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P. Dudley · SciRah

Researcher profile · Semantic Scholar

P. Dudley

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P. Dudley — researcher profile on SciRah

h-index: 9
Works: 17
Citations: 1,462

Most-cited papers

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity.
C. Chresta, B. Davies, Ian D. Hickson, Tom C. Harding +20 more
2010Cancer Research811 citations
Semantic Scholar
Preclinical Pharmacology of AZD5363, an Inhibitor of AKT: Pharmacodynamics, Antitumor Activity, and Correlation of Monotherapy Activity with Genetic Background
B. Davies, Hannah E. Greenwood, P. Dudley, C. Crafter +17 more
2012Molecular Cancer Therapeutics433 citations
Semantic Scholar
Diverse heterocyclic scaffolds as allosteric inhibitors of AKT.
J. Kettle, Simon Brown, C. Crafter, B. Davies +13 more
2012Journal of Medicinal Chemistry46 citations Open access
Semantic Scholar
Intermittent High-Dose Scheduling of AZD8835, a Novel Selective Inhibitor of PI3Kα and PI3Kδ, Demonstrates Treatment Strategies for PIK3CA-Dependent Breast Cancers
K. Hudson, Urs J Hancox, C. Trigwell, R. McEwen +14 more
2016Molecular Cancer Therapeutics38 citations Open access
Semantic Scholar
Combining AZD8931, a novel EGFR/HER2/HER3 signalling inhibitor, with AZD5363 limits AKT inhibitor induced feedback and enhances antitumour efficacy in HER2-amplified breast cancer models
C. Crafter, J. Vincent, Eric Tang, P. Dudley +3 more
2015International Journal of Oncology36 citations Open access
Semantic Scholar
Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells
A. G. Trinidad, Nicky Whalley, R. Rowlinson, O. Delpuech +3 more
2017Oncogene30 citations Open access
Semantic Scholar
Preclinical Development Preclinical Pharmacology of AZD 5363 , an Inhibitor of AKT : Pharmacodynamics , Antitumor Activity , and Correlation of Monotherapy Activity with Genetic Background
B. Davies, Hannah E. Greenwood, P. Dudley, C. Crafter +18 more
201227 citations
Semantic Scholar
2-Deoxy-2-[18F]fluoro-d-glucose Positron Emission Tomography Demonstrates Target Inhibition with the Potential to Predict Anti-Tumour Activity Following Treatment with the AKT Inhibitor AZD5363
J. Maynard, Sally-Ann Ricketts, C. Gendrin, P. Dudley +1 more
2013Molecular Imaging and Biology21 citations
Semantic Scholar
Validation of a predictive modeling approach to demonstrate the relative efficacy of three different schedules of the AKT inhibitor AZD5363
J. Yates, P. Dudley, Jane Cheng, C. D'Cruz +1 more
2015Cancer Chemotherapy and Pharmacology15 citations
Semantic Scholar
Preclinical Pharmacology of AZD5363, an Orally Bioavailable Inhibitor of AKT: Pharmacodynamics, Antitumor Activity and Correlation of Monotherapy Activity with Genetic Background
B. Davies, Hannah E. Greenwood, P. Dudley, C. Crafter +19 more
20125 citations
Semantic Scholar
Abstract 2665: High dose intermittent scheduling of AZD8835, a novel potent and selective inhibitor of PI3Kα and PI3Kδ, identifies potential treatment strategies for PIK3CA-dependent cancers
K. Hudson, Urs J Hancox, C. Trigwell, P. Dudley +11 more
20151 citations
Semantic Scholar
319 POSTER Pharmacodynamics and anti-tumour activity of KU-0063794, a potent and specific inhibitor of mTOR kinase
B. Davies, C. Chresta, P. Dudley, N. Hewitt +6 more
20081 citations
Semantic Scholar
Abstract 4696: Combining AZD8186, an inhibitor of PI3Kbeta, with inhibitors of PI3Kalpha and mTORC1/2 gives comprehensive pathway suppression and enhanced antitumor activity in PTEN null tumors
Urs J Hancox, U. Polanska, James T. Lynch, Carol Lenaghan +11 more
20150 citations
Semantic Scholar
546 The PI3Kbeta/delta inhibitor AZD8186 combines with the dual mTORC1/2 inhibitor AZD2014 to give comprehensive PI3K pathway inhibition and drive tumour regression in vivo
B. Simon, U. Hancox, U. Polanska, L. Hanson +10 more
20140 citations
Semantic Scholar
Abstract 1030: Use of18F-FDG-PET as a biomarker to demonstrate activity of the novel AKT inhibitor AZD5363 in a xenograft model
J. Bales, Sally-Ann Ricketts, J. Halliday, A. Parmar +5 more
20110 citations
Semantic Scholar
Abstract 4477: Characterization of AZD5363, an orally bioavailable, potent ATP-competitive inhibitor of AKT kinases with pharmacodynamic and antitumor activity in preclinical models
B. Davies, R. Luke, P. Dudley, Hannah E. Greenwood +8 more
20110 citations
Semantic Scholar
GROCERY PRICE DIFFERENTIALS ADVERSE TO THE ELDERLY IN RURAL COMMUNITIES
P. Dudley
19810 citations
Semantic Scholar

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