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Jianjun Chang · SciRah

Researcher profile · Semantic Scholar

Jianjun Chang

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Jianjun Chang — researcher profile on SciRah

h-index: 19
Works: 41
Citations: 2,003

Most-cited papers

Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson’s disease
V. Aho, Madelyn C. Houser, Pedro A. B. Pereira, Jianjun Chang +6 more
2020Molecular Neurodegeneration270 citations Open access
Semantic Scholar
LRRK2 levels in immune cells are increased in Parkinson’s disease
Darcie Cook, G. Kannarkat, Amarallys F. Cintron, Laura M. Butkovich +7 more
2017npj Parkinson's Disease240 citations Open access
Semantic Scholar
Stool immune profiles evince gastrointestinal inflammation in Parkinson’s disease
Madelyn C. Houser, Jianjun Chang, S. Factor, E. Molho +5 more
2018Movement Disorders167 citations Open access
Semantic Scholar
Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice
Kathryn P. Macpherson, P. Sompol, G. Kannarkat, Jianjun Chang +4 more
2017Neurobiology of Disease143 citations Open access
Semantic Scholar
Common genetic variant association with altered HLA expression, synergy with pyrethroid exposure, and risk for Parkinson’s disease: an observational and case–control study
G. Kannarkat, Darcie Cook, Jae-Kyung Lee, Jianjun Chang +8 more
2015npj Parkinson's Disease127 citations Open access
Semantic Scholar
Targeting soluble tumor necrosis factor as a potential intervention to lower risk for late-onset Alzheimer’s disease associated with obesity, metabolic syndrome, and type 2 diabetes
Maria Elizabeth De Sousa Rodrigues, Madelyn C. Houser, D. Walker, Dean P. Jones +3 more
2019Alzheimer's Research & Therapy114 citations Open access
Semantic Scholar
Peripheral administration of the selective inhibitor of soluble Tumor Necrosis Factor (TNF) XPro®1595 attenuates nigral cell loss and glial activation in 6-OHDA hemiparkinsonian rats
C. Barnum, Xi Chen, Jaegwon Chung, Jianjun Chang +4 more
2014Journal of Parkinson's Disease109 citations Open access
Semantic Scholar
Lipopolysaccharide and Tumor Necrosis Factor Regulate Parkin Expression via Nuclear Factor-Kappa B
Thi A. Tran, Andrew D. Nguyen, Jianjun Chang, M. Goldberg +2 more
2011PLoS ONE105 citations Open access
Semantic Scholar
Lysosome and Inflammatory Defects in GBA1-Mutant Astrocytes Are Normalized by LRRK2 Inhibition
Anwesha Sanyal, M. Deandrade, H. Novis, Steven Lin +5 more
2020Movement Disorders104 citations Open access
Semantic Scholar
Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice
Maria Elizabeth De Sousa Rodrigues, M. Bekhbat, Madelyn C. Houser, Jianjun Chang +5 more
2016Brain, behavior, and immunity97 citations Open access
Semantic Scholar
Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells
X. Chen, Jianjun Chang, Qiu-Dong Deng, Jie Xu +12 more
2013Journal of Neuroscience94 citations Open access
Semantic Scholar
Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s disease
Lori N. Eidson, G. Kannarkat, C. Barnum, Jianjun Chang +12 more
2017Journal of Neuroinflammation91 citations Open access
Semantic Scholar
Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards
N. Seyfried, Y. Gozal, Laura E. Donovan, Jeremy H. Herskowitz +14 more
2012Journal of Proteome Research64 citations Open access
Semantic Scholar
Regulation of Microglia Effector Functions by Tumor Necrosis Factor (TNF) Signaling
A. Harms, Jae-Kyung Lee, Thi A Nguyen, Jianjun Chang +3 more
2011Glia58 citations Open access
Semantic Scholar
Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology
