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Adrien Herledan · SciRah

Researcher profile · Semantic Scholar

Adrien Herledan

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Adrien Herledan — researcher profile on SciRah

h-index: 17
Works: 31
Citations: 858

Most-cited papers

Receptor-interacting protein 140 differentially regulates estrogen receptor-related receptor transactivation depending on target genes.
A. Castet, Adrien Herledan, S. Bonnet, S. Jalaguier +2 more
2006Molecular Endocrinology108 citations Open access
Semantic Scholar
Dynamin 2 mutations associated with human diseases impair clathrin‐mediated receptor endocytosis
M. Bitoun, A. Durieux, Bernard Prudhon, J. Bevilacqua +6 more
2009Human Mutation88 citations Open access
Semantic Scholar
Catalytic Site Inhibition of Insulin Degrading Enzyme by a Small Molecule Induces Glucose Intolerance in Mice
R. Deprez-Poulain, N. Hennuyer, D. Bosc, W. Liang +26 more
2015Nature Communications83 citations Open access
Semantic Scholar
Genome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism
J. Chapuis, Amandine Flaig, B. Grenier-Boley, Fanny Eysert +35 more
2016Acta Neuropathologica72 citations Open access
Semantic Scholar
BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation
M. Sartori, T. Mendes, Shruti N. Desai, Alessia Lasorsa +21 more
2018bioRxiv63 citations Open access
Semantic Scholar
Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps
C. Ple, H. Tam, A. Vieira Da Cruz, Nina Compagne +16 more
2022Nature Communications59 citations Open access
Semantic Scholar
Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance.
M. Lasalle, Vanessa Hoguet, N. Hennuyer, F. Leroux +15 more
2017Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox.
Paul Hermant, D. Bosc, C. Piveteau, Ronan Gealageas +14 more
2017Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
New active leads for tuberculosis booster drugs by structure-based drug discovery.
N. Tatum, J. W. Liebeschuetz, J. Cole, Rosangela Frita +4 more
2017Organic and biomolecular chemistry27 citations Open access
Semantic Scholar
Structure-activity relationships of Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human Insulin-Degrading Enzyme
Julie Charton, Marion Gauriot, Jane Totobenazara, N. Hennuyer +17 more
2014European journal of medicinal chemistry27 citations Open access
Semantic Scholar
A highly sensitive near‐infrared fluorescent detection method to analyze signalling pathways by reverse‐phase protein array
L. Dupuy, C. Gauthier, Guillaume Durand, Astrid Musnier +5 more
2009Proteomics25 citations Open access
Semantic Scholar
Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening.
L. Faion, Kamel Djaout, Rosangela Frita, C. Pintiala +17 more
2020European journal of medicinal chemistry22 citations Open access
Semantic Scholar
Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic-Target Guided Synthesis
V. Camberlein, Charlotte Fleau-Tabey, Pierre Sierocki, Le-Nong Li +25 more
2022Angewandte Chemie20 citations Open access
Semantic Scholar
Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses
Lucile Brier, Haitham Hassan, X. Hanoulle, V. Landry +16 more
2023European journal of medicinal chemistry19 citations Open access
Semantic Scholar
Tricyclic SpiroLactams Kill Mycobacteria In Vitro and In Vivo by Inhibiting Type II NADH Dehydrogenases
Sushovan Dam, Salia Tangara, C. Hamela, Theo Hattabi +13 more
2022Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Identification of ebselen as a potent inhibitor of Insulin Degrading Enzyme by a drug repurposing screening
F. Leroux, D. Bosc, Terence Beghyn, Paul Hermant +12 more
2019European journal of medicinal chemistry19 citations Open access
Semantic Scholar
Identification of Small Inhibitory Molecules Targeting the Bfl-1 Anti-Apoptotic Protein That Alleviates Resistance to ABT-737
Anne-Laure Mathieu, O. Sperandio, Virginie Pottiez, Sophie Balzarin +9 more
2014Journal of biomolecular screening19 citations Open access
Semantic Scholar
Drug Target Engagement Using Coupled Cellular Thermal Shift Assay—Acoustic Reverse-Phase Protein Array
Adrien Herledan, Marine Andres, A. Lejeune-Dodge, F. Leroux +6 more
2019SLAS discovery : advancing life sciences R & D14 citations Open access
Semantic Scholar
A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2.
Hugues Prevet, M. Moune, A. Tanina, C. Kemmer +12 more
2019European journal of medicinal chemistry12 citations Open access
Semantic Scholar
Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps
C. Ple, H. Tam, A. Vieira Da Cruz, Nina Compagne +16 more
2022Nature Communications11 citations Open access
Semantic Scholar
Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure-Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor.
Vanessa Hoguet, M. Lasalle, Mathieu Maingot, Geoffroy Dequirez +19 more
2021Journal of Medicinal Chemistry10 citations
Semantic Scholar
Insulin‐degrading enzyme inhibition increases the unfolded protein response and favours lipid accumulation in the liver
Marine Andres, N. Hennuyer, K. Zibar, Marie Bicharel-Leconte +10 more
2024British Journal of Pharmacology9 citations Open access
Semantic Scholar
Rubrolone production by Dactylosporangium vinaceum: biosynthesis, modulation and possible biological function
Sophie Moureu, T. Caradec, X. Trivelli, H. Drobecq +11 more
2021Applied Microbiology and Biotechnology9 citations
Semantic Scholar
Identification of indole-based activators of insulin degrading enzyme.
Nicolas Kraupner, C. Dinh, X. Wen, V. Landry +12 more
2021European journal of medicinal chemistry8 citations Open access
Semantic Scholar
High-Throughput Quantitative Screening of Glucose-Stimulated Insulin Secretion and Insulin Content Using Automated MALDI-TOF Mass Spectrometry
C. Delannoy, E. Heuson, Adrien Herledan, F. Oger +8 more
2023bioRxiv6 citations Open access
Semantic Scholar
N-acylbenzimidazoles as selective Acylators of the catalytic cystein of the coronavirus 3CL protease.
Fatima-Zahra Chaibi, Lucile Brier, Paul Carré, Valérie Landry +16 more
2024European journal of medicinal chemistry4 citations Open access
Semantic Scholar
Small molecule MarR modulators potentiate metronidazole antibiotic activity in aerobic E. coli by inducing activation by the nitroreductase NfsA
Thibault Caradec, C. Ple, Giuseppe Sicoli, Ravil Petrov +7 more
2024Journal of Biological Chemistry3 citations Open access
Semantic Scholar
ERAP2 inhibitor -incorporated nanofibers: Characterization and biological assessment.
F. Vasconcelos, Laetitia Lesire, Adrien Herledan, C. Piveteau +3 more
2026International journal of pharmaceutics2 citations Open access
Semantic Scholar
High‐Content Screening for Protein‐Protein Interaction Modulators Using Proximity Ligation Assay in Primary Neurons
T. Mendes, Adrien Herledan, F. Leroux, B. Déprez +2 more
2020Current Protocols in Cell Biology2 citations
Semantic Scholar
Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma
Laetitia Lesire, R. Deprez-Poulain, D. Bosc, F. Leroux +25 more
2026British Journal of Pharmacology0 citations Open access
Semantic Scholar
Exploiting DprE2 pathway redundancy to enhance potency and overcome resistance to pretomanid in Mycobacterium tuberculosis
Kamel Djaout, Aurore Dreneau, L. Faion, Marion Prieri +22 more
2026npj Antimicrobials and Resistance0 citations Open access
Semantic Scholar

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