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Y. Deguchi · SciRah

Researcher profile · Semantic Scholar

Y. Deguchi

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Y. Deguchi — researcher profile on SciRah

h-index: 32
Works: 126
Citations: 2,721

Most-cited papers

Involvement of the Pyrilamine Transporter, a Putative Organic Cation Transporter, in Blood-Brain Barrier Transport of Oxycodone
T. Okura, Asami Hattori, Yusuke Takano, Takenori Sato +3 more
2008Drug Metabolism And Disposition167 citations
Semantic Scholar
Positively charged gelatin microspheres as gastric mucoadhesive drug delivery system for eradication of H. pylori.
Jian Wang, Y. Tauchi, Y. Deguchi, K. Morimoto +2 more
2000Drug Delivery114 citations Open access
Semantic Scholar
Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo.
M. W. Sadiq, Annika Borgs, T. Okura, Keita Shimomura +6 more
2011Journal of Pharmacy and Science92 citations Open access
Semantic Scholar
Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood–brain barrier model
Keita Shimomura, T. Okura, Sayaka Kato, P. Couraud +3 more
2013Fluids and Barriers of the CNS68 citations Open access
Semantic Scholar
Internalization of basic fibroblast growth factor at the mouse blood–brain barrier involves perlecan, a heparan sulfate proteoglycan
Y. Deguchi, Hiroshi Okutsu, T. Okura, S. Yamada +8 more
2002Journal of Neurochemistry67 citations Open access
Semantic Scholar
Epidermal growth factor radiopharmaceuticals: 111In chelation, conjugation to a blood-brain barrier delivery vector via a biotin-polyethylene linker, pharmacokinetics, and in vivo imaging of experimental brain tumors.
Atsushi Kurihara, Y. Deguchi, W. Pardridge
1999Bioconjugate chemistry67 citations
Semantic Scholar
Blood-Brain Barrier Transport of 125I-Labeled Basic Fibroblast Growth Factor
Y. Deguchi, T. Naito, T. Yuge, Akihiko Furukawa +3 more
2004Pharmaceutical Research66 citations Open access
Semantic Scholar
Efficient drug delivery to atherosclerotic lesions and the antiatherosclerotic effect by dexamethasone incorporated into liposomes in atherogenic mice
S. Chono, Y. Tauchi, Y. Deguchi, K. Morimoto
2005Journal of drug targeting (Print)64 citations
Semantic Scholar
Determination of lipophilicity of two quinolone antibacterials, ciprofloxacin and grepafloxacin, in the protonation equilibrium.
Jin Sun, Shigeko Sakai, Y. Tauchi, Y. Deguchi +3 more
2002European journal of pharmaceutics and biopharmaceutics62 citations Open access
Semantic Scholar
Transport characteristics of tramadol in the blood-brain barrier.
Atsushi Kitamura, K. Higuchi, T. Okura, Y. Deguchi
2014Journal of Pharmacy and Science55 citations Open access
Semantic Scholar
Blood-brain barrier transport of pramipexole, a dopamine D2 agonist.
T. Okura, Rieno Ito, N. Ishiguro, I. Tamai +1 more
2007Life Science54 citations
Semantic Scholar
Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line
Yu Takahashi, T. Nishimura, K. Higuchi, Saki Noguchi +4 more
2018Pharmaceutical Research50 citations Open access
Semantic Scholar
Brain distribution of 6-mercaptopurine is regulated by the efflux transport system in the blood-brain barrier.
Y. Deguchi, Yoshinari Yokoyama, T. Sakamoto, Hideki Hayashi +3 more
2000Life Science50 citations Open access
Semantic Scholar
Aminated gelatin as a nasal absorption enhancer for peptide drugs: evaluation of absorption enhancing effect and nasal mucosa perturbation in rats
Jian Wang, Shigeko Sakai, Y. Deguchi, Dian-zhou Bi +2 more
2002The Journal of pharmacy and pharmacology49 citations
Semantic Scholar
Expression and Functional Characterization of Drug Transporters in Brain Microvascular Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.
Toshiki Kurosawa, Yuma Tega, K. Higuchi, Tomoko Yamaguchi +5 more
2018Molecular Pharmaceutics45 citations Open access
Semantic Scholar
Retention of biologic activity of human epidermal growth factor following conjugation to a blood-brain barrier drug delivery vector via an extended poly(ethylene glycol) linker.
Y. Deguchi, Atsushi Kurihara, W. Pardridge
1999Bioconjugate chemistry44 citations
Semantic Scholar
Memantine transport by a proton-coupled organic cation antiporter in hCMEC/D3 cells, an in vitro human blood-brain barrier model.
K. Higuchi, Atsushi Kitamura, T. Okura, Y. Deguchi
2015Drug Metabolism and Pharmacokinetics41 citations
Semantic Scholar
Functional characterization of rat plasma membrane monoamine transporter in the blood-brain and blood-cerebrospinal fluid barriers.
T. Okura, Sayaka Kato, Yusuke Takano, Takenori Sato +5 more