Madelyn C. Houser, W. M. Caudle, Jianjun Chang, G. Kannarkat +7 more
2021Acta Neuropathologica Communications53 citations Open access
Semantic Scholar
Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Coeruleus Pathology and Nonmotor Features of Parkinson's Disease
Laura M. Butkovich, Madelyn C. Houser, T. Chalermpalanupap, Kirsten A. Porter-Stransky +15 more
2020Journal of Neuroscience32 citations Open access
Semantic Scholar
Low-dose IL-2 improved clinical symptoms by restoring reduced regulatory T cells in patients with refractory rheumatoid arthritis: A randomized controlled trial
Jia Wang, Sheng-Xiao Zhang, Jianjun Chang, T. Cheng +5 more
2022Frontiers in Immunology30 citations Open access
Semantic Scholar
Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system
Madelyn C. Houser, Oihane Uriarte Huarte, R. Wallings, C. Keating +8 more
2022Frontiers in Immunology23 citations Open access
Semantic Scholar
Age-related changes in Regulator of G-protein Signaling (RGS)-10 expression in peripheral and central immune cells may influence risk for age-related degeneration
G. Kannarkat, Jae-Kyung Lee, Chenere P. Ramsey, Jaegwon Chung +5 more
2015Neurobiology of Aging23 citations Open access
Semantic Scholar
Chronic psychological stress during adolescence induces sex-dependent adulthood inflammation, increased adiposity, and abnormal behaviors that are ameliorated by selective inhibition of soluble tumor necrosis factor with XPro1595
Lori N. Eidson, Maria Elizabeth De Sousa Rodrigues, Michelle A. Johnson, C. Barnum +7 more
2019Brain, behavior, and immunity17 citations Open access
Semantic Scholar
Soluble TNF mediates amyloid-independent, diet-induced alterations to immune and neuronal functions in an Alzheimer’s disease mouse model
Kathryn P. Macpherson, Lori N. Eidson, Madelyn C. Houser, Blaine E. Weiss +13 more
2023Frontiers in Cellular Neuroscience16 citations Open access
Semantic Scholar
The second generation mixed-lineage kinase-3 (MLK3) inhibitor CLFB-1134 protects against neurotoxin-induced nigral dopaminergic neuron loss
Elizabeth M. Kline, Laura M. Butkovich, Joshua M. Bradner, Jianjun Chang +4 more
2019Experimental Neurology11 citations Open access
Semantic Scholar
Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1
Jesse R. Schank, Soojung Lee, Carlos E. Gonzalez-Islas, Sadie E. Nennig +11 more
2020Scientific Reports9 citations Open access
Semantic Scholar
Effect of SARS-CoV-2 infection on seizure, anxiety and depression in 107 epilepsy patients
Si-Qian Zhou, Dexin Zhang, Jianjun Chang, Zhilun Xia +3 more
2023Epilepsy & Behavior3 citations Open access
Semantic Scholar
Transgenic Mice Expressing Human a -Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson ’ s Disease
Laura M. Butkovich, Madelyn C. Houser, T. Chalermpalanupap, Kirsten A. Porter-Stransky +15 more
20203 citations
Semantic Scholar
Loss of progranulin leads to dysregulation of innate and adaptive immune cell populations, increased susceptibility to experimental colitis, and brain infiltration of peripheral immune cells
C. Keating, Madelyn C. Houser, Kathryn P. Macpherson, Mary K. Herrick +9 more
20202 citations Open access
Semantic Scholar
LRRK2 G2019S reprograms innate and adaptive immunity to drive context-dependent host defense outcomes
Andrea R. Merchak, Mary K. Herrick, Madelyn C. Houser, D. Moustafa +8 more
2026Frontiers in Cellular Neuroscience1 citations Open access
Semantic Scholar
Low-dose oral pyrethroid exposure induces gastrointestinal dysfunction and alters nigrostriatal dopamine signaling pathways in mice
