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A. Trigos · SciRah

Researcher profile · Semantic Scholar

A. Trigos

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A. Trigos — researcher profile on SciRah

h-index: 13
Works: 49
Citations: 799

Most-cited papers

Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors
A. Trigos, R. Pearson, A. Papenfuss, D. Goode
2017Proceedings of the National Academy of Sciences of the United States of America188 citations Open access
Semantic Scholar
How the evolution of multicellularity set the stage for cancer
A. Trigos, R. Pearson, A. Papenfuss, D. Goode
2018British Journal of Cancer122 citations Open access
Semantic Scholar
Spatial analysis with SPIAT and spaSim to characterize and simulate tissue microenvironments
Yuzhou Feng, Tian-Pei Yang, John Zhu, Mabel Li +16 more
2023Nature Communications112 citations Open access
Semantic Scholar
A functional genetic screen defines the AKT-induced senescence signaling network
K. Chan, S. Blake, Hao-Ran Zhu, Jian Kang +11 more
2019Cell Death and Differentiation65 citations Open access
Semantic Scholar
Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer
A. Trigos, R. Pearson, A. Papenfuss, D. Goode
2018bioRxiv62 citations Open access
Semantic Scholar
Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma
Lorey K. Smith, T. Parmenter, Margarete Kleinschmidt, E. Kusnadi +21 more
2022Nature Communications31 citations Open access
Semantic Scholar
Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation
Hao-Ran Zhu, K. Chan, Xin-Ran Huang, Carmelo Cerra +11 more
2022eLife26 citations Open access
Semantic Scholar
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis
E. Kusnadi, A. Trigos, C. Cullinane, D. Goode +13 more
2020EMBO Journal26 citations Open access
Semantic Scholar
Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells
Emily Gruber, J. So, Alexander C. Lewis, Rheana L Franich +17 more
2022bioRxiv25 citations Open access
Semantic Scholar
Tumor immune microenvironment of primary prostate cancer with and without germline mutations in homologous recombination repair genes
A. Trigos, Anupama Pasam, P. Banks, R. Wallace +21 more
2022Journal for ImmunoTherapy of Cancer21 citations Open access
Semantic Scholar
A functional genetic screen defines the AKT-induced senescence signaling network
K. Chan, S. Blake, Hao-Ran Zhu, Jian Kang +11 more
2019Cell Death and Differentiation19 citations Open access
Semantic Scholar
Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer
Kei Mizuno, Sheng-Yu Ku, V. B. Venkadakrishnan, Martin K. Bakht +19 more
2025Nature Communications18 citations Open access
Semantic Scholar
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer
E. Sanij, K. Hannan, Jiachen Xuan, Shunfei Yan +24 more
2020Nature Communications18 citations Open access
Semantic Scholar
Copy number architectures define treatment-mediated selection of lethal prostate cancer clones
A. M. Mahedi Hasan, P. Cremaschi, D. Wetterskog, A. Jayaram +19 more
2023Nature Communications10 citations Open access
Semantic Scholar
SPIAT: An R package for the Spatial Image Analysis of Cells in Tissues
Tian-Pei Yang, Volkan Ozcoban, Anupama Pasam, Nikolce Kocovski +8 more
2020bioRxiv10 citations Open access
Semantic Scholar
Sensitivity to immune checkpoint inhibitors in BRAF/MEK inhibitor refractory melanoma
Riyaben P. Patel, L. Lim, Reem Saleh, D. Schenk +9 more
2025Journal for ImmunoTherapy of Cancer9 citations Open access
Semantic Scholar
Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular origins
