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Christine M. Fandozzi · SciRah

Researcher profile · Semantic Scholar

Christine M. Fandozzi

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Christine M. Fandozzi — researcher profile on SciRah

h-index: 15
Works: 32
Citations: 929

Most-cited papers

MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants
V. Summa, S. Ludmerer, J. Mccauley, Christine M. Fandozzi +22 more
2012Antimicrobial Agents and Chemotherapy250 citations Open access
Semantic Scholar
MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease
N. Liverton, S. Carroll, J. DiMuzio, Christine M. Fandozzi +10 more
2009Antimicrobial Agents and Chemotherapy129 citations Open access
Semantic Scholar
Molecular modeling based approach to potent P2-P4 macrocyclic inhibitors of hepatitis C NS3/4A protease.
N. Liverton, M. Holloway, J. Mccauley, M. Rudd +13 more
2008Journal of the American Chemical Society102 citations
Semantic Scholar
Use of density functional calculations to predict the regioselectivity of drugs and molecules metabolized by aldehyde oxidase.
Rhonda A. Torres, K. Korzekwa, D. McMasters, Christine M. Fandozzi +1 more
2007Journal of Medicinal Chemistry65 citations
Semantic Scholar
The combination of MK-5172, peginterferon, and ribavirin is effective in treatment-naive patients with hepatitis C virus genotype 1 infection without cirrhosis.
M. Manns, J. Vierling, B. Bacon, S. Bruno +15 more
2014Gastroenterology40 citations Open access
Semantic Scholar
Preclinical pharmacology and pharmacokinetics of CERC‐301, a GluN2B‐selective N‐methyl‐D‐aspartate receptor antagonist
R. Garner, S. Gopalakrishnan, J. Mccauley, R. A. Bednar +12 more
2015Pharmacology Research & Perspectives37 citations Open access
Semantic Scholar
Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
I. Raheem, M. J. Breslin, Christine M. Fandozzi, J. Fuerst +14 more
2012Bioorganic & Medicinal Chemistry Letters35 citations Open access
Semantic Scholar
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
I. M. Bell, Craig A. Stump, S. N. Gallicchio, D. Staas +16 more
2012Bioorganic & Medicinal Chemistry Letters27 citations Open access
Semantic Scholar
Assessment of drug interaction potential between the HCV direct-acting antiviral agents elbasvir/grazoprevir and the HIV integrase inhibitors raltegravir and dolutegravir
Hwa-ping Feng, Zi-Fang Guo, L. Ross, I. Fraser +12 more
2018Journal of Antimicrobial Chemotherapy25 citations
Semantic Scholar
Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists.
Jeffrey Y. Melamed, A. Zartman, Nathan R Kett, Anthony L. Gotter +13 more
2010Bioorganic & Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Novel oxazolidinone calcitonin gene-related peptide (CGRP) receptor antagonists for the acute treatment of migraine.
Brendan M. Crowley, Craig A. Stump, Diem N. Nguyen, Craig M. Potteiger +21 more
2015Bioorganic & Medicinal Chemistry Letters23 citations
Semantic Scholar
Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists.
M. E. Layton, M. Kelly, K. Rodzinak, P. Sanderson +17 more
2011ACS Chemical Neuroscience21 citations Open access
Semantic Scholar
Assessment of Drug Interaction Potential Between the Hepatitis C Virus Direct‐Acting Antiviral Agents Elbasvir/Grazoprevir and the Nucleotide Analog Reverse‐Transcriptase Inhibitor Tenofovir Disoproxil Fumarate
Hwa-ping Feng, Zi-Fang Guo, L. Caro, J. Talaty +13 more
2019Clinical pharmacology in drug development20 citations
Semantic Scholar
2019 White Paper on Recent Issues in Bioanalysis: Chromatographic Assays (Part 1 - Innovation in Small Molecules and Oligonucleotides & Mass Spectrometric Method Development Strategies for Large Molecule Bioanalysis).
Christine M. Fandozzi, C. Evans, Amanda Wilson, Dian Su +27 more
2019Bioanalysis19 citations Open access
Semantic Scholar
[791] HCV ANTIVIRAL ACTIVITY AND RESISTANCE ANALYSIS IN CHRONICALLY INFECTED CHIMPANZEES TREATED WITH NS3/4A PROTEASE AND NS5B POLYMERASE INHIBITORS
D. Olsen, S. Carroll, L. Handt, S. Ludmerer +6 more
200716 citations Open access
Semantic Scholar
