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Y. Higuchi · SciRah

Researcher profile · Semantic Scholar

Y. Higuchi

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Y. Higuchi — researcher profile on SciRah

h-index: 28
Works: 99
Citations: 2,543

Most-cited papers

Luminescent proteins for high-speed single-cell and whole-body imaging
Kenta Saito, Y-F. Chang, Kazuki Horikawa, N. Hatsugai +6 more
2012Nature Communications289 citations Open access
Semantic Scholar
Efficient gene transfection by histidine-modified chitosan through enhancement of endosomal escape.
Kai-Ling Chang, Y. Higuchi, S. Kawakami, F. Yamashita +1 more
2010Bioconjugate chemistry147 citations
Semantic Scholar
Nonviral approaches for targeted delivery of plasmid DNA and oligonucleotide.
S. Kawakami, Y. Higuchi, M. Hashida
2008Journal of Pharmacy and Science143 citations
Semantic Scholar
Strategies for In Vivo Delivery of siRNAs
Y. Higuchi, S. Kawakami, M. Hashida
2010BioDrugs137 citations
Semantic Scholar
Systemic Targeting of Lymph Node Metastasis through the Blood Vascular System by Using Size-Controlled Nanocarriers.
H. Cabral, Jun Makino, Yu Matsumoto, P. Mi +11 more
2015ACS Nano136 citations Open access
Semantic Scholar
piggyBac Transposon-mediated Long-term Gene Expression in Mice
Hideyuki Nakanishi, Y. Higuchi, S. Kawakami, F. Yamashita +1 more
2010Molecular Therapy98 citations Open access
Semantic Scholar
Novel histidine-conjugated galactosylated cationic liposomes for efficient hepatocyte-selective gene transfer in human hepatoma HepG2 cells.
Kosuke Shigeta, S. Kawakami, Y. Higuchi, Tatsuya Okuda +3 more
2007Journal of Controlled Release88 citations
Semantic Scholar
Photothermic regulation of gene expression triggered by laser-induced carbon nanohorns
Eijiro Miyako, Tomonori Deguchi, Y. Nakajima, M. Yudasaka +9 more
2012Proceedings of the National Academy of Sciences of the United States of America86 citations Open access
Semantic Scholar
Gamma-polyglutamic acid-coated vectors for effective and safe gene therapy.
Tomoaki Kurosaki, T. Kitahara, S. Kawakami, Y. Higuchi +6 more
2010Journal of Controlled Release86 citations Open access
Semantic Scholar
Enhanced Anti-Inflammation of Inhaled Dexamethasone Palmitate Using Mannosylated Liposomes in an Endotoxin-Induced Lung Inflammation Model
W. Wijagkanalan, Y. Higuchi, S. Kawakami, Mugen Teshima +2 more
2008Molecular Pharmacology67 citations
Semantic Scholar
Mannosylated semiconductor quantum dots for the labeling of macrophages.
Y. Higuchi, M. Oka, S. Kawakami, M. Hashida
2008Journal of Controlled Release61 citations
Semantic Scholar
Intratracheally instilled mannosylated cationic liposome/NFκB decoy complexes for effective prevention of LPS-induced lung inflammation.
W. Wijagkanalan, S. Kawakami, Y. Higuchi, F. Yamashita +1 more
2011Journal of Controlled Release60 citations
Semantic Scholar
Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer.
Tomoaki Kurosaki, N. Higuchi, S. Kawakami, Y. Higuchi +4 more
2012Gene48 citations Open access
Semantic Scholar
Polyamidoamine dendrimer-conjugated quantum dots for efficient labeling of primary cultured mesenchymal stem cells.
Y. Higuchi, Can Wu, Kai-Ling Chang, K. Irie +3 more
2011Biomaterials48 citations Open access
Semantic Scholar
Uptake characteristics of mannosylated and fucosylated bovine serum albumin in primary cultured rat sinusoidal endothelial cells and Kupffer cells.
Y. Higuchi, M. Nishikawa, S. Kawakami, F. Yamashita +1 more
2004International journal of pharmaceutics47 citations
Semantic Scholar
The potential role of fucosylated cationic liposome/NFkappaB decoy complexes in the treatment of cytokine-related liver disease.
Y. Higuchi, S. Kawakami, F. Yamashita, M. Hashida
2007Biomaterials46 citations
Semantic Scholar
Development of lysine-histidine dendron modified chitosan for improving transfection efficiency in HEK293 cells.
Kai-Ling Chang, Y. Higuchi, S. Kawakami, F. Yamashita +1 more
2011Journal of Controlled Release45 citations
Semantic Scholar
Encapsulation of the synthetic retinoids Am80 and LE540 into polymeric micelles and the retinoids' release control.
T. Satoh, Y. Higuchi, S. Kawakami, M. Hashida +3 more