2011Journal of Pharmacy and Science41 citations Open access
Semantic Scholar
Prostaglandin Transporter OATP2A1/SLCO2A1 Is Essential for Body Temperature Regulation during Fever
Yoshinobu Nakamura, T. Nakanishi, Hiroaki Shimada, Junya Shimizu +6 more
2018Journal of Neuroscience37 citations Open access
Semantic Scholar
Functional expression of organic cation/carnitine transporter 2 (OCTN2/SLC22A5) in human brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model.
T. Okura, Sayaka Kato, Y. Deguchi
2014Drug Metabolism and Pharmacokinetics33 citations
Semantic Scholar
Pharmacokinetic interactions between warfarin and kangen-karyu, a Chinese traditional herbal medicine, and their synergistic action.
T. Makino, H. Wakushima, T. Okamoto, Yasuhiro Okukubo +2 more
2002Journal of Ethnopharmacology33 citations Open access
Semantic Scholar
Blood–brain barrier transport of a novel µ1‐specific opioid peptide, H‐Tyr‐d‐Arg‐Phe‐β‐Ala‐OH (TAPA)
Y. Deguchi, Y. Miyakawa, S. Sakurada, Y. Naito +4 more
200332 citations
Semantic Scholar
Improved Brain Delivery of a Nonsteroidal Anti-Inflammatory Drug with a Synthetic Glyceride Ester: a Preliminary Attempt at a CNS Drug Delivery System for the Therapy of Alzheimer's Disease
Y. Deguchi, Hideki Hayashi, Shinobu Fujii, T. Naito +3 more
2000Journal of drug targeting (Print)32 citations
Semantic Scholar
Cocktail-Dosing Microdialysis Study to Simultaneously Assess Delivery of Multiple Organic-Cationic Drugs to the Brain.
Atsushi Kitamura, T. Okura, K. Higuchi, Y. Deguchi
2016Journal of Pharmacy and Science30 citations Open access
Semantic Scholar
Construction and Functional Evaluation of a Three-Dimensional Blood–Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells
Toshiki Kurosawa, Daiki Sako, Yuma Tega, Yasuyuki Debori +5 more
2022Pharmaceutical Research29 citations Open access
Semantic Scholar
Application of in vivo brain microdialysis to the study of blood-brain barrier transport of drugs.
Y. Deguchi
2002Drug Metabolism and Pharmacokinetics28 citations
Semantic Scholar
In vivo measurement by [3H]Tamsulosin of alpha1 adrenoceptors in rat tissues in relation to the pharmacokinetics.
Shizuo Yamada, Takashi Ohkura, Y. Deguchi, Ryohei Kimura
1999Journal of Pharmacology and Experimental Therapeutics28 citations
Semantic Scholar
Ex vivo occupancy by tamsulosin of alpha1-adrenoceptors in rat tissues in relation to the plasma concentration.
T. Ohkura, S. Yamada, Y. Deguchi, R. Kimura +5 more
1998Life Science25 citations
Semantic Scholar
Design, Synthesis, and Blood-Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors.
Seiya Hiranaka, Yuma Tega, K. Higuchi, Toshiki Kurosawa +6 more
2018ACS Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Pharmacokinetic and pharmacological interactions between ticlopidine hydrochloride and Kangen‐Karyu – Chinese traditional herbal medicine
T. Makino, H. Wakushima, T. Okamoto, Yasuhiro Okukubo +2 more
2003Phytotherapy Research24 citations
Semantic Scholar
Proton-coupled organic cation antiporter-mediated uptake of apomorphine enantiomers in human brain capillary endothelial cell line hCMEC/D3.
T. Okura, K. Higuchi, Atsushi Kitamura, Y. Deguchi
2014Biological and Pharmaceutical Bulletin23 citations Open access
Semantic Scholar
Drug-drug interaction between oxycodone and adjuvant analgesics in blood-brain barrier transport and antinociceptive effect.
Yusuke Nakazawa, T. Okura, Keita Shimomura, T. Terasaki +1 more
2010Journal of Pharmacy and Science23 citations Open access
Semantic Scholar
Involvement of Proton-Coupled Organic Cation Antiporter in Varenicline Transport at Blood-Brain Barrier of Rats and in Human Brain Capillary Endothelial Cells.
Toshiki Kurosawa, K. Higuchi, T. Okura, Kazumasa Kobayashi +2 more
2017Journal of Pharmacy and Science22 citations Open access
Semantic Scholar
Ependymal cells of the mouse brain express urate transporter 1 (URAT1)
Naoko H. Tomioka, M. Nakamura, M. Doshi, Y. Deguchi +3 more
2013Fluids and Barriers of the CNS22 citations Open access
Semantic Scholar
Histamine elimination from the cerebrospinal fluid across the blood–cerebrospinal fluid barrier: involvement of plasma membrane monoamine transporter (PMAT/SLC29A4)
Takuya Usui, Ayumi Nakazawa, T. Okura, Y. Deguchi +3 more
2016Journal of Neurochemistry21 citations
Semantic Scholar
Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier
Tatsuki Mochizuki, T. Mizuno, Toshiki Kurosawa, Tomoko Yamaguchi +6 more
2020Drug Metabolism And Disposition19 citations Open access
Semantic Scholar
