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S. Ludmerer · SciRah

Researcher profile · Semantic Scholar

S. Ludmerer

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S. Ludmerer — researcher profile on SciRah

h-index: 21
Works: 54
Citations: 2,417

Most-cited papers

Characterization of Resistance to Non-obligate Chain-terminating Ribonucleoside Analogs That Inhibit Hepatitis C Virus Replication in Vitro*
G. Migliaccio, J. Tomassini, S. Carroll, L. Tomei +19 more
2003Journal of Biological Chemistry318 citations Open access
Semantic Scholar
MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants
V. Summa, S. Ludmerer, J. Mccauley, Christine M. Fandozzi +22 more
2012Antimicrobial Agents and Chemotherapy250 citations Open access
Semantic Scholar
Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin.
Nanci S. Kane, B. Hirschberg, S. Qian, D. Hunt +10 more
2000Proceedings of the National Academy of Sciences of the United States of America191 citations Open access
Semantic Scholar
Identification of Two Novel Drosophila melanogaster Histamine-gated Chloride Channel Subunits Expressed in the Eye*
Yingcong Zheng, B. Hirschberg, Jeffrey Yuan, Alice P. Wang +4 more
2002Journal of Biological Chemistry186 citations Open access
Semantic Scholar
Human Monoclonal Antibody HCV1 Effectively Prevents and Treats HCV Infection in Chimpanzees
Trevor J. Morin, T. Broering, B. Leav, Barbra M. Blair +14 more
2012PLoS Pathogens164 citations Open access
Semantic Scholar
Hybrid papillomavirus L1 molecules assemble into virus-like particles that reconstitute conformational epitopes and induce neutralizing antibodies to distinct HPV types.
Neil D. Christensen, N. Cladel, C. A. Reed, L. Budgeon +5 more
2001Virology131 citations Open access
Semantic Scholar
MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease
N. Liverton, S. Carroll, J. DiMuzio, Christine M. Fandozzi +10 more
2009Antimicrobial Agents and Chemotherapy129 citations Open access
Semantic Scholar
Replication Fitness and NS5B Drug Sensitivity of Diverse Hepatitis C Virus Isolates Characterized by Using a Transient Replication Assay
S. Ludmerer, Donald J. Graham, Evelyn Boots, E. Murray +7 more
2005Antimicrobial Agents and Chemotherapy128 citations Open access
Semantic Scholar
Ivermectin and nodulisporic acid receptors in Drosophila melanogaster contain both gamma-aminobutyric acid-gated Rdl and glutamate-gated GluCl alpha chloride channel subunits.
S. Ludmerer, Vivien A. Warren, Brande S. Williams, Yingcong Zheng +10 more
2002Biochemistry97 citations
Semantic Scholar
Robust Antiviral Efficacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected Chimpanzees
S. Carroll, S. Ludmerer, L. Handt, K. Koeplinger +6 more
2008Antimicrobial Agents and Chemotherapy93 citations Open access
Semantic Scholar
Susceptibilities of Genotype 1a, 1b, and 3 Hepatitis C Virus Variants to the NS5A Inhibitor Elbasvir
Rong Liu, S. Curry, Patricia McMonagle, W. Yeh +9 more
2015Antimicrobial Agents and Chemotherapy75 citations Open access
Semantic Scholar
Gene for yeast glutamine tRNA synthetase encodes a large amino-terminal extension and provides a strong confirmation of the signature sequence for a group of the aminoacyl-tRNA synthetases.
S. Ludmerer, Paul R. Schimmel
1987Journal of Biological Chemistry66 citations Open access
Semantic Scholar
Two amino acid residues confer type specificity to a neutralizing, conformationally dependent epitope on human papillomavirus type 11
S. Ludmerer, D. Benincasa, G. Mark
1996Journal of Virology63 citations Open access
Semantic Scholar
Identification of a Key Determinant of Hepatitis C Virus Cell Culture Adaptation in Domain II of NS3 Helicase*
J. Grobler, E. Markel, John F. Fay, Donald J. Graham +5 more
2003Journal of Biological Chemistry57 citations Open access
Semantic Scholar
Virologic resistance analysis from a phase 2 study of MK-5172 combined with pegylated interferon/ribavirin in treatment-naive patients with hepatitis C virus genotype 1 infection.
A. Howe, Stuart Black, S. Curry, S. Ludmerer +9 more