Pharmacokinetic Interactions between the Hepatitis C Virus Inhibitors Elbasvir and Grazoprevir and HIV Protease Inhibitors Ritonavir, Atazanavir, Lopinavir, and Darunavir in Healthy Volunteers
Hwa-ping Feng, L. Caro, Christine M. Fandozzi, X. Chu +20 more
2019Antimicrobial Agents and Chemotherapy15 citations Open access
Semantic Scholar
MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants
V. Summa, S. Ludmerer, J. Mccauley, Christine M. Fandozzi +22 more
2014Antimicrobial Agents and Chemotherapy14 citations Open access
Semantic Scholar
Effect of Hepatic Impairment on the Pharmacokinetics of Grazoprevir, a Hepatitis C Virus Protease Inhibitor
L. Caro, Larissa A. Wenning, Zi-Fang Guo, I. Fraser +13 more
2017Antimicrobial Agents and Chemotherapy12 citations Open access
Semantic Scholar
Pharmacokinetics of elbasvir and grazoprevir in subjects with end-stage renal disease or severe renal impairment
L. Caro, Larissa A. Wenning, Hwa-ping Feng, Zi-Fang Guo +8 more
2019European Journal of Clinical Pharmacology11 citations Open access
Semantic Scholar
In Vitro Assessment of Transporter Mediated Perpetrator DDIs for Several Hepatitis C Virus Direct-Acting Antiviral Drugs and Prediction of DDIs with Statins Using Static Models
X. Chu, G. Chan, R. Houle, Mei-Hong Lin +2 more
2022AAPS Journal9 citations
Semantic Scholar
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.
M. Rudd, C. J. Mcintyre, Joseph J. Romano, J. W. Butcher +26 more
2012Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Pharmacokinetics, Safety, and Tolerability of Single-Dose Elbasvir in Participants with Hepatic Impairment
W. Marshall, Hwa-ping Feng, Larissa A. Wenning, Graigory C. Garrett +11 more
2017European journal of drug metabolism and pharmacokinetics6 citations
Semantic Scholar
Pharmacokinetic Interactions Between the Fixed‐Dose Combinations of Elvitegravir/Cobicistat/Tenofovir Disoproxil Fumarate/Emtricitabine and Elbasvir/Grazoprevir in Healthy Adult Participants
Hwa-ping Feng, Zi-Fang Guo, Christine M. Fandozzi, D. Panebianco +8 more
2019Clinical pharmacology in drug development5 citations
Semantic Scholar
Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease.
M. Rudd, J. Mccauley, Joseph J. Romano, J. W. Butcher +26 more
2012Bioorganic & Medicinal Chemistry Letters5 citations
Semantic Scholar
39 MK-5172: A NOVEL HCV NS3/4A PROTEASE INHIBITOR WITH POTENT ACTIVITY AGAINST KNOWN RESISTANCE MUTANTS
S. Carroll, J. Mccauley, S. Ludmerer, S. Harper +24 more
20105 citations
Semantic Scholar
Evaluation of Pharmacokinetic Drug Interactions of the Direct-Acting Antiviral Agents Elbasvir and Grazoprevir with Pitavastatin, Rosuvastatin, Pravastatin, and Atorvastatin in Healthy Adults
L. Caro, T. Prueksaritanont, Christine M. Fandozzi, Hwa-ping Feng +9 more
2021Clinical drug investigation3 citations
Semantic Scholar
Evaluation of MK-7009, A Novel Macrocyclic Inhibitor of NS3/4A Protease, in the Chimpanzee Model of Chronic Hepatitis C Virus Infection
S. Ludmerer, Donald J. Graham, L. Handt, Christine M. Fandozzi +7 more
20083 citations
Semantic Scholar
MK-5172, a Novel Macrocyclic Inhibitor of NS3/4a Protease Demonstrates Efficacy Against Viral Resistance in the Chimpanzee Model of Chronic Hepatitis C Virus Infection
S. Ludmerer, S. Carroll, J. Mccauley, M. Rudd +12 more
20101 citations
Semantic Scholar
A Human Mass Balance and Metabolism Study of [14C]‐Ubrogepant in Healthy Male Adults
Ramesh R. Boinpally, Josh Rowe, Pushpa Chandrasekar, Rebecca B. White +10 more
2026Clinical pharmacology in drug development0 citations Open access
Semantic Scholar
Novel techniques and the new age of biomarkers: panel discussion report.
Stephanie Pasas-Farmer, Chris James, Christine M. Fandozzi, Dominic E. Warrino +4 more
2021Bioanalysis0 citations
Semantic Scholar
S11.3 - Zepatier: The tale of two novels
Christine M. Fandozzi
20200 citations
Semantic Scholar
Fine‐Needle Aspiration for the Evaluation of Hepatic Pharmacokinetics of Vaniprevir: A Randomized Trial in Patients With Hepatitis C Virus Infection
Wei Gao, Andrea L. Webber, J. Maxwell, M. Anderson +14 more
2019Clinical pharmacology and therapy0 citations Open access
Semantic Scholar

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