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H. Fuchs · SciRah

Researcher profile · Semantic Scholar

H. Fuchs

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H. Fuchs — researcher profile on SciRah

h-index: 30
Works: 112
Citations: 2,791

Most-cited papers

Chemistry and pharmacology of saponins: special focus on cytotoxic properties
M. Thakur, M. Melzig, H. Fuchs, Alexander Weng
2011141 citations Open access
Semantic Scholar
Saponins in tumor therapy.
C. Bachran, Silke Bachran, M. Sutherland, D. Bachran +1 more
2008Mini-Reviews in Medical Chemistry104 citations
Semantic Scholar
A colorimetric assay for the quantitation of free adenine applied to determine the enzymatic activity of ribosome-inactivating proteins.
I. Heisler, Jutta Keller, R. Tauber, M. Sutherland +1 more
2002Analytical Biochemistry98 citations
Semantic Scholar
Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy
R. Gilabert-Oriol, Alexander Weng, B. von Mallinckrodt, M. Melzig +2 more
2014Current pharmaceutical design84 citations Open access
Semantic Scholar
Saponins as tool for improved targeted tumor therapies.
H. Fuchs, D. Bachran, H. Panjideh, N. Schellmann +4 more
2009Current Drug Targets77 citations
Semantic Scholar
Combined application of saponin and chimeric toxins drastically enhances the targeted cytotoxicity on tumor cells.
I. Heisler, M. Sutherland, C. Bachran, P. Hebestreit +3 more
2005Journal of Controlled Release72 citations
Semantic Scholar
Saponins modulate the intracellular trafficking of protein toxins.
Alexander Weng, M. Thakur, B. von Mallinckrodt, Figen Beceren-Braun +6 more
2012Journal of Controlled Release71 citations
Semantic Scholar
Biocompatible protein nanocontainers for controlled drugs release.
Yong-Sheng Han, D. Shchukin, Juan-Yu Yang, C. Simon +2 more
2010ACS Nano67 citations
Semantic Scholar
The Saponin-Mediated Enhanced Uptake of Targeted Saporin-Based Drugs is Strongly Dependent on the Saponin Structure
C. Bachran, M. Sutherland, I. Heisler, P. Hebestreit +2 more
2006Experimental biology and medicine63 citations
Semantic Scholar
Small Cleavable Adapters Enhance the Specific Cytotoxicity of a Humanized Immunotoxin Directed Against CD64-positive Cells
C. Hetzel, C. Bachran, R. Fischer, H. Fuchs +2 more
2008Journal of immunotherapy60 citations
Semantic Scholar
Real-time analysis of membrane permeabilizing effects of oleanane saponins.
R. Gilabert-Oriol, K. Mergel, M. Thakur, B. von Mallinckrodt +3 more
2013Bioorganic & Medicinal Chemistry57 citations
Semantic Scholar
A cleavable adapter to reduce nonspecific cytotoxicity of recombinant immunotoxins
I. Heisler, Jutta Keller, R. Tauber, M. Sutherland +1 more
2003International Journal of Cancer54 citations Open access
Semantic Scholar
Glycosylated Triterpenoids as Endosomal Escape Enhancers in Targeted Tumor Therapies
H. Fuchs, Nicole Niesler, A. Trautner, S. Sama +3 more
2017Biomedicines53 citations Open access
Semantic Scholar
Targeted Enzyme Prodrug Therapies
N. Schellmann, P. Deckert, D. Bachran, H. Fuchs +1 more
201052 citations
Semantic Scholar
Epidermal growth factor receptor expression affects the efficacy of the combined application of saponin and a targeted toxin on human cervical carcinoma cells
D. Bachran, S. Schneider, C. Bachran, R. Urban +5 more
2009International Journal of Cancer49 citations Open access
Semantic Scholar
The toxin component of targeted anti‐tumor toxins determines their efficacy increase by saponins
Alexander Weng, M. Thakur, Figen Beceren-Braun, D. Bachran +6 more
2012Molecular Oncology48 citations Open access
Semantic Scholar
Shedding of the Transferrin Receptor Is Mediated Constitutively by an Integral Membrane Metalloprotease Sensitive to Tumor Necrosis Factor α Protease Inhibitor-2*
Matthias Kaup, K. Dassler, C. Weise, H. Fuchs
2002Journal of Biological Chemistry47 citations Open access
Semantic Scholar
