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A. Suttle · SciRah

Researcher profile · Semantic Scholar

A. Suttle

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A. Suttle — researcher profile on SciRah

h-index: 23
Works: 37
Citations: 2,201

Most-cited papers

Phase I Trial of Pazopanib in Patients with Advanced Cancer
H. Hurwitz, A. Dowlati, S. Saini, S. Savage +5 more
2009Clinical Cancer Research414 citations
Semantic Scholar
The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia.
E. Stein, G. Garcia-Manero, D. Rizzieri, R. Tibes +17 more
2018Blood403 citations Open access
Semantic Scholar
Relationships between pazopanib exposure and clinical safety and efficacy in patients with advanced renal cell carcinoma
A. Suttle, H. Ball, M. Molimard, Thomas E. Hutson +6 more
2014British Journal of Cancer179 citations Open access
Semantic Scholar
A Phase I/II Trial of Pazopanib in Combination with Lapatinib in Adult Patients with Relapsed Malignant Glioma
D. Reardon, M. Groves, P. Wen, L. Nabors +10 more
2013Clinical Cancer Research113 citations Open access
Semantic Scholar
Effects of ketoconazole and esomeprazole on the pharmacokinetics of pazopanib in patients with solid tumors
A. Tan, D. Gibbon, M. Stein, Diana Lindquist +7 more
2013Cancer Chemotherapy and Pharmacology111 citations
Semantic Scholar
An Evaluation of the Drug Interaction Potential of Pazopanib, an Oral Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, Using a Modified Cooperstown 5+1 Cocktail in Patients With Advanced Solid Tumors
B. Goh, N. Reddy, UB Dandamudi, KH Laubscher +9 more
2010Clinical pharmacology and therapy87 citations
Semantic Scholar
Phase I Dose-Finding Study of Pazopanib in Hepatocellular Carcinoma: Evaluation of Early Efficacy, Pharmacokinetics, and Pharmacodynamics
T. Yau, Pei-Jer Chen, P. Chan, C. Curtis +6 more
2011Clinical Cancer Research84 citations Open access
Semantic Scholar
Bioavailability, metabolism and disposition of oral pazopanib in patients with advanced cancer
Yanli Deng, Caroline Sychterz, A. Suttle, Mohammed M. Dar +6 more
2013Xenobiotica; the fate of foreign compounds in biological systems83 citations
Semantic Scholar
Phase 1 Study of Pazopanib in Patients with Advanced Solid Tumors and Hepatic Dysfunction: A National Cancer Institute Organ Dysfunction Working Group Study
S. Shibata, V. Chung, T. Synold, J. Longmate +17 more
2013Clinical Cancer Research67 citations Open access
Semantic Scholar
Vascular endothelial growth factor inhibition is not an effective therapeutic strategy for relapsed or refractory multiple myeloma: a phase 2 study of pazopanib (GW786034).
H. Prince, D. Hönemann, A. Spencer, D. Rizzieri +9 more
2009Blood53 citations Open access
Semantic Scholar
A phase I pharmacokinetic and safety evaluation of oral pazopanib dosing administered as crushed tablet or oral suspension in patients with advanced solid tumors
E. Heath, Karen M. Forman, L. Malburg, S. Gainer +4 more
2012Investigational new drugs47 citations
Semantic Scholar
Phase I study of pazopanib in combination with weekly paclitaxel in patients with advanced solid tumors.
A. Tan, A. Dowlati, S. Jones, J. Infante +9 more
2010The Oncologist46 citations Open access
Semantic Scholar
Phase I Study of Pazopanib in Combination with Paclitaxel and Carboplatin Given Every 21 Days in Patients with Advanced Solid Tumors
H. Burris, A. Dowlati, R. Moss, J. Infante +9 more
2012Molecular Cancer Therapeutics44 citations
Semantic Scholar
A randomized, double-blind, placebo-controlled study to evaluate the effect of repeated oral doses of pazopanib on cardiac conduction in patients with solid tumors
E. Heath, J. Infante, L. Lewis, T. Luu +9 more
2013Cancer Chemotherapy and Pharmacology42 citations Open access
Semantic Scholar
Phase I and pharmacokinetic study of pazopanib and lapatinib combination therapy in patients with advanced solid tumors
M. D. de Jonge, P. Hamberg, J. Verweij, S. Savage +5 more
2013Investigational new drugs37 citations
Semantic Scholar
Use of a Pharmacokinetic Model Incorporating Discontinuous Gastrointestinal Absorption to Examine the Occurrence of Double Peaks in Oral Concentration–Time Profiles
A. Suttle, G. M. Pollack, K. R. Brouwer
1992Pharmaceutical Research37 citations
Semantic Scholar
A Multicenter Phase I Study of Pazopanib in Combination with Paclitaxel in First-Line Treatment of Patients with Advanced Solid Tumors
K. Kendra, R. Plummer, R. Salgia, M. O'Brien +6 more
2014Molecular Cancer Therapeutics32 citations Open access
