Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

Shih-Hsun Chen · SciRah

Researcher profile · Semantic Scholar

Shih-Hsun Chen

Share profile

Shih-Hsun Chen — researcher profile on SciRah

h-index: 24
Works: 39
Citations: 2,592

Most-cited papers

Water Permeation Drives Tumor Cell Migration in Confined Microenvironments
Kimberly M. Stroka, Hongyuan Jiang, Shih-Hsun Chen, Zi-Qiu Tong +3 more
2014Cell502 citations Open access
Semantic Scholar
Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.
Sheng-Bin Peng, J. Henry, M. Kaufman, Wei-Ping Lu +26 more
2015Cancer Cell269 citations Open access
Semantic Scholar
Mesothelin Binding to CA125/MUC16 Promotes Pancreatic Cancer Cell Motility and Invasion via MMP-7 Activation
Shih-Hsun Chen, Wei-Chien Hung, Pu Wang, C. Paul +1 more
2013Scientific Reports218 citations Open access
Semantic Scholar
Distinct signaling mechanisms regulate migration in unconfined versus confined spaces
Wei-Chien Hung, Shih-Hsun Chen, C. Paul, Kimberly M. Stroka +3 more
2013Journal of Cell Biology149 citations Open access
Semantic Scholar
Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120.
Shih-Hsun Chen, Youyan Zhang, R. V. Van Horn, T. Yin +11 more
2016Cancer Discovery144 citations
Semantic Scholar
Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon,
M. Streppel, Audrey Vincent, Radha Mukherjee, Nathaniel R. Campbell +6 more
2012Human Pathology123 citations Open access
Semantic Scholar
Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes antitumor immunity
Shih-Hsun Chen, Pawel K. Dominik, Jessica Stanfield, Sheng Ding +10 more
2021Journal for ImmunoTherapy of Cancer117 citations Open access
Semantic Scholar
Super-resolution imaging identifies PARP1 and the Ku complex acting as DNA double-strand break sensors
Guang Yang, Chao Liu, Shih-Hsun Chen, M. Kassab +3 more
2018Nucleic Acids Research109 citations Open access
Semantic Scholar
Metabolic Flux Increases Glycoprotein Sialylation: Implications for Cell Adhesion and Cancer Metastasis*
Ruben T. Almaraz, Yuan Tian, Rahul Bhattarcharya, Elaine Tan +7 more
2012Molecular & Cellular Proteomics98 citations Open access
Semantic Scholar
Targeting dePARylation selectively suppresses DNA repair–defective and PARP inhibitor–resistant malignancies
Shih-Hsun Chen, Xiaochun Yu
2019Science Advances88 citations Open access
Semantic Scholar
An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity
Yuanming Xu, Lucia Campos Carrascosa, Yik A. Yeung, M. Chu +41 more
2021Cancer immunology research76 citations Open access
Semantic Scholar
Sialofucosylated podocalyxin is a functional E- and L-selectin ligand expressed by metastatic pancreatic cancer cells.
Matthew R. Dallas, Shih-Hsun Chen, M. Streppel, S. Sharma +2 more
2012American Journal of Physiology - Cell Physiology71 citations Open access
Semantic Scholar
Mucin 16 is a functional selectin ligand on pancreatic cancer cells
Shih-Hsun Chen, Matthew R. Dallas, Eric M. Balzer, K. Konstantopoulos
2012The FASEB Journal70 citations Open access
Semantic Scholar
Poly-ADP ribosylation in DNA damage response and cancer therapy
W. Hou, Shih-Hsun Chen, Xiaochun Yu
2017Mutation research68 citations Open access
Semantic Scholar
NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression
C. Bian, Chao Zhang, T. Luo, Aditi Vyas +6 more
2019Nature Communications62 citations Open access
Semantic Scholar
The PIN domain of EXO1 recognizes poly(ADP-ribose) in DNA damage response
Feng Zhang, Jiazhong Shi, Shih-Hsun Chen, C. Bian +1 more
2015Nucleic Acids Research51 citations Open access
Semantic Scholar
Truncated PARP1 mediates ADP-ribosylation of RNA polymerase III for apoptosis
Qian Chen, Kaiyu Ma, Xiu-Hua Liu, Shih-Hsun Chen +4 more
2022Cell Discovery46 citations Open access
Semantic Scholar
ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection
Fei Zhao, Wootae Kim, Huan-Yao Gao, Chao Liu +20 more
2021Nature Cell Biology45 citations
Semantic Scholar
Poly(ADP-ribosyl)ation mediates early phase histone eviction at DNA lesions
Guang Yang, Yibin Chen, Jiaxue Wu, Shih-Hsun Chen +3 more
2020Nucleic Acids Research44 citations Open access
Semantic Scholar
Up-regulation of fibronectin and tissue transglutaminase promotes cell invasion involving increased association with integrin and MMP expression in A431 cells.
Shih-Hsun Chen, Chun-Yu Lin, Lung-Ta Lee, G. Chang +7 more
2010Anticancer Research43 citations
Semantic Scholar
Co-targeting BRAF and cyclin dependent kinases 4/6 for BRAF mutant cancers.
V. Yadav, Shih-Hsun Chen, Y. Yue, S. Buchanan +2 more
2015Pharmacology and Therapeutics37 citations
Semantic Scholar
Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies.
Yuan-Feng Lin, T. Lai, Chih-Kang Chang, Chi-Long Chen +11 more
2013Journal of Clinical Investigation36 citations Open access
