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Y. Minegishi · SciRah

Researcher profile · Semantic Scholar

Y. Minegishi

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Y. Minegishi — researcher profile on SciRah

h-index: 38
Works: 88
Citations: 7,626

Most-cited papers

Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
Y. Minegishi, M. Saito, S. Tsuchiya, I. Tsuge +8 more
2007Nature973 citations
Semantic Scholar
Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity.
Y. Minegishi, M. Saito, T. Morio, Ken Watanabe +32 more
2006Immunity697 citations Open access
Semantic Scholar
Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis.
Y. Tsujimura, K. Obata, K. Mukai, H. Shindou +6 more
2008Immunity398 citations Open access
Semantic Scholar
An essential role for BLNK in human B cell development.
Y. Minegishi, J. Rohrer, E. Coustan-Smith, H. Lederman +4 more
1999Science338 citations
Semantic Scholar
Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome
A. Kreins, Michael J. Ciancanelli, S. Okada, Xiao-Fei Kong +50 more
2015Journal of Experimental Medicine323 citations Open access
Semantic Scholar
Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells.
K. Mukai, K. Matsuoka, C. Taya, Hidenori Suzuki +9 more
2005Immunity315 citations Open access
Semantic Scholar
Basophils are essential initiators of a novel type of chronic allergic inflammation.
K. Obata, K. Mukai, Y. Tsujimura, K. Ishiwata +4 more
2007Blood311 citations
Semantic Scholar
Functional STAT3 deficiency compromises the generation of human T follicular helper cells.
Cindy S. Ma, D. Avery, Anna Chan, M. Batten +21 more
2012Blood310 citations Open access
Semantic Scholar
Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks.
T. Wada, K. Ishiwata, H. Koseki, Tomoyuki Ishikura +11 more
2010Journal of Clinical Investigation305 citations Open access
Semantic Scholar
Mutations in the Human λ5/14.1 Gene Result in B Cell Deficiency and Agammaglobulinemia
Y. Minegishi, E. Coustan-Smith, Yui-Hsi Wang, M. Cooper +2 more
1998Journal of Experimental Medicine274 citations Open access
Semantic Scholar
Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome
Y. Minegishi, M. Saito, M. Nagasawa, H. Takada +8 more
2009Journal of Experimental Medicine252 citations Open access
Semantic Scholar
Mutations in the mu heavy-chain gene in patients with agammaglobulinemia.
L. Yel, Y. Minegishi, E. Coustan-Smith, Rebecca H. Buckley +6 more
1996New England Journal of Medicine239 citations Open access
Semantic Scholar
Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4.
Mayumi Egawa, K. Mukai, S. Yoshikawa, Misako Iki +4 more
2013Immunity223 citations Open access
Semantic Scholar
Monogenic mutations differentially impact the quantity and quality of T follicular helper cells in human primary immunodeficiencies
Cindy S. Ma, Natalie Wong, G. Rao, D. Avery +46 more
2015Journal of Allergy and Clinical Immunology191 citations Open access
Semantic Scholar
Mutations in Igα (CD79a) result in a complete block in B-cell development
Y. Minegishi, E. Coustan-Smith, L. Rapalus, F. Ersoy +2 more
1999191 citations Open access
Semantic Scholar
Mutations in btk in patients with presumed X-linked agammaglobulinemia.
Mary Ellen Conley, D. Mathias, Jason Treadaway, Y. Minegishi +1 more
1998American Journal of Human Genetics170 citations Open access
Semantic Scholar
Mutations in activation-induced cytidine deaminase in patients with hyper IgM syndrome.
Y. Minegishi, A. Lavoie, C. Cunningham-Rundles, P. Bédard +8 more
2000Clinical Immunology143 citations
Semantic Scholar
The skin is an important bulwark of acquired immunity against intestinal helminths
