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G. Goldsteins · SciRah

Researcher profile · Semantic Scholar

G. Goldsteins

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G. Goldsteins — researcher profile on SciRah

h-index: 38
Works: 72
Citations: 6,080

Most-cited papers

A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window.
J. Yrjänheikki, Tiina M. Tikka, R. Keinänen, G. Goldsteins +2 more
1999Proceedings of the National Academy of Sciences of the United States of America1,086 citations Open access
Semantic Scholar
Minocycline, a Tetracycline Derivative, Is Neuroprotective against Excitotoxicity by Inhibiting Activation and Proliferation of Microglia
Tiina M. Tikka, B. Fiebich, G. Goldsteins, R. Keinänen +1 more
2001Journal of Neuroscience988 citations Open access
Semantic Scholar
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid.
K. Kanninen, T. Malm, Henna-Kaisa Jyrkkänen, G. Goldsteins +6 more
2008Molecular and cellular neurosciences248 citations
Semantic Scholar
Age‐related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild‐type mice
R. Minkeviciene, J. Ihalainen, T. Malm, O. Matilainen +8 more
2008Journal of Neurochemistry211 citations
Semantic Scholar
Pyrrolidine Dithiocarbamate Activates Akt and Improves Spatial Learning in APP/PS1 Mice without Affecting β-Amyloid Burden
T. Malm, H. Iivonen, G. Goldsteins, V. Keksa-Goldsteine +7 more
2007Journal of Neuroscience161 citations Open access
Semantic Scholar
Metabolic alterations in Parkinson’s disease astrocytes
Tuuli-Maria Sonninen, R. Hämäläinen, M. Koskuvi, M. Oksanen +10 more
2020Scientific Reports159 citations Open access
Semantic Scholar
β-Amyloid precursor protein transgenic mice that harbor diffuse Aβ deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation
M. Koistinaho, M. Kettunen, G. Goldsteins, R. Keinänen +7 more
2002Proceedings of the National Academy of Sciences of the United States of America154 citations Open access
Semantic Scholar
The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis
E. Pollari, G. Goldsteins, G. Bart, J. Koistinaho +1 more
2014Frontiers in Cellular Neuroscience150 citations Open access
Semantic Scholar
Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease.
Tiina M. Tikka, N. Vartiainen, G. Goldsteins, S. Oja +3 more
2002Brain : a journal of neurology144 citations Open access
Semantic Scholar
Nrf2 Regulates Antioxidant Gene Expression Evoked by Oxidized Phospholipids in Endothelial Cells and Murine Arteries In Vivo
Henna-Kaisa Jyrkkänen, Emilia Kansanen, M. Inkala, Annukka M. Kivelä +13 more
2008Circulation Research141 citations Open access
Semantic Scholar
Dysfunction of Cellular Proteostasis in Parkinson’s Disease
Š. Lehtonen, Tuuli-Maria Sonninen, S. Wojciechowski, G. Goldsteins +1 more
2019Frontiers in Neuroscience133 citations Open access
Semantic Scholar
Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms
M. Oksanen, Š. Lehtonen, Merja Jaronen, G. Goldsteins +2 more
2019Cellular and Molecular Life Sciences129 citations Open access
Semantic Scholar
Proteomic analysis of protein oxidation in Alzheimer's disease brain
M. Korolainen, G. Goldsteins, I. Alafuzoff, J. Koistinaho +1 more
2002Electrophoresis127 citations
Semantic Scholar
Minocycline Protects against Permanent Cerebral Ischemia in Wild Type but Not in Matrix Metalloprotease-9-Deficient Mice
M. Koistinaho, T. Malm, M. Kettunen, G. Goldsteins +4 more
2005Journal of Cerebral Blood Flow and Metabolism120 citations Open access
Semantic Scholar
Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke
Natalia Kołosowska, M. Keuters, S. Wojciechowski, V. Keksa-Goldsteine +5 more
2019Neurotherapeutics118 citations Open access
Semantic Scholar
Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's disease
