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R. Hartkoorn · SciRah

Researcher profile · Semantic Scholar

R. Hartkoorn

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R. Hartkoorn — researcher profile on SciRah

h-index: 32
Works: 90
Citations: 3,941

Most-cited papers

Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis
R. Hartkoorn, S. Uplekar, S. Cole
2014Antimicrobial Agents and Chemotherapy443 citations Open access
Semantic Scholar
Towards a new combination therapy for tuberculosis with next generation benzothiazinones
Vadim Makarov, Benoit Lechartier, Ming Zhang, J. Neres +13 more
2014EMBO Molecular Medicine355 citations Open access
Semantic Scholar
Towards a new tuberculosis drug: pyridomycin – nature's isoniazid
R. Hartkoorn, C. Sala, J. Neres, F. Pojer +6 more
2012EMBO Molecular Medicine179 citations Open access
Semantic Scholar
HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms
R. Hartkoorn, Wai-San Kwan, V. Shallcross, Ammara Chaikan +9 more
2010Pharmacogenetics & Genomics178 citations Open access
Semantic Scholar
Virulence Regulator EspR of Mycobacterium tuberculosis Is a Nucleoid-Associated Protein
B. Blasco, Jeffrey M. Chen, R. Hartkoorn, C. Sala +4 more
2012PLoS Pathogens139 citations Open access
Semantic Scholar
Differential drug susceptibility of intracellular and extracellular tuberculosis, and the impact of P-glycoprotein.
R. Hartkoorn, B. Chandler, A. Owen, S. Ward +3 more
2007Tuberculosis135 citations
Semantic Scholar
Simple Model for Testing Drugs against Nonreplicating Mycobacterium tuberculosis
C. Sala, Neeraj Dhar, R. Hartkoorn, Ming Zhang +3 more
2010Antimicrobial Agents and Chemotherapy132 citations Open access
Semantic Scholar
2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1.
J. Neres, R. Hartkoorn, L. Chiarelli, Ramakrishna Gadupudi +25 more
2015ACS Chemical Biology131 citations Open access
Semantic Scholar
Low Levels of Pyrazinamide and Ethambutol in Children with Tuberculosis and Impact of Age, Nutritional Status, and Human Immunodeficiency Virus Infection
S. Graham, D. J. Bell, S. K. Nyirongo, R. Hartkoorn +2 more
2006Antimicrobial Agents and Chemotherapy124 citations Open access
Semantic Scholar
In Vitro Combination Studies of Benzothiazinone Lead Compound BTZ043 against Mycobacterium tuberculosis
Benoit Lechartier, R. Hartkoorn, S. Cole
2012Antimicrobial Agents and Chemotherapy123 citations Open access
Semantic Scholar
Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria
Nina Compagne, A. Vieira Da Cruz, Reinke T. Müller, R. Hartkoorn +2 more
2023Antibiotics107 citations Open access
Semantic Scholar
Leads for antitubercular compounds from kinase inhibitor library screens.
S. Magnet, R. Hartkoorn, R. Székely, J. Pató +10 more
2010Tuberculosis104 citations Open access
Semantic Scholar
Anticytolytic screen identifies inhibitors of mycobacterial virulence protein secretion.
J. Rybniker, Jeffrey M. Chen, C. Sala, R. Hartkoorn +11 more
2014Cell Host and Microbe95 citations Open access
Semantic Scholar
The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis
Vinayak Singh, S. Donini, A. Pacitto, C. Sala +18 more
2016ACS Infectious Diseases94 citations Open access
Semantic Scholar
Modulation of the intracellular accumulation of saquinavir in peripheral blood mononuclear cells by inhibitors of MRP1, MRP2, P-gp and BCRP
O. Janneh, A. Owen, B. Chandler, R. Hartkoorn +5 more
2005AIDS (London)92 citations Open access
Semantic Scholar
Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis.
Li-Jiang Song, M. Jenner, J. Masschelein, Cerith Jones +14 more
2017Journal of the American Chemical Society91 citations Open access
Semantic Scholar
Assessing the essentiality of the decaprenyl‐phospho‐d‐arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants
