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Ryan J. Paxman · SciRah

Researcher profile · Semantic Scholar

Ryan J. Paxman

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Ryan J. Paxman — researcher profile on SciRah

h-index: 10
Works: 28
Citations: 888

Most-cited papers

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
L. Plate, Christina B. Cooley, John J. Chen, Ryan J. Paxman +14 more
2016eLife216 citations Open access
Semantic Scholar
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
Erik A. Blackwood, Khalid M. Azizi, D. Thuerauf, Ryan J. Paxman +4 more
2018Nature Communications170 citations Open access
Semantic Scholar
Pharmacologic IRE1/XBP1s Activation Confers Targeted ER Proteostasis Reprogramming
Julia M. Grandjean, Aparajita Madhavan, Lauren Cech, Bryan O. Seguinot +9 more
2020Nature Chemical Biology150 citations Open access
Semantic Scholar
Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins
Ryan J. Paxman, L. Plate, Erik A. Blackwood, C. Glembotski +3 more
2018eLife101 citations Open access
Semantic Scholar
The unfolded protein response regulator ATF6 promotes mesodermal differentiation
Heike Kroeger, Neil J. Grimsey, Ryan J. Paxman, W. Chiang +9 more
2018Science Signaling70 citations Open access
Semantic Scholar
Blinded potency comparison of transthyretin kinetic stabilizers by subunit exchange in human plasma
Luke T. Nelson, Ryan J. Paxman, Jin Xu, B. Webb +2 more
2020Amyloid: Journal of Protein Folding Disorders52 citations Open access
Semantic Scholar
Criteria for selecting PEGylation sites on proteins for higher thermodynamic and proteolytic stability.
P. B. Lawrence, Yulian Gavrilov, S. S. Matthews, Minnie I Langlois +11 more
2014Journal of the American Chemical Society51 citations
Semantic Scholar
Two structural scenarios for protein stabilization by PEG.
Shu-Han Chao, S. S. Matthews, Ryan J. Paxman, A. Aksimentiev +2 more
2014Journal of Physical Chemistry B39 citations
Semantic Scholar
Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion.
Bibiana Rius, Jaleh S. Mesgarzadeh, Isabelle C. Romine, Ryan J. Paxman +2 more
2021Blood Advances20 citations Open access
Semantic Scholar
Modulating protein quality control
L. Plate, Ryan J. Paxman, R. Wiseman, J. Kelly
2016eLife15 citations Open access
Semantic Scholar
Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators
Gabe M. Kline, Ryan J. Paxman, Chung-Yon Lin, Nicole Madrazo +6 more
2023bioRxiv2 citations Open access
Semantic Scholar
Author response: Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins
Ryan J. Paxman, L. Plate, Erik A. Blackwood, C. Glembotski +3 more
20182 citations Open access
Semantic Scholar
Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity
Gabe M. Kline, Lisa Boinon, Adrian Guerrero, Sergei Kutseikin +7 more
2025bioRxiv1 citations Open access
Semantic Scholar
ER Proteostasis Regulators Reduce Amyloidogenic Light Chain Secretion Through an On-Target, ATF6-Independent Mechanism
Bibiana Rius, Jaleh S. Mesgarzadeh, Isabelle C. Romine, Ryan J. Paxman +2 more
2020bioRxiv1 citations Open access
Semantic Scholar
Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity
Gabe M. Kline, Lisa Boinon, Adrian Guerrero, Sergei Kutseikin +7 more
2026eLife0 citations
Semantic Scholar
Divergent Proteome Reactivity Influences Arm-Selective Activation of the Unfolded Protein Response by Pharmacological Endoplasmic Reticulum Proteostasis Regulators
Gabe M. Kline, Ryan J. Paxman, Chung-Yon Lin, Nicole Madrazo +7 more
2023ACS Chemical Biology0 citations Open access
Semantic Scholar
ER Proteostasis Regulators Reduce Amyloidogenic Light Chain Secretion Through an On-Target, 1 ATF6-Independent Mechanism 2
Bibiana Rius, Jaleh S. Mesgarzadeh, Isabelle C. Romine, Ryan J. Paxman +4 more
20200 citations
Semantic Scholar
The Photoreceptor Dystrophy and Unfolded Protein Response Regulator Gene, ATF6, Promotes Mesodermal Differentiation in Human Stem Cells
Heike Kroeger, Neil J. Grimsey, Ryan J. Paxman, W. Chiang +9 more
20180 citations
Semantic Scholar
Abstract 547: Pharmacologic ATF6 Activation Confers Global Protection in Widespread Disease Models by Reprogramming Cellular Proteostasis
Erik A. Blackwood, Khalid M. Azizi, D. Thuerauf, Ryan J. Paxman +4 more
2018Circulation Research0 citations
Semantic Scholar
Small Molecule ER Proteostasis Regulators Rescue Activity of ATF6 Disease Mutants
W. Chiang, Priscilla Chan, Ryan J. Paxman, Jeffery W. Kelly +2 more
20180 citations
Semantic Scholar
060High-Throughput Screen Identifies Novel Small Molecule Stress Regulator That Confers Cardioprotection During Ischemia-Reperfusion Injury
Erik A. Blackwood, L. Plate, Ryan J. Paxman, K. Malter +2 more
20170 citations
Semantic Scholar
Abstract 19303: A Small Molecular Activator of the ER Proteostasis Regulator, ATF6, is Beneficial in the Ischemic Heart
Erik A. Blackwood, Khalid M. Azizi, Jung-kang Jin, L. Plate +5 more
20170 citations
Semantic Scholar
Abstract 138: Identification of a Novel Small Molecule Activator of ATF6 that Confers Protection Against Ischemia/reperfusion Injury in the Heart
Erik A. Blackwood, L. Plate, Ryan J. Paxman, K. Malter +3 more
2017Circulation Research0 citations
Semantic Scholar
potential to treat a variety of human protein misfolding diseases.
L. Plate, Ryan J. Paxman, R. Wiseman, J. Kelly
20160 citations
Semantic Scholar
Author response: Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
L. Plate, Christina B. Cooley, John J. Chen, Ryan J. Paxman +14 more
20160 citations Open access
Semantic Scholar
Biological.
Gabe M. Kline, Lisa Boinon, Adrian Guerrero, Sergei Kutseikin +9 more
2016The journals of gerontology. Series A, Biological sciences and medical sciences0 citations
Semantic Scholar
Digital Commons @ Trinity Digital Commons @ Trinity Pharmacologic IRE1/XBP1s Activation Confers Targeted ER Pharmacologic IRE1/XBP1s Activation Confers Targeted ER Proteostasis Reprogramming Proteostasis Reprogramming
Julia M. Grandjean, Aparajita Madhavan, Lauren Cech, Bryan O. Seguinot +11 more
0 citations
Semantic Scholar
Digital Commons @ Trinity Digital Commons @ Trinity
Lars Plate, Christina B. Cooley, John J. Chen, Ryan J. Paxman +14 more
0 citations
Semantic Scholar

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L. Plate — researcher profile on SciRah
J. Kelly×9
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Erik A. Blackwood

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Jeffery W. Kelly×7

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C. Glembotski — researcher profile on SciRah

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Gabe M. Kline — researcher profile on SciRah

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