Semantic Scholar
Investigation of MMP-2 and -9 in a highly invasive A431 tumor cell sub-line selected from a Boyden chamber assay.
Wen-Te Kao, Chun-Yu Lin, Lung-Ta Lee, P. Lee +6 more
2008Anticancer Research36 citations
Semantic Scholar
Human DNA ligase IV is able to use NAD+ as an alternative adenylation donor for DNA ends ligation
Shih-Hsun Chen, Xiaochun Yu
2018Nucleic Acids Research25 citations Open access
Semantic Scholar
Identification, synthesis, and evaluation of new neuraminidase inhibitors.
Vathan Kumar, Chih-Kang Chang, K. Tan, Young-Sik Jung +3 more
2014Organic Letters20 citations
Semantic Scholar
Roles of amino acids in the Escherichia coli octaprenyl diphosphate synthase active site probed by structure-guided site-directed mutagenesis.
Keng-Ming Chang, Shih-Hsun Chen, Chih-Jung Kuo, Chi-Kang Chang +3 more
2012Biochemistry14 citations
Semantic Scholar
AI26 inhibits the ADP-ribosylhydrolase ARH3 and suppresses DNA damage repair
Xiu-Hua Liu, Rong Xie, Lily L. Yu, Shih-Hsun Chen +5 more
2020Journal of Biological Chemistry11 citations Open access
Semantic Scholar
Combined experimental and theoretical study of long-range interactions modulating dimerization and activity of yeast geranylgeranyl diphosphate synthase.
Chai-Ho Lo, Ying-Hsuan Chang, Jon D. Wright, Shih-Hsun Chen +3 more
2009Journal of the American Chemical Society10 citations
Semantic Scholar
Conjugation of Benzylvanillin and Benzimidazole Structure Improves DNA Binding with Enhanced Antileukemic Properties
Zena A. Al-Mudaris, A. A. Majid, Dan Ji, B. Almudarris +5 more
2013PLoS ONE9 citations Open access
Semantic Scholar
Moiety-Linkage Map Reveals Selective Nonbisphosphonate Inhibitors of Human Geranylgeranyl Diphosphate Synthase
Shih-Hsun Chen, Sheng-Wei Lin, Shen-Rong Lin, P. Liang +1 more
2013Journal of Chemical Information and Modeling7 citations
Semantic Scholar
Abstract 2818: An unbiased tumor cell panel profiling method to identify drug-drug interactions reveals synergy between the CDK4 and CDK 6 inhibitor abemaciclib and the Raf dimer and pan-Raf inhibitor LY3009120 in Ras mutant cancers
Xue-Qian Gong, Wenjuan Wu, L. Chio, S. Pratt +11 more
20161 citations
Semantic Scholar
Abstract C042: TOP1i-ADC demonstrates immune-stimulating activity in colorectal cancer explants
D. Dandamudi, Irene Lee, Yoshiko Hashikawa, M. Refici +10 more
2026Cancer immunology research0 citations
Semantic Scholar
267 Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes anti-tumor immunity and improves therapeutic window
Shih-Hsun Chen, Pawel K. Dominik, Jessica Stanfield, Sheng Ding +10 more
2021Journal for ImmunoTherapy of Cancer0 citations Open access
Semantic Scholar
Abstract 282: Pan-RAF inhibitor LY3009120 sensitizes RAS or BRAF mutant cancer to CDK4 and 6 inhibition by abemaciclib via superior inhibition of phospho-RB and suppression of cyclin D1
Shih-Hsun Chen, Youyan Zhang, R. V. Van Horn, T. Yin +9 more
20160 citations
Semantic Scholar
Pan-RAF blockade alters intra-tumor immune balance resulting in a CD4+ T cell dominated tumor microenvironment
Nelusha Amaladas, Bao-Hui Zhao, Shih-Hsun Chen, L. Huber +9 more
20160 citations
Semantic Scholar
Abstract A07: The identification of combinations for the CDK4 and CDK6 inhibitor, abemaciclib
Xue-Qian Gong, L. Chio, Y. Webster, M. Lallena +14 more
20160 citations
Semantic Scholar
Inhibition of RAF Isoforms and Active Dimers by LY 3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers Graphical
Sheng-Bin Peng, J. Henry, M. Kaufman, Wei-Ping Lu +26 more
20150 citations
Semantic Scholar
Abstract 2142: Novel oncogenic BRaf deletions functioning as BRaf homodimer and sensitive to inhibition by LY3009120, a pan Raf and Raf dimer inhibitor
Shih-Hsun Chen, S. Buchanan, Youyan Zhang, R. V. Van Horn +9 more
20150 citations
Semantic Scholar
Abstract 3777: Low physiological fluid shear exposure induces metastatic potential of chondrosarcoma cells via MMP-12 activation.
Shih-Hsun Chen, Pu Wang, Wei-Chien Hung, K. Konstantopoulos
20130 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

Sheng-Bin Peng×9
Invite
Sheng-Bin Peng — researcher profile on SciRah
Xiaochun Yu×9
Invite
Xiaochun Yu — researcher profile on SciRah
K. Konstantopoulos×8
Invite
K. Konstantopoulos — researcher profile on SciRah
S. Buchanan×8
Invite
S. Buchanan — researcher profile on SciRah

×6

Invite

L. Huber — researcher profile on SciRah

Invite

P. Liang — researcher profile on SciRah

Youyan Zhang×5

Invite

Youyan Zhang — researcher profile on SciRah

Invite

T. Yin — researcher profile on SciRah

Invite

V. Yadav — researcher profile on SciRah

Xue-Qian Gong×5

Invite

Xue-Qian Gong — researcher profile on SciRah

Invite

J. Henry — researcher profile on SciRah

R. V. Van Horn×4

Invite

R. V. Van Horn — researcher profile on SciRah