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C. Bonfils · SciRah

Researcher profile · Semantic Scholar

C. Bonfils

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C. Bonfils — researcher profile on SciRah

h-index: 12
Works: 37
Citations: 1,293

Most-cited papers

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo
M. Fournel, C. Bonfils, Yunyan Hou, P. Yan +16 more
2008Molecular Cancer Therapeutics309 citations Open access
Semantic Scholar
Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia.
G. Garcia-Manero, S. Assouline, J. Cortes, Z. Estrov +15 more
2008Blood241 citations Open access
Semantic Scholar
Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity.
O. Moradei, Tammy C. Mallais, Sylvie Fréchette, I. Paquin +14 more
2007Journal of Medicinal Chemistry165 citations Open access
Semantic Scholar
Phase II Study of the Histone Deacetylase Inhibitor MGCD0103 in Patients with Previously Treated Chronic Lymphocytic Leukemia
K. Blum, A. Advani, L. Fernández, R. van der Jagt +11 more
2009British Journal of Haematology113 citations Open access
Semantic Scholar
A phase I pharmacokinetic and pharmacodynamic study of the DNA methyltransferase 1 inhibitor MG98 administered twice weekly.
David J. Stewart, R. Donehower, Elizabeth A. Eisenhauer, N. Wainman +5 more
2003Annals of Oncology95 citations Open access
Semantic Scholar
Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumors.
M. Fournel, Marie-Claude Trachy-Bourget, P. Yan, Ann Kalita +10 more
2002Cancer Research92 citations
Semantic Scholar
Evaluation of the Pharmacodynamic Effects of MGCD0103 from Preclinical Models to Human Using a Novel HDAC Enzyme Assay
C. Bonfils, Ann Kalita, M. Dubay, L. Siu +5 more
2008Clinical Cancer Research90 citations Open access
Semantic Scholar
Characterization of the Human DNA Methyltransferase Splice Variant Dnmt1b*
C. Bonfils, N. Beaulieu, Eric Chan, Judith Cotton-Montpetit +1 more
2000Journal of Biological Chemistry51 citations Open access
Semantic Scholar
Potent preclinical antitumor activity of MGCD265, an oral Met/VEGFR kinase inhibitor in phase II clinical development, in combination with taxanes or erlotinib.
J. Besterman, M. Fournel, I. Dupont, C. Bonfils +3 more
201020 citations
Semantic Scholar
Biphasic expression of rnrB in Dictyostelium discoideum suggests a direct relationship between cell cycle control and cell differentiation.
H. Macwilliams, Heike Deichsel, P. Gaudet, C. Bonfils +1 more
2001Differentiation; research in biological diversity17 citations
Semantic Scholar
Abstract 1790: The combination of MGCD265, a Met/VEGFR inhibitor in clinical development, and erlotinib potently inhibits tumor growth by altering multiple pathways including glycolysis
C. Bonfils, N. Beaulieu, M. Fournel, H. Ste-Croix +2 more
201216 citations
Semantic Scholar
Expression and characterization of a dictyostelium discoideum annexin
C. Bonfils, Michael T. Greenwood, A. Tsang
1994Molecular and Cellular Biochemistry16 citations
Semantic Scholar
Pharmacodynamic effect of MGCD0103, an oral isotype-selective histone deacetylase (HDAC) inhibitor, on HDAC enzyme inhibition and histone acetylation induction in phase I clinical trials in patients (pts) with advanced solid tumors or non-Hodgkin’s lymphoma (NHL)
Ann Kalita, C. Maroun, C. Bonfils, K. Gelmon +6 more
200512 citations
Semantic Scholar
A prespore-specific gene of Dictyostelium discoideum encodes the small subunit of ribonucleotide reductase.
Adrian S. Tsang, C. Bonfils, Guy Czaika, Abraham Shtevi +1 more
1996Biochimica et Biophysica Acta12 citations
Semantic Scholar
Identification of cis-Regulating Elements andtrans-Acting Factors Regulating the Expression of the Gene Encoding the Small Subunit of Ribonucleotide Reductase inDictyostelium discoideum *
C. Bonfils, P. Gaudet, A. Tsang
1999Journal of Biological Chemistry11 citations Open access
Semantic Scholar
Pharmacological inhibition of histone deacetylases for the treatment of cancer, neurodegenerative disorders and inflammatory diseases
C. Bonfils, Donald R. Walkinshaw, J. Besterman, Xiang-Jiao Yang +1 more
2008Expert Opinion on Drug Discovery10 citations
Semantic Scholar
Abstract 930: Preclinical characterization of MG516, a novel inhibitor of receptor tyrosine kinases involved in resistance to targeted therapies.
N. Beaulieu, H. Sainte-Croix, C. Bonfils, M. Mannion +10 more
20135 citations
Semantic Scholar
312 A Novel Assay for the Met Inhibitory Activity of MGCD265 in Plasma From Solid Tumor Patients in a Dose Escalating Phase I Study
M. Fournel, James Wang, N. Beaulieu, C. Bonfils +6 more
20124 citations
Semantic Scholar
395 MGCD265, an orally active Met/VEGFR multitargeted kinase inhibitor, in combination with erlotinib: clinical and preclinical experience
