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L. Ivanciu · SciRah

Researcher profile · Semantic Scholar

L. Ivanciu

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L. Ivanciu — researcher profile on SciRah

h-index: 20
Works: 53
Citations: 1,923

Most-cited papers

An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia
A. Sehgal, Scott A. Barros, L. Ivanciu, B. Cooley +28 more
2015Nature Medicine290 citations
Semantic Scholar
Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice.
Jian-Xin Fu, H. Gerhardt, J. M. Mcdaniel, B. Xia +13 more
2008Journal of Clinical Investigation241 citations Open access
Semantic Scholar
Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis.
R. Silasi-Mansat, Hua Zhu, N. Popescu, G. Peer +9 more
2010Blood194 citations Open access
Semantic Scholar
Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1–derived O-glycans
Li-Jun Xia, T. Ju, A. Westmuckett, G. An +5 more
2004Journal of Cell Biology186 citations Open access
Semantic Scholar
Design and characterization of an APC-specific serpin for the treatment of hemophilia.
S. Polderdijk, T. Adams, L. Ivanciu, R. Camire +2 more
2017Blood138 citations Open access
Semantic Scholar
Tissue factor-dependent coagulation is preferentially up-regulated within arterial branching areas in a baboon model of Escherichia coli sepsis.
C. Lupu, A. Westmuckett, G. Peer, L. Ivanciu +3 more
2005American Journal of Pathology115 citations Open access
Semantic Scholar
New insights into the spatiotemporal localization of prothrombinase in vivo.
L. Ivanciu, S. Krishnaswamy, R. Camire
2014Blood96 citations Open access
Semantic Scholar
Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor.
Haiwang Tang, L. Ivanciu, N. Popescu, G. Peer +4 more
2007American Journal of Pathology95 citations Open access
Semantic Scholar
AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes
Daniel J. Hui, Shyrie C. Edmonson, G. Podsakoff, Gary C. Pien +6 more
2015Molecular Therapy: Methods & Clinical Development78 citations Open access
Semantic Scholar
Correction of the coagulation defect in hemophilia using a factor Xa variant with novel engineered protease function
L. Ivanciu, R. Toso, P. Margaritis, Giulia Pavani +11 more
2011Nature Biotechnology64 citations Open access
Semantic Scholar
In vivo detection of c-Met expression in a rat C6 glioma model
R. Towner, N. Smith, S. Doblas, Y. Tesiram +8 more
2007Journal of Cellular and Molecular Medicine56 citations Open access
Semantic Scholar
Spatio-temporal regulation of coagulation and platelet activation during the hemostatic response in vivo
L. Ivanciu, Timothy J. Stalker
2015Journal of Thrombosis and Haemostasis54 citations Open access
Semantic Scholar
Assessing blood clotting and coagulation factors in mice
Marisa A. Brake, L. Ivanciu, S. Maroney, Nicolas D. Martinez +2 more
2019Current Protocols in Mouse Biology39 citations Open access
Semantic Scholar
A rapid pro-hemostatic approach to overcome direct oral anticoagulants
N. Thalji, L. Ivanciu, R. Davidson, P. Gimotty +2 more
2016Nature Medicine39 citations Open access
Semantic Scholar
Adenovirus-mediated expression of tissue factor pathway inhibitor-2 inhibits endothelial cell migration and angiogenesis.
L. Ivanciu, R. Gerard, Haiwang Tang, F. Lupu +1 more
2006Arteriosclerosis, Thrombosis and Vascular Biology39 citations
Semantic Scholar
Engineered factor IX variants bypass FVIII and correct hemophilia A phenotype in mice.
P. Milanov, L. Ivanciu, Daniela Abriss, Patricia Quade-Lyssy +6 more
2012Blood31 citations Open access
Semantic Scholar
The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo.
Giulia Pavani, L. Ivanciu, A. Faella, Oscar A. Marcos-Contreras +1 more
