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L. Vrang · SciRah

Researcher profile · Semantic Scholar

L. Vrang

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L. Vrang — researcher profile on SciRah

h-index: 28
Works: 108
Citations: 2,808

Most-cited papers

In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435
O. Lenz, T. Verbinnen, Tse-i Lin, L. Vijgen +15 more
2010Antimicrobial Agents and Chemotherapy227 citations Open access
Semantic Scholar
In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor
Tse-i Lin, O. Lenz, G. Fanning, T. Verbinnen +11 more
2009Antimicrobial Agents and Chemotherapy185 citations Open access
Semantic Scholar
HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase.
J. Balzarini, Anna Karlsson, M. Pérez-Pérez, L. Vrang +6 more
1993Virology142 citations
Semantic Scholar
Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350.
P. Raboisson, H. D. De Kock, Å. Rosenquist, Magnus Nilsson +22 more
2008Bioorganic & Medicinal Chemistry Letters123 citations
Semantic Scholar
Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.
A. Cantrell, P. Engelhardt, M. Högberg, S. Jaskunas +16 more
1996Journal of Medicinal Chemistry115 citations Open access
Semantic Scholar
Prevention of simian immunodeficiency virus, SIVsm, or HIV‐2 infection in cynomolgus monkeys by pre‐ and postexposure administration of BEA‐005
D. Böttiger, N. Johansson, B. Samuelsson, Hong Zhang +3 more
1997AIDS (London)113 citations Open access
Semantic Scholar
Induced-fit binding of the macrocyclic noncovalent inhibitor TMC435 to its HCV NS3/NS4A protease target.
M. Cummings, J. Lindberg, Tse-i Lin, H. D. De Kock +12 more
2010Angewandte Chemie91 citations Open access
Semantic Scholar
Design and synthesis of plasmepsin I and plasmepsin II inhibitors with activity in Plasmodium falciparum-infected cultured human erythrocytes.
Daniel Nöteberg, Elizabeth Hamelink, J. Hulten, M. Wahlgren +3 more
2003Journal of Medicinal Chemistry80 citations Open access
Semantic Scholar
Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues
M. Högberg, Christer Sahlberg, P. Engelhardt, R. Noréen +10 more
1999Journal of Medicinal Chemistry76 citations Open access
Semantic Scholar
Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro- 5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)]-beta-D-pentofurano syl (TSAO) nucleoside analogues retain sensitivity to HIV-1-specific nonnucleo
J. Balzarini, Anna Karlsson, A. Vandamme, M. Pérez-Pérez +6 more
1993Proceedings of the National Academy of Sciences of the United States of America63 citations Open access
Semantic Scholar
An analysis of the inhibition of replication of HIV and MuLV by some 3'-blocked pyrimidine analogs.
H. Bazin, J. Chattopadhyaya, R. Datema, A. Ericson +11 more
1989Biochemical Pharmacology61 citations
Semantic Scholar
High-speed optimization of inhibitors of the malarial proteases plasmepsin I and II.
Daniel Nöteberg, Wesley Schaal, Elizabeth Hamelink, L. Vrang +1 more
2003Journal of combinatorial chemistry57 citations Open access
Semantic Scholar
Design and fast synthesis of C-terminal duplicated potent C(2)-symmetric P1/P1'-modified HIV-1 protease inhibitors.
M. Alterman, H. Andersson, Neeraj Garg, G. Ahlsen +8 more
1999Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs.
Per-Ola Johansson, Yantao Chen, A. Belfrage, M. Blackman +7 more
2004Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors.
H. Andersson, K. Fridborg, Seved Löwgren, M. Alterman +15 more
2003European Journal of Biochemistry42 citations Open access
Semantic Scholar
Cyclic sulfamide HIV-1 protease inhibitors, with sidechains spanning from P2/P2' to P1/P1'.
A. Ax, Wesley Schaal, L. Vrang, B. Samuelsson +2 more
2005Bioorganic & Medicinal Chemistry41 citations Open access
Semantic Scholar
Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data.