Johanna Magga, Lakshman Puli, Rea Pihlaja, K. Kanninen +8 more
2010Journal of Neuroinflammation106 citations Open access
Semantic Scholar
Glycosylation changes in Alzheimer's disease as revealed by a proteomic approach.
K. Kanninen, G. Goldsteins, S. Auriola, I. Alafuzoff +1 more
2004Neuroscience Letters104 citations
Semantic Scholar
Oxidative modification of proteins in the frontal cortex of Alzheimer's disease brain.
M. Korolainen, G. Goldsteins, T. Nyman, I. Alafuzoff +2 more
2006Neurobiology of Aging99 citations
Semantic Scholar
Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation.
M. Koistinaho, M. Kettunen, G. Goldsteins, R. Keinänen +7 more
2002Proceedings of the National Academy of Sciences of the United States of America91 citations
Semantic Scholar
Pyrrolidine dithiocarbamate inhibits translocation of nuclear factor kappa‐B in neurons and protects against brain ischaemia with a wide therapeutic time window
A. Nurmi, N. Vartiainen, Rea Pihlaja, G. Goldsteins +2 more
2004Journal of Neurochemistry86 citations
Semantic Scholar
Deleterious Role of Superoxide Dismutase in the Mitochondrial Intermembrane Space*
G. Goldsteins, V. Keksa-Goldsteine, T. Ahtoniemi, Merja Jaronen +4 more
2008Journal of Biological Chemistry85 citations Open access
Semantic Scholar
Neuron-astrocyte transmitophagy is altered in Alzheimer's disease.
Riikka Lampinen, I. Belaya, L. Saveleva, J. R. Liddell +21 more
2022Neurobiology of Disease75 citations Open access
Semantic Scholar
ER stress and unfolded protein response in amyotrophic lateral sclerosis—a controversial role of protein disulphide isomerase
Merja Jaronen, G. Goldsteins, J. Koistinaho
2014Frontiers in Cellular Neuroscience75 citations Open access
Semantic Scholar
Exposure of cryptic epitopes on transthyretin only in amyloid and in amyloidogenic mutants.
G. Goldsteins, H. Persson, K. Andersson, A. Olofsson +4 more
1999Proceedings of the National Academy of Sciences of the United States of America75 citations Open access
Semantic Scholar
Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis
E. Pollari, E. Savchenko, Merja Jaronen, K. Kanninen +8 more
2011Journal of Neuroinflammation72 citations Open access
Semantic Scholar
Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases
Tuuli-Maria Sonninen, G. Goldsteins, N. Laham-Karam, J. Koistinaho +1 more
2020Cells69 citations Open access
Semantic Scholar
The Microglia-activating Potential of Thrombin
U. Hanisch, D. van Rossum, Yiheng Xie, K. Gast +6 more
2004Journal of Biological Chemistry64 citations Open access
Semantic Scholar
Glycogen Synthase Kinase-3β: A Mediator of Inflammation in Alzheimer's Disease?
J. Koistinaho, T. Malm, G. Goldsteins
2011International Journal of Alzheimer's Disease54 citations Open access
Semantic Scholar
Induction of Protein Kinase Cδ Subspecies in Neurons and Microglia after Transient Global Brain Ischemia
Susanna Koponen, G. Goldsteins, R. Keinänen, J. Koistinaho
2000Journal of Cerebral Blood Flow and Metabolism53 citations Open access
Semantic Scholar
Mutant SOD1 from spinal cord of G93A rats is destabilized and binds to inner mitochondrial membrane.
T. Ahtoniemi, Merja Jaronen, V. Keksa-Goldsteine, G. Goldsteins +1 more
2008Neurobiology of Disease52 citations Open access
Semantic Scholar
PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes
Henna Konttinen, I. Gureviciene, M. Oksanen, A. Grubman +12 more
2018Glia49 citations Open access
Semantic Scholar
Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes
J. R. Liddell, Š. Lehtonen, C. Duncan, V. Keksa-Goldsteine +6 more
2016Journal of Neuroinflammation49 citations Open access
Semantic Scholar
Characterization of two highly amyloidogenic mutants of transthyretin.
G. Goldsteins, Karin Andersson, Anders Olofsson, Ingrid Dacklin +6 more
1997Biochemistry45 citations
Semantic Scholar