2009Journal of Controlled Release43 citations
Semantic Scholar
In vitro evaluation of inhibitory effect of nuclear factor-kappaB activity by small interfering RNA on pro-tumor characteristics of M2-like macrophages.
Y. Kono, S. Kawakami, Y. Higuchi, F. Yamashita +1 more
2014Biological and Pharmaceutical Bulletin40 citations Open access
Semantic Scholar
Efficient suppression of murine intracellular adhesion molecule‐1 using ultrasound‐responsive and mannose‐modified lipoplexes inhibits acute hepatic inflammation
K. Un, S. Kawakami, Mitsuru Yoshida, Y. Higuchi +4 more
2012Hepatology40 citations Open access
Semantic Scholar
PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma
Masaharu Kawashima, J. Carreras, H. Higuchi, R. Kotaki +17 more
2020Leukemia39 citations
Semantic Scholar
Intravenous administration of mannosylated cationic liposome/NFκB decoy complexes effectively prevent LPS‐induced cytokine production in a murine liver failure model
Y. Higuchi, S. Kawakami, M. Oka, Y. Yabe +2 more
2006FEBS Letters38 citations
Semantic Scholar
Effect of the particle size of galactosylated lipoplex on hepatocyte-selective gene transfection after intraportal administration.
Y. Higuchi, S. Kawakami, S. Fumoto, F. Yamashita +1 more
2006Biological and Pharmaceutical Bulletin37 citations Open access
Semantic Scholar
The development of mechanically formed stable nanobubbles intended for sonoporation-mediated gene transfection
R. Abdalkader, S. Kawakami, J. Unga, Y. Higuchi +4 more
2017Drug Delivery35 citations Open access
Semantic Scholar
Neutralized Nanoparticle Composed of SS‐Cleavable and pH‐Activated Lipid‐Like Material as a Long‐Lasting and Liver‐Specific Gene Delivery System
Masami Ukawa, H. Akita, Y. Hayashi, R. Ishiba +8 more
2014Advanced Healthcare Materials32 citations
Semantic Scholar
Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles.
T. Okuda, S. Kawakami, Y. Higuchi, T. Satoh +4 more
2009International journal of pharmaceutics32 citations
Semantic Scholar
Interaction with Blood Components Plays a Crucial Role in Asialoglycoprotein Receptor-Mediated in Vivo Gene Transfer by Galactosylated Lipoplex
S. Fumoto, S. Kawakami, Kosuke Shigeta, Y. Higuchi +2 more
2005Journal of Pharmacology and Experimental Therapeutics29 citations
Semantic Scholar
Evaluation of proinflammatory cytokine production and liver injury induced by plasmid DNA/cationic liposome complexes with various mixing ratios in mice.
Yoshitaka Ito, S. Kawakami, Pensri Charoensit, Y. Higuchi +1 more
2009European journal of pharmaceutics and biopharmaceutics28 citations
Semantic Scholar
Enhancement of the anti-tumor effect of DNA vaccination using an ultrasound-responsive mannose-modified gene carrier in combination with doxorubicin-encapsulated PEGylated liposomes.
Mitsuru Yoshida, S. Kawakami, Y. Kono, K. Un +4 more
2014International journal of pharmaceutics27 citations
Semantic Scholar
Development of anionic bubble lipopolyplexes for efficient and safe gene transfection with ultrasound exposure in mice.
Tomoaki Kurosaki, S. Kawakami, Y. Higuchi, R. Suzuki +4 more
2014Journal of Controlled Release27 citations Open access
Semantic Scholar
Biodistribution characteristics of mannosylated and fucosylated O/W emulsions in mice
Wassana Yeeprae, S. Kawakami, Y. Higuchi, F. Yamashita +1 more
2005Journal of drug targeting (Print)26 citations
Semantic Scholar
Synthesis and Functional Characterization of Novel Sialyl LewisX Mimic-Decorated Liposomes for E-selectin-Mediated Targeting to Inflamed Endothelial Cells.
Chanikarn Chantarasrivong, A. Ueki, Ryutaro Ohyama, J. Unga +10 more
2017Molecular Pharmaceutics25 citations
Semantic Scholar
The elucidation of gene transferring mechanism by ultrasound-responsive unmodified and mannose-modified lipoplexes.
K. Un, S. Kawakami, Mitsuru Yoshida, Y. Higuchi +4 more
2011Biomaterials24 citations
Semantic Scholar
Development of fluorous lipid-based nanobubbles for efficiently containing perfluoropropane.
Y. Oda, R. Suzuki, Tatsuya Mori, Hideyo Takahashi +10 more
2015International journal of pharmaceutics23 citations Open access
Semantic Scholar
Enhanced gene transfection in macrophages by histidine-conjugated mannosylated cationic liposomes.