A. Patnaik, J. Besterman, A. Tolcher, M. Mehran +6 more
20103 citations
Semantic Scholar
Abstract 3612: Potent preclinical anti-tumor activity of MGCD265, an orally active Met/VEGFR multitargeted kinase inhibitor in Phase II clinical development, in combination with an EGFR inhibitor
M. Fournel, I. Dupont, C. Bonfils, M. Dubay +15 more
20103 citations
Semantic Scholar
Determination of the maximum tolerated dose (MTD) of MGCD265, an oral Met/VEGFR multitargeted receptor tyrosine kinase inhibitor, in combination with docetaxel.
D. Rasco, A. Patnaik, R. Amaravadi, K. Papadopoulos +13 more
2011Journal of Clinical Oncology2 citations
Semantic Scholar
Induction of an anti-angiogenesis factor, Thrombospondin 1 (TSP-1), by a novel histone deacetylase inhibitor, MGCD0103, in human cancer cells in vitro and in vivo
Jianhong Liu, C. Bonfils, M. Dubay, Hannah Nguyen +6 more
20082 citations
Semantic Scholar
Abstract P200: Pre-clinical development of a dopamine receptor 2, PD-1 and CD47 trispecific antibody for treatment of small cell lung cancer
S. Yao, Yun Cui, Anna Kazanats, Liying Gong +16 more
2021Poster Presentations - Proffered Abstracts1 citations
Semantic Scholar
MGCD265, a multitargeted oral tyrosine kinase receptor inhibitor of Met and VEGFR: Dose-escalation phase I study.
C. Kollmannsberger, H. Hurwitz, J. Cleary, J. Strickler +11 more
20121 citations
Semantic Scholar
[Preparation, physical constants and chemical composition of lamb fetuin].
J. Marti, S. Aliau, C. Bonfils, C. Vigne +1 more
1973Biochimica et Biophysica Acta1 citations
Semantic Scholar
Abstract 324: Discovery of novel functional TROP2 antibodies for treatment of epithelial cancers
Israel Matos, Y. Ashraf, H. Zahreddine, Liying Gong +15 more
2022Cancer Research0 citations
Semantic Scholar
Abstract LB094: KisoBody: Development and pre-clinical assessment of a novel multispecific antibody platform
Richard Wargachuk, Dominic Hou, C. Bonfils, Nicolas Morin +11 more
2021Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract LBA018: Discovery of novel functional TROP2 antibodies for treatment of epithelial cancers
Israel Matos, H. Zahreddine, Y. Ashraf, A. Pandey +14 more
2021Poster Presentations - Late-Breaking Proffered Abstracts0 citations
Semantic Scholar
488. Development of a Robust Non-Viral Gene Delivery System for Gut Mucosal Cells
E. Hsu, Majid Mojibian, Jun Gao, C. Fleet +6 more
20150 citations Open access
Semantic Scholar
A Phase I, Dose-Escalation Study of Mgcd265, A Multi-Targeted Oral Tyrosine Kinase Receptor Inhibitor, for Treatment of Advanced Solid Tumors
H. Hurwitz, C. Kollmannsberger, M. Juretic, J. Wang +6 more
20120 citations Open access
Semantic Scholar
Abstract 3610: Potent preclinical anti-tumor activity of MGCD265, an oral Met/VEGFR multitargeted kinase inhibitor in clinical development, in combination with taxanes
C. Maroun, H. Ste-Croix, N. Beaulieu, C. Bonfils +5 more
20110 citations
Semantic Scholar
Abstract A95: The determination of the maximum tolerated dose (MTD) of MGCD265 on an intermittent schedule: Phase I study results (Study 265-102).
J. Wheler, R. Kurzrock, E. Heath, G. Falchook +8 more
20110 citations
Semantic Scholar
Abstract 3609: MGCD265, an orally active Met/VEGFR multitargeted kinase inhibitor in Phase II clinical development, potently inhibits clinically relevant Met mutants
N. Beaulieu, I. Dupont, C. Bonfils, M. Dubay +10 more
20100 citations
Semantic Scholar
Enhanced Isotype-Selectivity and Antiproliferative Activity of Thiophenyl Derivatives of Benzamide HDAC Inhibitors In Human Cancer Cells
M. Fournel, O. Moradei, I. Paquin, C. Bonfils +11 more
20060 citations
Semantic Scholar
A 27-bp deletion is responsible for the expression of a variant CABP1, a cyclic AMP-binding protein of Dictyostelium discoideum.
C. Bonfils, J. Hébert, Adrian S. Tsang
1991Biochimica et Biophysica Acta0 citations
Semantic Scholar
[Microheterogenity of lamb fetuin].
J. Marti, C. Bonfils, J. Moretti
1974Biochimie0 citations
Semantic Scholar
Soils and erosion in the semi-arid pa upas region.
C. Bonfils, J. Calcagno, P. H. Etchevehere, A. Et
19600 citations
Semantic Scholar

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J. Besterman×22
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C. Maroun×12
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M. Fournel×11
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Zuo-Mei Li×9
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H. Ste-Croix×6

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Ann Kalita — researcher profile on SciRah

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