Antioxidant pyrrolidine dithiocarbamate activates Akt-GSK signaling and is neuroprotective in neonatal hypoxia-ischemia.
A. Nurmi, G. Goldsteins, J. Närväinen, Rea Pihlaja +3 more
2006Free Radical Biology & Medicine44 citations
Semantic Scholar
The "edge strand" hypothesis: Prediction and test of a mutational "hot-spot" on the transthyretin molecule associated with FAP amyloidogenesis
L. Serpell, G. Goldsteins, I. Dacklin, E. Lundgren +1 more
199644 citations Open access
Semantic Scholar
Pyrrolidine Dithiocarbamate Inhibits Induction of Immunoproteasome and Decreases Survival in a Rat Model of Amyotrophic Lateral Sclerosis
T. Ahtoniemi, G. Goldsteins, V. Keksa-Goldsteine, T. Malm +3 more
2007Molecular Pharmacology43 citations
Semantic Scholar
β-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or β-amyloid deposits
T. Malm, M. Ort, Leena Tähtivaara, Niko Jukarainen +16 more
200641 citations
Semantic Scholar
Aspirin Inhibits p44/42 Mitogen-Activated Protein Kinase and Is Protective Against Hypoxia/Reoxygenation Neuronal Damage
N. Vartiainen, G. Goldsteins, V. Keksa-Goldsteine, P. H. Chan +1 more
2003Stroke40 citations Open access
Semantic Scholar
Piroxicam and NS‐398 rescue neurones from hypoxia/reoxygenation damage by a mechanism independent of cyclo‐oxygenase inhibition
N. Vartiainen, Chiung-Ying Huang, A. Salminen, G. Goldsteins +2 more
2001Journal of Neurochemistry39 citations
Semantic Scholar
Protein disulfide isomerase in ALS mouse glia links protein misfolding with NADPH oxidase-catalyzed superoxide production.
Merja Jaronen, P. Vehviläinen, T. Malm, V. Keksa-Goldsteine +4 more
2013Human Molecular Genetics38 citations
Semantic Scholar
Aspirin provides cyclin‐dependent kinase 5‐dependent protection against subsequent hypoxia/reoxygenation damage in culture
N. Vartiainen, V. Keksa-Goldsteine, G. Goldsteins, J. Koistinaho
2002Journal of Neurochemistry38 citations Open access
Semantic Scholar
CNS Redox Homeostasis and Dysfunction in Neurodegenerative Diseases
G. Goldsteins, Vili Hakosalo, Merja Jaronen, M. Keuters +2 more
2022Antioxidants37 citations Open access
Semantic Scholar
Isoform-Specific Membrane Translocation of Protein Kinase C After Ischemic Preconditioning
K. Kurkinen, R. Busto, G. Goldsteins, J. Koistinaho +1 more
2001Neurochemical Research34 citations
Semantic Scholar
Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy
M. Huuskonen, S. Loppi, H. Dhungana, V. Keksa-Goldsteine +12 more
2016Scientific Reports33 citations Open access
Semantic Scholar
Induction and activation of protein kinase C delta in hippocampus and cortex after kainic acid treatment.
Selma K. Kaasinen, G. Goldsteins, L. Alhonen, J. Jänne +1 more
2002Experimental Neurology33 citations
Semantic Scholar
An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo
M. Keuters, V. Keksa-Goldsteine, H. Dhungana, M. Huuskonen +13 more
2021Scientific Reports30 citations Open access
Semantic Scholar
ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
Sighild Lemarchant, Yuriy Pomeshchik, Iurii Kidin, Virve Kärkkäinen +6 more
2016Molecular Neurodegeneration30 citations Open access
Semantic Scholar
Kinetics and mathematical model of hydrolysis and transglycosylation catalysed by cellobiase
A. Gusakov, A. Sinitsyn, G. Goldsteins, A. Klyosov
198429 citations
Semantic Scholar
Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation
H. Dhungana, M. Huuskonen, Merja Jaronen, Sighild Lemarchant +6 more
2017Journal of Neuroinflammation28 citations Open access
Semantic Scholar
Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP+ Toxicity-Induced Parkinson's Disease Models
Š. Lehtonen, Merja Jaronen, P. Vehviläinen, M. Lakso +6 more
2016Antioxidants and Redox Signaling26 citations
Semantic Scholar

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