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A. Reyes · SciRah

Researcher profile · Semantic Scholar

A. Reyes

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A. Reyes — researcher profile on SciRah

h-index: 14
Works: 27
Citations: 526

Most-cited papers

Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188
G. J. Lockbaum, A. Reyes, Jeong Min Lee, R. Tilvawala +5 more
2021Viruses102 citations Open access
Semantic Scholar
Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2
S. Mondal, Yong-Zhi Chen, G. J. Lockbaum, Sudeshna Sen +10 more
2022Journal of the American Chemical Society52 citations Open access
Semantic Scholar
The Activating Oxydianion Binding Domain for Enzyme-Catalyzed Proton Transfer, Hydride Transfer, and Decarboxylation: Specificity and Enzyme Architecture
A. Reyes, Xiang Zhai, Kelsey T. Morgan, Christopher J. Reinhardt +2 more
2015Journal of the American Chemical Society48 citations Open access
Semantic Scholar
Orotidine 5′-Monophosphate Decarboxylase: Probing the Limits of the Possible for Enzyme Catalysis
J. Richard, T. L. Amyes, A. Reyes
2018Accounts of Chemical Research42 citations Open access
Semantic Scholar
Enzyme Architecture: Optimization of Transition State Stabilization from a Cation–Phosphodianion Pair
A. Reyes, A. Koudelka, T. L. Amyes, J. Richard
2015Journal of the American Chemical Society31 citations Open access
Semantic Scholar
Enzyme activation through the utilization of intrinsic dianion binding energy.
T. L. Amyes, M. Malabanan, Xiang Zhai, A. Reyes +1 more
2017Protein engineering, design & selection : PEDS30 citations Open access
Semantic Scholar
The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo
Michael H. J. Rhodin, A. Reyes, Anand Balakrishnan, N. Bisht +24 more
2024Nature Communications29 citations Open access
Semantic Scholar
Enzyme Architecture: The Role of a Flexible Loop in Activation of Glycerol-3-phosphate Dehydrogenase for Catalysis of Hydride Transfer
Rui He, A. Reyes, T. L. Amyes, J. Richard
2018Biochemistry25 citations Open access
Semantic Scholar
Enzyme Architecture: Self-Assembly of Enzyme and Substrate Pieces of Glycerol-3-Phosphate Dehydrogenase into a Robust Catalyst of Hydride Transfer
A. Reyes, T. L. Amyes, J. Richard
2016Journal of the American Chemical Society22 citations Open access
Semantic Scholar
The Role of SERPIN Citrullination in Thrombosis
R. Tilvawala, Venkatesh V. Nemmara, A. Reyes, N. Sorvillo +6 more
2021Cell Chemical Biology21 citations Open access
Semantic Scholar
Human Glycerol 3-Phosphate Dehydrogenase: X-Ray Crystal Structures that Guide the Interpretation of Mutagenesis Studies.
L. S. Mydy, Judith R. Cristobal, Roberto D Katigbak, Paul Bauer +4 more
2019Biochemistry19 citations Open access
Semantic Scholar
Enzyme Architecture: Breaking Down the Catalytic Cage that Activates Orotidine 5′-Monophosphate Decarboxylase for Catalysis
A. Reyes, David Plache, A. Koudelka, T. L. Amyes +2 more
2018Journal of the American Chemical Society19 citations Open access
Semantic Scholar
Enzyme Architecture: Erection of Active Orotidine 5′-Monophosphate Decarboxylase by Substrate-Induced Conformational Changes
A. Reyes, T. L. Amyes, J. Richard
2017Journal of the American Chemical Society15 citations Open access
Semantic Scholar
Structure–Reactivity Effects on Intrinsic Primary Kinetic Isotope Effects for Hydride Transfer Catalyzed by Glycerol-3-phosphate Dehydrogenase
A. Reyes, T. L. Amyes, J. Richard
2016Journal of the American Chemical Society14 citations Open access
Semantic Scholar
Enzyme Architecture: A Startling Role for Asn270 in Glycerol 3-Phosphate Dehydrogenase-Catalyzed Hydride Transfer
A. Reyes, T. L. Amyes, J. Richard
2016Biochemistry14 citations Open access
Semantic Scholar
Primary Deuterium Kinetic Isotope Effects: A Probe for the Origin of the Rate Acceleration for Hydride Transfer Catalyzed by Glycerol-3-Phosphate Dehydrogenase
A. Reyes, T. L. Amyes, J. Richard
2018Biochemistry13 citations Open access
Semantic Scholar
The Organization of Active Site Side Chains of Glycerol-3-phosphate Dehydrogenase Promotes Efficient Enzyme Catalysis and Rescue of Variant Enzymes
Judith R. Cristobal, A. Reyes, J. Richard
2020Biochemistry12 citations Open access
Semantic Scholar
Protein-Ribofuranosyl Interactions Activate Orotidine 5’-Monophosphate Decarboxylase for Catalysis
Judith R. Cristobal, Tiago A. S. Brandão, A. Reyes, J. Richard
2021Biochemistry9 citations Open access
Semantic Scholar
Molecular Basis for Antiviral Action of EDP‐235: A Potent and Selective SARS‐CoV‐2 3CLpro Inhibitor for the Treatment of Covid 19
Anand Balakrishnan, A. Reyes, R. Shen, N. Bisht +10 more
2022The FASEB Journal5 citations Open access
Semantic Scholar
A Reevaluation of the Origin of the Rate Acceleration for Enzyme-Catalyzed Hydride Transfer
A. Reyes, T. L. Amyes, J. Richard
2017Organic and biomolecular chemistry4 citations Open access
Semantic Scholar
Discovery of a Potent and Selective KIT inhibitor for Treatment of Mast Cell-Mediated Diseases
M. Roqueta-Rivera, Tessa N. Cressey, Shu-Fan Chou, M. Crepeau +9 more
2026Journal of Allergy and Clinical Immunology1 citations
Semantic Scholar
Discovery and Characterization of a Potent and Selective Oral Inhibitor of STAT6 for the Treatment of Allergic Diseases 2257118
K. Garlick, J. Sweeney, M. Chau, Yaohui Nie +10 more
2026Journal of Immunology0 citations Open access
Semantic Scholar
SARS-CoV-2 resistance pathways to EDP-235.
Kevin Wang, J. Gibbons, N. Bisht, A. Reyes +10 more
2026Antiviral Research0 citations
Semantic Scholar
HSD17B13 inhibitors are hepatoprotective and anti-inflammatory in a mouse model of autoimmune hepatitis
Manuel Roqueta‐Rivera, Yao-Hui Nie, Jordan Butts, M. Chau +6 more
2023Journal of Hepatology0 citations
Semantic Scholar
Pharmacologic inhibition of HSD17B13 is hepatoprotective in mouse models of liver injury
Manuel Roqueta‐Rivera, M. Chau, K. Garlick, Anand Balakrishnan +12 more
2022Journal of Hepatology0 citations
Semantic Scholar
SARS-CoV-2 Main Protease (Mpro) in Complex with ML188
G. J. Lockbaum, J. M. Lee, A. Reyes, E. Nalivaika +4 more
20210 citations
Semantic Scholar
The Complex Role of Asn270 in Dianion Activation of Glycerol 3‐Phosphate Dehydrogenase‐Catalyzed Hydride Transfer
A. Reyes, T. L. Amyes, John P. Richard
2016The FASEB Journal0 citations Open access
Semantic Scholar

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