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T. Lai · SciRah

Researcher profile · Semantic Scholar

T. Lai

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T. Lai — researcher profile on SciRah

h-index: 28
Works: 79
Citations: 4,615

Most-cited papers

MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis.
W. Tsai, Sheng-Da Hsu, Chu-Sui Hsu, T. Lai +12 more
2012Journal of Clinical Investigation817 citations Open access
Semantic Scholar
MicroRNA‐122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma
W. Tsai, Paul Wei-Che Hsu, T. Lai, G. Chau +10 more
2009Hepatology591 citations
Semantic Scholar
H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM.
Min-Wei Chen, K. Hua, Hsin-Jung Kao, Chia-Chun Chi +14 more
2012Cancer Research345 citations
Semantic Scholar
Biocompatibility of Fe3O4 nanoparticles evaluated by in vitro cytotoxicity assays using normal, glia and breast cancer cells
B. Ankamwar, T. Lai, Jing-Hong Huang, Ru-Shi Liu +3 more
2010Nanotechnology251 citations
Semantic Scholar
Enhancement of cell radiation sensitivity by pegylated gold nanoparticles
Chi-Jen Liu, Chang-Hai Wang, Shin-Tai Chen, Hsiang-Hsin Chen +10 more
2010Physics in Medicine and Biology245 citations Open access
Semantic Scholar
Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signaling.
Yu-Peng Liu, Chih-Jen Yang, Ming-Shyan Huang, Chi-Tai Yeh +9 more
2013Cancer Research210 citations
Semantic Scholar
Seedless, silver-induced synthesis of star-shaped gold/silver bimetallic nanoparticles as high efficiency photothermal therapy reagent
Liang-Chien Cheng, Jing-Hong Huang, Hao-Ming Chen, T. Lai +6 more
2012194 citations
Semantic Scholar
IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer.
C. Lo, Min-Wei Chen, M. Hsiao, Shiuan Wang +7 more
2011Cancer Research193 citations
Semantic Scholar
Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis.
Z. Chen, T. Lai, Y. Jan, F. Lin +16 more
2013Journal of Clinical Investigation192 citations Open access
Semantic Scholar
Biosensing, Cytotoxicity, and Cellular Uptake Studies of Surface-Modified Gold Nanorods
Harshala Parab, Hao-Ming Chen, T. Lai, Jing-Hong Huang +6 more
2009129 citations Open access
Semantic Scholar
N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity.
K. Hua, Ching-Ting Tan, G. Johansson, Jang-Ming Lee +22 more
2011Cancer Cell100 citations Open access
Semantic Scholar
Adenylate kinase-4 is a marker of poor clinical outcomes that promotes metastasis of lung cancer by downregulating the transcription factor ATF3.
Y. Jan, Hong-Yuan Tsai, Chih-Jen Yang, Ming-Shyan Huang +8 more
2012Cancer Research96 citations Open access
Semantic Scholar
Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis
Y. Jan, T. Lai, Chih-Jen Yang, Yuan-Feng Lin +2 more
2019Journal of Hematology & Oncology78 citations Open access
Semantic Scholar
Squalene synthase induces tumor necrosis factor receptor 1 enrichment in lipid rafts to promote lung cancer metastasis.
Yi-Fang Yang, Y. Jan, Yu-Peng Liu, Chih-Jen Yang +12 more
2014American Journal of Respiratory and Critical Care Medicine67 citations
Semantic Scholar
The Diverse Roles of TAO Kinases in Health and Diseases
Chih-Yeu Fang, T. Lai, M. Hsiao, Yu-Chan Chang
2020International Journal of Molecular Sciences65 citations Open access
Semantic Scholar
Leukocyte cell‐derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment
Chi-Kuan Chen, Ching-Yao Yang, K. Hua, M. Ho +15 more
2014Hepatology62 citations Open access
Semantic Scholar
Targeting polymeric fluorescent nanodiamond-gold/silver multi-functional nanoparticles as a light-transforming hyperthermia reagent for cancer cells.
Liang-Chien Cheng, Hao-Ming Chen, T. Lai, Yung-Chieh Chan +6 more
2013Nanoscale59 citations
Semantic Scholar
Essential roles of caspases and their upstream regulators in rotenone-induced apoptosis.
Jih-Jong Lee, Ming-Shyan Huang, I-Chi Yang, T. Lai +4 more
2008Biochemical and Biophysical Research Communications - BBRC53 citations
Semantic Scholar
Selective killing of cancer cells by nanoparticle-assisted ultrasound
