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J. Lai · SciRah

Researcher profile · Semantic Scholar

J. Lai

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J. Lai — researcher profile on SciRah

h-index: 20
Works: 43
Citations: 2,225

Most-cited papers

A motif-based profile scanning approach for genome-wide prediction of signaling pathways
M. Yaffe, G. Leparc, J. Lai, T. Obata +2 more
2001Nature Biotechnology556 citations
Semantic Scholar
DPP8/9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis
Marian C. Okondo, Darren C. Johnson, Ramya Sridharan, Eun Bin Go +11 more
2016Nature Chemical Biology261 citations Open access
Semantic Scholar
Utilization of Oriented Peptide Libraries to Identify Substrate Motifs Selected by ATM*
T. O'Neill, A. J. O. Dwyer, Y. Ziv, Doug W. Chan +7 more
2000Journal of Biological Chemistry197 citations Open access
Semantic Scholar
Abrogation of fibroblast activation protein enzymatic activity attenuates tumor growth
Jonathan D. Cheng, Matthildi Valianou, A. Canutescu, E. Jaffe +5 more
2005Molecular Cancer Therapeutics132 citations
Semantic Scholar
Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs
F. M. Keane, Tsun-Wen Yao, Stefanie Seelk, Margaret G. Gall +22 more
2013FEBS Open Bio129 citations Open access
Semantic Scholar
Identification of Selective and Potent Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase
Sarah E. Poplawski, J. Lai, You-Hua Li, Zhi-Ping Jin +7 more
2013Journal of Medicinal Chemistry106 citations Open access
Semantic Scholar
An atypical parvovirus driving chronic tubulointerstitial nephropathy and kidney fibrosis
B. Roediger, Q. Lee, Shweta Tikoo, J. Cobbin +26 more
2018Cell102 citations Open access
Semantic Scholar
A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity
D. Bachovchin, Luke W. Koblan, Wen-Gen Wu, Yuxin Liu +13 more
2014Nature Chemical Biology77 citations Open access
Semantic Scholar
Human FGF-21 Is a Substrate of Fibroblast Activation Protein
Andrew L. Coppage, Kathryn R Heard, Matthew T DiMare, Yuxin Liu +3 more
2016PLoS ONE67 citations Open access
Semantic Scholar
Chemical and biological evaluation of dipeptidyl boronic acid proteasome inhibitors for use in prodrugs and pro-soft drugs targeting solid tumors.
Lawrence J. Milo, J. Lai, Wen-Gen Wu, Yuxin Liu +9 more
2011Journal of Medicinal Chemistry66 citations
Semantic Scholar
Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety.
Beth A. Connolly, D. Sanford, Amrita K. Chiluwal, Sarah E. Healey +11 more
2008Journal of Medicinal Chemistry61 citations Open access
Semantic Scholar
Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity*
T. Akopian, Olga Kandror, C. Tsu, J. Lai +9 more
2015Journal of Biological Chemistry47 citations Open access
Semantic Scholar
Phosphorylation by LAMMER protein kinases: determination of a consensus site, identification of in vitro substrates, and implications for substrate preferences.
E. Nikolakaki, Cheng Du, J. Lai, T. Giannakouros +2 more
2002Biochemistry45 citations
Semantic Scholar
Preclinical Development of PNT6555, a Boronic Acid–Based, Fibroblast Activation Protein-α (FAP)–Targeted Radiotheranostic for Imaging and Treatment of FAP-Positive Tumors
Sarah E. Poplawski, R. Hallett, M. Dornan, Kyle E. Novakowski +12 more
2023Journal of Nuclear Medicine39 citations Open access
Semantic Scholar
A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase.
K. Nishikawa, S. Sawasdikosol, D. Fruman, J. Lai +4 more
2000Molecules and Cells36 citations Open access
Semantic Scholar
Reverse D4F, an Apolipoprotein-AI Mimetic Peptide, Inhibits Atherosclerosis in ApoE-null Mice
S. Qin, V. Kamanna, J. Lai, Tianjiao Liu +4 more
2012Journal of Cardiovascular Pharmacology and Therapeutics29 citations
Semantic Scholar
Dipeptidyl Peptidase Inhibition Enhances CD8 T Cell Recruitment and Activates Intrahepatic Inflammasome in a Murine Model of Hepatocellular Carcinoma
James M Henderson, M. Xiang, Jiali Carrie Huang, S. Wetzel +9 more
2021Cancers26 citations Open access
Semantic Scholar
Intramolecular dative bonds involving boron with oxygen and nitrogen in boronic acids and esters : a computational study
K. Bhat, N. Howard, H. Rostami, J. Lai +1 more
200526 citations
Semantic Scholar
Sphingosine kinase 1 isoform-specific interactions in breast cancer.
Daniel Yagoub, M. Wilkins, Angelina J. Lay, D. Kaczorowski +8 more
2014Molecular Endocrinology25 citations Open access
Semantic Scholar
Pro-soft Val-boroPro: a strategy for enhancing in vivo performance of boronic acid inhibitors of serine proteases.
Sarah E. Poplawski, J. Lai, D. Sanford, J. Sudmeier +2 more
2011Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Fibroblast activation protein is dispensable for control of glucose homeostasis and body weight in mice
Brandon L. Panaro, Andrew L. Coppage, Jacqueline L Beaudry, Elodie M. Varin +6 more
2018Molecular Metabolism20 citations Open access
Semantic Scholar
A pan-inhibitor of DASH family enzymes induces immune-mediated regression of murine sarcoma and is a potent adjuvant to dendritic cell vaccination and adoptive T-cell therapy