Semantic Scholar
The absolute bioavailability of oral vinorelbine in patients with solid tumors
R. Lush, J. McCune, Leticia F. Tetteh, John A. Thompson +4 more
2005Cancer Chemotherapy and Pharmacology29 citations
Semantic Scholar
A phase I open-label study of the safety, tolerability, and pharmacokinetics of pazopanib in combination with irinotecan and cetuximab for relapsed or refractory metastatic colorectal cancer
J. Bennouna, M. Deslandres, H. Sénellart, C. D. de-Labareyre +5 more
2015Investigational new drugs28 citations
Semantic Scholar
Pharmacokinetics (PK) and tolerability of GW786034, a VEGFR tyrosine kinase inhibitor, after daily oral administration to patients with solid tumors.
A. Suttle, Herbert Hurwitz, A. Dowlati, N. Fernando +6 more
2004Journal of Clinical Oncology28 citations
Semantic Scholar
Bile flow but not enterohepatic recirculation influences the pharmacokinetics of ranitidine in the rat.
A. Suttle, K. L. R. Brouwer
1994Drug Metabolism And Disposition26 citations
Semantic Scholar
Preclinical Modeling of Tumor Growth and Angiogenesis Inhibition to Describe Pazopanib Clinical Effects in Renal Cell Carcinoma
A. Ouerdani, H. Struemper, A. Suttle, D. Ouellet +1 more
2015CPT: Pharmacometrics & Systems Pharmacology25 citations Open access
Semantic Scholar
A phase I, open-label study of the safety and pharmacokinetics (PK) of pazopanib (P) and lapatinib (L) administered concurrently.
M. Dejonge, S. Savage, J. Verweij, T. S. Collins +6 more
2006Journal of Clinical Oncology24 citations
Semantic Scholar
Comparison of Zafirlukast (Accolate®) Absorption After Oral and Colonic Administration in Humans
J. D. Fischer, Min H. Song, A. Suttle, W. Heizer +3 more
2004Pharmaceutical Research22 citations
Semantic Scholar
Pazopanib exposure decreases as a result of an ifosfamide-dependent drug–drug interaction: results of a phase I study
Paul Hamberg, M. Boers-Sonderen, W. V. D. van der Graaf, P. de Bruijn +5 more
2013British Journal of Cancer21 citations Open access
Semantic Scholar
A phase I study of pazopanib in patients with advanced hepatocellular carcinoma.
C. Yau, P.-J. Chen, C. Curtis, P. Murphy +5 more
2009Journal of Clinical Oncology21 citations
Semantic Scholar
Modeling tumor growth kinetics after treatment with pazopanib or placebo in patients with renal cell carcinoma
P. Bonate, A. Suttle
2013Cancer Chemotherapy and Pharmacology19 citations
Semantic Scholar
Phase I study of weekly paclitaxel in combination with pazopanib and lapatinib in advanced solid malignancies
A. Tan, A. Dowlati, M. Stein, S. Jones +6 more
2014British Journal of Cancer18 citations Open access
Semantic Scholar
Phase Ib trial of the oral angiogenesis inhibitor pazopanib administered concurrently with pemetrexed in patients with advanced solid tumors
J. Infante, S. Novello, Wen W. Ma, G. Dy +9 more
2013Investigational new drugs15 citations
Semantic Scholar
Gastrointestinal Transit and Distribution of Ranitidine in the Rat
A. Suttle, K. Brouwer
1995Pharmaceutical Research13 citations
Semantic Scholar
Pazopanib and lapatinib in patients with relapsed malignant glioma: Results of a phase I/II study.
S. Frentzas, M. Groves, J. Barriuso, D. Harris +6 more
2009Journal of Clinical Oncology11 citations
Semantic Scholar
Phase Ib trial of the oral angiogenesis inhibitor pazopanib administered concurrently with erlotinib
Grace K. Dy, J. Infante, S. Eckhardt, S. Novello +8 more
2013Investigational new drugs9 citations
Semantic Scholar
Changes in polyvinylpyrrolidone coil dimensions by complexation with organic anions: effect of chain length
C. M. Klech, A. Cato, A. Suttle
19916 citations
Semantic Scholar
1206 Phase I study of Pazopanib (PAZ) in Hepatocellular Carcinoma (HCC): evaluation of clinical activity, Pharmacokinetics (PK), and Dynamic Contrast Enhanced MRI (DCE-MRI)
C. Yau, Pei-Jer Chen, C. Curtis, P. Murphy +6 more
20094 citations
Semantic Scholar
Ranitidine does not alter adinazolam pharmacokinetics or pharmacodynamics.
A. Suttle, S. Songer, G. Dukes, Lawrence J. Hak +3 more
1992Journal of Clinical Psychopharmacology4 citations
Semantic Scholar
A method for cancer treatment
A. Pandite, B. Whitehead, P. Ho, A. Suttle
20062 citations
Semantic Scholar
1207 POSTER Phase I Dose-Finding Study for Pazopanib (P) and Paclitaxel (T) in Combination in the First-line Setting in Patients (pts) With Advanced Solid Tumours
K. Kendra, R. Plummer, R. Salgia, M. O'Brien +4 more
20110 citations
Semantic Scholar

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