Real time monitoring of the cell viability during treatment with tumor-targeted toxins and saponins using impedance measurement.
M. Thakur, K. Mergel, Alexander Weng, S. Frech +4 more
2012Biosensors & bioelectronics45 citations
Semantic Scholar
Rasayana properties of Ayurvedic herbs: Are polysaccharides a major contributor.
M. Thakur, Alexander Weng, H. Fuchs, V. Sharma +4 more
2012Carbohydrate Polymers44 citations
Semantic Scholar
A cleavable molecular adapter reduces side effects and concomitantly enhances efficacy in tumor treatment by targeted toxins in mice.
H. Fuchs, C. Bachran, Tongyu Li, I. Heisler +2 more
2007Journal of Controlled Release44 citations
Semantic Scholar
Inhibition of Tumor Growth by Targeted Toxins in Mice is Dramatically Improved by Saponinum Album in a Synergistic Way
C. Bachran, H. Dürkop, M. Sutherland, D. Bachran +4 more
2009Journal of immunotherapy41 citations
Semantic Scholar
Targeted tumor therapies at a glance.
H. Fuchs, C. Bachran
2009Current Drug Targets40 citations
Semantic Scholar
A convenient method for saponin isolation in tumour therapy.
Alexander Weng, K. Jenett‐Siems, P. Schmieder, D. Bachran +5 more
2010Journal of chromatography. B, Analytical technologies in the biomedical and life sciences39 citations
Semantic Scholar
Targeted tumor therapy by epidermal growth factor appended toxin and purified saponin: An evaluation of toxicity and therapeutic potential in syngeneic tumor bearing mice
M. Thakur, K. Mergel, Alexander Weng, B. von Mallinckrodt +4 more
2013Molecular Oncology38 citations Open access
Semantic Scholar
Targeted enzyme prodrug therapies.
N. Schellmann, P. Deckert, D. Bachran, H. Fuchs +1 more
2010Mini-Reviews in Medical Chemistry37 citations
Semantic Scholar
Augmenting the Efficacy of Immunotoxins and Other Targeted Protein Toxins by Endosomal Escape Enhancers
H. Fuchs, Alexander Weng, R. Gilabert-Oriol
2016Toxins35 citations Open access
Semantic Scholar
Expression of interleukin 15 in primary adult acute lymphoblastic leukemia
Shuling Wu, L. Fischer, N. Gokbuget, S. Schwartz +7 more
2010Cancer35 citations
Semantic Scholar
Dianthin-EGF is an effective tumor targeted toxin in combination with saponins in a xenograft model for colon carcinoma.
B. von Mallinckrodt, M. Thakur, Alexander Weng, R. Gilabert-Oriol +6 more
2014Future Oncology30 citations
Semantic Scholar
Design, construction, and in vitro analysis of A33scFv::CDy, a recombinant fusion protein for antibody-directed enzyme prodrug therapy in colon cancer.
Vânia Coelho, J. Dernedde, U. Petrausch, H. Panjideh +6 more
2007International Journal of Oncology29 citations Open access
Semantic Scholar
Processing of the Human Transferrin Receptor at Distinct Positions within the Stalk Region by Neutrophil Elastase and Cathepsin G
Matthias Kaup, K. Dassler, U. Reineke, C. Weise +2 more
2002Biological chemistry29 citations
Semantic Scholar
The transferrin receptor‐1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase‐like 2b
C. Zahn, Matthias Kaup, R. Fluhrer, H. Fuchs
2013The FEBS Journal28 citations Open access
Semantic Scholar
Delayed allogeneic skin graft rejection in CD26-deficient mice
Xiangli Zhao, Kai Zhang, P. Daniel, Natali Wisbrun +2 more
2018Cellular & Molecular Immunology27 citations Open access
Semantic Scholar
Modified trastuzumab and cetuximab mediate efficient toxin delivery while retaining antibody-dependent cell-mediated cytotoxicity in target cells.
R. Gilabert-Oriol, M. Thakur, B. von Mallinckrodt, T. Hug +5 more
2013Molecular Pharmaceutics26 citations
Semantic Scholar
Diving through Membranes: Molecular Cunning to Enforce the Endosomal Escape of Antibody-Targeted Anti-Tumor Toxins
H. Fuchs, C. Bachran, D. Flavell, S. Flavell
201324 citations Open access
Semantic Scholar
Triterpenoid saponin augmention of saporin-based immunotoxin cytotoxicity for human leukaemia and lymphoma cells is partially immunospecific and target molecule dependent