2014Clinical Infectious Diseases54 citations
Semantic Scholar
A neutralizing epitope of human papillomavirus type 11 is principally described by a continuous set of residues which overlap a distinct linear, surface-exposed epitope
S. Ludmerer, D. Benincasa, George E. Mark, Neil D. Christensen
1997Journal of Virology54 citations Open access
Semantic Scholar
Sustained Viral Response in a Hepatitis C Virus-Infected Chimpanzee via a Combination of Direct-Acting Antiviral Agents
D. Olsen, M. Davies, L. Handt, K. Koeplinger +7 more
2010Antimicrobial Agents and Chemotherapy51 citations Open access
Semantic Scholar
A novel human papillomavirus type 6 neutralizing domain comprising two discrete regions of the major capsid protein L1.
William L. Mcclements, Xin-Min Wang, J. Ling, DeeMarie Skulsky +3 more
2001Virology41 citations Open access
Semantic Scholar
RdlDv, a novel GABA-gated chloride channel gene from the American dog tick Dermacentor variabilis.
Yingcong Zheng, B. Priest, Doris F. Cully, S. Ludmerer
2003Insect Biochemistry and Molecular Biology26 citations
Semantic Scholar
Construction and analysis of deletions in the amino-terminal extension of glutamine tRNA synthetase of Saccharomyces cerevisiae.
S. Ludmerer, Paul R. Schimmel
1987Journal of Biological Chemistry25 citations Open access
Semantic Scholar
Purification of glutamine tRNA synthetase from Saccharomyces cerevisiae. A monomeric aminoacyl-tRNA synthetase with a large and dispensable NH2-terminal domain.
S. Ludmerer, David J. Wright, Paul R. Schimmel
1993Journal of Biological Chemistry21 citations Open access
Semantic Scholar
Vaniprevir plus peginterferon alfa-2b and ribavirin in treatment-naive Japanese patients with hepatitis C virus genotype 1 infection: a randomized phase III study
N. Hayashi, M. Nakamuta, T. Takehara, H. Kumada +4 more
2015Journal of gastroenterology18 citations Open access
Semantic Scholar
Structural basis for resistance of the genotype 2b hepatitis C virus NS5B polymerase to site A non-nucleoside inhibitors.
E. H. Rydberg, Antonella Cellucci, L. Bartholomew, M. Mattu +8 more
2009Journal of Molecular Biology18 citations
Semantic Scholar
A transient cell-based phenotype assay for hepatitis C NS3/4A protease: application to potency determinations of a novel macrocyclic inhibitor against diverse protease sequences isolated from plasma infected with HCV.
S. Ludmerer, Donald J. Graham, Mihir R. Patel, K. F. Gilbert +2 more
2008Journal of Virological Methods17 citations
Semantic Scholar
A genotype 2b NS5B polymerase with novel substitutions supports replication of a chimeric HCV 1b:2b replicon containing a genotype 1b NS3-5A background.
Donald J. Graham, M. Stahlhut, O. Flores, D. Olsen +3 more
2006Antiviral Research17 citations
Semantic Scholar
Development of a New Structural Class of Broadly Acting HCV Non‐Nucleoside Inhibitors Leading to the Discovery of MK‐8876
C. McComas, A. Palani, Wei Chang, M. Holloway +12 more
2017ChemMedChem16 citations
Semantic Scholar
[791] HCV ANTIVIRAL ACTIVITY AND RESISTANCE ANALYSIS IN CHRONICALLY INFECTED CHIMPANZEES TREATED WITH NS3/4A PROTEASE AND NS5B POLYMERASE INHIBITORS
D. Olsen, S. Carroll, L. Handt, S. Ludmerer +6 more
200716 citations Open access
Semantic Scholar
MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants
V. Summa, S. Ludmerer, J. Mccauley, Christine M. Fandozzi +22 more
2014Antimicrobial Agents and Chemotherapy14 citations Open access
Semantic Scholar
858 IN VITRO RESISTANCE ANALYSIS OF HCV NS5A INHIBITOR: MK-8742 DEMONSTRATES INCREASED POTENCY AGAINST CLINICAL RESISTANCE VARIANTS AND HIGHER RESISITANCE BARRIER
Rong Liu, R. Kong, P. Mann, P. Ingravallo +5 more
201210 citations
Semantic Scholar
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.
M. Rudd, C. J. Mcintyre, Joseph J. Romano, J. W. Butcher +26 more
2012Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Cloning of GLN4: an essential gene that encodes glutaminyl-tRNA synthetase in Saccharomyces cerevisiae
S. Ludmerer, Paul R. Schimmel
1985Journal of Bacteriology9 citations Open access
Semantic Scholar