A. Trigos, Felicia Bongiovanni, Yang-Yang Zhang, Maia Zethoven +4 more
2024Genome Biology9 citations Open access
Semantic Scholar
Comprehensive profiling identifies tumour and immune-microenvironmental differences in clinical subsets of cutaneous squamous cell carcinoma.
A. Thai, R. Young, M. Bressel, C. Angel +8 more
2023British Journal of Dermatology9 citations
Semantic Scholar
Collateral Sensitivity to β-Lactam Drugs in Drug-Resistant Tuberculosis Is Driven by the Transcriptional Wiring of BlaI Operon Genes
A. Trigos, Benjamin Goudey, J. Bedő, Thomas C. Conway +2 more
2017bioRxiv6 citations Open access
Semantic Scholar
Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation
Hao-Ran Zhu, K. Chan, Xin-Ran Huang, S. Blake +10 more
2021bioRxiv4 citations Open access
Semantic Scholar
Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer
E. Sanij, K. Hannan, Shunfei Yan, Jiachen Xuan +22 more
2019bioRxiv3 citations Open access
Semantic Scholar
Reprogrammed mRNA translation drives metabolic response to therapeutic targeting of ribosome biogenesis
E. Kusnadi, A. Trigos, C. Cullinane, D. Goode +13 more
2019bioRxiv3 citations Open access
Semantic Scholar
ProNGF derived from rat sciatic nerves downregulates neurite elongation and axon specification in PC12 cells
A. Trigos, M. Longart, Lisbeth García, C. Castillo +2 more
2015Frontiers in Cellular Neuroscience2 citations Open access
Semantic Scholar
2D spatial tissue analysis often misrepresents true biological patterns of 3D tissues
David Le, David I. Kaplan, A. Trigos
2026bioRxiv1 citations Open access
Semantic Scholar
ATAClone: Cancer Clone Identification and Copy Number Estimation from Single-cell ATAC-seq
Lachlan Cain, A. Trigos
2026bioRxiv1 citations Open access
Semantic Scholar
Convergent evolution of complex structural variants drives therapy resistance in metastatic prostate cancer
Thaidy Moreno-Rodriguez, Meng Zhang, Arian Lundberg, Raunak Shrestha +19 more
2026Genome Biology1 citations Open access
Semantic Scholar
The 2023 generation
Joanna Achinger-Kawecka, Santiago Correa, Jing Hu, Gao-Peng Li +8 more
2023Nature Cancer1 citations
Semantic Scholar
RNA binding kinase UHMK1 regulates therapy induced metabolic adaptation in BRAFV600 melanoma
Lorey K. Smith, T. Parmenter, Margarete Kleinschmidt, E. Kusnadi +18 more
20191 citations Open access
Semantic Scholar
Immunospatial tumor microenvironment analysis identifies B cell aggregates associated with recurrence-free survival in primary melanoma
G. Attrill, Nicholas Canete, Yuzhou Feng, Eva R. Shteinman +11 more
2026Cancer Immunology and Immunotherapy0 citations Open access
Semantic Scholar
Abstract 601: Translational reprogramming disrupts mitosis to drive SMAD4-deficient esophageal adenocarcinoma.
Julia V. Milne, Ka-Meng Wu, S. Witts, E. Kusnadi +11 more
2026Cancer Research0 citations
Semantic Scholar
Spatial Profiling Reveals Immune Escape Pathways and Therapeutic Vulnerabilities in Prostate Cancer Bone Metastases.
Katie L. Owen, L. Gearing, B. Niranjan, Madawa W. Jayawardana +14 more
2026Cancer Research0 citations Open access
Semantic Scholar
SMAD4 loss drives chromosomal instability during tumourigenesis via translational reprogramming
Julia V. Milne, Ka-Meng Wu, E. Kusnadi, S. Brosda +21 more
2026bioRxiv0 citations Open access
Semantic Scholar
SAT-111 FSH+ gonadotroph adenomas have greater MRI apparent diffusion coefficients and gross total resection rates than FSH- gonadotroph adenomas
Yeung-Ae Park, D. McArdle, Frank Gaillard, Rosalyn Ly +4 more
2025Journal of the Endocrine Society0 citations Open access