Suzanne E. Holmes, C. Bachran, H. Fuchs, Alexander Weng +3 more
2015Immunopharmacology and immunotoxicology23 citations
Semantic Scholar
Combinatorial approach to increase efficacy of Cetuximab, Panitumumab and Trastuzumab by dianthin conjugation and co-application of SO1861.
R. Gilabert-Oriol, Alexander Weng, A. Trautner, C. Weise +6 more
2015Biochemical Pharmacology23 citations
Semantic Scholar
Development of a novel molecular adapter for the optimization of immunotoxins.
Jutta Keller, I. Heisler, R. Tauber, H. Fuchs
2001Journal of Controlled Release23 citations
Semantic Scholar
Release of the Soluble Transferrin Receptor Is Directly Regulated by Binding of Its Ligand Ferritransferrin*
K. Dassler, M. Zydek, Krzysztof Wandzik, Matthias Kaup +1 more
2006Journal of Biological Chemistry22 citations Open access
Semantic Scholar
Creation and characterization of a xenograft model for human cervical cancer.
C. Hoffmann, C. Bachran, J. Stanke, S. Elezkurtaj +5 more
2010Gynecologic Oncology21 citations
Semantic Scholar
The distribution of saponins in vivo affects their synergy with chimeric toxins against tumours expressing human epidermal growth factor receptors in mice
C. Bachran, Alexander Weng, D. Bachran, Sebastian B. Riese +3 more
2010British Journal of Pharmacology21 citations Open access
Semantic Scholar
Enhancement of saporin cytotoxicity by Gypsophila saponins--more than stimulation of endocytosis.
Alexander Weng, Christopher Bachran, H. Fuchs, E. Krause +2 more
2009Chemico-Biological Interactions21 citations
Semantic Scholar
Macromolecular interactions of triterpenoids and targeted toxins: role of saponins charge.
M. Thakur, Alexander Weng, Alexandra Pieper, K. Mergel +7 more
2013International Journal of Biological Macromolecules20 citations
Semantic Scholar
A Simple Method for Isolation of Gypsophila Saponins for the Combined Application of Targeted Toxins and Saponins in Tumor Therapy
Alexander Weng, D. Bachran, C. Görick, Christopher Bachran +2 more
2009Planta Medica19 citations
Semantic Scholar
Improved immunotoxins with novel functional elements.
C. Hetzel, C. Bachran, M. Tur, H. Fuchs +1 more
2009Current pharmaceutical design19 citations
Semantic Scholar
Chimeric toxins inhibit growth of primary oral squamous cell carcinoma cells
C. Bachran, I. Heisler, D. Bachran, K. Dassler +3 more
2008Cancer Biology & Therapy19 citations Open access
Semantic Scholar
Pseudomonas Exotoxin A Based Toxins Targeting Epidermal Growth Factor Receptor for the Treatment of Prostate Cancer
A. Fischer, I. Wolf, H. Fuchs, A. P. Masilamani +1 more
2020Toxins18 citations Open access
Semantic Scholar
Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma
R. Gilabert-Oriol, S. Furness, B. Stringer, Alexander Weng +8 more
2017Cancer Immunology and Immunotherapy18 citations Open access
Semantic Scholar
High-speed countercurrent chromatographic recovery and off-line electrospray ionization mass spectrometry profiling of bisdesmodic saponins from Saponaria officinalis possessing synergistic toxicity enhancing properties on targeted antitumor toxins.
M. Thakur, G. Jerz, Dorota Tuwalska, R. Gilabert-Oriol +4 more
2014Journal of chromatography. B, Analytical technologies in the biomedical and life sciences18 citations
Semantic Scholar
Production of bifunctional single-chain antibody-based fusion proteins in Pichia pastoris supernatants
H. Panjideh, Vânia Coelho, J. Dernedde, H. Fuchs +3 more
2008Bioprocess and biosystems engineering (Print)18 citations
Semantic Scholar
Targeted dianthin is a powerful toxin to treat pancreatic carcinoma when applied in combination with the glycosylated triterpene SO1861
Cheenu Bhargava, H. Dürkop, Xiangli Zhao, Alexander Weng +2 more
2017Molecular Oncology17 citations Open access
Semantic Scholar

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