Researcher profile · Semantic Scholar

I. Heisler

h-index: 14
Works: 30
Citations: 1,239

Most-cited papers

Anetumab Ravtansine: A Novel Mesothelin-Targeting Antibody–Drug Conjugate Cures Tumors with Heterogeneous Target Expression Favored by Bystander Effect
S. Golfier, C. Kopitz, Antje Kahnert, I. Heisler +12 more
2014Molecular Cancer Therapeutics232 citations Open access
Semantic Scholar
BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I
P. Ellinghaus, I. Heisler, Kerstin Unterschemmann, M. Haerter +10 more
2013Cancer Medicine216 citations Open access
Semantic Scholar
Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides
K. Kapoor, J. Finer-Moore, B. P. Pedersen, L. Caboni +7 more
2016Proceedings of the National Academy of Sciences of the United States of America198 citations Open access
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A colorimetric assay for the quantitation of free adenine applied to determine the enzymatic activity of ribosome-inactivating proteins.
I. Heisler, Jutta Keller, R. Tauber, M. Sutherland +1 more
2002Analytical Biochemistry98 citations
Semantic Scholar
Caenorhabditis elegans in anthelmintic research – Old model, new perspectives
Steffen R. Hahnel, Clayton M. Dilks, I. Heisler, Erik C. Andersen +1 more
2020International Journal for Parasitology: Drugs and Drug Resistance81 citations Open access
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Combined application of saponin and chimeric toxins drastically enhances the targeted cytotoxicity on tumor cells.
I. Heisler, M. Sutherland, C. Bachran, P. Hebestreit +3 more
2005Journal of Controlled Release72 citations
Semantic Scholar
The Saponin-Mediated Enhanced Uptake of Targeted Saporin-Based Drugs is Strongly Dependent on the Saponin Structure
C. Bachran, M. Sutherland, I. Heisler, P. Hebestreit +2 more
2006Experimental biology and medicine63 citations
Semantic Scholar
A cleavable adapter to reduce nonspecific cytotoxicity of recombinant immunotoxins
I. Heisler, Jutta Keller, R. Tauber, M. Sutherland +1 more
2003International Journal of Cancer54 citations Open access
Semantic Scholar
A cleavable molecular adapter reduces side effects and concomitantly enhances efficacy in tumor treatment by targeted toxins in mice.
H. Fuchs, C. Bachran, Tongyu Li, I. Heisler +2 more
2007Journal of Controlled Release44 citations
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Identification of novel GLUT inhibitors.
H. Siebeneicher, M. Bauser, B. Buchmann, I. Heisler +5 more
2016Bioorganic & Medicinal Chemistry Letters43 citations Open access
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Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A
A. Friberg, H. Rehwinkel, Duy Nguyen, Vera Pütter +5 more
2020ACS Omega40 citations Open access
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Development of a novel molecular adapter for the optimization of immunotoxins.
Jutta Keller, I. Heisler, R. Tauber, H. Fuchs
2001Journal of Controlled Release23 citations
Semantic Scholar
Chimeric toxins inhibit growth of primary oral squamous cell carcinoma cells
C. Bachran, I. Heisler, D. Bachran, K. Dassler +3 more
2008Cancer Biology & Therapy19 citations Open access
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A Closer Look at Protein Transduction Domains as a Tool in Drug Delivery
H. Fuchs, C. Bachran, I. Heisler, M. Sutherland
200515 citations
Semantic Scholar
Comparison of electrophysiological and motility assays to study anthelmintic effects in Caenorhabditis elegans
Steffen R. Hahnel, W. M. Roberts, I. Heisler, D. Kulke +1 more
2021International Journal for Parasitology: Drugs and Drug Resistance12 citations Open access
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Influence of protein transduction domains on target-specific chimeric proteins.
C. Bachran, I. Heisler, H. Fuchs, M. Sutherland
2005Biochemical and Biophysical Research Communications - BBRC11 citations
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Abstract 4746: Pharmacological characterization of BAY-876, a novel highly selective inhibitor of glucose transporter (GLUT)-1 in vitro and in vivo
C. Kopitz, L. Toschi, Carolyn Algire, M. Héroult +12 more
20166 citations
Semantic Scholar
Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY‐876
H. Siebeneicher, A. Cleve, H. Rehwinkel, R. Neuhaus +4 more
2016ChemMedChem5 citations Open access
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Abstract 1754: Identification of BAY 94-9343, a mesothelin antibody-drug conjugate (ADC): Characterization and anti-tumor activity in mesothelin-positive preclinical tumor models
S. Golfier, Antje Kahnert, I. Heisler, C. Kopitz +10 more
20115 citations
Semantic Scholar
Abstract 4509: BAY 87-2243 targets hypoxia-induced activation and stabilization of HIF-1α: A novel approach to overcome resistance mechanisms in cancer therapy
Kerstin Berhoerster, M. Haerter, P. Ellinghaus, I. Heisler +7 more
20112 citations
Semantic Scholar
Abstract 1164: Metabolic responses in cancer cells with differential susceptibility to GLUT1 inhibition
Sylvia Gruenewald, U. Rennefahrt, S. G. Maldonado, Alexander Walter +7 more
20151 citations
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Abstract 1442: Effects of selective and broad glucose transporter (GLUT) inhibition on glucose distribution in tumor bearing mice
M. Héroult, W. Steinke, A. Frisk, S. Borkowski +11 more
20141 citations
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Human GLUT1 in complex with inhibitor (2~{S})-3-(4-fluorophenyl)-2-[2-(3-hydroxyphenyl)ethanoylamino]-~{N}-[(1~{S})-1-phenylethyl]propanamide
K. Kapoor, J. Finer-Moore, B. P. Pedersen, L. Caboni +7 more
20160 citations
Semantic Scholar
Cover Picture: Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY‐876 (ChemMedChem 20/2016)
H. Siebeneicher, A. Cleve, H. Rehwinkel, R. Neuhaus +4 more
20160 citations
Semantic Scholar
Abstract 4333: Identification and optimization of the first highly selective GLUT-1 inhibitors
M. Bauser, B. Buchmann, H. Siebeneicher, A. Cleve +5 more
20160 citations
Semantic Scholar
Human GLUT1 in complex with Cytochalasin B
K. Kapoor, J. Finer-Moore, B. P. Pedersen, L. Caboni +7 more
20160 citations
Semantic Scholar
Inhibiteurs de transport du glucose
I. Heisler, Thomas Müller, S. Golz, J. Telser +9 more
20130 citations
Semantic Scholar
Mesothelin immunoconjugates and uses thereof
Antje Kahnert, Kerstin Berhörster, I. Heisler, C. Kopitz +1 more
20100 citations
Semantic Scholar
Immunoconjugués anti-mésothéline et utilisations associées
Antje Kahnert, Kerstin Unterschemmann, I. Heisler, C. Kopitz +1 more
20100 citations
Semantic Scholar
Bedeutung spaltbarer Peptidlinker für die Funktion rekombinanter Saporin-EGF-Immunotoxine
I. Heisler
20030 citations
Semantic Scholar

K. Ziegelbauer

×6

C. Bachran×6

M. Bauser×6

R. Neuhaus×6

H. Rehwinkel×6

C. Kopitz×5

Thomas Müller×5

M. Héroult×4