2014Blood28 citations Open access
Semantic Scholar
Adenovirus-Mediated Expression of Tissue Factor Pathway Inhibitor-2 Inhibits Endothelial Cell Migration and Angiogenesis
L. Ivanciu, R. Gerard, Haiwang Tang, F. Lupu +1 more
200628 citations Open access
Semantic Scholar
Temporal dynamics of gene expression in the lung in a baboon model of E. coli sepsis
Hua Zhu, Yu-Hong Tang, L. Ivanciu, M. Centola +3 more
2007BMC Genomics26 citations Open access
Semantic Scholar
Hemostatic agents of broad applicability produced by selective tuning of factor Xa zymogenicity.
L. Ivanciu, R. Camire
2015Blood20 citations Open access
Semantic Scholar
Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo.
P. Margaritis, Elise Roy, A. Faella, H. Downey +5 more
2011Blood20 citations Open access
Semantic Scholar
Blood Coagulation Factor IX: Structure, Function, and Regulation
L. Ivanciu, Rodney M. Camire
2025IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology9 citations Open access
Semantic Scholar
Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of E. coli sepsis
F. Lupu, R. Silasi-Mansat, Hua Zhu, N. Popescu +6 more
20107 citations
Semantic Scholar
Microfluidic hemophilia models using blood from healthy donors
Xin-Ren Yu, K. Panckeri, L. Ivanciu, R. Camire +3 more
2019Research and Practice in Thrombosis and Haemostasis5 citations Open access
Semantic Scholar
One amino acid in mouse activated factor VII defines its endothelial protein C receptor (EPCR) binding and modulates its EPCR‐dependent hemostatic activity in vivo
G. Pavani, S. M. Zintner, L. Ivanciu, J. C. Small +3 more
2017Journal of Thrombosis and Haemostasis5 citations Open access
Semantic Scholar
Factor IXa variants resistant to plasma inhibitors enhance clot formation in vivo.
L. Ivanciu, V. Arruda, R. Camire
2023Blood4 citations Open access
Semantic Scholar
Hepatic plasminogen lowering with a galnac-conjugated siRNA reduces plasmin generation and fibrinolysis but has no effect on thrombin generation in rats and mice
Caitlin Cevasco, L. Ivanciu, J. Gansner, Rodney Camire +1 more
2025Blood3 citations
Semantic Scholar
Imaging coagulation reactions in vivo
L. Ivanciu, S. Krishnaswamy, R. Camire
2012Thrombosis Research3 citations Open access
Semantic Scholar
Caveolin-1 Deficiency in Mice Leads to Increased Protection Against Endotoxemia.
L. Ivanciu, C. Lupu, F. Lupu
20063 citations
Semantic Scholar
Packaging of supplemented urokinase into alpha granules of in vitro–grown megakaryocytes for targeted nascent clot lysis
M. Poncz, S. Zaitsev, H. Ahn, M. Kowalska +6 more
2024Blood Advances2 citations Open access
Semantic Scholar
Zymogen-like FXa Is a Potent Bypassing Agent for Reversal of Direct FXa Inhibitors in Vivo
N. Thalji, L. Ivanciu, R. Jasuja, S. Patel-Hett +3 more
20142 citations Open access
Semantic Scholar
Imaging of Coagulation Reactions During Thrombus Formation In Vivo with Novel Fluorescent Protein Derivatives
L. Ivanciu, R. Camire, S. Krishnaswamy
20102 citations
Semantic Scholar
Identification of Regulatory Loci for Megakaryocyte and Hepatocyte Coagulation Factor V Expression in Mice
Adrianna M. Jurek, Kailey MacFadyen, Marisa A. Brake, L. Ivanciu +2 more
2025bioRxiv1 citations Open access
Semantic Scholar
phenotype in mice Engineered factor IX variants bypass FVIII and correct hemophilia A
T. Tonn, M. Grez, E. Seifried, L. Ivanciu +2 more
20131 citations
Semantic Scholar
Bioengineering Factor VIII B-Domain Sequences Improves Function and Efficacy in Hemophilia A Models.
J. I. Siner, Nicholas P. Iacobelli, L. Ivanciu, D. Sabatino +3 more
20121 citations
Semantic Scholar
Phenotypic Correction of a Mouse Model of Hemophilia B by In Vivo Genetic Correction of the F9 Gene
