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T. Okura · SciRah

Researcher profile · Semantic Scholar

T. Okura

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T. Okura — researcher profile on SciRah

h-index: 21
Works: 53
Citations: 1,187

Most-cited papers

Involvement of the Pyrilamine Transporter, a Putative Organic Cation Transporter, in Blood-Brain Barrier Transport of Oxycodone
T. Okura, Asami Hattori, Yusuke Takano, Takenori Sato +3 more
2008Drug Metabolism And Disposition167 citations
Semantic Scholar
Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo.
M. W. Sadiq, Annika Borgs, T. Okura, Keita Shimomura +6 more
2011Journal of Pharmacy and Science92 citations Open access
Semantic Scholar
Effects of dietary ingredients on function and expression of P-glycoprotein in human intestinal epithelial cells.
T. Okura, M. Ibe, K. Umegaki, K. Shinozuka +1 more
2010Biological and Pharmaceutical Bulletin71 citations Open access
Semantic Scholar
Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood–brain barrier model
Keita Shimomura, T. Okura, Sayaka Kato, P. Couraud +3 more
2013Fluids and Barriers of the CNS68 citations Open access
Semantic Scholar
Internalization of basic fibroblast growth factor at the mouse blood–brain barrier involves perlecan, a heparan sulfate proteoglycan
Y. Deguchi, Hiroshi Okutsu, T. Okura, S. Yamada +8 more
2002Journal of Neurochemistry67 citations Open access
Semantic Scholar
Transport characteristics of tramadol in the blood-brain barrier.
Atsushi Kitamura, K. Higuchi, T. Okura, Y. Deguchi
2014Journal of Pharmacy and Science55 citations Open access
Semantic Scholar
Blood-brain barrier transport of pramipexole, a dopamine D2 agonist.
T. Okura, Rieno Ito, N. Ishiguro, I. Tamai +1 more
2007Life Science54 citations
Semantic Scholar
Memantine transport by a proton-coupled organic cation antiporter in hCMEC/D3 cells, an in vitro human blood-brain barrier model.
K. Higuchi, Atsushi Kitamura, T. Okura, Y. Deguchi
2015Drug Metabolism and Pharmacokinetics41 citations
Semantic Scholar
Functional characterization of rat plasma membrane monoamine transporter in the blood-brain and blood-cerebrospinal fluid barriers.
T. Okura, Sayaka Kato, Yusuke Takano, Takenori Sato +5 more
2011Journal of Pharmacy and Science41 citations Open access
Semantic Scholar
In Vivo Demonstration of α1A-Adrenoceptor Subtype Selectivity of KMD-3213 in Rat Tissues
S. Yamada, T. Okura, R. Kimura
2001Journal of Pharmacology and Experimental Therapeutics41 citations
Semantic Scholar
Prostaglandin Transporter OATP2A1/SLCO2A1 Is Essential for Body Temperature Regulation during Fever
Yoshinobu Nakamura, T. Nakanishi, Hiroaki Shimada, Junya Shimizu +6 more
2018Journal of Neuroscience37 citations Open access
Semantic Scholar
Functional expression of organic cation/carnitine transporter 2 (OCTN2/SLC22A5) in human brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model.
T. Okura, Sayaka Kato, Y. Deguchi
2014Drug Metabolism and Pharmacokinetics33 citations
Semantic Scholar
Cocktail-Dosing Microdialysis Study to Simultaneously Assess Delivery of Multiple Organic-Cationic Drugs to the Brain.
Atsushi Kitamura, T. Okura, K. Higuchi, Y. Deguchi
2016Journal of Pharmacy and Science30 citations Open access
Semantic Scholar
Different distribution of morphine and morphine‐6β‐glucuronide after intracerebroventricular injection in rats
T. Okura, M. Saito, Misato Nakanishi, Noriyuki Komiyama +3 more
2003British Journal of Pharmacology29 citations Open access
Semantic Scholar
Enhancement by grapefruit juice of morphine antinociception.
T. Okura, Tadahiro Ozawa, Yoshihiko Ito, M. Kimura +2 more
2008Biological and Pharmaceutical Bulletin27 citations Open access
Semantic Scholar
Agonist-specific down-regulation of the human δ-opioid receptor
T. Okura, E. Varga, Y. Hosohata, E. Navratilova +6 more
200326 citations
Semantic Scholar
Proton-coupled organic cation antiporter-mediated uptake of apomorphine enantiomers in human brain capillary endothelial cell line hCMEC/D3.
T. Okura, K. Higuchi, Atsushi Kitamura, Y. Deguchi
2014Biological and Pharmaceutical Bulletin23 citations Open access
Semantic Scholar
Drug-drug interaction between oxycodone and adjuvant analgesics in blood-brain barrier transport and antinociceptive effect.
Yusuke Nakazawa, T. Okura, Keita Shimomura, T. Terasaki +1 more
2010Journal of Pharmacy and Science23 citations Open access
Semantic Scholar