Cynthia F. Shuman, L. Vrang, U. Danielson
2004Journal of Medicinal Chemistry41 citations Open access
Semantic Scholar
Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethyl thiazolyl thiourea derivatives trovirdine and MSC-127.
Hong Zhang, L. Vrang, Kristina Bäckbro, P. Lind +3 more
1995Antiviral Research41 citations
Semantic Scholar
Characterization of a Set of HIV-1 Protease Inhibitors Using Binding Kinetics Data from a Biosensor-Based Screen
Markku D. Hämäläinen, P. Markgren, Wesley Schaal, A. Karlén +5 more
2000Journal of biomolecular screening40 citations Open access
Semantic Scholar
Synthesis, biological evaluation, and modeling studies of inhibitors aimed at the malarial proteases plasmepsins I and II.
Daniel Muthas, Daniel Nöteberg, Y. Sabnis, Elizabeth Hamelink +4 more
2005Bioorganic & Medicinal Chemistry39 citations
Semantic Scholar
Human immunodeficiency virus type 1 proteinase resistance to symmetric cyclic urea inhibitor analogs
U. Nillroth, L. Vrang, P. Markgren, J. Hulten +2 more
1997Antimicrobial Agents and Chemotherapy37 citations Open access
Semantic Scholar
Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II.
Per-Ola Johansson, J. Lindberg, M. Blackman, I. Kvarnström +5 more
2005Journal of Medicinal Chemistry36 citations Open access
Semantic Scholar
Anti-HIV Type 1 Activity of 3′-Fluoro-3′-Deoxythymidine for Several Different Multidrug-Resistant Mutants
Eun-Young Kim, L. Vrang, B. Öberg, T. Merigan
2001AIDS Research and Human Retroviruses33 citations
Semantic Scholar
Synergistic Inhibition of Human Immunodeficiency Virus Replication In Vitro by Combinations of 3′-Azido-3′-Deoxythymidine and 3′-Fluoro-3′-Deoxythymidine
Johan Harmenberg, A. Åkesson-Johansson, L. Vrang, S. Cox
1990AIDS Research and Human Retroviruses31 citations
Semantic Scholar
Novel potent macrocyclic inhibitors of the hepatitis C virus NS3 protease: use of cyclopentane and cyclopentene P2-motifs.
Marcus Bäck, Per-Ola Johansson, Fredrik Wångsell, F. Thorstensson +14 more
2007Bioorganic & Medicinal Chemistry28 citations Open access
Semantic Scholar
Design and synthesis of potent and selective BACE-1 inhibitors.
Catarina Björklund, S. Oscarson, K. Benkestock, N. Borkakoti +6 more
2010Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
High-speed synthesis of potent C2-symmetric HIV-1 protease inhibitors by in-situ aminocarbonylations.
J. Wannberg, N. Kaiser, L. Vrang, B. Samuelsson +2 more
2005Journal of combinatorial chemistry27 citations Open access
Semantic Scholar
Synthesis and anti-HIV activities of urea-PETT analogs belonging to a new class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
C. Sahlberg, R. Noréen, P. Engelhardt, M. Högberg +3 more
1998Bioorganic & Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors
Xiong-Yu Wu, Per Ohrngren, A. Joshi, Alejandro Trejos +8 more
2012Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues.
M. Högberg, C. Sahlberg, P. Engelhardt, R. Noréen +10 more
1999Journal of Medicinal Chemistry25 citations
Semantic Scholar
Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: exploration of P2 quinazoline substituents.
Magnus Nilsson, A. Belfrage, S. Lindström, Horst Wähling +20 more
2010Bioorganic & Medicinal Chemistry Letters24 citations
Semantic Scholar
New potent C2-symmetric malaria plasmepsin I and II inhibitors.
K. Oscarsson, S. Oscarson, L. Vrang, Elizabeth Hamelink +2 more
2003Bioorganic & Medicinal Chemistry24 citations
Semantic Scholar
Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors.
S. Vendeville, Magnus Nilsson, H. D. De Kock, Tse-i Lin +25 more
2008Bioorganic & Medicinal Chemistry Letters23 citations
Semantic Scholar
A new structural theme in C2-symmetric HIV-1 protease inhibitors: ortho-substituted P1/P1' side chains.
J. Wannberg, Y. Sabnis, L. Vrang, B. Samuelsson +3 more
2006Bioorganic & Medicinal Chemistry23 citations