K. Obata-Ninomiya, K. Ishiwata, H. Tsutsui, Y. Nei +7 more
2013Journal of Experimental Medicine142 citations Open access
Semantic Scholar
Defects in early B‐cell development: comparing the consequences of abnormalities in pre‐BCR signaling in the human and the mouse
Mary Ellen Conley, J. Rohrer, L. Rapalus, Elizabeth C. Boylin +1 more
2000Immunological Reviews137 citations
Semantic Scholar
NK Cell-Depleting Anti-Asialo GM1 Antibody Exhibits a Lethal Off-Target Effect on Basophils In Vivo
Hideto Nishikado, K. Mukai, Y. Kawano, Y. Minegishi +1 more
2011Journal of Immunology136 citations Open access
Semantic Scholar
Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells
M. Saito, M. Nagasawa, H. Takada, T. Hara +9 more
2011Journal of Experimental Medicine111 citations Open access
Semantic Scholar
Basophils preferentially express mouse mast cell protease 11 among the mast cell tryptase family in contrast to mast cells
T. Ugajin, Toshiyuki Kojima, K. Mukai, K. Obata +5 more
2009Journal of Leukocyte Biology104 citations Open access
Semantic Scholar
Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets
Cindy S. Ma, Natalie Wong, G. Rao, A. Nguyen +42 more
2016Journal of Experimental Medicine92 citations Open access
Semantic Scholar
Mast Cells and Basophils Are Selectively Activated In Vitro and In Vivo through CD200R3 in an IgE-Independent Manner1
Toshiyuki Kojima, K. Obata, K. Mukai, Shingo Sato +3 more
2007Journal of Immunology80 citations Open access
Semantic Scholar
Hyper-IgE syndrome.
Y. Minegishi
2009Current Opinion in Immunology71 citations
Semantic Scholar
Unusual mutations in Btk: an insertion, a duplication, an inversion, and four large deletions.
J. Rohrer, Y. Minegishi, D. Richter, Jose Eguiguren +1 more
1999Clinical Immunology71 citations
Semantic Scholar
X-linked agammaglobulinemia
Mary Ellen Conley, J. Rohrer, Y. Minegishi
2000Clinical reviews in allergy and immunology66 citations
Semantic Scholar
Mutations in Igalpha (CD79a) result in a complete block in B-cell development.
Y. Minegishi, E. Coustan-Smith, L. Rapalus, F. Ersoy +2 more
1999Journal of Clinical Investigation66 citations
Semantic Scholar
Novel mechanisms control the folding and assembly of lambda5/14.1 and VpreB to produce an intact surrogate light chain.
Y. Minegishi, L. Hendershot, Mary Ellen Conley
1999Proceedings of the National Academy of Sciences of the United States of America63 citations Open access
Semantic Scholar
Impaired IL-23–dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency
Masato Ogishi, A. Arias, Rui Yang, Ji Eun Han +63 more
2022Journal of Experimental Medicine59 citations Open access
Semantic Scholar
Ataxia‐telangiectasia‐mutated dependent phosphorylation of Artemis in response to DNA damage
Ling Chen, T. Morio, Y. Minegishi, S. Nakada +7 more
2005Cancer Science58 citations Open access
Semantic Scholar
Negative selection at the pre-BCR checkpoint elicited by human mu heavy chains with unusual CDR3 regions.
Y. Minegishi, M. Conley
2001Immunity58 citations Open access
Semantic Scholar
Hyper-IgE syndrome, 2021 update.
Y. Minegishi
2021Allergology International55 citations Open access
Semantic Scholar
Allogeneic hematopoietic stem cell transplantation for seven children with X‐linked hyper‐IgM syndrome: A single center experience
D. Tomizawa, K. Imai, Sukeyuki Ito, M. Kajiwara +5 more
2004American journal of hematology/oncology44 citations
Semantic Scholar
Cutaneous manifestations of Hyper IgE syndrome.
Y. Minegishi, M. Saito
2012Allergology International42 citations Open access
Semantic Scholar
