3 more
2009Journal of Immunology89 citations Open access
Semantic Scholar
CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers
N. Huntington, Yuekang Xu, H. Puthalakath, A. Light +3 more
2006Nature Immunology83 citations
Semantic Scholar
Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-XL upon IgE-receptor activation
J. Alfredsson, H. Puthalakath, H. Martin, A. Strasser +1 more
2005Cell Death and Differentiation82 citations
Semantic Scholar
DR5 and caspase-8 are dispensable in ER stress-induced apoptosis
Jason Glab, Marcel Doerflinger, Christina Nedeva, Irvin Jose +9 more
2017Cell Death and Differentiation81 citations Open access
Semantic Scholar
Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands.
C. Day, H. Puthalakath, Gretchen L Skea, A. Strasser +4 more
2004Biochemical Journal77 citations Open access
Semantic Scholar
What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain
A. Strasser, H. Puthalakath, L. O'Reilly, P. Bouillet
2008Immunology and Cell Biology75 citations
Semantic Scholar
ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly
Rochelle Tixeira, T. Phan, Sarah Caruso, Bo Shi +7 more
2019Cell Death and Differentiation69 citations Open access
Semantic Scholar
TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis
Christina Nedeva, Joseph Menassa, M. Duan, Chuanxin Liu +10 more
2020Nature Immunology63 citations Open access
Semantic Scholar
Cyclic‐AMP‐dependent protein kinase A regulates apoptosis by stabilizing the BH3‐only protein Bim
Diane Moujalled, R. Weston, H. Anderton, R. Ninnis +6 more
2011EMBO Reports63 citations Open access
Semantic Scholar
Endogenous bcl-2 is not required for the development of Emu-myc-induced B-cell lymphoma.
Priscilla N. Kelly, H. Puthalakath, J. Adams, A. Strasser
2007Blood62 citations Open access
Semantic Scholar
Glycosylation Defect in Lec1 Chinese Hamster Ovary Mutant Is Due to a Point Mutation in N-Acetylglucosaminyltransferase I Gene*
H. Puthalakath, J. Burke, P. Gleeson
1996Journal of Biological Chemistry62 citations Open access
Semantic Scholar
Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes
LA O'Reilly, U. Divisekera, K. Newton, K. Scalzo +5 more
2004Cell Death and Differentiation52 citations
Semantic Scholar
CREB-binding protein (CBP) regulates β-adrenoceptor (β-AR)−mediated apoptosis
Y. Lee, D. Moujalled, M. Doerflinger, L. Gangoda +9 more
2013Cell Death and Differentiation49 citations Open access
Semantic Scholar
Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim
B. Marshall, H. Puthalakath, S. Caria, S. Chugh +3 more
2015Cell Death and Disease43 citations Open access
Semantic Scholar
Control of apoptosis in hematopoietic cells by the Bcl-2 family of proteins.
Jerry M. Adams, David C. S. Huang, H. Puthalakath, P. Bouillet +11 more
1999Cold Spring Harbor Symposia on Quantitative Biology41 citations
Semantic Scholar
CPD Damage Recognition by Transcribing RNA Polymerase II
Andrea Cuconati, K. Degenhardt, Ramya Sundararajan, Alan Anschel +25 more
200737 citations
Semantic Scholar
Stimulation of β‐adrenoceptors up‐regulates cardiac expression of galectin‐3 and BIM through the Hippo signalling pathway
Wei-Bo Zhao, Qun Lu, M. Nguyen, Yi-Dan Su +7 more
2019British Journal of Pharmacology36 citations Open access
Semantic Scholar
BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals
R. Srivastava, Zhipeng Cao, Christina Nedeva, Samara Naim +21 more
2019Proceedings of the National Academy of Sciences of the United States of America36 citations Open access
Semantic Scholar
Subversion of the Bcl-2 life/death switch in cancer development and therapy.
J. Adams, David C. S. Huang, A. Strasser, S. Willis +18 more
2005Cold Spring Harbor Symposia on Quantitative Biology36 citations
Semantic Scholar
Bcl-2 family proteins, beyond the veil.
Jason Glab, Zhipeng Cao, H. Puthalakath
2020International Review of Cell and Molecular Biology34 citations
Semantic Scholar
The Role of the Pro‐Apoptotic Bcl‐2 Family Member Bim in Physiological Cell Death
P. Bouillet, David C. S. Huang, L. O'Reilly, H. Puthalakath +4 more
2000Annals of the New York Academy of Sciences33 citations
Semantic Scholar
Hoxb8 regulates expression of microRNAs to control cell death and differentiation
M. Salmanidis, G. Brumatti, N. Narayan, BD Green +13 more
2013Cell Death and Differentiation32 citations Open access
Semantic Scholar
Endoplasmic reticulum stress and BCL-2 family members.
R. Weston, H. Puthalakath
2010Advances in Experimental Medicine and Biology29 citations
Semantic Scholar
Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome
Luke Isbel, R. Srivastava, Harald Oey, A. Spurling +3 more
2015PLoS Genetics28 citations Open access
Semantic Scholar
BH3-Only Proteins in Health and Disease.
Jason Glab, G. Mbogo, H. Puthalakath
2017International Review of Cell and Molecular Biology26 citations
Semantic Scholar
Genetic defect in N-acetylglucosaminyltransferase I gene of a ricin-resistant baby hamster kidney mutant.
Andrew S. Opat, H. Puthalakath, J. Burke, Paul A. Gleeson
1998Biochemical Journal26 citations Open access
Semantic Scholar
Role of p53 in cAMP/PKA pathway mediated apoptosis
A. Rahimi, Ying-Ying Lee, Hassen Abdella, M. Doerflinger +5 more
2013Apoptosis24 citations Open access
Semantic Scholar
Circulating BiP/Grp78 is a novel prognostic marker for sepsis‐mediated immune cell death
M. Doerflinger, B. Reljić, Joseph Menassa, Christina Nedeva +7 more
2020The FEBS Journal18 citations Open access
Semantic Scholar
Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice
M. Doerflinger, Jason Glab, Christina Nedeva, Irvin Jose +6 more
2016Scientific Reports18 citations Open access
Semantic Scholar
Fold up or perish: unfolded protein response and chemotherapy
Andreas Strasser, H. Puthalakath
2008Cell Death and Differentiation18 citations Open access
Semantic Scholar

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