Ho-Jun Li, V. Haurigot, Y. Doyon, James Li +12 more
20101 citations
Semantic Scholar
Factor Xa Variants as Novel Bypass Agents for the Treatment of Hemophilia in Murine Models
L. Ivanciu, R. Toso, A. Schlachterman, H. Downey +3 more
20081 citations
Semantic Scholar
Enhanced factor VIII activation accelerates thrombin generation and hemostatic potency in mice.
L. Ivanciu, M. Bos, S. Parthasarathy, R. Toso +1 more
2026Blood0 citations Open access
Semantic Scholar
Mim8 improves the In Vivo hemostasis of select hemophilia B causing factor IX variants
Sebastian E. Leyes Porello, Kyumin Lee, Julia Q Chau, L. Ivanciu +4 more
2025Blood0 citations
Semantic Scholar
A structural spotlight on extrinsic Xase complex.
L. Ivanciu
2025Blood0 citations
Semantic Scholar
Identification of genetic loci regulating plasma and platelet factor v expression in mice
Arina Rodionova, Adrianna M. Jurek, Kailey MacFadyen, Marisa Brake +3 more
2025Blood0 citations
Semantic Scholar
Comparison of hemostatic dosing of factor IX wild-type and padua (R338L) in multiple hemophilia B mouse models
Julia Q Chau, Sebastian E. Leyes Porello, L. Ivanciu, B. Samelson-Jones
2025Blood0 citations
Semantic Scholar
Optimization of a tail vein transection bleeding model in hemophilia A rats.
L. Ivanciu
2023Journal of Thrombosis and Haemostasis0 citations Open access
Semantic Scholar
An Antibody Targeting Human FV Promotes Thrombin Generation and Reduces Bleeding in a Hemophilic Mouse Model
Sean Quinn, L. Ivanciu, R. Davidson, Francis Ayombil +1 more
2022Blood0 citations Open access
Semantic Scholar
Protection of Human Factor V from Activated Protein C Using a Monoclonal Antibody-Biochemical Characterization and Evaluation Using a Mouse Injury Model
Sean Quinn, L. Ivanciu, R. Davidson, F. Ayombil +5 more
2021Blood0 citations Open access
Semantic Scholar
Abstract 144: The Contribution of Antithrombin-mediated FIXa Inhibition to the Regulation of Clot Formation in vivo
L. Ivanciu, V. Arruda, R. Camire
2019Arteriosclerosis, Thrombosis and Vascular Biology0 citations
Semantic Scholar
A Single Amino Acid in the Gla Domain Mouse FVIIa Allows Its Binding to the Endothelial Protein C Receptor and Enhances Its Coagulant Activity In Vivo
Giulia Pavani, L. Ivanciu, K. Stafford, P. Margaritis
20150 citations
Semantic Scholar
FVIIa Binding to the Endothelial Protein C Receptor Reduces Protein Recovery in Vivo
Giulia Pavani, L. Ivanciu, P. Margaritis
20120 citations
Semantic Scholar
Selective Alteration of FXa Zymogenicity Provides a Dynamic Range of Variants that Improve Hemostasis in Hemophilia
L. Ivanciu, R. Camire
20110 citations
Semantic Scholar
The Development of Novel Hemostatic Bypassing Molecules.
R. Camire, M. Bunce, L. Ivanciu, R. Toso +3 more
20090 citations
Semantic Scholar

Frequent co-authors

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R. Camire×20
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R. Camire — researcher profile on SciRah
F. Lupu×11
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C. Lupu×8
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V. Arruda×6
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P. Margaritis — researcher profile on SciRah

Giulia Pavani×5

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Giulia Pavani — researcher profile on SciRah

R. Silasi-Mansat×4

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Hua Zhu — researcher profile on SciRah

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G. Peer — researcher profile on SciRah

S. Krishnaswamy×4

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R. Toso — researcher profile on SciRah

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N. Popescu — researcher profile on SciRah