Brynn B. Duncan, S. Highfill, Haiying Qin, N. Bouchkouj +11 more
2013Journal of immunotherapy17 citations Open access
Semantic Scholar
Synthesis and characterization of constrained peptidomimetic dipeptidyl peptidase IV inhibitors: amino-lactam boroalanines.
J. Lai, Wen-Gen Wu, Yuhong Zhou, H. Maw +7 more
2007Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
A pan inhibitor of DASH family enzymes induces immunogenic modulation and sensitizes murine and human carcinoma cells to antigen-specific cytotoxic T lymphocyte killing: implications for combination therapy with cancer vaccines
R. Donahue, Brynn B. Duncan, T. Fry, B. Jones +8 more
2014Vaccine15 citations Open access
Semantic Scholar
A general method for making peptide therapeutics resistant to serine protease degradation: application to dipeptidyl peptidase IV substrates.
Kathryn R Heard, Wen-Gen Wu, You-Hua Li, Peng Zhao +10 more
2013Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
4-Substituted boro-proline dipeptides: synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities.
Wen-Gen Wu, Yuxin Liu, Lawrence J. Milo, Ying Shu +11 more
2012Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Synthesis and structural investigation of internally coordinated alpha-amidoboronic acids.
J. Lai, Yuxin Liu, Wen-Gen Wu, Yuhong Zhou +4 more
2006Journal of Organic Chemistry11 citations
Semantic Scholar
Synthesis of a Vicinal Tricarbonyl Amide Derivative of L-Phenylalanine.
J. Lai, H. Pham, D. Hangauer
1996Journal of Organic Chemistry11 citations
Semantic Scholar
The design, synthesis and activity of pentapeptide pp60c-src inhibitors containing L-phosphotyrosine mimics.
J. Lai, T. Marsilje, Sun Choi, S. A. Nair +1 more
2009Journal of Peptide Research10 citations
Semantic Scholar
A computational investigation of the geometrical structure and protodeboronation of boroglycine, H2N-CH2-B(OH)2.
Joseph D. Larkin, K. Bhat, G. Markham, B. Brooks +2 more
2007Journal of Physical Chemistry A10 citations
Semantic Scholar
Quantitation of ﬁbroblast activation protein (FAP)-speciﬁc protease activity in mouse, baboon and human ﬂuids and organs (cid:2)
F. M. Keane, Tsun-Wen Yao, Stefanie Seelk, Margaret G. Gall +25 more
20138 citations
Semantic Scholar
Autochelation in dipeptide boronic acids: pH-dependent structures and equilibria of Asp-boroPro and His-boroPro by NMR spectroscopy.
J. Sudmeier, Yuhong Zhou, J. Lai, H. Maw +2 more
2005Journal of the American Chemical Society7 citations
Semantic Scholar
Activation Mechanism and Structural Assembly of the Mycobacterium tuberculosis ClpP1P2 Protease and Its Associated ATPases
Katharina Weinhäupl, Tatos Akopian, D. Semchonok, Olga Krandor +14 more
2025bioRxiv6 citations
Semantic Scholar
Recent Progress in the Synthesis of Pyridinylboronic Acids and Esters
Yu-Xin Liu, Lawrence J. Milo, J. Lai
20135 citations Open access
Semantic Scholar
Tetrapeptide tyrosine kinase inhibitors
M. Kim, J. Lai, D. Hangauer
20094 citations
Semantic Scholar
Abstract 1815: AVA6000, a novel Precision medicine, targeted to the tumor microenvironment via Fibroblast Activation Protein (FAP) mediated cleavage
Fiona McLaughlin, Sarah E. Poplawski, David G. Sanford, A. Saunders +4 more
2022Cancer Research3 citations
Semantic Scholar
ATM and lymphoid malignancies; use of oriented peptide libraries to identify novel substrates of ATM critical in downstream signaling pathways.
G. Rathbun, Y. Ziv, J. Lai, D. Hill +3 more
1999Current Topics in Microbiology and Immunology3 citations
Semantic Scholar
Abstract 3303: Pre-clinical characterization of the novel FAP targeting ligand PNT6555 for imaging and therapy of cancer
R. Hallett, Sarah E. Poplawski, M. Dornan, S. Ahn +10 more
2022Cancer Research2 citations
Semantic Scholar
Abstract 660: Reverse-D4F (Rev-D4F), an Apolipoprotein-AI Mimetic Peptide, Reduces Plaque Macrophage Content in Apolipoprotein E-null Mice
S. Qin, V. Kamanna, J. Lai, W. Bachovchin +1 more
20061 citations
Semantic Scholar
Tetrapeptide tyrosine kinase inhibitors. Enantioselective synthesis of p-hydroxymethyl-L-phenylalanine, incorporation into a tetrapeptide, and subsequent elaboration into p-(R,S-hydroxyphosphonomethyl)-L-phenylalanine.
M. H. Kim, J. Lai, D. Hangauer
1994International journal of peptide & protein research1 citations
Semantic Scholar
Overcoming the KRAS resistance mechanism by augmenting antibody-dependent cellular cytotoxicity
H. Borghaei, B. Jones, C. Kiritsy, J. Lai +1 more
20120 citations
Semantic Scholar
Amine-Catalyzed B-O-C Bond Formation: Mechanistic Insights from Density Functional Theory and Second-Order Moller-Plesset Perturbation Theory
K. Bhat, J. Lai, G. Markham, Anthony M. Dijulio +1 more
20060 citations
Semantic Scholar
Microscopic acid-base equilibra of alanyl-boroAlanine.
J. Lai, Yuhong Zhou, J. Sudmeier, Wen-Gen Wu +4 more
2003Advances in Experimental Medicine and Biology0 citations
Semantic Scholar

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