Kazumi Nakamura, Yukari Kuramoto, Hidefumi Mukai, S. Kawakami +2 more
2009Biological and Pharmaceutical Bulletin22 citations Open access
Semantic Scholar
Tumour-associated macrophages targeted transfection with NF-κB decoy/mannose-modified bubble lipoplexes inhibits tumour growth in tumour-bearing mice
Y. Kono, S. Kawakami, Y. Higuchi, K. Maruyama +2 more
2014Journal of drug targeting (Print)20 citations
Semantic Scholar
Involvement of activated transcriptional process in efficient gene transfection using unmodified and mannose-modified bubble lipoplexes with ultrasound exposure.
K. Un, S. Kawakami, Y. Higuchi, R. Suzuki +3 more
2011Journal of Controlled Release18 citations Open access
Semantic Scholar
Evaluation of Osteoclastogenesis via NFκB Decoy/mannosylated Cationic Liposome-Mediated Inhibition of Pro-inflammatory Cytokine Production from Primary Cultured Macrophages
T. Dinh, Y. Higuchi, S. Kawakami, F. Yamashita +1 more
2011Pharmaceutical Research17 citations Open access
Semantic Scholar
Kidney-selective gene transfection using anionic bubble lipopolyplexes with renal ultrasound irradiation in mice.
Tomoaki Kurosaki, S. Kawakami, Y. Higuchi, R. Suzuki +4 more
2014Nanomedicine: Nanotechnology, Biology and Medicine16 citations
Semantic Scholar
Antitumor effect of nuclear factor-κB decoy transfer by mannose-modified bubble lipoplex into macrophages in mouse malignant ascites
Y. Kono, S. Kawakami, Y. Higuchi, K. Maruyama +2 more
2014Cancer Science16 citations Open access
Semantic Scholar
Immunostimulatory Characteristics Induced by Linear Polyethyleneimine–Plasmid DNA Complexes in Cultured Macrophages
Yasunori Saito, Y. Higuchi, S. Kawakami, F. Yamashita +1 more
2008Human Gene Therapy15 citations
Semantic Scholar
The involvement of NK cell activation following intranasal administration of CpG DNA lipoplex in the prevention of pulmonary metastasis and peritoneal dissemination in mice
Shuwen Zhou, S. Kawakami, Y. Higuchi, F. Yamashita +1 more
2011Clinical and Experimental Metastasis14 citations
Semantic Scholar
An Evolutionary Search Algorithm for Covariate Models in Population Pharmacokinetic Analysis.
F. Yamashita, Atsuto Fujita, Yukako Sasa, Y. Higuchi +2 more
2017Journal of Pharmacy and Science13 citations
Semantic Scholar
Bovine serum albumin as a lyoprotectant for preparation of DNA dry powder formulations using the spray-freeze drying method.
M. Tsukamoto, T. Okuda, H. Okamoto, Y. Higuchi +3 more
2012Biological and Pharmaceutical Bulletin13 citations Open access
Semantic Scholar
Development of a suction device for stabilizing in vivo real-time imaging of murine tissues.
K. Shimizu, Y. Higuchi, Y. Kozu, M. Hashida +1 more
2011Journal of Bioscience and Bioengineering13 citations
Semantic Scholar
NFkappaB decoy delivery using dendritic poly(l-lysine) for treatment of endotoxin-induced hepatitis in mice.
Yusuke Sugao, Kazuto Watanabe, Y. Higuchi, Ryohsuke Kurihara +4 more
2009Bioorganic & Medicinal Chemistry13 citations
Semantic Scholar
Suppressive effects of sugar-modified cationic liposome/NF-kappaB decoy complexes on adenovirus vector-induced innate immune responses.
Haiying Huang, F. Sakurai, Y. Higuchi, S. Kawakami +3 more
2009Journal of Controlled Release13 citations
Semantic Scholar
Prediction of HIV drug resistance based on the 3D protein structure: Proposal of molecular field mapping
Ryosaku Ota, Kanako So, Masahiro Tsuda, Y. Higuchi +1 more
2021PLoS ONE12 citations Open access
Semantic Scholar
Comparison of piggyBac transposition efficiency between linear and circular donor vectors in mammalian cells.
Hideyuki Nakanishi, Y. Higuchi, S. Kawakami, F. Yamashita +1 more
2011Journal of Biotechnology12 citations
Semantic Scholar
Intracellular distribution of NFκB decoy and its inhibitory effect on TNFα production by LPS stimulated RAW 264.7 cells
Y. Higuchi, S. Kawakami, M. Nishikawa, F. Yamashita +1 more
200512 citations
Semantic Scholar

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M. Hashida×47
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F. Yamashita×34
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R. Suzuki — researcher profile on SciRah

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