A. C. White, Shreya Bandlamudi, Jianjun Chang, Sean D. Kelly +2 more
2021ISEE Conference Abstracts1 citations Open access
Semantic Scholar
Soluble TNF mediates high‐fat and high‐carbohydrate diet–induced inflammation, alterations in peripheral blood and brain immunophenotype, and gut microbiome in a mouse model of amyloid pathology
Mary K. Herrick, Kathryn P. Macpherson, Lori N. Eidson, Maria Elizabeth De Sousa Rodrigues +14 more
20201 citations Open access
Semantic Scholar
P4‐480: WESTERN DIET PROMOTES CENTRAL INSULIN IMPAIRMENT AND THE DYSREGULATION OF METABOLITES ASSOCIATED WITH ALZHEIMER'S DISEASE: THE ROLE OF SOLUBLE TNF
Maria Elizabeth de Sousa Rodrigues, Madelyn C. Houser, D. Walker, Dean P. Jones +3 more
2019Alzheimer's & Dementia1 citations Open access
Semantic Scholar
Blocking soluble TNF decreases diet‐induced hyperglycemia and modulates immune alterations in 5xFAD animal model of Alzheimer’s disease
Maria Elizabeth De Sousa Rodrigues, Lisa Blackmer-Raynolds, Jianjun Chang, T. Sampson +1 more
2023Alzheimer's & Dementia0 citations Open access
Semantic Scholar
The role of soluble TNF in mediating immune and metabolic alterations in a mouse model of amyloid‐beta pathology
Maria Elizabeth De Sousa Rodrigues, Jianjun Chang, T. Sampson, M. Tansey
2021Alzheimer's & Dementia0 citations
Semantic Scholar
Su547 MICROBIOME ALTERATIONS LEAD TO IMPAIRED GASTROINTESTINAL MOTILITY FOLLOWING SPINAL CORD INJURY
Adam M. Hamilton, Jianjun Chang, S. Garraway, S. Srinivasan +1 more
20210 citations
Semantic Scholar
P3-263: PERIPHERAL AND CENTRAL INFLAMMATION ASSOCIATE WITH PHOSPHO-TAU IN A POPULATION AT RISK FOR ALZHEIMER'S DISEASE
M. Tansey, Lori N. Eidson, Kaitlin Sandor, V. Hertzberg +10 more
2019Alzheimer's & Dementia0 citations Open access
Semantic Scholar
P2‐190: SOLUBLE TNF MEDIATES HIGH‐FAT‐HIGH‐CARBOHYDRATE DIET–INDUCED ALTERATIONS IN PERIPHERAL AND BRAIN IMMUNOPHENOTYPE IN A MOUSE MODEL OF ALZHEIMER'S DISEASE
Lori N. Eidson, Kathryn P. Macpherson, Mary K. Herrick, Maria Elizabeth de Sousa Rodrigues +7 more
2019Alzheimer's & Dementia0 citations Open access
Semantic Scholar
P3-264: PERIPHERAL AND CENTRAL INFLAMMATION DIFFER BY RACE AND ASSOCIATE WITH COGNITIVE PERFORMANCE IN A POPULATION AT RISK FOR ALZHEIMER'S DISEASE
Lori N. Eidson, Kaitlin Sandor, V. Hertzberg, Amarallys F. Cintron +9 more
2019Alzheimer's & Dementia0 citations
Semantic Scholar
O2‐11‐02: THE ROLE OF SOLUBLE TNF IN METABOLIC DYSFUNCTION AND BBB ALTERATIONS IN A MOUSE MODEL OF ALZHEIMER'S DISEASE
M. Tansey, Kathryn P. Macpherson, Lori N. Eidson, Mary K. Herrick +6 more
20180 citations
Semantic Scholar
Additional file 8: of Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s disease
Lori N. Eidson, G. Kannarkat, C. Barnum, Jianjun Chang +12 more
20170 citations
Semantic Scholar
[P2–090]: ROLE OF SOLUBLE TNF IN DIET‐INDUCED PERIPHERAL AND CENTRAL INFLAMMATION IN A MOUSE MODEL OF ALZHEIMER's DISEASE
M. Tansey, Kathryn P. Macpherson, Lori N. Eidson, Mary K. Herrick +6 more
20170 citations Open access
Semantic Scholar
Additional file 9: of Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s disease
Lori N. Eidson, G. Kannarkat, C. Barnum, Jianjun Chang +12 more
20170 citations
Semantic Scholar
Transgenic Mice Expressing Human a -Synuclein in Noradrenergic Neurons Develop Locus Coeruleus Pathology and Nonmotor Features of Parkinson ’ s Disease
Laura M. Butkovich, Madelyn C. Houser, T. Chalermpalanupap, Kirsten A. Porter-Stransky +16 more
0 citations
Semantic Scholar

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