O. Kosheleva, T. Lai, N. Chen, M. Hsiao +1 more
2016Journal of Nanobiotechnology52 citations Open access
Semantic Scholar
Investigation of the Growth Mechanism of Iron Oxide Nanoparticles via a Seed-Mediated Method and Its Cytotoxicity Studies
Jing-Hong Huang, Harshala Parab, Ru-Shi Liu, T. Lai +6 more
200850 citations Open access
Semantic Scholar
Dysregulation of RUNX2/Activin-A Axis upon miR-376c Downregulation Promotes Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma.
Wei-Min Chang, Yuan-Feng Lin, Chia-Yi Su, Hsuan-Yu Peng +11 more
2016Cancer Research45 citations Open access
Semantic Scholar
The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation
Tsung-Chieh Lin, Chia-Yi Su, Pei-Yu Wu, T. Lai +14 more
2016eLife44 citations Open access
Semantic Scholar
Chitosan-Modified Stable Colloidal Gold Nanostars for the Photothermolysis of Cancer Cells
I. Baginskiy, T. Lai, Liang-Chien Cheng, Yung-Chieh Chan +7 more
201343 citations
Semantic Scholar
Monoamine Oxidase B Expression Correlates with a Poor Prognosis in Colorectal Cancer Patients and Is Significantly Associated with Epithelial-to-Mesenchymal Transition-Related Gene Signatures
Yi-Chieh Yang, M. Chien, T. Lai, Chia-Yi Su +3 more
2020International Journal of Molecular Sciences41 citations Open access
Semantic Scholar
Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies.
Yuan-Feng Lin, T. Lai, Chih-Kang Chang, Chi-Long Chen +11 more
2013Journal of Clinical Investigation36 citations Open access
Semantic Scholar
X-ray synthesized PEGylated (polyethylene glycol coated) gold nanoparticles in mice strongly accumulate in tumors
Chang-Hai Wang, Chi-Jen Liu, Chia‐Chi Chien, Hsin Chen +12 more
201132 citations Open access
Semantic Scholar
Suppressive function of low‐dose deguelin on the invasion of oral cancer cells by downregulating tumor necrosis factor alpha–induced nuclear factor‐kappa B signaling
Yu-Peng Liu, Jih-Jong Lee, T. Lai, Chien-Hsin Lee +8 more
2016Head and Neck31 citations
Semantic Scholar
Biocompatible transferrin-conjugated sodium hexametaphosphate-stabilized gold nanoparticles: synthesis, characterization, cytotoxicity and cellular uptake
Harshala Parab, Jing-Hong Huang, T. Lai, Y. Jan +8 more
2011Nanotechnology30 citations Open access
Semantic Scholar
Blocking MMP-12-modulated epithelial-mesenchymal transition by repurposing penfluridol restrains lung adenocarcinoma metastasis via uPA/uPAR/TGF-β/Akt pathway
Wen-Yueh Hung, Wei-Jiunn Lee, G. Cheng, Ching-Han Tsai +6 more
2021Cellular Oncology26 citations Open access
Semantic Scholar
A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma
Y. Jan, T. Lai, Chih-Jen Yang, Ming-Shyan Huang +1 more
2019Scientific Reports26 citations Open access
Semantic Scholar
The novel DNA alkylating agent BO‐1090 suppresses the growth of human oral cavity cancer in xenografted and orthotopic mouse models
K. Sanjiv, T. Su, Sharda Suman, R. Kakadiya +4 more
2012International Journal of Cancer26 citations Open access
Semantic Scholar
Kinase shRNA screening reveals that TAOK3 enhances microtubule-targeted drug resistance of breast cancer cells via the NF-κB signaling pathway
T. Lai, Chih-Yeu Fang, Y. Jan, Hsiao-Ling Hsieh +4 more
2020Cell communication and signaling : CCS25 citations Open access
Semantic Scholar
Global Proteomics-based Identification and Validation of Thymosin Beta-4 X-Linked as a Prognostic Marker for Head and Neck Squamous Cell Carcinoma
L. Chi, Wei-Min Chang, Yu-Chan Chang, Yung-Chieh Chan +7 more
2017Scientific Reports25 citations Open access
Semantic Scholar
The significance of ANXA7 expression and its correlation with poor cellular differentiation and enhanced metastatic potential of gastric cancer
Ping-I Hsu, Ming-Shyan Huang, Hui-Chun Chen, P. Hsu +6 more
2008Journal of Surgical Oncology25 citations
Semantic Scholar
FAS receptor regulates NOTCH activity through ERK-JAG1 axis activation and controls oral cancer stemness ability and pulmonary metastasis
Li-Jie Li, P. Chang, Chien-Hsiu Li, Yu-Chan Chang +6 more
2022Cell Death Discovery24 citations Open access
Semantic Scholar