Gaëlle S. Kolly, Francesca Boldrin, C. Sala, Neeraj Dhar +6 more
2014Molecular Microbiology87 citations Open access
Semantic Scholar
A druggable secretory protein maturase of Toxoplasma essential for invasion and egress
Sunil Kumar Dogga, B. Mukherjee, D. Jacot, T. Kockmann +5 more
2017eLife86 citations Open access
Semantic Scholar
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG
G. Mori, L. Chiarelli, M. Esposito, V. Makarov +25 more
2015Chemistry and Biology85 citations Open access
Semantic Scholar
Streptomycin-Starved Mycobacterium tuberculosis 18b, a Drug Discovery Tool for Latent Tuberculosis
Ming Zhang, C. Sala, R. Hartkoorn, Neeraj Dhar +2 more
2012Antimicrobial Agents and Chemotherapy83 citations Open access
Semantic Scholar
Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA.
R. Hartkoorn, F. Pojer, J. Read, H. Gingell +4 more
2014Nature Chemical Biology72 citations Open access
Semantic Scholar
The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis
V. Makarov, J. Neres, R. Hartkoorn, O. Ryabova +9 more
2015Antimicrobial Agents and Chemotherapy66 citations Open access
Semantic Scholar
Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps
C. Ple, H. Tam, A. Vieira Da Cruz, Nina Compagne +16 more
2022Nature Communications59 citations Open access
Semantic Scholar
Intracellular accumulation of efavirenz and nevirapine is independent of P-glycoprotein activity in cultured CD4 T cells and primary human lymphocytes.
O. Janneh, B. Chandler, R. Hartkoorn, Wai-San Kwan +5 more
2009Journal of Antimicrobial Chemotherapy52 citations Open access
Semantic Scholar
Genome-Wide Definition of the SigF Regulon in Mycobacterium tuberculosis
R. Hartkoorn, C. Sala, S. Uplekar, Philippe Busso +2 more
2012Journal of Bacteriology45 citations Open access
Semantic Scholar
Tuberculosis drugs: new candidates and how to find more.
C. Sala, R. Hartkoorn
2011Future Microbiology45 citations Open access
Semantic Scholar
Tacrine-induced liver damage: an analysis of 19 candidate genes
A. Alfirevic, T. Mills, D. Carr, B. Barratt +8 more
2007Pharmacogenetics & Genomics43 citations
Semantic Scholar
A rapid and sensitive HPLC-MS method for the detection of plasma and cellular rifampicin.
R. Hartkoorn, S. Khoo, D. Back, J. Tjia +6 more
2007Journal of chromatography. B, Analytical technologies in the biomedical and life sciences43 citations
Semantic Scholar
Micrococcin P1 - A bactericidal thiopeptide active against Mycobacterium tuberculosis.
Giulia Degiacomi, Yoann Personne, Guillaume Mondésert, X. Ge +16 more
2016Tuberculosis36 citations Open access
Semantic Scholar
Accelerated microfluidic native chemical ligation at difficult amino acids toward cyclic peptides
N. Ollivier, Thomas Toupy, R. Hartkoorn, R. Desmet +2 more
2018Nature Communications35 citations Open access
Semantic Scholar
Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis.
D. Albesa-Jové, L. Chiarelli, V. Makarov, M. Pasca +19 more
2014ACS Chemical Biology35 citations Open access
Semantic Scholar
Lead selection and characterization of antitubercular compounds using the Nested Chemical Library.
Anna Sipos, J. Pató, R. Székely, R. Hartkoorn +13 more
2015Tuberculosis32 citations Open access
Semantic Scholar
Bioluminescence for Assessing Drug Potency against Nonreplicating Mycobacterium tuberculosis
Anthony Vocat, R. Hartkoorn, Benoit Lechartier, Ming Zhang +3 more
2015Antimicrobial Agents and Chemotherapy32 citations Open access
Semantic Scholar
Whole cell screen based identification of spiropiperidines with potent antitubercular properties.
S. Tantry, Giulia Degiacomi, Sreevalli Sharma, L. K. Jena +23 more
2015Bioorganic & Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Pyrrolomycins Are Potent Natural Protonophores
Katherine Valderrama, E. Pradel, A. M. Firsov, H. Drobecq +4 more