Differential down-regulation of the human δ-opioid receptor by SNC80 and [d-Pen2,d-Pen5]enkephalin
T. Okura, S. Cowell, E. Varga, T. Burkey +3 more
200023 citations
Semantic Scholar
Involvement of Proton-Coupled Organic Cation Antiporter in Varenicline Transport at Blood-Brain Barrier of Rats and in Human Brain Capillary Endothelial Cells.
Toshiki Kurosawa, K. Higuchi, T. Okura, Kazumasa Kobayashi +2 more
2017Journal of Pharmacy and Science22 citations Open access
Semantic Scholar
Histamine elimination from the cerebrospinal fluid across the blood–cerebrospinal fluid barrier: involvement of plasma membrane monoamine transporter (PMAT/SLC29A4)
Takuya Usui, Ayumi Nakazawa, T. Okura, Y. Deguchi +3 more
2016Journal of Neurochemistry21 citations
Semantic Scholar
Effects of repeated morphine treatment on the antinociceptive effects, intestinal absorption, and efflux from intestinal epithelial cells of morphine.
T. Okura, Tadahiro Ozawa, M. Ibe, Yuko Taki +4 more
2009Biological and Pharmaceutical Bulletin17 citations Open access
Semantic Scholar
Prediction of α1-Adrenoceptor Occupancy in the Human Prostate from Plasma Concentrations of Silodosin, Tamsulosin and Terazosin to Treat Urinary Obstruction in Benign Prostatic Hyperplasia
S. Yamada, Yasuhiro Kato, T. Okura, Y. Kagawa +1 more
200717 citations Open access
Semantic Scholar
Possible Involvement of Muscarinic Receptor Blockade in Mirabegron Therapy for Patients with Overactive Bladder
S. Yamada, Junko Chimoto, Mizuki Shiho, T. Okura +3 more
2021Journal of Pharmacology and Experimental Therapeutics15 citations Open access
Semantic Scholar
Selective and sustained occupancy of prostatic α1‐adrenoceptors by oral administration of KMD‐3213 and its plasma concentration in rats
T. Okura, S. Yamada, Y. Abe, Ryohei Kimura
2002The Journal of pharmacy and pharmacology15 citations
Semantic Scholar
Muscarinic receptor binding activity in rat tissues by vibegron and prediction of its receptor occupancy levels in the human bladder
S. Yamada, Junko Chimoto, Mizuki Shiho, T. Okura +3 more
2021International journal of urology14 citations Open access
Semantic Scholar
Effects of quinidine on antinociception and pharmacokinetics of morphine in rats
T. Okura, Y. Morita, Yoshihiko Ito, Y. Kagawa +1 more
200914 citations Open access
Semantic Scholar
Agonist-specific down-regulation of the human delta-opioid receptor.
T. Okura, E. Varga, Y. Hosohata, E. Navratilova +6 more
2003European Journal of Pharmacology14 citations
Semantic Scholar
Comparative measurement of spinal CSF microdialysate concentrations and concomitant antinociception of morphine and morphine-6beta-glucuronide in rats.
T. Okura, Noriyuki Komiyama, Y. Morita, M. Kimura +2 more
2007Life Science13 citations
Semantic Scholar
In vivo demonstration of alpha(1A)-adrenoceptor subtype selectivity of KMD-3213 in rat tissues.
S. Yamada, T. Okura, R. Kimura
2001Journal of Pharmacology and Experimental Therapeutics11 citations
Semantic Scholar
A Possible Mechanism for the Decrease in Serum Thyroxine Level by a 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Like Polychlorinated Biphenyl Congener, 3,3′,4,4′,5-Pentachlorobiphenyl in Mice
Y. Kato, K. Haraguchi, Makiko Kubota, Yoshiki Seto +5 more
2010Drug Metabolism And Disposition10 citations
Semantic Scholar
[The blood-brain barrier transport mechanism controlling analgesic effects of opioid drugs in CNS].
T. Okura, K. Higuchi, Y. Deguchi
2015Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan8 citations Open access
Semantic Scholar
Different effects of morphine and morphine-6beta-glucuronide on formalin-evoked spinal glutamate release in conscious and freely moving rats.
T. Okura, Noriyuki Komiyama, Y. Morita, M. Kimura +1 more
2007Neuroscience Letters7 citations Open access
Semantic Scholar
Muscarinic receptor binding of the novel radioligand, [3h]imidafenacin in the human bladder and parotid gland.
A. Yoshida, S. Kuraoka, Yoshihiko Ito, T. Okura +7 more
2014Journal of Pharmacological Sciences6 citations Open access
Semantic Scholar
Endothelin-1 receptors in rat tissues: characterization by bosentan, ambrisentan and CI-1020.
Yoshinari Yokoyama, A. Osano, Hideki Hayashi, K. Itoh +4 more
2014Biological and Pharmaceutical Bulletin5 citations Open access
Semantic Scholar
Effects of quinidine on antinociception and pharmacokinetics of morphine in rats.
T. Okura, Y. Morita, Yoshihiko Ito, Y. Kagawa +1 more