Semantic Scholar
Bioisosteric modification of PETT-HIV-1 RT-inhibitors: synthesis and biological evaluation.
M. Högberg, P. Engelhardt, L. Vrang, Hong Zhang
2000Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Potent inhibitors of the hepatitis C virus NS3 protease: use of a novel P2 cyclopentane-derived template.
Per-Ola Johansson, Marcus Bäck, I. Kvarnström, K. Jansson +5 more
2006Bioorganic & Medicinal Chemistry22 citations
Semantic Scholar
Design and synthesis of potent C(2)-symmetric diol-based HIV-1 protease inhibitors: effects of fluoro substitution.
David Pyring, J. Lindberg, Å. Rosenquist, Guido Zuccarello +7 more
2001Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
Inhibition of HIV-1 by non-nucleoside reverse transcriptase inhibitors via an induced fit mechanism-Importance of slow dissociation and relaxation rates for antiviral efficacy.
Malin Elinder, P. Selhorst, G. Vanham, B. Öberg +2 more
2010Biochemical Pharmacology20 citations Open access
Semantic Scholar
Resolution of the interaction mechanisms and characteristics of non-nucleoside inhibitors of hepatitis C virus polymerase.
J. Winquist, E. Abdurakhmanov, V. Baraznenok, Ian Henderson +2 more
2013Antiviral Research19 citations
Semantic Scholar
Discovery of 4'-azido-2'-deoxy-2'-C-methyl cytidine and prodrugs thereof: a potent inhibitor of Hepatitis C virus replication.
Magnus Nilsson, G. Kalayanov, A. Winqvist, P. Pinho +26 more
2012Bioorganic & Medicinal Chemistry Letters19 citations
Semantic Scholar
Preclinical Evaluation of 1H-Benzylindole Derivatives as Novel Human Immunodeficiency Virus Integrase Strand Transfer Inhibitors
A. Hombrouck, B. Van Remoortel, Martine Michiels, W. Noppe +12 more
2008Antimicrobial Agents and Chemotherapy19 citations Open access
Semantic Scholar
New inhibitors of the malaria aspartyl proteases plasmepsin I and II.
Anders Dahlgren, I. Kvarnström, L. Vrang, Elizabeth Hamelink +3 more
2003Bioorganic & Medicinal Chemistry19 citations
Semantic Scholar
Symmetric fluoro-substituted diol-based HIV protease inhibitors. Ortho-fluorinated and meta-fluorinated P1/P1'-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacy.
J. Lindberg, D. Pyring, Seved Löwgren, Å. Rosenquist +8 more
2004European Journal of Biochemistry17 citations
Semantic Scholar
Influence of the Infectious Dose of Simian Immunodeficiency Virus on the Acute Infection in Cynomolgus Monkeys and on the Effect of Treatment with 3′-Fluorothymidine
D. Böttiger, L. Vrang, B. Öberg
199217 citations
Semantic Scholar
Synthesis of P1'-functionalized macrocyclic transition-state mimicking HIV-1 protease inhibitors encompassing a tertiary alcohol.
M. De Rosa, J. Unge, Hitesh V. Motwani, Å. Rosenquist +3 more
2014Journal of Medicinal Chemistry15 citations
Semantic Scholar
HIV-1 Protease Inhibitors with a Tertiary Alcohol Containing Transition-State Mimic and Various P2 and P1' Substituents
Per Ohrngren, Xiong-Yu Wu, M. Persson, J. Ekegren +6 more
201115 citations
Semantic Scholar
Quantification of interactions between drug leads and serum proteins by use of "binding efficiency".
S. Gustafsson, L. Vrang, Y. Terelius, U. H. Danielson
2011Analytical Biochemistry15 citations
Semantic Scholar
Characterization of HIV Reverse Transcriptases with Tyr181→Cys and Leu100→lle Mutations
Hong Zhang, L. Vrang, Torsten Unge, B. Öberg
199315 citations Open access
Semantic Scholar
Design and synthesis of potent macrocyclic renin inhibitors.
C. Sund, O. Belda, D. Wiktelius, C. Sahlberg +10 more
2011Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Design and synthesis of novel P2 substituents in diol-based HIV protease inhibitors.
Jenny Adrian Meredith, H. Wallberg, L. Vrang, S. Oscarson +3 more
2010European journal of medicinal chemistry14 citations Open access
Semantic Scholar

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