Molecular mechanisms of the immunological abnormalities in hyper‐IgE syndrome
Y. Minegishi, M. Saito
2011Annals of the New York Academy of Sciences42 citations
Semantic Scholar
Hyperimmunoglobulin E syndrome and tyrosine kinase 2 deficiency
Y. Minegishi, H. Karasuyama
2007Current Opinion in Allergy and Clinical Immunology42 citations
Semantic Scholar
An Atopic Dermatitis-Like Skin Disease with Hyper-IgE-emia Develops in Mice Carrying a Spontaneous Recessive Point Mutation in the Traf3ip2 (Act1/CIKS) Gene
Y. Matsushima, Y. Kikkawa, Toyoyuki Takada, K. Matsuoka +5 more
2010Journal of Immunology40 citations Open access
Semantic Scholar
Recent progress in the diagnosis and treatment of patients with defects in early B-cell development.
Y. Minegishi, J. Rohrer, M. Conley
1999Current opinion in pediatrics35 citations
Semantic Scholar
Genetic origins of hyper-IgE syndrome
Y. Minegishi, H. Karasuyama
2008Current Allergy and Asthma Reports34 citations
Semantic Scholar
IgG-mediated systemic anaphylaxis to protein antigen can be induced even under conditions of limited amounts of antibody and antigen.
Ryosuke Ishikawa, Y. Tsujimura, K. Obata, Y. Kawano +2 more
2010Biochemical and Biophysical Research Communications - BBRC32 citations
Semantic Scholar
Pre-B Cell Receptor Assesses the Quality of IgH Chains and Tunes the Pre-B Cell Repertoire by Delivering Differential Signals1
Y. Kawano, S. Yoshikawa, Y. Minegishi, H. Karasuyama
2006Journal of Immunology26 citations Open access
Semantic Scholar
Epstein-Barr virus-associated malignant lymphoma with macroamylasemia and monoclonal gammopathy in a patient with Wiskott-Aldrich syndrome.
Kunie Yoshida, Y. Minegishi, H. Okawa, J. Yata +3 more
1997Pediatric Hematology & Oncology22 citations
Semantic Scholar
Novel human mutation and CRISPR/Cas genome-edited mice reveal the importance of C-terminal domain of MSX1 in tooth and palate development
S. N. Mitsui, Akihiro Yasue, Kiyoshi Masuda, T. Naruto +5 more
2016Scientific Reports18 citations Open access
Semantic Scholar
Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF-α on macrophages through the autocrine action of IL-6.
Hiromi Ogawa, K. Mukai, Y. Kawano, Y. Minegishi +1 more
2012Biochemical and Biophysical Research Communications - BBRC18 citations
Semantic Scholar
Different Stabilities of the Structurally Related Receptors for IgE and IgG on the Cell Surface Are Determined by Length of the Stalk Region in Their α-Chains1
Toshiyuki Kubota, K. Mukai, Y. Minegishi, H. Karasuyama
2006Journal of Immunology18 citations
Semantic Scholar
Preferential utilization of the immature JH segment and absence of somatic mutation in the CDR3 junction of the Ig H chain gene in three X-linked severe combined immunodeficiency patients.
Y. Minegishi, H. Okawa, K. Sugamura, Jun-ichi Yata
1994International Immunology18 citations
Semantic Scholar
The skewed heavy-chain repertoire in peritoneal B-1 cells is predetermined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver.
S. Yoshikawa, Y. Kawano, Y. Minegishi, H. Karasuyama
2009International Immunology16 citations
Semantic Scholar
Selection of stereotyped VH81X-{micro}H chains via pre-B cell receptor early in ontogeny and their conservation in adults by marginal zone B cells.
Y. Kawano, S. Yoshikawa, Y. Minegishi, H. Karasuyama
2005International Immunology15 citations Open access
Semantic Scholar
Basophils play a pivotal role in IgG‐ but not IgE‐mediated systemic anaphylaxis in contrast to mast cells
H. Karasuyama, Y. Tsujimura, K. Obata, K. Mukai +3 more
200814 citations
Semantic Scholar

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