Distribution characteristics of grepafloxacin, a fluoroquinolone antibiotic, in lung epithelial lining fluid and alveolar macrophage.
Y. Deguchi, Jin Sun, Y. Tauchi, Shigeko Sakai +1 more
2003Drug Metabolism and Pharmacokinetics19 citations
Semantic Scholar
Application of an in vivo brain microdialysis technique to studies of drug transport across the blood-brain barrier.
Y. Deguchi, K. Morimoto
2001Current drug metabolism17 citations
Semantic Scholar
Brain receptor binding characteristics and pharmacokinetic-pharmacodynamic analysis of thyrotropin-releasing hormone analogues.
A. Urayama, Shizuo Yamada, Kazufumi Hirano, Y. Deguchi +1 more
2001Life Science17 citations
Semantic Scholar
Structural Requirements for Uptake of Diphenhydramine Analogs into hCMEC/D3 Cells Via the Proton-Coupled Organic Cation Antiporter.
Yuma Tega, H. Tabata, Toshiki Kurosawa, Atsushi Kitamura +3 more
2020Journal of Pharmacy and Science16 citations Open access
Semantic Scholar
Fibronectin is essential for formation of fenestrae in endothelial cells of the fenestrated capillary
T. Nakakura, Takeshi Suzuki, Hideyuki Tanaka, K. Arisawa +6 more
2020Cell and Tissue Research15 citations Open access
Semantic Scholar
Blood-Brain Barrier Permeability of Novel [d-Arg2]Dermorphin (1-4) Analogs: Transport Property Is Related to the Slow Onset of Antinociceptive Activity in the Central Nervous System
Y. Deguchi, Y. Naito, S. Ohtsuki, Y. Miyakawa +4 more
2004Journal of Pharmacology and Experimental Therapeutics15 citations Open access
Semantic Scholar
Proteomics-Based Transporter Identification by the PICK Method: Involvement of TM7SF3 and LHFPL6 in Proton-Coupled Organic Cation Antiport at the Blood–Brain Barrier
Toshiki Kurosawa, Yuma Tega, Yasuo Uchida, K. Higuchi +5 more
2022Pharmaceutics14 citations Open access
Semantic Scholar
Comparative measurement of spinal CSF microdialysate concentrations and concomitant antinociception of morphine and morphine-6beta-glucuronide in rats.
T. Okura, Noriyuki Komiyama, Y. Morita, M. Kimura +2 more
2007Life Science13 citations
Semantic Scholar
Protonation equilibrium and lipophilicity of olamufloxacin (HSR-903), a newly synthesized fluoroquinolone antibacterial.
Jin Sun, Shigeko Sakai, Y. Tauchi, Y. Deguchi +3 more
2003European journal of pharmaceutics and biopharmaceutics13 citations
Semantic Scholar
Distribution characteristics of orally administered olamufloxacin, a newly synthesized fluoroquinolone antibacterial, in lung epithelial lining fluid and alveolar macrophage in rats.
Jin Sun, Y. Deguchi, Y. Tauchi, Zhong-Gui He +2 more
2006European journal of pharmaceutics and biopharmaceutics12 citations Open access
Semantic Scholar
Genetic deficiency of carnitine/organic cation transporter 2 (slc22a5) is associated with altered tissue distribution of its substrate pyrilamine in mice
Sayaka Kato, Y. Kato, Tadakatsu Nakamura, T. Sugiura +3 more
2009Biopharmaceutics & drug disposition11 citations Open access
Semantic Scholar
Blood-brain permeability of [3H]-(3-methyl-His2)thyrotropin-releasing hormone (MeTRH) in mice: effects of TRH and its analogues.
A. Urayama, S. Yamada, Y. Ohmori, Y. Deguchi +2 more
2003Drug Metabolism and Pharmacokinetics10 citations Open access
Semantic Scholar
Studies on the transport of thyrotropin‐releasing hormone (TRH) analogues in Caco‐2 cell monolayers
A. Urayama, S. Yamada, Y. Deguchi, Y. Ohmori +1 more
2003The Journal of pharmacy and pharmacology10 citations Open access
Semantic Scholar
Brain receptor binding characteristics and pharmacokinetics of JTP-2942, a novel thyrotropin-releasing hormone (TRH) analogue.
A. Urayama, Shizuo Yamada, Y. Deguchi, Ryohei Kimura +2 more
1999Life Science10 citations
Semantic Scholar

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T. Okura×16
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T. Okura — researcher profile on SciRah
K. Morimoto×11
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K. Higuchi×11
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K. Higuchi — researcher profile on SciRah
T. Terasaki×9
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T. Terasaki — researcher profile on SciRah

Toshiki Kurosawa

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Yuma Tega — researcher profile on SciRah

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S. Yamada — researcher profile on SciRah

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Y. Tauchi — researcher profile on SciRah

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Sayaka Kato — researcher profile on SciRah

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