2019Antimicrobial Agents and Chemotherapy31 citations Open access
Semantic Scholar
Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae
A. Vieira Da Cruz, Juan-Carlos Jiménez-Castellanos, Clara Börnsen, L. Van Maele +15 more
2023EMBO Molecular Medicine29 citations Open access
Semantic Scholar
Synthesis and antimycobacterial activity of 2,1'-dihydropyridomycins.
O. Horlacher, R. Hartkoorn, S. Cole, K. Altmann
2013ACS Medicinal Chemistry Letters28 citations Open access
Semantic Scholar
Down regulation of multidrug resistance protein-1 expression in patients with early rheumatoid arthritis exposed to methotrexate as a first disease-modifying antirheumatic drug
Samantha L. Hider, Andrew Owen, R. Hartkoorn, S. Khoo +3 more
2006Annals of the Rheumatic Diseases27 citations Open access
Semantic Scholar
Identification of aminopyrimidine‐sulfonamides as potent modulators of Wag31‐mediated cell elongation in mycobacteria
Vinayak Singh, Neeraj Dhar, J. Pató, Gaëlle S. Kolly +27 more
2017Molecular Microbiology25 citations Open access
Semantic Scholar
MoS2/TiO2/SiNW surface as an effective substrate for LDI-MS detection of glucose and glutathione in real samples.
A. Hamdi, I. Hosu, A. Addad, R. Hartkoorn +5 more
2017Talanta: The International Journal of Pure and Applied Analytical Chemistry24 citations
Semantic Scholar
Mechanism of Action of 5-Nitrothiophenes against Mycobacterium tuberculosis
R. Hartkoorn, O. Ryabova, L. Chiarelli, G. Riccardi +2 more
2014Antimicrobial Agents and Chemotherapy24 citations Open access
Semantic Scholar
In Vitro Synergy and Enhanced Murine Brain Penetration of Saquinavir Coadministered with Mefloquine
A. Owen, O. Janneh, R. Hartkoorn, B. Chandler +6 more
2005Journal of Pharmacology and Experimental Therapeutics23 citations Open access
Semantic Scholar
A Novel Natural Siderophore Antibiotic Conjugate Reveals a Chemical Approach to Macromolecule Coupling
Thibault Caradec, Ernesto Anoz-Carbonell, Ravil Petrov, Muriel Billamboz +8 more
2023ACS Central Science19 citations Open access
Semantic Scholar
Tricyclic SpiroLactams Kill Mycobacteria In Vitro and In Vivo by Inhibiting Type II NADH Dehydrogenases
Sushovan Dam, Salia Tangara, C. Hamela, Theo Hattabi +13 more
2022Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Total Synthesis of Ripostatin B and Structure-Activity Relationship Studies on Ripostatin Analogs.
F. Glaus, Darija Dedić, Priyanka Tare, V. Nagaraja +7 more
2018Journal of Organic Chemistry19 citations Open access
Semantic Scholar
Synthesis and Structure-Activity Relationship Studies of C2-Modified Analogs of the Antimycobacterial Natural Product Pyridomycin.
M. Kienle, Patrick Eisenring, Barbara Stoessel, O. Horlacher +6 more
2020Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Sigma Factor F Does Not Prevent Rifampin Inhibition of RNA Polymerase or Cause Rifampin Tolerance in Mycobacterium tuberculosis
R. Hartkoorn, C. Sala, S. Magnet, Jeffrey M. Chen +2 more
2010Journal of Bacteriology15 citations Open access
Semantic Scholar
Intracellular 'boosting' of darunavir using known transport inhibitors in primary PBMC.
Wai-San Kwan, O. Janneh, R. Hartkoorn, B. Chandler +3 more
2009British Journal of Clinical Pharmacology15 citations Open access
Semantic Scholar
Intragenic Distribution of IS6110 in Clinical Mycobacterium tuberculosis Strains: Bioinformatic Evidence for Gene Disruption Leading to Underdiagnosed Antibiotic Resistance
R. Antoine, C. Gaudin, R. Hartkoorn
2021Microbiology spectrum14 citations Open access
Semantic Scholar
2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1.
Vladimir Finger, T. Kučera, Radka Kafková, Ľ. Múčková +22 more
2023European journal of medicinal chemistry13 citations Open access
Semantic Scholar

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