Semantic Scholar
Abstract A006: Delineating functional drivers of esophageal adenocarcinoma to identify synthetic lethal interactions
Julia V. Milne, Ebtihal Mustafa, Kenji M. Fujihara, E. Kusnadi +10 more
2024Molecular Cancer Therapeutics0 citations
Semantic Scholar
Abstract PR007: Delineating functional drivers of esophageal adenocarcinoma to identify synthetic lethal interactions
Julia V. Milne, Ebtihal Mustafa, Kenji M. Fujihara, E. Kusnadi +10 more
2024Molecular Cancer Therapeutics0 citations
Semantic Scholar
Abstract PR003: Convergent evolution in DNA repair-deficient mCRPC in response to targeted therapy
T. Moreno, Meng Zhang, Arian Lundberg, Raunak Shrestha +7 more
2023Cancer Research0 citations
Semantic Scholar
Heterogeneity of canonical prostate cancer markers across lesions in metastatic castration-resistant prostate cancer.
A. Trigos, Anupama Pasam, A. Inderjeeth, Lachlan Cain +11 more
2023Journal of Clinical Oncology0 citations
Semantic Scholar
Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular origins
A. Trigos, Felicia Bongiovanni, Magnus Zethoven, Richard W. Tothill +3 more
2023bioRxiv0 citations Open access
Semantic Scholar
Abstract 5941: Sequencing of targeted- and immune-therapy: delineating time dependent changes in both melanoma cells and the immune microenvironment
Riyaben P. Patel, A. Trigos, N. Haynes, Emily J. Lelliott +2 more
2023Cancer Research0 citations
Semantic Scholar
Treatment-mediated selection of lethal prostate cancer clones defined by copy number architectures
A. M. Mahedi Hasan, P. Cremaschi, D. Wetterskog, A. Jayaram +15 more
2022bioRxiv0 citations Open access
Semantic Scholar
The heterogeneity of the tumor immune microenvironment of patients with germline mutations in DNA repair genes
A. Trigos
20200 citations Open access
Semantic Scholar
Single-nucleus RNAseq uncovers multiple tumor lineages in 5 metastatic sites of a prostate adenocarcinoma rapid-autopsy patient
A. Trigos
20200 citations Open access
Semantic Scholar
Abstract PR13: Inhibition of RNA polymerase I transcription activates targeted DNA damage response and enhances the efficacy of PARP inhibitors in high-grade serous ovarian cancer
E. Sanij, K. Hannan, Jiachen Xuan, Shunfei Yan +20 more
2020Oral Presentations - Proffered Abstracts0 citations
Semantic Scholar
The tumor immune microenvironment of germline BRCA1/2 and sporadic prostate cancer.
A. Trigos, Anupama Pasam, P. Banks, R. Wallace +16 more
20200 citations
Semantic Scholar
668 A toolkit for the quantitative analysis of the spatial distribution of cells of the tumor immune microenvironment
A. Trigos, Tian-Pei Yang, Yuzhou Feng, Volkan Ozcoban +11 more
20200 citations Open access
Semantic Scholar
Immune Profiling of Primary Prostate Cancer Arising in Men with and Without Germline DNA Repair Defects
S. Sandhu, A. Trigos, Anupama Pasam, P. Banks +11 more
20190 citations
Semantic Scholar
Adaptive post-transcriptional reprogramming of metabolism limits response to targeted therapy in BRAFV600 melanoma
Lorey K. Smith, T. Parmenter, Margarete Kleinschmidt, E. Kusnadi +18 more
20190 citations Open access
Semantic Scholar
Author response: Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer
A. Trigos, R. Pearson, A. Papenfuss, D. Goode
20190 citations Open access
Semantic Scholar
Abstract 1301: Using the evolutionary ages of genes to understand hallmark features of cancer
D. Goode, A. Trigos, A. Papenfuss, R. Pearson
2018Bioinformatics and Systems Biology0 citations
Semantic Scholar

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