2009The Journal of pharmacy and pharmacology5 citations Open access
Semantic Scholar
Prediction of alpha1-adrenoceptor occupancy in the human prostate from plasma concentrations of silodosin, tamsulosin and terazosin to treat urinary obstruction in benign prostatic hyperplasia.
S. Yamada, Yasuhiro Kato, T. Okura, Y. Kagawa +1 more
2007Biological and Pharmaceutical Bulletin5 citations
Semantic Scholar
Relationship between Prostatic α1-Adrenoceptor Binding and Reduction in Intraurethral Pressure following Continuous Infusion of KMD-3213 in Rats
K. Akiyama, S. Tatemichi, S. Katayama, M. Nakajima +4 more
2002Pharmacology5 citations
Semantic Scholar
Differential down-regulation of the human delta-opioid receptor by SNC80 and [D-Pen(2),D-Pen(5)]enkephalin.
T. Okura, S. Cowell, E. Varga, T. Burkey +3 more
2000European Journal of Pharmacology5 citations
Semantic Scholar
Muscarinic Receptor Binding and Plasma Drug Concentration after the Oral Administration of Propiverine in Mice
Yoshihiko Ito, Aya Kato, Tomomi Fujino Oki, T. Okura +3 more
2010Lower urinary tract symptoms4 citations
Semantic Scholar
Effects of Anticholinergic Drugs Used for the Therapy of Overactive Bladder on P-Glycoprotein Activity.
H. Wakuda, T. Okura, Kana Maruyama-Fumoto, S. Kagota +6 more
2019Biological and Pharmaceutical Bulletin3 citations Open access
Semantic Scholar
Naltrexone Transport by a Proton-Coupled Organic Cation Antiporter in hCMEC/D3 Cells, an in Vitro Human Blood-Brain Barrier Model.
Atsushi Kitamura, K. Higuchi, Toshiki Kurosawa, T. Okura +2 more
2022Biological and Pharmaceutical Bulletin2 citations Open access
Semantic Scholar
Bladder endothelin-1 receptor binding of bosentan and ambrisentan.
A. Osano, Yoshinari Yokoyama, Hideki Hayashi, K. Itoh +4 more
2014Journal of Pharmacological Sciences1 citations Open access
Semantic Scholar
Disposition and α1-Adrenoceptor Binding Characteristics of JTH-601 and Its Metabolites in Rat Tissues
Shizuo Yamada, T. Okura, Ryohei Kimura, Y. Deguchi +3 more
2000Drug Metabolism And Disposition1 citations Open access
Semantic Scholar
Histamine H1-receptor signaling in human blood-brain barrier cells
T. Okura
20150 citations
Semantic Scholar
WITHDRAWN: Memantine uptake mediated by a functionally diverse proton-coupled organic cation antiporter in human brain endothelial cells
K. Higuchi, T. Okura, Y. Deguchi
20150 citations Open access
Semantic Scholar
Pharmacokinetic and Pharmacodynamic Interaction of Functional Foods with Medicines
S. Yamada, Yuko Taki, S. Misaka, T. Okura +5 more
20130 citations
Semantic Scholar
ヒト脳毛細血管内皮細胞株hCMEC/D3を用いたヒトにおけるカチオン性薬物の血液脳関門透過性の予測 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
T. Okura, Keita Shimomura, K. Higuchi, Couraud Pierre-Oliver +1 more
20120 citations
Semantic Scholar
A Possible Mechanism for the Decrease in Serum Thyroxine Level by a 2,3,7,8-Tetrachlorodibenzo- p -dioxin-Like Polychlorinated Biphenyl Congener, 3,3 (cid:1) ,4,4 (cid:1) ,5-Pentachlorobiphenyl in Mice
Y. Kato, K. Haraguchi, Makiko Kubota, Yoshiki Seto +5 more
20090 citations
Semantic Scholar
Reduction Process of Gypsum with Polyethylene at High Temperature
K. Uotani, S. Ueda, K. Yamaguchi, T. Okura
20080 citations Open access
Semantic Scholar

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Y. Deguchi×25
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Y. Deguchi — researcher profile on SciRah
S. Yamada×25
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S. Yamada — researcher profile on SciRah
K. Higuchi×10
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K. Higuchi — researcher profile on SciRah
Yoshihiko Ito×8
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Yoshihiko Ito — researcher profile on SciRah

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T. Terasaki — researcher profile on SciRah

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Y. Kagawa — researcher profile on SciRah

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R. Kimura — researcher profile on SciRah

Atsushi Kitamura×5

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Atsushi Kitamura — researcher profile on SciRah

Keita Shimomura×4

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Keita Shimomura — researcher profile on SciRah

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Sayaka Kato — researcher profile on SciRah

K. Shinozuka×4

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M. Kimura — researcher profile on SciRah