Recombinant viral protein promotes apoptosis and suppresses invasion of ovarian adenocarcinoma cells by targeting α5β1 integrin to down‐regulate Akt and MMP‐2
Jei-Ming Peng, Yee-Hsiung Chen, Shao-Wen Hung, Ching-Feng Chiu +6 more
2012British Journal of Pharmacology24 citations Open access
Semantic Scholar
Proteomics-based identification of TMED9 is linked to vascular invasion and poor prognoses in patients with hepatocellular carcinoma
Yi-Chieh Yang, M. Chien, T. Lai, M.-C. Tung +6 more
2021Journal of Biomedical Sciences23 citations Open access
Semantic Scholar
IMPAD1 functions as mitochondrial electron transport inhibitor that prevents ROS production and promotes lung cancer metastasis through the AMPK-Notch1-HEY1 pathway.
Yi-Fang Yang, Yen-Yun Wang, M. Hsiao, S. Lo +6 more
2020Cancer Letters21 citations Open access
Semantic Scholar
Dermcidin identification from exhaled air for lung cancer diagnosis
Wei-Chao Chang, Ming-Shyan Huang, Chih-Jen Yang, W.-Y. Wang +3 more
2010European Respiratory Journal20 citations Open access
Semantic Scholar
A Fas Ligand (FasL)-Fused Humanized Antibody Against Tumor-Associated Glycoprotein 72 Selectively Exhibits the Cytotoxic Effect Against Oral Cancer Cells with a Low FasL/Fas Ratio
M. Chien, Wei-Min Chang, Wei-Jiunn Lee, Yu-Chan Chang +5 more
2017Molecular Cancer Therapeutics19 citations Open access
Semantic Scholar
The aberrant cancer metabolic gene carbohydrate sulfotransferase 11 promotes non-small cell lung cancer cell metastasis via dysregulation of ceruloplasmin and intracellular iron balance
Wei-Min Chang, Li-Jie Li, I. Chiu, T. Lai +8 more
2022Translational Oncology18 citations Open access
Semantic Scholar
Sustaining the Activation of EGFR Signal by Inflammatory Cytokine IL17A Prompts Cell Proliferation and EGFR-TKI Resistance in Lung Cancer
Kai-Ling Lee, T. Lai, Wei-Jiunn Lee, Yuchyau Chen +8 more
2023Cancers14 citations Open access
Semantic Scholar
Inhibition of Metastatic Potential in Breast Carcinoma In Vivo and In Vitro through Targeting VEGFRs and FGFRs
M. Chien, Liang-Ming Lee, M. Hsiao, Lin-Hung Wei +6 more
2013Evidence-Based Complementary and Alternative Medicine14 citations Open access
Semantic Scholar
Defective Phosphatidylinositol 3-Kinase Signaling in Central Control of Cardiovascular Effects in the Nucleus Tractus Solitarii of Spontaneously Hypertensive Rats
M. Hsiao, Pei-Jung Lu, Hsiao-Ning Huang, Wan-Chen Lo +4 more
2008Hypertension Research13 citations Open access
Semantic Scholar
ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: a multi-omics analysis
Yu-Feng Hu, Chih-Hsun Wu, T. Lai, Yu-Chan Chang +8 more
2021Biochimica et Biophysica Acta - Molecular Basis of Disease12 citations Open access
Semantic Scholar
Associations of TIMP-3 Genetic Polymorphisms with EGFR Statuses and Cancer Clinicopathologic Development in Lung Adenocarcinoma Patients
Jer-Hwa Chang, T. Lai, Po-Jen Yang, P. Shih +6 more
2020International Journal of Molecular Sciences12 citations Open access
Semantic Scholar
Dehydroepiandrosterone (DHEA) Sensitizes Irinotecan to Suppress Head and Neck Cancer Stem-Like Cells by Downregulation of WNT Signaling
Li-Jie Li, Chien-Hsiu Li, P. Chang, T. Lai +5 more
2022Frontiers in Oncology11 citations Open access
Semantic Scholar
Over-expression of lysyl oxidase is associated with poor prognosis and response to therapy of patients with lower grade gliomas.
Shang-Pen Huang, Jean Chiou, Y. Jan, T. Lai +3 more
2018Biochemical and Biophysical Research Communications - BBRC11 citations
Semantic Scholar
Evaluation of the intracellular uptake and cytotoxicity effect of TiO2 nanostructures for various human oral and lung cells under dark conditions.
Chieh-Wei Chen, Jing-Hong Huang, T. Lai, Y. Jan +4 more
2016Toxicological Research11 citations Open access
Semantic Scholar
Synergistic Tumor Inhibition via Energy Elimination by Repurposing Penfluridol and 2-Deoxy-D-Glucose in Lung Cancer
T. Lai, Yueh-Lun Lee, Wei-Jiunn Lee, Wen-Yueh Hung +5 more
2022Cancers9 citations Open access
Semantic Scholar

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