Susceptibilities of Genotype 1 a , 1 b , and 3 Hepatitis C Virus Variants to the NS 5 A Inhibitor Elbasvir
Rong Liu, S. Curry, Patricia McMonagle, W. Yeh +9 more
20158 citations
Semantic Scholar
Human papillomavirus type 6 virus-like particles present overlapping yet distinct conformational epitopes.
Xin-min Wang, J. Cook, Jessica Lee, K. Jansen +3 more
2003Journal of General Virology8 citations Open access
Semantic Scholar
Rapid, high-level transient expression of papillomavirus-like particles in insect cells.
D. Benincasa, M. Silberklang, George E. Mark, S. Ludmerer
1996BioTechniques6 citations Open access
Semantic Scholar
Multi-step parallel synthesis enabled optimization of benzofuran derivatives as pan-genotypic non-nucleoside inhibitors of HCV NS5B.
D. Xiao, X. Dai, Hong Liu, Shu-Wen He +5 more
2020Bioorganic & Medicinal Chemistry Letters5 citations Open access
Semantic Scholar
Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease.
M. Rudd, J. Mccauley, Joseph J. Romano, J. W. Butcher +26 more
2012Bioorganic & Medicinal Chemistry Letters5 citations
Semantic Scholar
39 MK-5172: A NOVEL HCV NS3/4A PROTEASE INHIBITOR WITH POTENT ACTIVITY AGAINST KNOWN RESISTANCE MUTANTS
S. Carroll, J. Mccauley, S. Ludmerer, S. Harper +24 more
20105 citations
Semantic Scholar
The C-terminus of the B cell activator Oct-2 functions as an activation domain in yeast.
J. Mead, Keith Owen Elliston, D. Mark, S. Ludmerer
1994Biochemical and Biophysical Research Communications - BBRC4 citations
Semantic Scholar
Design and evaluation of novel tetracyclic benzofurans as palm site allosteric inhibitors of HCV NS5B polymerase.
Hong Liu, X. Dai, Shu-Wen He, L. Brockunier +6 more
2019Bioorganic & Medicinal Chemistry Letters3 citations Open access
Semantic Scholar
Efficacy and safety of 8 weeks of elbasvir/grazoprevir in HCV GT4-infected treatment-naīve participants
T. Asselah, S. Pol, C. Hézode, V. Loustaud-Ratti +22 more
20183 citations
Semantic Scholar
Evaluation of MK-7009, A Novel Macrocyclic Inhibitor of NS3/4A Protease, in the Chimpanzee Model of Chronic Hepatitis C Virus Infection
S. Ludmerer, Donald J. Graham, L. Handt, Christine M. Fandozzi +7 more
20083 citations
Semantic Scholar
HCV evolutionary genetics of SVR versus virologic failure assessed from the vaniprevir phase III registration trials.
S. Ludmerer, Tomona Hirano, Stuart Black, A. Howe +7 more
2016Antiviral Research2 citations Open access
Semantic Scholar
MK-5172, a Novel Macrocyclic Inhibitor of NS3/4a Protease Demonstrates Efficacy Against Viral Resistance in the Chimpanzee Model of Chronic Hepatitis C Virus Infection
S. Ludmerer, S. Carroll, J. Mccauley, M. Rudd +12 more
20101 citations
Semantic Scholar
Front Cover: Development of a New Structural Class of Broadly Acting HCV Non-Nucleoside Inhibitors Leading to the Discovery of MK-8876 (ChemMedChem 17/2017)
C. McComas, A. Palani, Wei Chang, M. Holloway +12 more
20170 citations Open access
Semantic Scholar
Chronic Hepatitis B ( CHB ) Infection – Unmet Need and Product Opportunity
L. Sepp-Lorenzino, D. Freedman, A. Sprague, Martin A. Maier +27 more
20140 citations
Semantic Scholar
P1228 COMPARATIVE RESISTANCE ANALYSIS BETWEEN CIRRHOTIC AND NON-CIRRHOTIC TREATMENT EXPERIENCED PATIENTS WHO FAILED TREATMENT WITH A COMBINATION OF VANIPREVIR (MK-7009) AND PEGYLATED INTERFERON AND RIBAVIRIN (P/R)
S. Ludmerer, R. Barnard, J. Brunhoffer, A. Howe +4 more
20140 citations
Semantic Scholar
Replication inhibitors of Hepatitis C virus
C. Coburn, J. Mccauley, S. Ludmerer, Kun Liu +11 more
20100 citations
Semantic Scholar
Robust Antiviral Efﬁcacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected Chimpanzees (cid:1)
S. Carroll, S. Ludmerer, L. Handt, K. Koeplinger +6 more
20090 citations
Semantic Scholar
Inhibitors of the HCV NS3 protease
Katharine M Holloway, N. Liverton, S. Ludmerer, J. Mccauley +4 more
20060 citations
Semantic Scholar
Particules viroides synthetiques a epitopes heterologues
K. Jansen, J. Ling, S. Ludmerer, W. Mcclements +1 more
19990 citations
Semantic Scholar

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